ATE233277T1 - Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden - Google Patents

Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden

Info

Publication number
ATE233277T1
ATE233277T1 AT97912822T AT97912822T ATE233277T1 AT E233277 T1 ATE233277 T1 AT E233277T1 AT 97912822 T AT97912822 T AT 97912822T AT 97912822 T AT97912822 T AT 97912822T AT E233277 T1 ATE233277 T1 AT E233277T1
Authority
AT
Austria
Prior art keywords
urokinase
bind
plasminogen activator
cyclic peptides
type plasminogen
Prior art date
Application number
AT97912822T
Other languages
English (en)
Inventor
Terence R Jones
David N Haney
Janos Varga
Original Assignee
Angstrom Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angstrom Pharmaceuticals Inc filed Critical Angstrom Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE233277T1 publication Critical patent/ATE233277T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT97912822T 1996-11-12 1997-10-21 Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden ATE233277T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/747,915 US5942492A (en) 1996-11-12 1996-11-12 Cyclic peptides that bind to urokinase-type plasminogen activator receptor
PCT/US1997/018967 WO1998021230A1 (en) 1996-11-12 1997-10-21 Cyclic peptides that bind to urokinase-type plasminogen activator receptor

Publications (1)

Publication Number Publication Date
ATE233277T1 true ATE233277T1 (de) 2003-03-15

Family

ID=25007232

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97912822T ATE233277T1 (de) 1996-11-12 1997-10-21 Cyklische peptide, die an den urokinase-type plasminogen aktivator rezeptor binden

Country Status (10)

