JOP20200190A1 - مشتقات أوكسادايازولو بيريدين بها استبدال ببنزيل -، (بيريدين -3- يل) ميثيل - أو (بيريدين -4- يل) ميثيل كمثبطات جريلين o- أسيل ترانسفيراز (goat) - Google Patents
مشتقات أوكسادايازولو بيريدين بها استبدال ببنزيل -، (بيريدين -3- يل) ميثيل - أو (بيريدين -4- يل) ميثيل كمثبطات جريلين o- أسيل ترانسفيراز (goat)Info
- Publication number
- JOP20200190A1 JOP20200190A1 JOP/2020/0190A JOP20200190A JOP20200190A1 JO P20200190 A1 JOP20200190 A1 JO P20200190A1 JO P20200190 A JOP20200190 A JO P20200190A JO P20200190 A1 JOP20200190 A1 JO P20200190A1
- Authority
- JO
- Jordan
- Prior art keywords
- pyridin
- methyl
- ghrelin
- goat
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
يتعلق الاختراع الحالي بمركبات بالصيغة العامة I، حيث تكون المجموعات R1 وR2 كما تم تعريفها في عنصر الحماية 1، حيث يكون لها خواص صيدلانية مفيدة، بالتحديد ترتبط بجريلين O- أسيل ترانسفيراز (GOAT) وتعدّل نشاطه. تكون المركبات مناسبة لمعالجة والوقاية من أمراض حيث يمكن أن تتأثر بهذا المستقبل، مثل الأمراض الأيضية، بالتحديد السمنة.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18154824 | 2018-02-02 | ||
PCT/EP2019/051989 WO2019149657A1 (en) | 2018-02-02 | 2019-01-28 | Benzyl-, (pyridin-3-yl)methyl- or (pyridin-4-yl)methyl-substituted oxadiazolopyridine derivatives as ghrelin o-acyl transferase (goat) inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20200190A1 true JOP20200190A1 (ar) | 2020-07-29 |
Family
ID=61157050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2020/0190A JOP20200190A1 (ar) | 2018-02-02 | 2019-01-28 | مشتقات أوكسادايازولو بيريدين بها استبدال ببنزيل -، (بيريدين -3- يل) ميثيل - أو (بيريدين -4- يل) ميثيل كمثبطات جريلين o- أسيل ترانسفيراز (goat) |
Country Status (21)
Country | Link |
---|---|
US (1) | US11254688B2 (ar) |
EP (1) | EP3746451B1 (ar) |
JP (1) | JP7015396B2 (ar) |
KR (1) | KR20200116978A (ar) |
CN (1) | CN111655700B (ar) |
AU (1) | AU2019215707A1 (ar) |
BR (1) | BR112020013082A2 (ar) |
CA (1) | CA3087826A1 (ar) |
CL (1) | CL2020001907A1 (ar) |
CO (1) | CO2020009299A2 (ar) |
CR (1) | CR20200332A (ar) |
EA (1) | EA202091805A1 (ar) |
EC (1) | ECSP20050785A (ar) |
IL (1) | IL276136A (ar) |
JO (1) | JOP20200190A1 (ar) |
MA (1) | MA53075A (ar) |
MX (1) | MX2020008053A (ar) |
PE (1) | PE20210174A1 (ar) |
PH (1) | PH12020551168A1 (ar) |
SG (1) | SG11202006125VA (ar) |
WO (1) | WO2019149657A1 (ar) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2874587T3 (es) | 2016-08-05 | 2021-11-05 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina para su uso como inhibidores de la grelina O-aciltransferasa (GOAT) |
WO2019149658A1 (en) * | 2018-02-02 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
CA3087925A1 (en) | 2018-02-02 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
EP3746451B1 (en) | 2018-02-02 | 2023-07-12 | Boehringer Ingelheim International GmbH | Benzyl-, (pyridin-3-yl)methyl- or (pyridin-4-yl)methyl-substituted oxadiazolopyridine derivatives as ghrelin o-acyl transferase (goat) inhibitors |
EP4153600A1 (en) | 2020-05-22 | 2023-03-29 | Boehringer Ingelheim International GmbH | Continuous process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate |
JP2023526351A (ja) | 2020-05-22 | 2023-06-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルキル7-アミノ-5-メチル-[1,2,5]オキサジアゾロ[3,4-b]ピリジンカルボキシレートの製造方法 |
WO2023114472A1 (en) * | 2021-12-16 | 2023-06-22 | Icahn School Of Medicine At Mount Sinai | Heterocyclic compounds as 5ht2a biased agonists |
CN114426516B (zh) * | 2022-02-16 | 2022-11-04 | 安徽有吉医药科技有限公司 | 一种2-氨基-3-溴吡啶的制备方法 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004082383A1 (en) | 2003-03-17 | 2004-09-30 | Basf Aktiengesellschaft | Use of triazolopyrimidines for combating nematode diseases of plants |
JP2009542809A (ja) * | 2006-07-12 | 2009-12-03 | メルク エンド カムパニー インコーポレーテッド | グレリン受容体アンタゴニストとしての置換ピラゾール |
EA017849B1 (ru) | 2007-02-15 | 2013-03-29 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Соагонисты глюкагоновых/glp-1-рецепторов |
IL309201A (en) | 2007-04-11 | 2024-02-01 | Canbas Co Ltd | Compounds with anticancer activity |
