ATE245435T1 - Totalsynthese des amino hip analogen von didemnin a - Google Patents

Totalsynthese des amino hip analogen von didemnin a

Info

Publication number
ATE245435T1
ATE245435T1 AT97946294T AT97946294T ATE245435T1 AT E245435 T1 ATE245435 T1 AT E245435T1 AT 97946294 T AT97946294 T AT 97946294T AT 97946294 T AT97946294 T AT 97946294T AT E245435 T1 ATE245435 T1 AT E245435T1
Authority
AT
Austria
Prior art keywords
didemnin
total synthesis
amino
hip analog
analog
Prior art date
Application number
AT97946294T
Other languages
English (en)
Inventor
Kenneth L Rinehart
Alexandra J Sanborn
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Application granted granted Critical
Publication of ATE245435T1 publication Critical patent/ATE245435T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT97946294T 1996-10-24 1997-10-24 Totalsynthese des amino hip analogen von didemnin a ATE245435T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2910996P 1996-10-24 1996-10-24
PCT/US1997/019211 WO1998017302A1 (en) 1996-10-24 1997-10-24 Total synthesis of the amino hip analogue of didemnin a

Publications (1)

Publication Number Publication Date
ATE245435T1 true ATE245435T1 (de) 2003-08-15

Family

ID=21847275

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97946294T ATE245435T1 (de) 1996-10-24 1997-10-24 Totalsynthese des amino hip analogen von didemnin a

Country Status (11)

Country Link
US (1) US6380156B1 (de)
EP (1) EP0956033B1 (de)
JP (1) JP2001504814A (de)
AT (1) ATE245435T1 (de)
AU (1) AU726146B2 (de)
CA (1) CA2269878A1 (de)
DE (1) DE69723728T2 (de)
DK (1) DK0956033T3 (de)
ES (1) ES2202644T3 (de)
PT (1) PT956033E (de)
WO (1) WO1998017302A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148933A1 (en) 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
MXPA02009943A (es) 2000-04-07 2003-04-25 Univ Pennsylvania Analogos de tamandarin y didemnin y metodos para hacerlos y usarlos.
US6509315B1 (en) 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk) * 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
GB0016148D0 (en) * 2000-06-30 2000-08-23 Pharma Mar Sa Synthetic methods for aplidine and new antitiumoral derivatives
NZ525196A (en) 2000-10-12 2004-09-24 Pharma Mar S Treatment of cancers by aplidine in conjunction with a myoprotector
MXPA05009742A (es) 2003-03-12 2006-05-25 Dana Farber Cancer Inst Inc Aplidina para tratamiento de mieloma multiple.
WO2004080421A2 (en) 2003-03-12 2004-09-23 Pharma Mar, S.A. Improved antitumoral treatments
CA2519234A1 (en) 2003-03-21 2004-10-07 Madeleine M. Joullie Tamandarin analogs and fragments thereof and methods of making and using
DE102004051023A1 (de) * 2004-10-20 2006-05-04 Bayer Healthcare Ag Desoxo-Nonadepsipeptide
DE102004051024A1 (de) * 2004-10-20 2006-04-27 Bayer Healthcare Ag Heterocyclyl-substituierte Nonadepsipeptide
DE102004051025A1 (de) * 2004-10-20 2006-04-27 Bayer Healthcare Ag Substituierte Nonadepsipeptide
DE102004053410A1 (de) * 2004-11-05 2006-05-11 Bayer Healthcare Ag Cyclische Nonadepsipeptidamide
DE102006003443A1 (de) * 2006-01-25 2007-07-26 Aicuris Gmbh & Co. Kg Asparagin-10-substituierte Nonadepsipeptide
CA2643238C (en) 2006-02-28 2016-05-03 Pharma Mar, S.A. Improved antitumoral treatments
DE102006018080A1 (de) * 2006-04-13 2007-10-18 Aicuris Gmbh & Co. Kg Lysobactinamide
DE102006018250A1 (de) * 2006-04-13 2007-10-18 Aicuris Gmbh & Co. Kg Verfahren zum Herstellen von cyclischen Depsipeptiden
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Also Published As

Publication number Publication date
EP0956033B1 (de) 2003-07-23
CA2269878A1 (en) 1998-04-30
DE69723728D1 (de) 2003-08-28
AU5149598A (en) 1998-05-15
AU726146B2 (en) 2000-11-02
ES2202644T3 (es) 2004-04-01
DE69723728T2 (de) 2004-06-03
PT956033E (pt) 2003-10-31
EP0956033A4 (de) 2000-06-21
US6380156B1 (en) 2002-04-30
EP0956033A1 (de) 1999-11-17
WO1998017302A1 (en) 1998-04-30
DK0956033T3 (da) 2003-10-06
JP2001504814A (ja) 2001-04-10

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