DZ3482A1 - Secretagogues de l'hormone de croissance - Google Patents

Secretagogues de l'hormone de croissance

Info

Publication number
DZ3482A1
DZ3482A1 DZ013482A DZ013482A DZ3482A1 DZ 3482 A1 DZ3482 A1 DZ 3482A1 DZ 013482 A DZ013482 A DZ 013482A DZ 013482 A DZ013482 A DZ 013482A DZ 3482 A1 DZ3482 A1 DZ 3482A1
Authority
DZ
Algeria
Prior art keywords
growth hormone
compounds
secretagogues
novel
mammal
Prior art date
Application number
DZ013482A
Other languages
English (en)
Inventor
Jeffrey Alan Dodge
Britta Evers
Louis Nickolaus Jungheim
Brian Stephen Muehl
Gerd Ruehter
Kenneth Jeff Thrasher
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DZ3482A1 publication Critical patent/DZ3482A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DZ013482A 2000-10-13 2001-10-09 Secretagogues de l'hormone de croissance DZ3482A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24045600P 2000-10-13 2000-10-13
PCT/US2001/027756 WO2002032888A1 (fr) 2000-10-13 2001-10-09 Dipeptides a substitution en tant que secretagogues d'hormone de croissance

Publications (1)

Publication Number Publication Date
DZ3482A1 true DZ3482A1 (fr) 2002-04-25

Family

ID=22906598

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ013482A DZ3482A1 (fr) 2000-10-13 2001-10-09 Secretagogues de l'hormone de croissance

Country Status (27)

Country Link
EP (1) EP1326851B1 (fr)
JP (1) JP2004511552A (fr)
KR (1) KR20030042014A (fr)
CN (1) CN1469871A (fr)
AT (1) ATE270280T1 (fr)
AU (2) AU2002211219B2 (fr)
BR (1) BR0114630A (fr)
CA (1) CA2419388A1 (fr)
CZ (1) CZ20031029A3 (fr)
DE (1) DE60104141T2 (fr)
DZ (1) DZ3482A1 (fr)
EA (1) EA006102B1 (fr)
EC (1) ECSP034551A (fr)
ES (1) ES2223926T3 (fr)
HK (1) HK1058194A1 (fr)
HR (1) HRP20030288B1 (fr)
HU (1) HUP0301351A3 (fr)
IL (1) IL154809A0 (fr)
MX (1) MXPA03003217A (fr)
NO (1) NO20031687L (fr)
NZ (1) NZ524232A (fr)
PL (1) PL361675A1 (fr)
PT (1) PT1326851E (fr)
SK (1) SK4182003A3 (fr)
TR (1) TR200402046T4 (fr)
WO (1) WO2002032888A1 (fr)
ZA (1) ZA200301720B (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7396846B2 (en) * 2002-04-09 2008-07-08 Eli Lilly And Company Growth hormone secretagogues
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CN1902177A (zh) 2003-09-22 2007-01-24 万有制药株式会社 新哌啶衍生物
EP1734963A4 (fr) 2004-04-02 2008-06-18 Merck & Co Inc Methode destinee a traiter des hommes presentant des troubles metaboliques et anthropometriques
RU2417985C2 (ru) 2005-05-30 2011-05-10 Баниу Фармасьютикал Ко., Лтд. Новые производные пиперидина
CA2618112A1 (fr) 2005-08-10 2007-02-15 Banyu Pharmaceutical Co., Ltd. Compose de pyridone
AU2006282260A1 (en) 2005-08-24 2007-03-01 Msd K.K. Phenylpyridone derivative
EP1939194A4 (fr) 2005-09-07 2010-12-08 Banyu Pharma Co Ltd Dérivé de pyridone substitué aromatique bicylique
BRPI0616463A2 (pt) 2005-09-29 2011-06-21 Merck & Co Inc composto, composição farmacêutica, e, uso de um composto
WO2007048027A2 (fr) 2005-10-21 2007-04-26 Novartis Ag Combinaison de composes organiques
AU2006307046A1 (en) 2005-10-27 2007-05-03 Msd K.K. Novel benzoxathiin derivative
NZ568292A (en) 2005-11-10 2011-08-26 Msd Kk Spiro[cyclohexane-1,1'-(3'H)-4'-azaisobenzofuran]-4-carboxamide derivatives
CA2664113C (fr) 2006-09-22 2013-05-28 Merck & Co., Inc. Utilisation de la platencine et de la platensimycine en tant qu'inhibiteurs de la synthese des acides gras pour traiter l'obesite, lediabete et le cancer
JPWO2008038692A1 (ja) 2006-09-28 2010-01-28 萬有製薬株式会社 ジアリールケチミン誘導体
CA2682727C (fr) 2007-04-02 2016-03-22 Banyu Pharmaceutical Co., Ltd. Derive d'indoledione
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2714617A1 (fr) 2008-03-06 2009-09-11 Banyu Pharmaceutical Co., Ltd. Derive d'alkylaminopyridine
US20110015198A1 (en) 2008-03-28 2011-01-20 Banyu Pharmaceutical Co., Inc. Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
CA2726917C (fr) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
EP2301936A1 (fr) 2008-06-19 2011-03-30 Banyu Pharmaceutical Co., Ltd. Dérivé de spirodiamine-diarylcétoxime
WO2010009319A2 (fr) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
EP2319841A1 (fr) 2008-07-30 2011-05-11 Msd K.K. Dérivé de cycloalkylamine à noyaux fusionnés à (5 chaînons)-(5 chaînons) ou (5 chaînons) (6 chaînons)
CA2741125A1 (fr) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Nouveaux derives de benzimidazole cycliques utiles comme agents anti-diabetiques
EP2350010B1 (fr) 2008-10-30 2014-03-26 Merck Sharp & Dohme Corp. Antagonistes d'isonicotinamide des récepteurs de l'orexine
CN102271509A (zh) 2008-10-31 2011-12-07 默沙东公司 用于抗糖尿病药的新型环苯并咪唑衍生物
US8314250B2 (en) * 2009-11-24 2012-11-20 Hoffmann-La Roche Inc. Sultam derivatives
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2677869B1 (fr) 2011-02-25 2017-11-08 Merck Sharp & Dohme Corp. Nouveaux dérivés d'azabenzimidazole cyclique utiles en tant qu'agents antidiabétiques
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
CA2880901A1 (fr) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Composes tricycliques antidiabetiques
WO2014130608A1 (fr) 2013-02-22 2014-08-28 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques
EP2970119B1 (fr) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Nouveaux dérivés d'indole utiles en tant qu'agents antidiabétiques
WO2014151200A2 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
EP2970384A1 (fr) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
WO2015051496A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
DK3186242T3 (da) 2014-08-29 2021-12-20 Tes Pharma S R L Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
AR109950A1 (es) 2016-10-14 2019-02-06 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
EP3551176A4 (fr) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. Composés hétérocycliques antidiabétiques
WO2018118670A1 (fr) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Composés de spirochromane antidiabétiques
KR20210111248A (ko) 2018-11-20 2021-09-10 테스 파마 에스.알.엘. α-아미노-β-카르복시뮤콘산 세미알데하이드 데카르복실라제의 저해제
US11098029B2 (en) 2019-02-13 2021-08-24 Merck Sharp & Dohme Corp. 5-alkyl pyrrolidine orexin receptor agonists
EP4010314B1 (fr) 2019-08-08 2024-02-28 Merck Sharp & Dohme LLC Agonistes du récepteur de l'orexine de type pyrrolidine et pipéridine hétéroaryle
TW202227417A (zh) 2020-08-18 2022-07-16 美商默沙東藥廠 雙環庚烷吡咯啶之食慾素受體促效劑