JP2010527951A (ja) | 2007-05-24 | 2010-08-19 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | キナーゼ阻害剤としての新規なスルホキシイミン置換型キノリン及びキナゾリン誘導体 |
JP5385266B2 (ja) | 2007-06-15 | 2014-01-08 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
FR2934058B1 (fr) | 2008-07-15 | 2010-09-24 | Centre Nat Rech Scient | Dispositif de projection interferometrique a trois ouvertures pour produire une tache constituee de structures fines |
FR2933989B1 (fr) | 2008-07-16 | 2013-03-08 | Commissariat Energie Atomique | Procede de purification de microorganismes presents dans des echantillons liquides |
FR2933975B1 (fr) | 2008-07-17 | 2011-02-18 | Servier Lab | Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
US8642540B2 (en) | 2008-12-15 | 2014-02-04 | Zealand Pharma A/S | Glucagon analogues |
CA2747109A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
PL2370462T3 (pl) | 2008-12-15 | 2015-01-30 | Zealand Pharma As | Analogi glukagonu |
EA020497B1 (ru) | 2008-12-15 | 2014-11-28 | Зилэнд Фарма А/С | Аналоги глюкагона |
EA022816B1 (ru) | 2009-07-13 | 2016-03-31 | Зилэнд Фарма А/С | Ацилированные аналоги глюкагона |
US20110078154A1 (en) | 2009-09-28 | 2011-03-31 | Accenture Global Services Gmbh | Recruitment screening tool |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
CA2802897A1 (en) | 2010-06-24 | 2011-12-29 | Zealand Pharma A/S | Glucagon analogues |
EP2793931A2 (en) | 2011-12-23 | 2014-10-29 | Zealand Pharma A/S | Glucagon analogues |
ES2640258T3 (es) * | 2012-02-24 | 2017-11-02 | Takeda Pharmaceutical Company Limited | Compuesto anular aromático como inhibidor de grelina o-aciltransferasa |
US9492448B2 (en) | 2012-06-20 | 2016-11-15 | University Of Virginia Patent Foundation | Compositions and methods for regulating glucose homeostasis and insulin action |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
US20170275249A1 (en) * | 2014-09-17 | 2017-09-28 | The Regents Of The University Of California | Small lipopeptidomimetic inhibitors of ghrelin o-acyl transferase |
JP6615896B2 (ja) * | 2015-01-30 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルドステロン合成酵素阻害剤 |
AR104672A1 (es) * | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
AR104673A1 (es) * | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
MX2018004947A (es) | 2015-10-22 | 2018-11-09 | Cavion Inc | Metodos para el tratamiento de sindrome de angelman y de los trastornos relacionados. |
ES2874587T3 (es) * | 2016-08-05 | 2021-11-05 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina para su uso como inhibidores de la grelina O-aciltransferasa (GOAT) |
SG10202101247QA (en) * | 2016-08-11 | 2021-03-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of irritable bowel syndrome |
WO2018044663A1 (en) | 2016-08-29 | 2018-03-08 | Merck Sharp & Dohme Corp. | Novel substituted n'-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
EP3746451B1 (en) | 2018-02-02 | 2023-07-12 | Boehringer Ingelheim International GmbH | Benzyl-, (pyridin-3-yl)methyl- or (pyridin-4-yl)methyl-substituted oxadiazolopyridine derivatives as ghrelin o-acyl transferase (goat) inhibitors |
WO2019149658A1 (en) | 2018-02-02 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
MX2020008116A (es) | 2018-02-02 | 2020-09-25 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina sustituidos con heterociclilo para usar como inhibidores de ghrelin o-aciltransferasa (goat). |
CA3087925A1 (en) | 2018-02-02 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
-
2019
- 2019-01-28 EP EP19702246.0A patent/EP3746451B1/en active Active
- 2019-01-28 US US16/966,483 patent/US11254688B2/en active Active
- 2019-01-28 AU AU2019215707A patent/AU2019215707A1/en not_active Abandoned
- 2019-01-28 EA EA202091805A patent/EA202091805A1/ru unknown
- 2019-01-28 CR CR20200332A patent/CR20200332A/es unknown
- 2019-01-28 PE PE2020001161A patent/PE20210174A1/es unknown
- 2019-01-28 CA CA3087826A patent/CA3087826A1/en not_active Abandoned
- 2019-01-28 JO JOP/2020/0190A patent/JOP20200190A1/ar unknown
- 2019-01-28 CN CN201980010416.2A patent/CN111655700B/zh active Active
