ATE290014T1 - Festphasen-peptidsynthese - Google Patents

Festphasen-peptidsynthese

Info

Publication number
ATE290014T1
ATE290014T1 AT97939974T AT97939974T ATE290014T1 AT E290014 T1 ATE290014 T1 AT E290014T1 AT 97939974 T AT97939974 T AT 97939974T AT 97939974 T AT97939974 T AT 97939974T AT E290014 T1 ATE290014 T1 AT E290014T1
Authority
AT
Austria
Prior art keywords
peptide synthesis
phase peptide
solid phase
solid
relates
Prior art date
Application number
AT97939974T
Other languages
English (en)
Inventor
Arne Holm
Bjarne Due Larsen
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Application granted granted Critical
Publication of ATE290014T1 publication Critical patent/ATE290014T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Prostheses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97939974T 1996-09-09 1997-09-09 Festphasen-peptidsynthese ATE290014T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK97196 1996-09-09
PCT/DK1997/000375 WO1998011125A1 (en) 1996-09-09 1997-09-09 Improved solid-phase peptide synthesis and agent for use in such synthesis

Publications (1)

Publication Number Publication Date
ATE290014T1 true ATE290014T1 (de) 2005-03-15

Family

ID=8099561

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97939974T ATE290014T1 (de) 1996-09-09 1997-09-09 Festphasen-peptidsynthese

Country Status (14)