Country Link
US (3) US5942492A (de)
EP (1) EP0941235B1 (de)
JP (2) JP2001504819A (de)
AT (1) ATE233277T1 (de)
AU (1) AU751146B2 (de)
CA (1) CA2277832C (de)
DE (1) DE69719359T2 (de)
DK (1) DK0941235T3 (de)
ES (1) ES2193363T3 (de)
WO (1) WO1998021230A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277818B1 (en) * 1998-10-29 2001-08-21 Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
US20040204348A1 (en) * 1996-11-12 2004-10-14 The Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
DE19933701A1 (de) 1999-07-19 2001-01-25 Wilex Biotechnology Gmbh Zyklische peptidomimetische Urokinaserezeptorantagonisten
US6896870B1 (en) 1999-10-01 2005-05-24 Angstrom Pharmaceuticals, Inc. Diagnostic probes and therapeutics targeting uPA and uPAR
AU780730B2 (en) * 1999-10-01 2005-04-14 Angstrom Pharmaceuticals, Inc. Diagnostic probes and therapeutics targeting uPA and uPAR
US6649597B1 (en) 2000-06-22 2003-11-18 The University Of Iowa Research Foundation Targeting vector to the urokinase plasminogen activator receptor
EP1311856A2 (de) * 2000-08-23 2003-05-21 Wilex AG Peptid-strukturmimetika der urokinase
JP2004137151A (ja) * 2002-10-15 2004-05-13 Keio Gijuku 脳腫瘍の治療・診断薬
BRPI0516168A (pt) * 2004-09-29 2008-08-26 Ge Healthcare As agente de formação de imagem upar, composição farmacêutica, e, método de geração de imagens de um corpo humano ou animal
US7173110B2 (en) * 2004-11-08 2007-02-06 New York University Peptide anti-tumor agent
ES2457822T3 (es) 2007-11-08 2014-04-29 The General Hospital Corporation Procedimientos y composiciones de tratamiento de enfermedades proteinúricas
WO2009076672A1 (en) * 2007-12-13 2009-06-18 Cytogel, Llc Advantageous salts of mu-opiate receptor peptides
JP5798037B2 (ja) * 2008-11-06 2015-10-21 ユニバーシティ オブ マイアミ 蛋白尿腎疾患の病因における可溶性ｕＰＡＲの役割
WO2010129609A2 (en) 2009-05-07 2010-11-11 The Regents Of The University Of California Antibodies and methods of use thereof
WO2011146922A2 (en) * 2010-05-21 2011-11-24 Cytogel Pharma, Llc Materials and methods for treatment of inflammation
EP2707055B1 (de) 2011-05-09 2019-10-23 The University of Miami Verminderung des löslichen urokinase-rezeptors im blutkreislauf
CA2905172C (en) 2012-05-08 2021-07-20 Andreas Kjaer 177-lu labeled peptide for site-specific upar-targeting
CA2903261C (en) 2012-12-03 2021-03-09 Curasight Aps Positron emitting radionuclide labeled peptides for human upar pet imaging
US9255155B2 (en) 2013-01-31 2016-02-09 The Regents Of The University Of California Antibodies specific for urokinase-type plasminogen activator and methods of treating cancer
PL2968443T3 (pl) 2013-03-15 2022-02-07 Protagonist Therapeutics, Inc. Analogi hepcydyny i ich zastosowania
US9308236B2 (en) * 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
KR20230036156A (ko) 2014-05-16 2023-03-14 프로타고니스트 테라퓨틱스, 인코포레이티드 α4β7 인테그린 티오에테르 펩티드 길항제
RU2736637C9 (ru) 2014-07-17 2021-02-08 Протагонист Терепьютикс, Инк. Пептидные ингибиторы рецептора интерлейкина-23 для перорального приема и их применение для лечения воспалительных заболеваний кишечника
TN2017000084A1 (en) * 2014-09-11 2018-07-04 Bristol Myers Squibb Co Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions
US10301371B2 (en) 2014-10-01 2019-05-28 Protagonist Therapeutics, Inc. Cyclic monomer and dimer peptides having integrin antagonist activity
AU2015328002A1 (en) 2014-10-01 2017-04-27 Protagonist Therapeutics, Inc. Novel alpha4beta7 peptide monomer and dimer antagonists
GB2538947A (en) * 2014-12-19 2016-12-07 Neuro-Bio Ltd Cancer
WO2017011820A2 (en) * 2015-07-15 2017-01-19 Protagonist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
US10787490B2 (en) 2015-07-15 2020-09-29 Protaganist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
CA3009834A1 (en) 2015-12-30 2017-07-06 Protagonist Therapeutics, Inc. Analogues of hepcidin mimetics with improved in vivo half lives
EP3432906A4 (de) 2016-03-23 2020-04-01 Protagonist Therapeutics, Inc. Verfahren zur synthetisierung von alpha4beta7-peptid-antagonisten
US10975121B2 (en) 2017-06-24 2021-04-13 Cytogel Pharma, Llc Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof
US10278957B2 (en) 2017-09-11 2019-05-07 Protagonist Therapeutics, Inc. Opioid agonist peptides and uses thereof
EP3749345A4 (de) 2018-02-08 2022-04-06 Protagonist Therapeutics, Inc. Konjugierte hepcidin-mimetika
EP3997105A4 (de) 2019-07-10 2023-09-13 Protagonist Therapeutics, Inc. Peptidinhibitoren des interleukin-23-rezeptors und deren verwendung zur behandlung entzündlicher erkrankungen
IL294680A (en) 2020-01-15 2022-09-01 Janssen Biotech Inc Peptide inhibitors of the interleukin-23 receptor and their use for the treatment of inflammatory diseases
KR20220141808A (ko) 2020-01-15 2022-10-20 얀센 바이오테크 인코포레이티드 인터루킨-23 수용체의 펩티드 억제제 및 염증성 질환을 치료하기 위한 이의 용도
PE20240631A1 (es) 2020-11-20 2024-03-26 Janssen Pharmaceutica Nv Composiciones de inhibidores peptidicos del receptor de interleucina-23

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033653T2 (de) * 1989-04-07 2001-06-07 Cancerforskningsfonden Af 1989 Plasminogen-aktivator-rezeptor vom urokinasetyp
US6120765A (en) * 1993-04-02 2000-09-19 Shiseido Co. Ltd. Urokinase plasminogen activator fragments
ATE182336T1 (de) * 1993-05-28 1999-08-15 Chiron Corp Peptidinhibitoren der urokinaserezeptor-aktivität
AU7137994A (en) * 1993-06-01 1994-12-20 Chiron Corporation Expression of urokinase plasminogen activator inhibitors
US6277818B1 (en) * 1998-10-29 2001-08-21 Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor

Also Published As

Publication number Publication date
EP0941235A1 (de) 1999-09-15
US20030166514A1 (en) 2003-09-04
JP2001504819A (ja) 2001-04-10
JP2009024015A (ja) 2009-02-05
EP0941235B1 (de) 2003-02-26
AU4991297A (en) 1998-06-03
DE69719359T2 (de) 2003-12-04
US5942492A (en) 1999-08-24
AU751146B2 (en) 2002-08-08
WO1998021230A1 (en) 1998-05-22
DK0941235T3 (da) 2003-06-23
WO1998021230A8 (en) 2000-12-21
CA2277832A1 (en) 1998-05-22
CA2277832C (en) 2007-04-24
US6514710B1 (en) 2003-02-04
DE69719359D1 (de) 2003-04-03
ES2193363T3 (es) 2003-11-01

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