- 2019-01-28 MX MX2020008053A patent/MX2020008053A/es unknown
- 2019-01-28 BR BR112020013082-6A patent/BR112020013082A2/pt not_active Application Discontinuation
- 2019-01-28 KR KR1020207025417A patent/KR20200116978A/ko unknown
- 2019-01-28 MA MA053075A patent/MA53075A/fr unknown
- 2019-01-28 JP JP2020541873A patent/JP7015396B2/ja active Active
- 2019-01-28 WO PCT/EP2019/051989 patent/WO2019149657A1/en unknown
- 2019-01-28 SG SG11202006125VA patent/SG11202006125VA/en unknown
-
2020
- 2020-07-19 IL IL276136A patent/IL276136A/en unknown
- 2020-07-21 CL CL2020001907A patent/CL2020001907A1/es unknown
- 2020-07-28 CO CONC2020/0009299A patent/CO2020009299A2/es unknown
- 2020-07-31 PH PH12020551168A patent/PH12020551168A1/en unknown
- 2020-08-24 EC ECSENADI202050785A patent/ECSP20050785A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CR20200332A (es) | 2020-09-03 |
US11254688B2 (en) | 2022-02-22 |
PH12020551168A1 (en) | 2021-05-31 |
JP2021512113A (ja) | 2021-05-13 |
KR20200116978A (ko) | 2020-10-13 |
JP7015396B2 (ja) | 2022-02-15 |
CN111655700A (zh) | 2020-09-11 |
CA3087826A1 (en) | 2019-08-08 |
ECSP20050785A (es) | 2020-09-30 |
CL2020001907A1 (es) | 2020-10-30 |
PE20210174A1 (es) | 2021-01-29 |
MX2020008053A (es) | 2020-09-07 |
IL276136A (en) | 2020-09-30 |
MA53075A (fr) | 2021-05-12 |
EA202091805A1 (ru) | 2020-12-16 |
AU2019215707A1 (en) | 2020-07-09 |
SG11202006125VA (en) | 2020-07-29 |
CN111655700B (zh) | 2023-07-18 |
BR112020013082A2 (pt) | 2020-12-01 |
US20210053985A1 (en) | 2021-02-25 |
WO2019149657A1 (en) | 2019-08-08 |
EP3746451A1 (en) | 2020-12-09 |
EP3746451B1 (en) | 2023-07-12 |
CO2020009299A2 (es) | 2020-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12020551168A1 (en) | Benzyl-, (pyridin-3-yl)methyl- or (pyridin-4-yl)methyl-substituted oxadiazolopyridine derivatives as ghrelin o-acyl transferase (goat) inhibitors | |
PH12020551170A1 (en) | Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors | |
PH12019500254A1 (en) | Oxadiazolopyridine derivates for use as ghrelin o-acyl transferase (goat) inhibitors | |
PH12020551169A1 (en) | Heterocyclyl-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors | |
MX2021005311A (es) | Salicilamidas de espiroheptanos y compuestos relacionados como inhibidores de cinasa rho (rock). | |
PH12020551062A1 (en) | 1,2,4-oxadiazole compounds as inhibitors of cd47 signalling pathways | |
PH12020551208A1 (en) | Compounds for the treatment of kinase-dependent disorders | |
MX2020001103A (es) | Inhibidores de tirosina cinasa 2 (tyk2) y usos de los mismos. | |
TN2017000009A1 (en) | Spirocycloheptanes as inhibitors of rock. | |
MX2020005515A (es) | Compuestos de indol sustituidos con amida, utiles como inhibidores de receptores de tipo toll (tlr). | |
MX2020006181A (es) | Componentes heterociclicos biciclicos sustituidos como inhibidores de prmt5. | |
MX2020006168A (es) | Compuestos de 4-azaindol. | |
MX369159B (es) | Derivados de 3-(2-aminopiridin-4-il)-5-(3-hidroxipropinil)-1h-pirr olo[2,3-c]piridina como inhibidores de la nik para el tratamiento del cancer. | |
MX2020005462A (es) | Compuestos de indol sustituidos utiles como inhibidores de receptores tipo toll (tlr). | |
MX2020006014A (es) | Compuestos de diazaindol. | |
MX2021006619A (es) | Inhibidores de la tirosina quinasa, composiciones y sus metodos. | |
MX2021001471A (es) | Benzimidazoles sustituidos como inhibidores de peptidil arginina deiminasa 4 (pad4). | |
MX2020001531A (es) | Nuevos compuestos hetorociclicos como inhibidores de cdk8/19. | |
MX2012001999A (es) | Uso de inhibidores nkg2d para tratar enfermedades cardiovasculares y metabolicas, tal como diabetes tipo 2. | |
MX2023000198A (es) | Inhibidores de atr y usos de estos. | |
MX2020005471A (es) | Compuestos para el tratamiento de trastornos neuromusculares. | |
EA201991509A1 (ru) | Аминозамещенные гетероциклические соединения в качестве ингибиторов ehmt2 и способы их применения | |
MX2020005398A (es) | Compuestos para el tratamiento de trastornos neuromusculares. |