Country Link
US (1) US7348404B2 (de)
EP (1) EP0929567B1 (de)
JP (1) JP4405594B2 (de)
AT (1) ATE290014T1 (de)
AU (1) AU723268B2 (de)
CA (1) CA2265900C (de)
CZ (1) CZ295838B6 (de)
DE (1) DE69732640T2 (de)
DK (1) DK0929567T3 (de)
ES (1) ES2239364T3 (de)
HU (1) HU230354B1 (de)
IL (1) IL128829A (de)
PT (1) PT929567E (de)
WO (1) WO1998011125A1 (de)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1950223A3 (de) * 1998-03-09 2009-05-13 Zealand Pharma A/S Pharmakologisch aktive Peptidkonjugate mit verringerter enzymatischer Hydrolysetendenz
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
US7550425B2 (en) 2000-06-16 2009-06-23 Zealand Pharma A/S Diuretic peptide conjugates
DE602005023429D1 (de) 2004-10-19 2010-10-21 Lonza Ag Verfahren zur festphasen-peptidsynthese
NZ591178A (en) 2005-05-04 2012-06-29 Zealand Pharma As Glucagon-like-peptide-2 (glp-2) analogues
GB0514071D0 (en) 2005-07-07 2005-08-17 Zealand Pharma As N- or C- terminally modified small peptides
EP1975142A4 (de) * 2005-11-22 2009-12-02 Univ Nihon Automatisierte festphasensynthese von pyrrol-imidazol-polyamid
PT1966130E (pt) 2005-12-23 2014-01-30 Zealand Pharma As Compostos miméticos de lisina modificados
EP1991560B1 (de) * 2006-02-20 2018-04-04 Ewha University-Industry Collaboration Foundation Peptid mit zellmembranpenetrierender wirkung
WO2007114454A1 (ja) * 2006-03-29 2007-10-11 Otsuka Chemical Co., Ltd. ペプチドのチオエステル化合物の製造方法
NZ576260A (en) 2006-11-08 2012-04-27 Zealand Pharma As GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) ANALOGUES comprising one of more substitutions as compared to h[Gly2]GLP-2
US7994122B2 (en) 2007-06-15 2011-08-09 Zealand Pharma A/S Glucagon analogues
JP5635529B2 (ja) 2008-12-15 2014-12-03 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
KR20110126591A (ko) 2008-12-15 2011-11-23 질랜드 파마 에이/에스 글루카곤 유사체
KR101593406B1 (ko) 2008-12-15 2016-02-12 질랜드 파마 에이/에스 글루카곤 유사체
CA2747112A1 (en) 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
ES2537287T3 (es) 2009-07-13 2015-06-05 Zealand Pharma A/S Análogos de glucagón acilados
SG184988A1 (en) 2010-04-27 2012-11-29 Zealand Pharma As Peptide conjugates of glp-1 receptor agonists and gastrin and their use
AR081975A1 (es) 2010-06-23 2012-10-31 Zealand Pharma As Analogos de glucagon
MX2012014961A (es) 2010-06-24 2013-02-26 Zealand Pharma As Analogos de glucagon.
US20140011733A1 (en) 2011-01-20 2014-01-09 Zealand Pharma A/S Combination of acylated glucagon analogues with insulin analogues
KR20140100947A (ko) 2011-11-03 2014-08-18 질랜드 파마 에이/에스 Ｇｌｐ-1 수용체 효능제 펩타이드 가스트린 접합체들
AU2012357739A1 (en) 2011-12-23 2014-07-03 Boehringer Ingelheim International Gmbh Glucagon analogues
WO2013098408A1 (en) 2011-12-30 2013-07-04 Zealand Pharma A/S Glucagon and cck receptor agonist peptide conjugates
AR089860A1 (es) 2012-02-03 2014-09-24 Zealand Pharma As Analogos de la grelina
NZ702333A (en) 2012-05-03 2017-06-30 Zealand Pharma As Gip-glp-1 dual agonist compounds and methods
BR112014027345A2 (pt) 2012-05-03 2019-09-03 Zealand Pharma As análogos de peptídeo 2 semelhante ao glucagon (glp-2)
CA2878991C (en) 2012-07-23 2021-12-07 Zealand Pharma A/S Glucagon analogues
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
MX2015012808A (es) 2013-03-12 2016-05-31 Molecular Templates Inc Inmunotoxinas de union a cd20 para inducir internalizacion celular y metodos que usan las mismas.
US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
US9169287B2 (en) 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
ES2624961T3 (es) 2013-03-21 2017-07-18 Sanofi-Aventis Deutschland Gmbh Síntesis de productos de péptido que contienen imida cíclica
US10087221B2 (en) 2013-03-21 2018-10-02 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
US9896495B2 (en) 2013-10-17 2018-02-20 Zealand Pharma A/S Acylated glucagon analogues
JP6682432B2 (ja) 2013-11-06 2020-04-15 ジーランド ファーマ アクティーゼルスカブ Ｇｉｐ−ｇｌｐ−１デュアルアゴニスト化合物及び方法
KR102310392B1 (ko) 2013-11-06 2021-10-13 질랜드 파마 에이/에스 글루카곤-ｇｌｐ-1-ｇｉｐ 삼원 효능제 화합물
WO2015100246A1 (en) 2013-12-24 2015-07-02 Ossianix, Inc. Baff selective binding compounds and related methods
CN106414483A (zh) 2014-01-27 2017-02-15 分子模板公司 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽
EP3604333B1 (de) 2014-03-11 2021-05-05 Molecular Templates, Inc. Proteine mit aminoterminalem proximalem shiga-toxin-a-untereinheiteneffektorregionen und auf zellen abgerichtete immunglobulinbindungsregionen, die cd38 spezifisch binden können
EP3825327A1 (de) 2014-03-11 2021-05-26 Molecular Templates, Inc. Proteine mit bindungsregionen, shiga-toxin-a-untereinheiteffektorregionen und carboxyterminale, endoplasmatische retikulumlokalisierungssignalmotive
US10815469B2 (en) 2014-06-11 2020-10-27 Molecular Templates, Inc. Cell-targeting molecules comprising protease-cleavage resistant, Shiga toxin A subunit effector polypeptides and carboxy-terminal moieties
EP3160995A2 (de) 2014-06-26 2017-05-03 Ossianix Inc. Halbsynthetische ammenhai-vnar-bibliotheken zur herstellung und verwendung von verbindungen mit selektiver bindung
WO2016066744A2 (en) 2014-10-29 2016-05-06 Zealand Pharma A/S Gip agonist compounds and methods
WO2016077840A2 (en) 2014-11-14 2016-05-19 Ossianix, Inc. TfR SELECTIVE BINDING COMPOUNDS AND RELATED METHODS
