UA66866C2 - Синтез морфолінових похідних - Google Patents

Синтез морфолінових похідних

Info

Publication number
UA66866C2
UA66866C2 UA2001010329A UA01010329A UA66866C2 UA 66866 C2 UA66866 C2 UA 66866C2 UA 2001010329 A UA2001010329 A UA 2001010329A UA 01010329 A UA01010329 A UA 01010329A UA 66866 C2 UA66866 C2 UA 66866C2
Authority
UA
Ukraine
Prior art keywords
mopholine
derivatives
synthesis
useful
formula
Prior art date
Application number
UA2001010329A
Other languages
English (en)
Russian (ru)
Inventor
Ян Френк Коттрелл
Ульф Х. Доллінг
Девід Хендс
Роберт Деррін Вілсон
Original Assignee
Мерк Шарп Енд Доме Лімітед
Мерк Шарп Энд Доме Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Шарп Енд Доме Лімітед, Мерк Шарп Энд Доме Лимитед filed Critical Мерк Шарп Енд Доме Лімітед
Publication of UA66866C2 publication Critical patent/UA66866C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Винахід стосується способу одержання морфолінових похідних формули (І), які придатні як терапевтичні засоби.
UA2001010329A 1998-06-16 1999-06-10 Синтез морфолінових похідних UA66866C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9813025.5A GB9813025D0 (en) 1998-06-16 1998-06-16 Chemical synthesis
PCT/GB1999/001842 WO1999065900A1 (en) 1998-06-16 1999-06-10 Chemical synthesis of morpholine derivatives

Publications (1)

Publication Number Publication Date
UA66866C2 true UA66866C2 (uk) 2004-06-15

Family

ID=10833892

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2001010329A UA66866C2 (uk) 1998-06-16 1999-06-10 Синтез морфолінових похідних

Country Status (28)

Country Link
US (2) US6297376B1 (uk)
EP (1) EP1087966B1 (uk)
JP (2) JP4647783B2 (uk)
KR (1) KR100619589B1 (uk)
CN (1) CN1131864C (uk)
AR (1) AR018877A1 (uk)
AT (1) ATE217308T1 (uk)
AU (1) AU746721B2 (uk)
BR (1) BR9911250A (uk)
CA (1) CA2334821C (uk)
CZ (1) CZ299257B6 (uk)
DE (1) DE69901444T2 (uk)
DK (1) DK1087966T3 (uk)
EA (1) EA003468B1 (uk)
ES (1) ES2176036T3 (uk)
GB (1) GB9813025D0 (uk)
HR (1) HRP20000878B1 (uk)
HU (1) HUP0102867A3 (uk)
IL (2) IL139946A0 (uk)
NZ (1) NZ508558A (uk)
PL (1) PL196778B1 (uk)
PT (1) PT1087966E (uk)
SI (1) SI1087966T1 (uk)
SK (1) SK283380B6 (uk)
TW (1) TW526199B (uk)
UA (1) UA66866C2 (uk)
WO (1) WO1999065900A1 (uk)
YU (1) YU76500A (uk)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030284A1 (es) 2000-06-08 2003-08-20 Merck & Co Inc Proceso para la sintesis de (2r, 2-alfa-r,3a) -2-[1-(3,5-bis(trifluorometil) fenil) etoxi]-3-(4-fluorofenil)-1,4-oxazina; dicho compuesto y sus formas polimorficas
GB0014876D0 (en) * 2000-06-16 2000-08-09 Merck Sharp & Dohme Chemical synthesis
UA76810C2 (uk) 2001-12-10 2006-09-15 Мерк Енд Ко., Інк. Фармацевтична композиція антагоніста рецептора тахікініну у формі наночастинок
AR039625A1 (es) 2002-04-18 2005-03-02 Merck & Co Inc Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
AU2003259866A1 (en) * 2002-08-21 2004-03-11 Merck And Co., Inc. Process for preparing 3-chloromethyl-1,2,4-triazolin-5-one
US9227958B2 (en) 2006-02-03 2016-01-05 Glenmark Pharmaceuticals Limited Amorphous and crystalline forms of aprepitant and processes for the preparation thereof
WO2012146692A1 (en) 2011-04-29 2012-11-01 Sandoz Ag Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
ITMI20130273A1 (it) * 2013-02-26 2014-08-27 Olon Spa Procedimento per la preparazione di aprepitant
CN103288813A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种阿瑞匹坦的制备方法
CN104628663A (zh) * 2013-11-08 2015-05-20 中山奕安泰医药科技有限公司 3-氯甲基-1,2,4-三唑啉-5-酮的合成方法
CN107698574B (zh) * 2017-11-23 2020-12-01 中山奕安泰医药科技有限公司 一种高纯度阿瑞匹坦的精制制备工艺
CN109485613B (zh) * 2018-11-21 2022-05-13 江苏慧聚药业股份有限公司 阿瑞匹坦和福沙匹坦边链片段的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111960A (en) 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
JP3071467B2 (ja) * 1993-12-29 2000-07-31 メルク シヤープ エンド ドーム リミテツド 置換モルホリン誘導体およびその治療剤としての使用
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
JPH10500944A (ja) * 1994-05-05 1998-01-27 メルク シヤープ エンド ドーム リミテツド モルホリン誘導体及びタキキニンのアンタゴニストとしてのそれらの使用

Also Published As

Publication number Publication date
US6297376B1 (en) 2001-10-02
US20020019524A1 (en) 2002-02-14
HUP0102867A2 (hu) 2002-05-29
PL344581A1 (en) 2001-11-05
EA003468B1 (ru) 2003-06-26
PT1087966E (pt) 2002-10-31
BR9911250A (pt) 2001-03-13
AU4281399A (en) 2000-01-05
ES2176036T3 (es) 2002-11-16
CA2334821C (en) 2009-02-03
IL139946A (en) 2007-05-15
KR100619589B1 (ko) 2006-09-05
IL139946A0 (en) 2002-02-10
AR018877A1 (es) 2001-12-12
JP2010195808A (ja) 2010-09-09
DE69901444T2 (de) 2002-11-28
CZ20004734A3 (cs) 2001-08-15
PL196778B1 (pl) 2008-01-31
GB9813025D0 (en) 1998-08-12
CN1305475A (zh) 2001-07-25
NZ508558A (en) 2003-07-25
SI1087966T1 (en) 2002-10-31
AU746721B2 (en) 2002-05-02
EA200100040A1 (ru) 2001-06-25
US6407255B2 (en) 2002-06-18
DE69901444D1 (de) 2002-06-13
DK1087966T3 (da) 2002-07-08
WO1999065900A1 (en) 1999-12-23
CN1131864C (zh) 2003-12-24
HUP0102867A3 (en) 2004-06-28
SK283380B6 (sk) 2003-06-03
JP2002518388A (ja) 2002-06-25
JP4647783B2 (ja) 2011-03-09
SK19212000A3 (sk) 2001-07-10
KR20010052886A (ko) 2001-06-25
EP1087966B1 (en) 2002-05-08
TW526199B (en) 2003-04-01
HRP20000878B1 (en) 2009-09-30
JP5285652B2 (ja) 2013-09-11
YU76500A (sh) 2003-02-28
EP1087966A1 (en) 2001-04-04
CA2334821A1 (en) 1999-12-23
HRP20000878A2 (en) 2001-12-31
ATE217308T1 (de) 2002-05-15
CZ299257B6 (cs) 2008-05-28

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