IL128829A - Solid phase sythesis of peptides with pre-sequences - Google Patents

Solid phase sythesis of peptides with pre-sequences

Info

Publication number
IL128829A
IL128829A IL12882997A IL12882997A IL128829A IL 128829 A IL128829 A IL 128829A IL 12882997 A IL12882997 A IL 12882997A IL 12882997 A IL12882997 A IL 12882997A IL 128829 A IL128829 A IL 128829A
Authority
IL
Israel
Prior art keywords
peptides
sythesis
sequences
solid phase
solid
Prior art date
Application number
IL12882997A
Other languages
English (en)
Other versions
IL128829A0 (en
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Publication of IL128829A0 publication Critical patent/IL128829A0/xx
Publication of IL128829A publication Critical patent/IL128829A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Prostheses (AREA)
IL12882997A 1996-09-09 1997-09-09 Solid phase sythesis of peptides with pre-sequences IL128829A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK97196 1996-09-09
PCT/DK1997/000375 WO1998011125A1 (en) 1996-09-09 1997-09-09 Improved solid-phase peptide synthesis and agent for use in such synthesis

Publications (2)

Publication Number Publication Date
IL128829A0 IL128829A0 (en) 2000-01-31
IL128829A true IL128829A (en) 2005-08-31

Family

ID=8099561

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12882997A IL128829A (en) 1996-09-09 1997-09-09 Solid phase sythesis of peptides with pre-sequences

Country Status (14)