US10392425B2 (en) 2015-02-05 2019-08-27 Molecular Templates, Inc. Multivalent CD20-binding molecules comprising Shiga toxin A subunit effector regions and enriched compositions thereof
EP3271381B1 (de) 2015-03-18 2021-09-08 Zealand Pharma A/S Amylin-analoga
GB201506380D0 (en) 2015-04-15 2015-05-27 Serodus Asa Materials and methods for treatment of pulmonary hypertension
KR20170137198A (ko) 2015-04-16 2017-12-12 질랜드 파마 에이/에스 아실화된 글루카곤 유사체
AU2016271124C1 (en) 2015-05-30 2020-05-14 Molecular Templates, Inc. De-immunized, Shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same
AU2016297920A1 (en) 2015-07-26 2018-01-18 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin A subunit effectors and CD8+ T-cell epitopes
WO2017049128A1 (en) * 2015-09-17 2017-03-23 Massachusetts Institute Of Technology Methods and systems for solid phase peptide synthesis
AU2017311040B2 (en) 2016-08-06 2023-08-31 Ossianix, Inc. In vivo methods for selecting peptides that cross the blood brain barrier, related compositions and methods of use
US10071140B2 (en) 2016-09-09 2018-09-11 Zealand Pharma A/S Amylin analogues
WO2018103868A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Acylated glp-1/glp-2 dual agonists
MX2019006486A (es) 2016-12-09 2019-08-01 Zealand Pharma As Agonistas duales acilados de glp-1/glp-2.
WO2018104558A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Acylated glp-1/glp-2 dual agonists
WO2018104559A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Glp-1/glp-2 dual agonists
KR102587196B1 (ko) 2016-12-09 2023-10-10 질랜드 파마 에이/에스 Glp-1/glp-2 이중 효능제
ES2971981T3 (es) 2017-01-25 2024-06-10 Molecular Templates Inc Moléculas de reconocimiento de células que comprenden efectores de la subunidad A de la toxina Shiga desinmunizados y epítopos de células T CD8+
EP3704149A1 (de) 2017-11-02 2020-09-09 Ossianix, Inc. Verbesserte tfr-selektive bindungspeptide mit der fähigkeit zum passieren der blut-hirn-schranke
RU2020128624A (ru) 2018-02-27 2022-03-28 Зп Спв 3 К/С Аналоги компстатина и их медицинское применение
CA3097178A1 (en) 2018-04-17 2019-10-24 Molecular Templates, Inc. Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds
US20220177597A1 (en) 2018-06-22 2022-06-09 Ossianix, Inc. Anti-CD98hc VNARs for Crossing the Blood Brain Barrier and Type IV VNAR Libraries
WO2020056327A1 (en) 2018-09-14 2020-03-19 Ossianix, Inc. Tfr-specific binding moieties and transcytosis method to select vnars that cross cellular barriers
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
MX2021008790A (es) 2019-01-23 2021-08-24 Millennium Pharm Inc Proteinas de union a cd38 que comprenden efectores de la subunidad a de la toxina shiga desinmunizada.
BR112021020941A2 (pt) 2019-06-14 2021-12-21 Zealand Pharma As Composição farmacêutica parenteral isotônica, método para melhoria da estabilidade química da dita composição e uso de manitol
EP4272751A3 (de) 2019-08-27 2024-02-14 Zp Spv 3 K/S Compstatin-analoga und deren medizinische verwendungen
WO2021055816A1 (en) 2019-09-18 2021-03-25 Molecular Templates, Inc. Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
JP2022548956A (ja) 2019-09-20 2022-11-22 ジーランド・ファーマ・ア／エス Ｋｖ１．３遮断剤
US20210155671A1 (en) 2019-11-24 2021-05-27 Molecular Templates, Inc. Uses of cd20-binding molecules and additional therapeutic agents
WO2021198195A1 (en) 2020-03-30 2021-10-07 Zealand Pharma A/S Agonist combination
EP4126003A1 (de) 2020-03-30 2023-02-08 Zealand Pharma A/S Duale glp-1-/glp-2-agonisten
KR20230039718A (ko) 2020-07-16 2023-03-21 제트피 에스피브이 3 케이/에스 보체 인자 c3의 억제제 및 이들의 의학적 용도
WO2022103769A1 (en) 2020-11-11 2022-05-19 Ossianix, Inc. High affinity human and monkey specific tfr-1 vnars
KR20230121824A (ko) 2020-12-16 2023-08-21 질랜드 파마 에이/에스 Glp-1/glp-2 이중 효능제의 약학적 조성물
WO2022129311A1 (en) 2020-12-16 2022-06-23 Zealand Pharma A/S Pharmaceutical composition of glp-1/glp-2 dual agonists
WO2022129305A1 (en) 2020-12-16 2022-06-23 Zealand Pharma A/S Pharmaceutical composition of glp-1/glp-2 dual agonists
US20240316155A1 (en) 2021-02-18 2024-09-26 Zealand Pharma A/S Composition for treating short bowel syndrome
CA3213295A1 (en) 2021-03-17 2022-09-22 Molecular Templates, Inc. Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens
US20240182531A1 (en) 2021-03-23 2024-06-06 Zealand Pharma A/S KV1.3 Blockers
WO2022260877A1 (en) 2021-06-07 2022-12-15 Ossianix, Inc. Shark vnars for treating covid-19
JP2024525144A (ja) 2021-06-18 2024-07-10 北京拓界生物医薬科技有限公司 グルカゴン類似体及びその医薬用途
WO2023023166A1 (en) 2021-08-17 2023-02-23 Ossianix, Inc. Deimmunized vnar domains and scaffolds
CA3228429A1 (en) 2021-09-03 2023-03-09 Mikkel Askjar Agersnap Dosage regime
MX2024006556A (es) 2021-12-01 2024-06-12 Zealand Pharma As Inhibidores de peptido del receptor de interleucina-23.
WO2024068848A1 (en) 2022-09-28 2024-04-04 Zealand Pharma A/S Methods for treating obesity
WO2024083919A1 (en) 2022-10-18 2024-04-25 Zealand Pharma A/S Inhibitors
WO2024168411A1 (pt) * 2023-02-15 2024-08-22 Proteimax Bio Technology Israel Ltd Aditivo de alimento e/ou suplemento alimentar, processo de obtenção, formulação de alimento funcional e/ou suplemento alimentar, uso

