DE60003711D1 - Verfahren zur herstellung von peptidzwischenprodukten - Google Patents

Verfahren zur herstellung von peptidzwischenprodukten

Info

Publication number
DE60003711D1
DE60003711D1 DE60003711T DE60003711T DE60003711D1 DE 60003711 D1 DE60003711 D1 DE 60003711D1 DE 60003711 T DE60003711 T DE 60003711T DE 60003711 T DE60003711 T DE 60003711T DE 60003711 D1 DE60003711 D1 DE 60003711D1
Authority
DE
Germany
Prior art keywords
producing intermediate
intermediate peptides
synthesis
peptides
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60003711T
Other languages
English (en)
Other versions
DE60003711T2 (de
Inventor
Michael Stewart Ashwood
Christopher Brian Bishop
Ian Frank Cottrell
Moneek Emerson
David Hands
Guo-Jie Ho
Edward Lynch
Yao-Jun Shi
Robert Darrin Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck and Co Inc
Original Assignee
Merck Sharp and Dohme Ltd
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck and Co Inc filed Critical Merck Sharp and Dohme Ltd
Publication of DE60003711D1 publication Critical patent/DE60003711D1/de
Application granted granted Critical
Publication of DE60003711T2 publication Critical patent/DE60003711T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/42—Glutaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60003711T 1999-10-19 2000-10-18 Verfahren zur herstellung von peptidzwischenprodukten Expired - Fee Related DE60003711T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9924759.5A GB9924759D0 (en) 1999-10-19 1999-10-19 Process for preparing peptide intermediates
GB9924759 1999-10-19
PCT/GB2000/004019 WO2001029065A1 (en) 1999-10-19 2000-10-18 Process for preparing peptide intermediates

Publications (2)

Publication Number Publication Date
DE60003711D1 true DE60003711D1 (de) 2003-08-07
DE60003711T2 DE60003711T2 (de) 2004-05-13

Family

ID=10863015

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60003711T Expired - Fee Related DE60003711T2 (de) 1999-10-19 2000-10-18 Verfahren zur herstellung von peptidzwischenprodukten

Country Status (10)

Country Link
US (1) US7262169B1 (de)
EP (1) EP1226158B1 (de)
JP (1) JP2003516319A (de)
AT (1) ATE244262T1 (de)
AU (1) AU7810000A (de)
CA (1) CA2387995A1 (de)
DE (1) DE60003711T2 (de)
ES (1) ES2200951T3 (de)
GB (1) GB9924759D0 (de)
WO (1) WO2001029065A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001028593A2 (en) * 1999-10-19 2001-04-26 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
EP3800192A1 (de) * 2015-03-06 2021-04-07 Stealth Biotherapeutics Corp Verfahren zur herstellung von pharmazeutisch relevanten peptiden
DK4201951T3 (da) * 2021-12-21 2024-01-15 Bachem Holding Ag Fremgangsmåde til syntese af et peptid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376765A (en) 1980-03-31 1983-03-15 Institut International De Pathologie Cellulaire Et Moleculaire Medicaments, their preparation and compositions containing same
FR2546163B1 (fr) 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
US6143864A (en) 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
WO1996005863A1 (fr) 1994-08-19 1996-02-29 La Region Wallonne Composes, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation
CA2265476A1 (en) 1996-09-12 1998-03-19 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
HRP970566A2 (en) 1996-10-30 1998-08-31 Jones Deborah Defeo Conjugates useful in the treatment of prostate canser
CA2295860A1 (en) 1997-07-10 1999-01-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
PL197006B1 (pl) * 1997-12-02 2008-02-29 Merck & Co Inc Koniugat do leczenia raka prostaty, zawierająca go kompozycja farmaceutyczna i jej zastosowanie
WO1999044628A1 (en) * 1998-03-05 1999-09-10 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
WO2001028593A2 (en) * 1999-10-19 2001-04-26 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer

Also Published As

Publication number Publication date
US7262169B1 (en) 2007-08-28
CA2387995A1 (en) 2001-04-26
EP1226158B1 (de) 2003-07-02
WO2001029065A1 (en) 2001-04-26
AU7810000A (en) 2001-04-30
JP2003516319A (ja) 2003-05-13
ES2200951T3 (es) 2004-03-16
GB9924759D0 (en) 1999-12-22
ATE244262T1 (de) 2003-07-15
EP1226158A1 (de) 2002-07-31
DE60003711T2 (de) 2004-05-13

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee