DK2370461T3 - Glucagonanaloger - Google Patents
GlucagonanalogerInfo
- Publication number
- DK2370461T3 DK2370461T3 DK08875672.1T DK08875672T DK2370461T3 DK 2370461 T3 DK2370461 T3 DK 2370461T3 DK 08875672 T DK08875672 T DK 08875672T DK 2370461 T3 DK2370461 T3 DK 2370461T3
- Authority
- DK
- Denmark
- Prior art keywords
- glucagon
- Prior art date
Links
- 102000051325 Glucagon Human genes 0.000 title 1
- 108060003199 Glucagon Proteins 0.000 title 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title 1
- 229960004666 glucagon Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2008/004132 WO2010070253A1 (en) | 2008-12-15 | 2008-12-15 | Glucagon analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2370461T3 true DK2370461T3 (da) | 2013-12-16 |
Family
ID=40591868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08875672.1T DK2370461T3 (da) | 2008-12-15 | 2008-12-15 | Glucagonanaloger |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8642541B2 (da) |
| EP (1) | EP2370461B1 (da) |
| JP (1) | JP5635531B2 (da) |
| KR (1) | KR20110126591A (da) |
| CN (1) | CN102282166B (da) |
| AU (1) | AU2008365557A1 (da) |
| BR (1) | BRPI0823379A2 (da) |
| CA (1) | CA2747155A1 (da) |
| DK (1) | DK2370461T3 (da) |
| EA (1) | EA020497B1 (da) |
| ES (1) | ES2439499T3 (da) |
| IL (1) | IL213479A0 (da) |
| MX (1) | MX2011006320A (da) |
| PL (1) | PL2370461T3 (da) |
| WO (1) | WO2010070253A1 (da) |
| ZA (1) | ZA201104592B (da) |
Families Citing this family (74)
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|---|---|---|---|---|
| KR101593406B1 (ko) | 2008-12-15 | 2016-02-12 | 질랜드 파마 에이/에스 | 글루카곤 유사체 |
| JP5635529B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| CA2747112A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| ES2537287T3 (es) | 2009-07-13 | 2015-06-05 | Zealand Pharma A/S | Análogos de glucagón acilados |
| SG184988A1 (en) | 2010-04-27 | 2012-11-29 | Zealand Pharma As | Peptide conjugates of glp-1 receptor agonists and gastrin and their use |
| AR081975A1 (es) | 2010-06-23 | 2012-10-31 | Zealand Pharma As | Analogos de glucagon |
| MX2012014961A (es) | 2010-06-24 | 2013-02-26 | Zealand Pharma As | Analogos de glucagon. |
| US20140011733A1 (en) * | 2011-01-20 | 2014-01-09 | Zealand Pharma A/S | Combination of acylated glucagon analogues with insulin analogues |
| EP3434687B1 (en) | 2011-06-10 | 2021-03-10 | Hanmi Science Co., Ltd. | Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same |
| CN109306015B (zh) | 2011-06-17 | 2022-04-26 | 韩美科学株式会社 | 包括泌酸调节肽和免疫球蛋白片段的结合物以及其应用 |
| EP2729493B1 (en) | 2011-07-04 | 2020-06-10 | IP2IPO Innovations Limited | Novel compounds and their effects on feeding behaviour |
| TWI596110B (zh) | 2011-09-23 | 2017-08-21 | 諾佛 儂迪克股份有限公司 | 新穎升糖素類似物 |
| KR20140100947A (ko) | 2011-11-03 | 2014-08-18 | 질랜드 파마 에이/에스 | Ｇｌｐ-1 수용체 효능제 펩타이드 가스트린 접합체들 |
| DE102012006242A1 (de) | 2012-03-28 | 2013-10-02 | Mitsubishi Polyester Film Gmbh | Biaxial gestreckte Polyesterfolie, die Ruß als Schwarzpigment enthält, sowie Verfahren zu ihrer Herstellung |
| NZ702333A (en) | 2012-05-03 | 2017-06-30 | Zealand Pharma As | Gip-glp-1 dual agonist compounds and methods |
| CN112142855A (zh) | 2012-05-18 | 2020-12-29 | 爱德迪安（北京）生物技术有限公司 | 用于糖尿病治疗的蛋白、蛋白缀合物及其应用 |
| AR091422A1 (es) | 2012-06-14 | 2015-02-04 | Sanofi Sa | Analogos peptidicos de la exendina 4 |
| CA2878991C (en) * | 2012-07-23 | 2021-12-07 | Zealand Pharma A/S | Glucagon analogues |
| KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| WO2014041375A1 (en) | 2012-09-17 | 2014-03-20 | Imperial Innovations Limited | Peptide analogues of glucagon and glp1 |
| GB2505941A (en) * | 2012-09-17 | 2014-03-19 | Imp Innovations Ltd | Peptide analogues of glucagon for the treatment of obesity and diabetes |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| AR092873A1 (es) | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| KR101993393B1 (ko) * | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
| CA2890324C (en) | 2012-11-06 | 2021-02-23 | Hanmi Pharm. Co., Ltd. | Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment |
| HUE035803T2 (en) | 2012-12-21 | 2018-05-28 | Sanofi Sa | Dual GLP1 / GIP or trigonal GLP1 / GIP / glucagon agonists |
| TWI629007B (zh) | 2012-12-21 | 2018-07-11 | Philip Morris Products S. A. | 包含氣流導向元件的煙品 |
| US10087221B2 (en) | 2013-03-21 | 2018-10-02 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
| ES2624961T3 (es) | 2013-03-21 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Síntesis de productos de péptido que contienen imida cíclica |
| AR095986A1 (es) | 2013-04-03 | 2015-11-25 | Sanofi Sa | Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas |
| AU2014255608B2 (en) | 2013-04-18 | 2018-01-25 | Novo Nordisk A/S | Stable, protracted GLP-1/glucagon receptor co-agonists for medical use |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| US9896495B2 (en) * | 2013-10-17 | 2018-02-20 | Zealand Pharma A/S | Acylated glucagon analogues |
| KR102310392B1 (ko) | 2013-11-06 | 2021-10-13 | 질랜드 파마 에이/에스 | 글루카곤-ｇｌｐ-1-ｇｉｐ 삼원 효능제 화합물 |
| JP6682432B2 (ja) | 2013-11-06 | 2020-04-15 | ジーランド ファーマ アクティーゼルスカブ | Ｇｉｐ−ｇｌｐ−１デュアルアゴニスト化合物及び方法 |
| WO2015081891A1 (en) | 2013-12-06 | 2015-06-11 | Baikang (Suzhou) Co., Ltd | Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／ｇｉｐ受體促效劑 |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086731A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| CN106536547A (zh) | 2014-06-04 | 2017-03-22 | 诺和诺德股份有限公司 | 用于医疗用途的glp‑1/胰高血糖素受体共激动剂 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| JP5912151B2 (ja) * | 2014-07-04 | 2016-04-27 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| TWI772252B (zh) | 2014-09-16 | 2022-08-01 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
| WO2016066744A2 (en) | 2014-10-29 | 2016-05-06 | Zealand Pharma A/S | Gip agonist compounds and methods |
| KR102418477B1 (ko) | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
| EP3271381B1 (en) | 2015-03-18 | 2021-09-08 | Zealand Pharma A/S | Amylin analogues |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| KR20170137198A (ko) | 2015-04-16 | 2017-12-12 | 질랜드 파마 에이/에스 | 아실화된 글루카곤 유사체 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| WO2016198628A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| WO2017214543A1 (en) | 2016-06-09 | 2017-12-14 | Amidebio, Llc | Glucagon analogs and methods of use thereof |
| ES2874587T3 (es) | 2016-08-05 | 2021-11-05 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina para su uso como inhibidores de la grelina O-aciltransferasa (GOAT) |
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| AR110299A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
| MX2019006486A (es) | 2016-12-09 | 2019-08-01 | Zealand Pharma As | Agonistas duales acilados de glp-1/glp-2. |
| KR102587196B1 (ko) | 2016-12-09 | 2023-10-10 | 질랜드 파마 에이/에스 | Glp-1/glp-2 이중 효능제 |
| US11236142B2 (en) * | 2017-08-16 | 2022-02-01 | Dong-A St Co., Ltd. | Acylated oxyntomodulin peptide analog |
| CN109942696A (zh) * | 2017-12-21 | 2019-06-28 | 中国药科大学 | 长效化胰高血糖素样肽－1（glp－1）类似物及其应用 |
| PE20210658A1 (es) | 2018-02-02 | 2021-03-31 | Boehringer Ingelheim Int | Derivados de triazolopirimidina para usar como inhibidores de ghrelin o-aciltransferasa (goat) |
| US11136337B2 (en) | 2018-02-02 | 2021-10-05 | Boehringer Ingelheim International Gmbh | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors |
| CN111655699B (zh) | 2018-02-02 | 2023-07-14 | 勃林格殷格翰国际有限公司 | 用作饥饿素o-酰基转移酶(goat)抑制剂的杂环基取代的噁二唑并吡啶衍生物 |
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| EP3901173A4 (en) | 2018-12-21 | 2022-11-23 | Jiangsu Hengrui Medicine Co., Ltd. | BISPECIFIC PROTEIN |
| CA3156452A1 (en) | 2019-11-11 | 2021-05-20 | Boehringer Ingelheim International Gmbh | NPY2 RECEPTOR AGONISTS |
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| EP4192853A1 (en) | 2020-08-07 | 2023-06-14 | Boehringer Ingelheim International GmbH | Soluble npy2 receptor agonists |
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|---|---|---|---|---|
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| EP1826216A1 (en) | 1996-08-30 | 2007-08-29 | Novo Nordisk A/S | Glp-1 derivatives |
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-
2008
- 2008-12-15 KR KR1020117016186A patent/KR20110126591A/ko not_active Application Discontinuation
- 2008-12-15 WO PCT/GB2008/004132 patent/WO2010070253A1/en active Application Filing
- 2008-12-15 CA CA2747155A patent/CA2747155A1/en not_active Abandoned
- 2008-12-15 MX MX2011006320A patent/MX2011006320A/es active IP Right Grant
- 2008-12-15 DK DK08875672.1T patent/DK2370461T3/da active
- 2008-12-15 EP EP08875672.1A patent/EP2370461B1/en not_active Not-in-force
- 2008-12-15 BR BRPI0823379-9A patent/BRPI0823379A2/pt not_active IP Right Cessation
- 2008-12-15 PL PL08875672T patent/PL2370461T3/pl unknown
- 2008-12-15 EA EA201190054A patent/EA020497B1/ru not_active IP Right Cessation
- 2008-12-15 AU AU2008365557A patent/AU2008365557A1/en not_active Abandoned
- 2008-12-15 ES ES08875672.1T patent/ES2439499T3/es active Active
- 2008-12-15 JP JP2011540189A patent/JP5635531B2/ja not_active Expired - Fee Related
- 2008-12-15 US US13/139,678 patent/US8642541B2/en not_active Expired - Fee Related
- 2008-12-15 CN CN200880132681.XA patent/CN102282166B/zh not_active Expired - Fee Related
-
2011
- 2011-06-12 IL IL213479A patent/IL213479A0/en unknown
- 2011-06-22 ZA ZA2011/04592A patent/ZA201104592B/en unknown
-
2014
- 2014-01-07 US US14/149,640 patent/US20140127174A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5635531B2 (ja) | 2014-12-03 |
| ES2439499T3 (es) | 2014-01-23 |
| US20110293587A1 (en) | 2011-12-01 |
| EA201190054A1 (ru) | 2012-02-28 |
| US20140127174A1 (en) | 2014-05-08 |
| AU2008365557A1 (en) | 2011-07-21 |
| EP2370461B1 (en) | 2013-10-02 |
| KR20110126591A (ko) | 2011-11-23 |
| PL2370461T3 (pl) | 2014-03-31 |
| ZA201104592B (en) | 2013-11-27 |
| EA020497B1 (ru) | 2014-11-28 |
| MX2011006320A (es) | 2011-09-22 |
| EP2370461A1 (en) | 2011-10-05 |
| WO2010070253A1 (en) | 2010-06-24 |
| CN102282166B (zh) | 2015-04-01 |
| IL213479A0 (en) | 2011-07-31 |
| CA2747155A1 (en) | 2010-06-24 |
| BRPI0823379A2 (pt) | 2015-07-14 |
| US8642541B2 (en) | 2014-02-04 |
| JP2012511901A (ja) | 2012-05-31 |
| CN102282166A (zh) | 2011-12-14 |
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