MX2011006320A - Analogos de glucagon. - Google Patents
Analogos de glucagon.Info
- Publication number
- MX2011006320A MX2011006320A MX2011006320A MX2011006320A MX2011006320A MX 2011006320 A MX2011006320 A MX 2011006320A MX 2011006320 A MX2011006320 A MX 2011006320A MX 2011006320 A MX2011006320 A MX 2011006320A MX 2011006320 A MX2011006320 A MX 2011006320A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- peptides
- glucagon
- glucagon analogues
- glp
- Prior art date
Links
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000007446 Glucagon-Like Peptide-1 Receptor Human genes 0.000 abstract 1
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 abstract 1
- 101500028775 Homo sapiens Glucagon Proteins 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000004584 weight gain Effects 0.000 abstract 1
- 235000019786 weight gain Nutrition 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La invención proporciona materiales y procedimientos para promover la pérdida de peso o prevenir el aumento de peso y en el tratamiento de diabetes, síndrome metabólico y trastornos asociados. En particular, la invención proporciona nuevos péptidos análogos de glucagón eficaces en tales procedimientos. Los péptidos pueden mediar su efecto teniendo selectividad aumentada para el receptor de GLP-1 en comparación con el glucagón humano.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2008/004132 WO2010070253A1 (en) | 2008-12-15 | 2008-12-15 | Glucagon analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011006320A true MX2011006320A (es) | 2011-09-22 |
Family
ID=40591868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011006320A MX2011006320A (es) | 2008-12-15 | 2008-12-15 | Analogos de glucagon. |
Country Status (16)
Country | Link |
---|---|
US (2) | US8642541B2 (es) |
EP (1) | EP2370461B1 (es) |
JP (1) | JP5635531B2 (es) |
KR (1) | KR20110126591A (es) |
CN (1) | CN102282166B (es) |
AU (1) | AU2008365557A1 (es) |
BR (1) | BRPI0823379A2 (es) |
CA (1) | CA2747155A1 (es) |
DK (1) | DK2370461T3 (es) |
EA (1) | EA020497B1 (es) |
ES (1) | ES2439499T3 (es) |
IL (1) | IL213479A0 (es) |
MX (1) | MX2011006320A (es) |
PL (1) | PL2370461T3 (es) |
WO (1) | WO2010070253A1 (es) |
ZA (1) | ZA201104592B (es) |
Families Citing this family (73)
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DK2370460T3 (da) | 2008-12-15 | 2014-08-04 | Zealand Pharma As | Glucagon analoger |
US8685919B2 (en) | 2008-12-15 | 2014-04-01 | Zealand Pharma A/S | Glucagon analogues |
HUE026255T2 (en) | 2009-07-13 | 2016-06-28 | Zealand Pharma As | Acylated glucagon analogues |
EP2563808B1 (en) | 2010-04-27 | 2016-12-07 | Zealand Pharma A/S | Peptide conjugates of glp-1 receptor agonists and gastrin and their use |
AR081975A1 (es) | 2010-06-23 | 2012-10-31 | Zealand Pharma As | Analogos de glucagon |
CN103068841A (zh) | 2010-06-24 | 2013-04-24 | 西兰制药公司 | 胰高血糖素类似物 |
WO2012098462A1 (en) * | 2011-01-20 | 2012-07-26 | Zealand Pharma A/S | Combination of acylated glucagon analogues with insulin analogues |
PT2718318T (pt) | 2011-06-10 | 2018-11-09 | Hanmi Science Co Ltd | Derivados de oxintomodulina inovadores e composição farmacêutica para tratar a obesidade compreendendo os mesmos |
PE20181268A1 (es) | 2011-06-17 | 2018-08-03 | Hanmi Science Co Ltd | Un conjugado que comprende oxintomodulina y un fragmento de inmunoglobulina, y el uso del mismo |
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WO2013064669A1 (en) | 2011-11-03 | 2013-05-10 | Zealand Pharma A/S | Glp-1 receptor agonist peptide gastrin conjugates |
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ES2620111T3 (es) * | 2012-07-23 | 2017-06-27 | Zealand Pharma A/S | Análogos de glucagón |
KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
WO2014041375A1 (en) | 2012-09-17 | 2014-03-20 | Imperial Innovations Limited | Peptide analogues of glucagon and glp1 |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
GB2505941A (en) * | 2012-09-17 | 2014-03-19 | Imp Innovations Ltd | Peptide analogues of glucagon for the treatment of obesity and diabetes |
WO2014049610A2 (en) | 2012-09-26 | 2014-04-03 | Cadila Healthcare Limited | Peptides as gip, glp-1 and glucagon receptors triple-agonist |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
PT2916819T (pt) | 2012-11-06 | 2019-10-28 | Hanmi Pharm Ind Co Ltd | Formulação líquida de conjugado proteico que compreende a oxintomodulina e um fragmento de imunoglobulina. |
KR101993393B1 (ko) * | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
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DK2976325T3 (en) | 2013-03-21 | 2017-06-06 | Sanofi Aventis Deutschland | SYNTHESIS OF PEPTIDE PRODUCTS CONTAINING CYCLIC IMID |
