SK283380B6 - Spôsob prípravy morfolínových derivátov a ich medziproduktov - Google Patents

Spôsob prípravy morfolínových derivátov a ich medziproduktov Download PDF

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Publication number
SK283380B6
SK283380B6 SK1921-2000A SK19212000A SK283380B6 SK 283380 B6 SK283380 B6 SK 283380B6 SK 19212000 A SK19212000 A SK 19212000A SK 283380 B6 SK283380 B6 SK 283380B6
Authority
SK
Slovakia
Prior art keywords
process according
base
carried out
organic solvent
morpholine
Prior art date
Application number
SK1921-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK19212000A3 (sk
Inventor
Ian Frank Cottrell
Ulf H. Dolling
David Hands
Robin Darrin Wilson
Original Assignee
Merck Sharp & Dohme Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited
Publication of SK19212000A3 publication Critical patent/SK19212000A3/sk
Publication of SK283380B6 publication Critical patent/SK283380B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1921-2000A 1998-06-16 1999-06-10 Spôsob prípravy morfolínových derivátov a ich medziproduktov SK283380B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9813025.5A GB9813025D0 (en) 1998-06-16 1998-06-16 Chemical synthesis
PCT/GB1999/001842 WO1999065900A1 (en) 1998-06-16 1999-06-10 Chemical synthesis of morpholine derivatives

Publications (2)

Publication Number Publication Date
SK19212000A3 SK19212000A3 (sk) 2001-07-10
SK283380B6 true SK283380B6 (sk) 2003-06-03

Family

ID=10833892

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1921-2000A SK283380B6 (sk) 1998-06-16 1999-06-10 Spôsob prípravy morfolínových derivátov a ich medziproduktov

Country Status (28)

Country Link
US (2) US6297376B1 (uk)
EP (1) EP1087966B1 (uk)
JP (2) JP4647783B2 (uk)
KR (1) KR100619589B1 (uk)
CN (1) CN1131864C (uk)
AR (1) AR018877A1 (uk)
AT (1) ATE217308T1 (uk)
AU (1) AU746721B2 (uk)
BR (1) BR9911250A (uk)
CA (1) CA2334821C (uk)
CZ (1) CZ299257B6 (uk)
DE (1) DE69901444T2 (uk)
DK (1) DK1087966T3 (uk)
EA (1) EA003468B1 (uk)
ES (1) ES2176036T3 (uk)
GB (1) GB9813025D0 (uk)
HR (1) HRP20000878B1 (uk)
HU (1) HUP0102867A3 (uk)
IL (2) IL139946A0 (uk)
NZ (1) NZ508558A (uk)
PL (1) PL196778B1 (uk)
PT (1) PT1087966E (uk)
SI (1) SI1087966T1 (uk)
SK (1) SK283380B6 (uk)
TW (1) TW526199B (uk)
UA (1) UA66866C2 (uk)
WO (1) WO1999065900A1 (uk)
YU (1) YU76500A (uk)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030284A1 (es) 2000-06-08 2003-08-20 Merck & Co Inc Proceso para la sintesis de (2r, 2-alfa-r,3a) -2-[1-(3,5-bis(trifluorometil) fenil) etoxi]-3-(4-fluorofenil)-1,4-oxazina; dicho compuesto y sus formas polimorficas
GB0014876D0 (en) 2000-06-16 2000-08-09 Merck Sharp & Dohme Chemical synthesis
UA76810C2 (uk) 2001-12-10 2006-09-15 Мерк Енд Ко., Інк. Фармацевтична композиція антагоніста рецептора тахікініну у формі наночастинок
AR039625A1 (es) 2002-04-18 2005-03-02 Merck & Co Inc Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
US7235671B2 (en) 2002-08-21 2007-06-26 Merck & Co. Inc. Process for preparing 3-chloromethyl-1,2,4-triazolin-5-one
US9227958B2 (en) 2006-02-03 2016-01-05 Glenmark Pharmaceuticals Limited Amorphous and crystalline forms of aprepitant and processes for the preparation thereof
WO2012146692A1 (en) 2011-04-29 2012-11-01 Sandoz Ag Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
ITMI20130273A1 (it) * 2013-02-26 2014-08-27 Olon Spa Procedimento per la preparazione di aprepitant
CN103288813A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种阿瑞匹坦的制备方法
CN104628663A (zh) * 2013-11-08 2015-05-20 中山奕安泰医药科技有限公司 3-氯甲基-1,2,4-三唑啉-5-酮的合成方法
CN107698574B (zh) * 2017-11-23 2020-12-01 中山奕安泰医药科技有限公司 一种高纯度阿瑞匹坦的精制制备工艺
CN109485613B (zh) * 2018-11-21 2022-05-13 江苏慧聚药业股份有限公司 阿瑞匹坦和福沙匹坦边链片段的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
CA2178219C (en) 1993-12-29 2005-03-22 Raymond Baker Substituted morpholine derivatives and their use as therapeutic agents
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US5747491A (en) * 1994-05-05 1998-05-05 Merck Sharp & Dohme Ltd. Morpholine derivatives and their use as antagonists of tachikinins

Also Published As

Publication number Publication date
JP2002518388A (ja) 2002-06-25
US6407255B2 (en) 2002-06-18
WO1999065900A1 (en) 1999-12-23
CA2334821A1 (en) 1999-12-23
PL344581A1 (en) 2001-11-05
AU4281399A (en) 2000-01-05
AR018877A1 (es) 2001-12-12
PL196778B1 (pl) 2008-01-31
CZ299257B6 (cs) 2008-05-28
DE69901444D1 (de) 2002-06-13
KR100619589B1 (ko) 2006-09-05
US6297376B1 (en) 2001-10-02
DE69901444T2 (de) 2002-11-28
CA2334821C (en) 2009-02-03
US20020019524A1 (en) 2002-02-14
JP4647783B2 (ja) 2011-03-09
BR9911250A (pt) 2001-03-13
EP1087966B1 (en) 2002-05-08
EP1087966A1 (en) 2001-04-04
NZ508558A (en) 2003-07-25
DK1087966T3 (da) 2002-07-08
GB9813025D0 (en) 1998-08-12
CZ20004734A3 (cs) 2001-08-15
EA003468B1 (ru) 2003-06-26
AU746721B2 (en) 2002-05-02
ATE217308T1 (de) 2002-05-15
KR20010052886A (ko) 2001-06-25
ES2176036T3 (es) 2002-11-16
SK19212000A3 (sk) 2001-07-10
IL139946A0 (en) 2002-02-10
TW526199B (en) 2003-04-01
YU76500A (sh) 2003-02-28
EA200100040A1 (ru) 2001-06-25
HUP0102867A3 (en) 2004-06-28
HUP0102867A2 (hu) 2002-05-29
JP2010195808A (ja) 2010-09-09
CN1305475A (zh) 2001-07-25
HRP20000878B1 (en) 2009-09-30
SI1087966T1 (en) 2002-10-31
PT1087966E (pt) 2002-10-31
CN1131864C (zh) 2003-12-24
IL139946A (en) 2007-05-15
HRP20000878A2 (en) 2001-12-31
UA66866C2 (uk) 2004-06-15
JP5285652B2 (ja) 2013-09-11

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20150610