Country Link
US (1) US7348404B2 (de)
EP (1) EP0929567B1 (de)
JP (1) JP4405594B2 (de)
AT (1) ATE290014T1 (de)
AU (1) AU723268B2 (de)
CA (1) CA2265900C (de)
CZ (1) CZ295838B6 (de)
DE (1) DE69732640T2 (de)
DK (1) DK0929567T3 (de)
ES (1) ES2239364T3 (de)
HU (1) HU230354B1 (de)
IL (1) IL128829A (de)
PT (1) PT929567E (de)
WO (1) WO1998011125A1 (de)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2321026A1 (en) * 1998-03-09 1999-09-16 Zealand Pharmaceuticals A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
US7550425B2 (en) 2000-06-16 2009-06-23 Zealand Pharma A/S Diuretic peptide conjugates
ATE480561T1 (de) 2004-10-19 2010-09-15 Lonza Ag Verfahren zur festphasen-peptidsynthese
WO2006117565A2 (en) 2005-05-04 2006-11-09 Zealand Pharma A/S Glucagon-like-peptide-2 (glp-2) analogues
GB0514071D0 (en) 2005-07-07 2005-08-17 Zealand Pharma As N- or C- terminally modified small peptides
WO2007060860A1 (ja) * 2005-11-22 2007-05-31 Nihon University ピロールイミダゾールポリアミドの固相自動合成
ES2443242T3 (es) 2005-12-23 2014-02-18 Zealand Pharma A/S Compuestos modificados miméticos de lisina
JP5295785B2 (ja) 2006-02-20 2013-09-18 エファ・ユニバーシティ・インダストリー・コラボレイション・ファウンデイション 細胞膜透過性ペプチド
CN101437836B (zh) * 2006-03-29 2013-07-24 株式会社糖锁工学研究所 肽的硫酯化合物的制造方法
UA102506C2 (ru) 2006-11-08 2013-07-25 Зиланд Фарма А/С Селективные аналоги глюкагоноподобного пептида-2 (glp-2)
US7994122B2 (en) 2007-06-15 2011-08-09 Zealand Pharma A/S Glucagon analogues
WO2010070251A1 (en) 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
JP5635531B2 (ja) 2008-12-15 2014-12-03 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
AU2008365559B2 (en) 2008-12-15 2016-02-25 Zealand Pharma A/S Glucagon analogues
DK2370460T3 (da) 2008-12-15 2014-08-04 Zealand Pharma As Glucagon analoger
ES2537287T3 (es) 2009-07-13 2015-06-05 Zealand Pharma A/S Análogos de glucagón acilados
CN107129538B (zh) 2010-04-27 2021-07-16 西兰制药公司 Glp-1受体激动剂和胃泌素的肽缀合物及其用途
UY33462A (es) 2010-06-23 2012-01-31 Zealand Pharma As Analogos de glucagon
CN103068841A (zh) 2010-06-24 2013-04-24 西兰制药公司 胰高血糖素类似物
PE20140969A1 (es) 2011-01-20 2014-07-24 Zealand Pharma As Combinacion de analogos del glucagon acilados con analogos de insulina
WO2013064669A1 (en) 2011-11-03 2013-05-10 Zealand Pharma A/S Glp-1 receptor agonist peptide gastrin conjugates
PE20142113A1 (es) 2011-12-23 2014-12-03 Zealand Pharma As Analogos de glucagon
WO2013098408A1 (en) 2011-12-30 2013-07-04 Zealand Pharma A/S Glucagon and cck receptor agonist peptide conjugates
AR089860A1 (es) 2012-02-03 2014-09-24 Zealand Pharma As Analogos de la grelina
EP2844669B1 (de) 2012-05-03 2018-08-01 Zealand Pharma A/S Gip-glp-1-dualagonistenverbindungen und verfahren
EA028929B1 (ru) 2012-05-03 2018-01-31 Зилэнд Фарма А/С Аналоги глюкагоноподобного пептида-2 (glp-2)
AU2013295035B2 (en) 2012-07-23 2017-08-03 Zealand Pharma A/S Glucagon analogues
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
PT2970487T (pt) 2013-03-12 2020-06-17 Molecular Templates Inc Proteínas citotóxicas compreendendo regiões de ligação de direcionamento para células e regiões de subunidades de toxina a shiga para a morte seletiva de tipos específicos de células
US9169287B2 (en) 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
US9695214B2 (en) 2013-03-15 2017-07-04 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
SG11201506885UA (en) 2013-03-21 2015-09-29 Sanofi Aventis Deutschland Synthesis of cyclic imide containing peptide products
AU2014234400B2 (en) 2013-03-21 2017-11-16 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
RS57632B1 (sr) 2013-10-17 2018-11-30 Zealand Pharma As Acilovani analozi glukagona
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
AU2014345569B2 (en) 2013-11-06 2020-08-13 Zealand Pharma A/S GIP-GLP-1 dual agonist compounds and methods
EP3066117B1 (de) 2013-11-06 2019-01-02 Zealand Pharma A/S Dreifache glucagon-glp-1-gip-agonistenverbindungen
US10435474B2 (en) 2013-12-24 2019-10-08 Ossianix, Inc. Baff selective binding compounds and related methods
AU2015209063C1 (en) 2014-01-27 2020-06-25 Molecular Templates, Inc. MHC class I epitope delivering polypeptides
MX2016011821A (es) 2014-03-11 2017-04-27 Molecular Templates Inc Proteinas que comprenden regiones efectoras de subunidad a de toxina shiga proximas a amino terminal y regiones de union de tipo inmunoglobulina de direccionamiento selectivo celular.
EP3825327A1 (de) 2014-03-11 2021-05-26 Molecular Templates, Inc. Proteine mit bindungsregionen, shiga-toxin-a-untereinheiteffektorregionen und carboxyterminale, endoplasmatische retikulumlokalisierungssignalmotive
ES2919749T3 (es) 2014-06-11 2022-07-28 Molecular Templates Inc Moléculas dirigidas a células citotóxicas resistentes a la escisión por proteasa
EP3160995A2 (de) 2014-06-26 2017-05-03 Ossianix Inc. Halbsynthetische ammenhai-vnar-bibliotheken zur herstellung und verwendung von verbindungen mit selektiver bindung
EP3985016A1 (de) 2014-10-29 2022-04-20 Zealand Pharma A/S Gip-agonisten-verbindungen und -verfahren
CA2967830A1 (en) 2014-11-14 2016-05-19 Ossianix, Inc. Tfr selective binding compounds and related methods
AU2016215205B2 (en) 2015-02-05 2021-10-21 Molecular Templates, Inc. Multivalent CD20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
CA2979950A1 (en) 2015-03-18 2016-09-22 Zealand Pharma A/S Amylin analogues
GB201506380D0 (en) 2015-04-15 2015-05-27 Serodus Asa Materials and methods for treatment of pulmonary hypertension
EP3283507B8 (de) 2015-04-16 2019-11-13 Zealand Pharma A/S Acyliertes glucagon-analogon
LT3303373T (lt) 2015-05-30 2020-07-10 Molecular Templates, Inc. Deimunizuoto shiga toksino a subvieneto karkasai ir juos apimančios ląstelės taikinio molekulės
KR20180030085A (ko) 2015-07-26 2018-03-21 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
CA2999031A1 (en) 2015-09-17 2017-03-23 Massachusetts Institute Of Technology Methods and systems for solid phase peptide synthesis
WO2018031424A1 (en) 2016-08-06 2018-02-15 Ossianix, Inc. In vivo methods for selecting peptides that cross the blood brain barrier, related compositions and methods of use
TWI784968B (zh) 2016-09-09 2022-12-01 丹麥商西蘭製藥公司 澱粉素類似物
WO2018104559A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Glp-1/glp-2 dual agonists
WO2018104558A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Acylated glp-1/glp-2 dual agonists
JP2020500890A (ja) 2016-12-09 2020-01-16 ジーランド・ファーマ・ア／エス Ｇｌｐ−１／ｇｌｐ−２二重アゴニスト
WO2018103868A1 (en) 2016-12-09 2018-06-14 Zealand Pharma A/S Acylated glp-1/glp-2 dual agonists
ES2979184T3 (es) 2016-12-09 2024-09-24 Zealand Pharma As Agonistas duales de glp-1/glp-2 acilados
US20200024312A1 (en) 2017-01-25 2020-01-23 Molecular Templates, Inc. Cell-targeting molecules comprising de-immunized, shiga toxin a subunit effectors and cd8+ t-cell epitopes
WO2019089395A1 (en) 2017-11-02 2019-05-09 Ossianix, Inc. Improved tfr-selective binding peptides capable of crossing the blood brain barrier
KR20200135797A (ko) 2018-02-27 2020-12-03 제트피 에스피브이 3 케이/에스 콤프스타틴 유사체 및 이들의 의학적 용도
CN110612117B (zh) 2018-04-17 2024-04-12 分子模板公司 包含去免疫化的志贺毒素a亚基支架的her2靶向分子
WO2019246288A1 (en) 2018-06-22 2019-12-26 Ossianix, Inc. Anti-cd98hc vnars for crossing the blood brain barrier and type iv vnar libraries
WO2020056327A1 (en) 2018-09-14 2020-03-19 Ossianix, Inc. Tfr-specific binding moieties and transcytosis method to select vnars that cross cellular barriers
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
CA3127660A1 (en) 2019-01-23 2020-07-30 Millennium Pharmaceuticals, Inc. Cd38-binding proteins comprising de-immunized shiga toxin a subunit effectors
US20220202704A1 (en) 2019-06-14 2022-06-30 Zealand Pharma A/S Pharmaceutical parenteral composition of dual glp1/2 agonist
US20220306695A1 (en) 2019-08-27 2022-09-29 Zp Spv 3 K/S Compstatin analogues and their medical uses
WO2021055816A1 (en) 2019-09-18 2021-03-25 Molecular Templates, Inc. Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
EP4031162A1 (de) 2019-09-20 2022-07-27 Zealand Pharma A/S Kv1.3-blocker
WO2021102445A1 (en) 2019-11-24 2021-05-27 Molecular Templates, Inc. Uses of cd20-binding molecules and additional therapeutic agents
WO2021198196A1 (en) 2020-03-30 2021-10-07 Zealand Pharma A/S Glp-1/glp-2 dual agonists
WO2021198195A1 (en) 2020-03-30 2021-10-07 Zealand Pharma A/S Agonist combination
CA3185730A1 (en) 2020-07-16 2022-01-20 Anne Pernille Tofteng SHELTON Inhibitors of complement factor c3 and their medical uses
WO2022103769A1 (en) 2020-11-11 2022-05-19 Ossianix, Inc. High affinity human and monkey specific tfr-1 vnars
CN116723850A (zh) 2020-12-16 2023-09-08 西兰制药公司 Glp-1/glp-2双重激动剂的药物组合物
CN116710114A (zh) 2020-12-16 2023-09-05 西兰制药公司 Glp-1/glp-2双重激动剂的药物组合物
WO2022129305A1 (en) 2020-12-16 2022-06-23 Zealand Pharma A/S Pharmaceutical composition of glp-1/glp-2 dual agonists
WO2022175410A1 (en) 2021-02-18 2022-08-25 Zealand Pharma A/S Composition for treating short bowel syndrome
CA3213295A1 (en) 2021-03-17 2022-09-22 Molecular Templates, Inc. Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens
AU2022245193A1 (en) 2021-03-23 2023-09-07 Zealand Pharma A/S Kv1.3 blockers
WO2022260877A1 (en) 2021-06-07 2022-12-15 Ossianix, Inc. Shark vnars for treating covid-19
CA3221829A1 (en) 2021-06-18 2022-12-22 Weibing LIU Glucagon analog and medical use thereof
EP4388001A1 (de) 2021-08-17 2024-06-26 Ossianix, Inc. Deimmunisierte vanar-domänen und gerüste
IL311166A (en) 2021-09-03 2024-04-01 Zealand Pharma As dosage regimen
AU2022402440A1 (en) 2021-12-01 2024-05-30 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
WO2024068848A1 (en) 2022-09-28 2024-04-04 Zealand Pharma A/S Methods for treating obesity
WO2024083919A1 (en) 2022-10-18 2024-04-25 Zealand Pharma A/S Inhibitors
WO2024168411A1 (pt) * 2023-02-15 2024-08-22 Proteimax Bio Technology Israel Ltd Aditivo de alimento e/ou suplemento alimentar, processo de obtenção, formulação de alimento funcional e/ou suplemento alimentar, uso