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116666A (de) * 1974-07-30 1976-02-10 Shionogi Seiyaku Kk
US5021550A (en) * 1986-10-07 1991-06-04 Thomas Jefferson University Method for preventing deletion sequences in solid phase synthesis
JP2807287B2 (ja) * 1989-10-13 1998-10-08 株式会社医学生物学研究所 ペプチドおよびその用途
CA2170030A1 (en) * 1993-09-14 1995-03-23 Robert A. Lazarus Pharmaceutical compositions containing ecotin and homologs thereof
US7176282B1 (en) * 1996-09-09 2007-02-13 Zealand Pharma A/S Solid-phase peptide synthesis and agent for use in such synthesis
EP1950223A3 (de) * 1998-03-09 2009-05-13 Zealand Pharma A/S Pharmakologisch aktive Peptidkonjugate mit verringerter enzymatischer Hydrolysetendenz

Also Published As

Publication number Publication date
HUP0102900A2 (hu) 2002-01-28
HUP0102900A3 (en) 2002-02-28
IL128829A (en) 2005-08-31
JP2001500134A (ja) 2001-01-09
US20070004905A1 (en) 2007-01-04
WO1998011125A1 (en) 1998-03-19
CZ80399A3 (cs) 1999-08-11
US7348404B2 (en) 2008-03-25
AU723268B2 (en) 2000-08-24
EP0929567B1 (de) 2005-03-02
PT929567E (pt) 2005-07-29
DK0929567T3 (da) 2005-06-27
AU4199397A (en) 1998-04-02
JP4405594B2 (ja) 2010-01-27
HU230354B1 (hu) 2016-02-29
DE69732640D1 (de) 2005-04-07
ES2239364T3 (es) 2005-09-16
EP0929567A1 (de) 1999-07-21
CA2265900A1 (en) 1998-03-19
IL128829A0 (en) 2000-01-31
DE69732640T2 (de) 2006-01-12
CZ295838B6 (cs) 2005-11-16
CA2265900C (en) 2007-07-31

Similar Documents

Publication Publication Date Title
ATE290014T1 (de) Festphasen-peptidsynthese
ATE271058T1 (de) Mycophenol bisphosponatverbindungen
TR200001985T2 (tr) Kapa reseptörü opioid peptidleri.
DK1144607T3 (da) Fremgangsmåde til præsentation af (poly)peptider/proteiner på bakteriofage partikler via disulfidbindinger
ATE233277T1 (de) Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden
ATE270303T1 (de) Gc1q-rezeptor, daran bindende hiv-1 gp120-region, verwandte peptide und antikörper
AU1121902A (en) Substituted dipeptides as growth hormone secretagogues
TR200000930T2 (tr) Büyüme hormonu sekretagogları.
ATE394482T1 (de) Verfahren und zusammensetzungen für peptid-, protein- und peptidomimetische synthese
SE9903291D0 (sv) New process
AU580350B2 (en) Process for synthesising peptides
IL187595A0 (en) Antitumor antibodies, proteins, and uses thereof
HUT55800A (en) Process for producing anticoagulant peptides
ATE173022T1 (de) Produktion von peptid-amiden
GR3021660T3 (en) Anticoagulant peptides
SE9800865D0 (sv) New Process
DE69812597D1 (de) Peptide zur Inhibition von HPV E7 Proteinen
SE9604439D0 (sv) New receptor
IT1264598B1 (it) Intermedi per la preparazione di peptidi retro-inversi
IT1270613B (it) Lattami biciclici come intermedi per la sintesi di peptidi biologicamente attivi
ATE417105T1 (de) Spleissvariante des kopftrauma induzierten zytoplasmatischen calcium-bindenden proteins

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0929567

Country of ref document: EP