BR112019010624A2 - agonistas duplos de glp-1/glp-2 acilados e composição - Google Patents

agonistas duplos de glp-1/glp-2 acilados e composição

Info

Publication number
BR112019010624A2
BR112019010624A2 BR112019010624A BR112019010624A BR112019010624A2 BR 112019010624 A2 BR112019010624 A2 BR 112019010624A2 BR 112019010624 A BR112019010624 A BR 112019010624A BR 112019010624 A BR112019010624 A BR 112019010624A BR 112019010624 A2 BR112019010624 A2 BR 112019010624A2
Authority
BR
Brazil
Prior art keywords
glp
agonists
composition
double acylated
glucagon
Prior art date
Application number
BR112019010624A
Other languages
English (en)
Inventor
Vincent Gordon Edwards Alistair
Due Larsen Bjarne
Griffin Jonathan
Giehm Lise
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Publication of BR112019010624A2 publication Critical patent/BR112019010624A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

a presente invenção refere-se a compostos que têm atividade agonista nos receptores de glp-1 (peptídeo semelhante a glucagon 1) e glp-2 (peptídeo semelhante a glucagon 2). os compostos encontram uso, entre outras coisas, na profilaxia ou tratamento de dano e disfunção intestinal, regulação do peso corporal e profilaxia ou tratamento da disfunção metabólica.
BR112019010624A 2016-12-09 2017-12-11 agonistas duplos de glp-1/glp-2 acilados e composição BR112019010624A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201600757 2016-12-09
PCT/EP2017/082290 WO2018104561A1 (en) 2016-12-09 2017-12-11 Acylated glp-1/glp-2 dual agonists

Publications (1)

Publication Number Publication Date
BR112019010624A2 true BR112019010624A2 (pt) 2019-10-22

Family

ID=61005766

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019010624A BR112019010624A2 (pt) 2016-12-09 2017-12-11 agonistas duplos de glp-1/glp-2 acilados e composição

Country Status (17)

Country Link
US (4) US20190142904A1 (pt)
EP (1) EP3551651B1 (pt)
JP (2) JP6563614B1 (pt)
KR (1) KR102502040B1 (pt)
CN (2) CN117384274A (pt)
AU (1) AU2017371516C1 (pt)
BR (1) BR112019010624A2 (pt)
CA (1) CA3043151A1 (pt)
CL (1) CL2019001552A1 (pt)
CO (1) CO2019005924A2 (pt)
DK (1) DK3551651T3 (pt)
IL (1) IL266219B2 (pt)
MX (1) MX2019006486A (pt)
PE (1) PE20191083A1 (pt)
RU (1) RU2753193C2 (pt)
SG (2) SG10201911851VA (pt)
WO (1) WO2018104561A1 (pt)

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CN113966226A (zh) * 2019-06-14 2022-01-21 西兰制药公司 双重glp1/2激动剂的药物肠胃外组合物
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
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US20230110689A1 (en) 2020-03-30 2023-04-13 Zealand Pharma A/S Agonist combination
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JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター
WO2022129311A1 (en) 2020-12-16 2022-06-23 Zealand Pharma A/S Pharmaceutical composition of glp-1/glp-2 dual agonists
CN116723850A (zh) 2020-12-16 2023-09-08 西兰制药公司 Glp-1/glp-2双重激动剂的药物组合物
TW202241492A (zh) 2020-12-16 2022-11-01 丹麥商西蘭製藥公司 Ｇｌｐ－１／ｇｌｐ－２雙重促效劑之醫藥組合物
EP4294424A1 (en) 2021-02-18 2023-12-27 Zealand Pharma A/S Composition for treating short bowel syndrome
CA3228429A1 (en) 2021-09-03 2023-03-09 Mikkel Askjar Agersnap Dosage regime
WO2023111273A1 (en) * 2021-12-17 2023-06-22 Bainan Biotech Aps Peptide dual agonists of gipr and glp2r
WO2023132609A1 (ko) * 2022-01-05 2023-07-13 주식회사 휴온스랩 지속형 지방산-펩타이드 유도체 및 이의 용도
CN116655772A (zh) * 2022-02-18 2023-08-29 成都奥达生物科技有限公司 一种长效的glp-1/glp-2双激动剂化合物
WO2024061919A1 (en) 2022-09-19 2024-03-28 Zealand Pharma A/S Combination therapy

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