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116666A (de) * 1974-07-30 1976-02-10 Shionogi Seiyaku Kk
US5021550A (en) * 1986-10-07 1991-06-04 Thomas Jefferson University Method for preventing deletion sequences in solid phase synthesis
JP2807287B2 (ja) * 1989-10-13 1998-10-08 株式会社医学生物学研究所 ペプチドおよびその用途
WO1995007986A1 (en) * 1993-09-14 1995-03-23 Genentech, Inc. Pharmaceutical compositions containing ecotin and homologs thereof
US7176282B1 (en) * 1996-09-09 2007-02-13 Zealand Pharma A/S Solid-phase peptide synthesis and agent for use in such synthesis
CA2321026A1 (en) * 1998-03-09 1999-09-16 Zealand Pharmaceuticals A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis

Also Published As

Publication number Publication date
JP4405594B2 (ja) 2010-01-27
AU4199397A (en) 1998-04-02
PT929567E (pt) 2005-07-29
CZ295838B6 (cs) 2005-11-16
HU230354B1 (hu) 2016-02-29
HUP0102900A3 (en) 2002-02-28
EP0929567A1 (de) 1999-07-21
DE69732640D1 (de) 2005-04-07
CA2265900C (en) 2007-07-31
US7348404B2 (en) 2008-03-25
CZ80399A3 (cs) 1999-08-11
IL128829A0 (en) 2000-01-31
WO1998011125A1 (en) 1998-03-19
HUP0102900A2 (hu) 2002-01-28
ATE290014T1 (de) 2005-03-15
AU723268B2 (en) 2000-08-24
ES2239364T3 (es) 2005-09-16
EP0929567B1 (de) 2005-03-02
DK0929567T3 (da) 2005-06-27
US20070004905A1 (en) 2007-01-04
DE69732640T2 (de) 2006-01-12
JP2001500134A (ja) 2001-01-09
CA2265900A1 (en) 1998-03-19

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