WO2014161835A1 (en) | 2013-04-03 | 2014-10-09 | Sanofi | Modified blood glucose regulating proteins with altered pharmacological activity profile and preparation thereof |
RS59124B1 (sr) | 2013-04-18 | 2019-09-30 | Novo Nordisk As | Stabilni, produženi koagonisti glp-1/glukagonskih receptora za medicinsku upotrebu |
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TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
CA2677932A1 (en) * | 2007-02-15 | 2008-08-21 | Indiana University Research And Technology Corporation | Glucagon/glp-1 receptor co-agonists |
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HUE030537T2 (en) | 2008-01-09 | 2017-05-29 | Sanofi Aventis Deutschland | New insulin analogues with a particularly prolonged effect profile |
AU2009203810B2 (en) | 2008-01-09 | 2013-07-25 | Sanofi-Aventis Deutschland Gmbh | Novel insulin derivatives having an extremely delayed time-action profile |
DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
US8993516B2 (en) | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
RU2010147076A (ru) | 2008-04-22 | 2012-05-27 | Кейз Вестерн Ризев Юнивесити (Us) | Аналоги инсулина специфичные к изоформам |
TWI451876B (zh) | 2008-06-13 | 2014-09-11 | Lilly Co Eli | 聚乙二醇化之離脯胰島素化合物 |
EP2300037B1 (en) | 2008-06-17 | 2016-03-30 | Indiana University Research and Technology Corporation | Glucagon/glp-1 receptor co-agonists |
MX2010012695A (es) | 2008-06-17 | 2011-03-15 | Univ Indiana Res & Tech Corp | Analogos de glucagon que exhiben solubilidad y estabilidad aumentadas en soluciones reguladoras de ph fisiologico. |
PL219335B1 (pl) | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
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DK2370460T3 (da) | 2008-12-15 | 2014-08-04 | Zealand Pharma As | Glucagon analoger |
MX2011006315A (es) | 2008-12-15 | 2011-09-22 | Zealand Pharma As | Analogos de glucagon. |
US8685919B2 (en) | 2008-12-15 | 2014-04-01 | Zealand Pharma A/S | Glucagon analogues |
AU2009335715B2 (en) | 2008-12-19 | 2016-09-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
CN102256992B (zh) | 2008-12-19 | 2015-04-22 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物 |
CN101519446A (zh) | 2009-03-31 | 2009-09-02 | 上海一就生物医药有限公司 | 一种重组人胰岛素及其类似物的制备方法 |
HUE026255T2 (en) | 2009-07-13 | 2016-06-28 | Zealand Pharma As | Acylated glucagon analogues |
KR20120128129A (ko) | 2010-01-20 | 2012-11-26 | 질랜드 파마 에이/에스 | 심장 병태의 치료 |
AR081975A1 (es) | 2010-06-23 | 2012-10-31 | Zealand Pharma As | Analogos de glucagon |
CN103068841A (zh) | 2010-06-24 | 2013-04-24 | 西兰制药公司 | 胰高血糖素类似物 |
WO2012098462A1 (en) | 2011-01-20 | 2012-07-26 | Zealand Pharma A/S | Combination of acylated glucagon analogues with insulin analogues |
-
2008
- 2008-12-15 KR KR1020117016186A patent/KR20110126591A/ko not_active Application Discontinuation
- 2008-12-15 AU AU2008365557A patent/AU2008365557A1/en not_active Abandoned
- 2008-12-15 CA CA2747155A patent/CA2747155A1/en not_active Abandoned
- 2008-12-15 ES ES08875672.1T patent/ES2439499T3/es active Active
- 2008-12-15 BR BRPI0823379-9A patent/BRPI0823379A2/pt not_active IP Right Cessation
- 2008-12-15 EA EA201190054A patent/EA020497B1/ru not_active IP Right Cessation
- 2008-12-15 JP JP2011540189A patent/JP5635531B2/ja not_active Expired - Fee Related
- 2008-12-15 CN CN200880132681.XA patent/CN102282166B/zh not_active Expired - Fee Related
- 2008-12-15 DK DK08875672.1T patent/DK2370461T3/da active
- 2008-12-15 PL PL08875672T patent/PL2370461T3/pl unknown
- 2008-12-15 EP EP08875672.1A patent/EP2370461B1/en not_active Not-in-force
- 2008-12-15 MX MX2011006320A patent/MX2011006320A/es active IP Right Grant
- 2008-12-15 WO PCT/GB2008/004132 patent/WO2010070253A1/en active Application Filing
- 2008-12-15 US US13/139,678 patent/US8642541B2/en not_active Expired - Fee Related
-
2011
- 2011-06-12 IL IL213479A patent/IL213479A0/en unknown
- 2011-06-22 ZA ZA2011/04592A patent/ZA201104592B/en unknown
-
2014
- 2014-01-07 US US14/149,640 patent/US20140127174A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20110126591A (ko) | 2011-11-23 |
EA201190054A1 (ru) | 2012-02-28 |
IL213479A0 (en) | 2011-07-31 |
BRPI0823379A2 (pt) | 2015-07-14 |
CN102282166B (zh) | 2015-04-01 |
ES2439499T3 (es) | 2014-01-23 |
AU2008365557A1 (en) | 2011-07-21 |
US8642541B2 (en) | 2014-02-04 |
PL2370461T3 (pl) | 2014-03-31 |
DK2370461T3 (da) | 2013-12-16 |
CN102282166A (zh) | 2011-12-14 |
JP5635531B2 (ja) | 2014-12-03 |
EP2370461A1 (en) | 2011-10-05 |
EA020497B1 (ru) | 2014-11-28 |
US20140127174A1 (en) | 2014-05-08 |
JP2012511901A (ja) | 2012-05-31 |
US20110293587A1 (en) | 2011-12-01 |
CA2747155A1 (en) | 2010-06-24 |
EP2370461B1 (en) | 2013-10-02 |
WO2010070253A1 (en) | 2010-06-24 |
ZA201104592B (en) | 2013-11-27 |
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