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018815A1 (fr) * 1996-10-25 1998-05-07 Merck & Co., Inc. Procede convergent de preparation d'un secretagogue d'hormone de croissance
UA53716C2 (uk) * 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)

Also Published As

Publication number Publication date
HRP20030288B1 (en) 2005-02-28
WO2002032888A1 (fr) 2002-04-25
EP1326851A1 (fr) 2003-07-16
EP1326851B1 (fr) 2004-06-30
SK4182003A3 (en) 2004-01-08
TR200402046T4 (tr) 2004-10-21
HK1058194A1 (en) 2004-05-07
NO20031687D0 (no) 2003-04-11
CA2419388A1 (fr) 2002-04-25
AU1121902A (en) 2002-04-29
EA006102B1 (ru) 2005-08-25
KR20030042014A (ko) 2003-05-27
ATE270280T1 (de) 2004-07-15
IL154809A0 (en) 2003-10-31
EA200300462A1 (ru) 2003-08-28
DE60104141D1 (de) 2004-08-05
JP2004511552A (ja) 2004-04-15
BR0114630A (pt) 2003-07-01
ECSP034551A (es) 2003-05-26
PT1326851E (pt) 2004-11-30
PL361675A1 (en) 2004-10-04
NZ524232A (en) 2005-01-28
MXPA03003217A (es) 2003-06-06
ES2223926T3 (es) 2005-03-01
HUP0301351A3 (en) 2007-05-29
HRP20030288A2 (en) 2004-02-29
AU2002211219B2 (en) 2006-09-14
NO20031687L (no) 2003-05-08
CZ20031029A3 (cs) 2003-09-17
ZA200301720B (en) 2004-06-21
CN1469871A (zh) 2004-01-21
DE60104141T2 (de) 2005-06-30
HUP0301351A2 (hu) 2003-11-28

Similar Documents

Publication Publication Date Title
DZ3482A1 (fr) Secretagogues de l'hormone de croissance
MY138258A (en) Growth hormone secretagogues
DE60012751D1 (de) Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz
BG105028A (en) Bridged indenopyrrolocarbazoles
NZ331875A (en) Asymmetric synthesis of R-alpha-propyl-piperonyl amine and its analogs
TR200002932T2 (tr) Azabisayklik 5HT1 Alıcı liganolları
BR9713176A (pt) Benzotiofenos amorfos,métodos de preparação e métodos de uso
AU2003218337A8 (en) Growth hormone secretagogues
DK0915858T3 (da) Mellemprodukter til fremstilling af 2-imidazolin-5-oner
PL343546A1 (en) Processes for preparing intermediates
DE60003711D1 (de) Verfahren zur herstellung von peptidzwischenprodukten
DK1572615T3 (da) Fremgangsmåde til syntese af peptider indeholdende en 4-hydroxyprolin-substruktur
ID27964A (id) Turuna-azabisikloheptana n-tersubstitusi, pembuatan dan penggunaannya