EA200100040A1 - Химический синтез морфолиновых производных - Google Patents

Химический синтез морфолиновых производных

Info

Publication number
EA200100040A1
EA200100040A1 EA200100040A EA200100040A EA200100040A1 EA 200100040 A1 EA200100040 A1 EA 200100040A1 EA 200100040 A EA200100040 A EA 200100040A EA 200100040 A EA200100040 A EA 200100040A EA 200100040 A1 EA200100040 A1 EA 200100040A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
morfoline
chemical synthesis
formula
therapeutic agents
Prior art date
Application number
EA200100040A
Other languages
English (en)
Other versions
EA003468B1 (ru
Inventor
Ян Фрэнк Коттрелл
Ульф Х. Доллинг
Дэвид Хэндс
Роберт Дэррин Вилсон
Original Assignee
Мерк Шарп Энд Домэ Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Шарп Энд Домэ Лимитед filed Critical Мерк Шарп Энд Домэ Лимитед
Publication of EA200100040A1 publication Critical patent/EA200100040A1/ru
Publication of EA003468B1 publication Critical patent/EA003468B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings

Abstract

Данное изобретение относится к способу получения морфолиновых производных формулы (I), которые пригодны в качестве терапевтических средств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100040A 1998-06-16 1999-06-10 Способ получения производных морфолина EA003468B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9813025.5A GB9813025D0 (en) 1998-06-16 1998-06-16 Chemical synthesis
PCT/GB1999/001842 WO1999065900A1 (en) 1998-06-16 1999-06-10 Chemical synthesis of morpholine derivatives

Publications (2)

Publication Number Publication Date
EA200100040A1 true EA200100040A1 (ru) 2001-06-25
EA003468B1 EA003468B1 (ru) 2003-06-26

Family

ID=10833892

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100040A EA003468B1 (ru) 1998-06-16 1999-06-10 Способ получения производных морфолина

Country Status (28)

Country Link
US (2) US6297376B1 (ru)
EP (1) EP1087966B1 (ru)
JP (2) JP4647783B2 (ru)
KR (1) KR100619589B1 (ru)
CN (1) CN1131864C (ru)
AR (1) AR018877A1 (ru)
AT (1) ATE217308T1 (ru)
AU (1) AU746721B2 (ru)
BR (1) BR9911250A (ru)
CA (1) CA2334821C (ru)
CZ (1) CZ299257B6 (ru)
DE (1) DE69901444T2 (ru)
DK (1) DK1087966T3 (ru)
EA (1) EA003468B1 (ru)
ES (1) ES2176036T3 (ru)
GB (1) GB9813025D0 (ru)
HR (1) HRP20000878B1 (ru)
HU (1) HUP0102867A3 (ru)
IL (2) IL139946A0 (ru)
NZ (1) NZ508558A (ru)
PL (1) PL196778B1 (ru)
PT (1) PT1087966E (ru)
SI (1) SI1087966T1 (ru)
SK (1) SK283380B6 (ru)
TW (1) TW526199B (ru)
UA (1) UA66866C2 (ru)
WO (1) WO1999065900A1 (ru)
YU (1) YU76500A (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030284A1 (es) 2000-06-08 2003-08-20 Merck & Co Inc Proceso para la sintesis de (2r, 2-alfa-r,3a) -2-[1-(3,5-bis(trifluorometil) fenil) etoxi]-3-(4-fluorofenil)-1,4-oxazina; dicho compuesto y sus formas polimorficas
GB0014876D0 (en) * 2000-06-16 2000-08-09 Merck Sharp & Dohme Chemical synthesis
UA76810C2 (ru) 2001-12-10 2006-09-15 Мерк Енд Ко., Інк. Фармацевтическая композиция антагониста рецептора тахикинина в форме наночастиц
AR039625A1 (es) 2002-04-18 2005-03-02 Merck & Co Inc Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
US7235671B2 (en) 2002-08-21 2007-06-26 Merck & Co. Inc. Process for preparing 3-chloromethyl-1,2,4-triazolin-5-one
CA2640966A1 (en) 2006-02-03 2007-08-09 Glenmark Pharmaceuticals Limited Amorphous and crystalline forms of aprepitant and processes for the preparation thereof
WO2012146692A1 (en) 2011-04-29 2012-11-01 Sandoz Ag Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
ITMI20130273A1 (it) * 2013-02-26 2014-08-27 Olon Spa Procedimento per la preparazione di aprepitant
CN103288813A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种阿瑞匹坦的制备方法
CN104628663A (zh) * 2013-11-08 2015-05-20 中山奕安泰医药科技有限公司 3-氯甲基-1,2,4-三唑啉-5-酮的合成方法
CN107698574B (zh) * 2017-11-23 2020-12-01 中山奕安泰医药科技有限公司 一种高纯度阿瑞匹坦的精制制备工艺
CN109485613B (zh) * 2018-11-21 2022-05-13 江苏慧聚药业股份有限公司 阿瑞匹坦和福沙匹坦边链片段的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
DE69434063D1 (de) * 1993-12-29 2004-11-11 Merck Sharp & Dohme Substituierte Morpholinderivate und ihre Verwendung als therapeutische Mittel
TW385308B (en) 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
US5747491A (en) * 1994-05-05 1998-05-05 Merck Sharp & Dohme Ltd. Morpholine derivatives and their use as antagonists of tachikinins

Also Published As

Publication number Publication date
EA003468B1 (ru) 2003-06-26
HUP0102867A3 (en) 2004-06-28
PL196778B1 (pl) 2008-01-31
US6407255B2 (en) 2002-06-18
SK19212000A3 (sk) 2001-07-10
ATE217308T1 (de) 2002-05-15
CA2334821A1 (en) 1999-12-23
YU76500A (sh) 2003-02-28
US20020019524A1 (en) 2002-02-14
IL139946A0 (en) 2002-02-10
BR9911250A (pt) 2001-03-13
NZ508558A (en) 2003-07-25
CZ20004734A3 (cs) 2001-08-15
EP1087966B1 (en) 2002-05-08
DE69901444D1 (de) 2002-06-13
SI1087966T1 (en) 2002-10-31
TW526199B (en) 2003-04-01
CN1131864C (zh) 2003-12-24
IL139946A (en) 2007-05-15
HRP20000878B1 (en) 2009-09-30
JP2002518388A (ja) 2002-06-25
HUP0102867A2 (hu) 2002-05-29
DE69901444T2 (de) 2002-11-28
CA2334821C (en) 2009-02-03
AR018877A1 (es) 2001-12-12
JP2010195808A (ja) 2010-09-09
KR20010052886A (ko) 2001-06-25
GB9813025D0 (en) 1998-08-12
WO1999065900A1 (en) 1999-12-23
UA66866C2 (ru) 2004-06-15
JP5285652B2 (ja) 2013-09-11
AU4281399A (en) 2000-01-05
US6297376B1 (en) 2001-10-02
JP4647783B2 (ja) 2011-03-09
ES2176036T3 (es) 2002-11-16
CN1305475A (zh) 2001-07-25
EP1087966A1 (en) 2001-04-04
DK1087966T3 (da) 2002-07-08
SK283380B6 (sk) 2003-06-03
CZ299257B6 (cs) 2008-05-28
AU746721B2 (en) 2002-05-02
PL344581A1 (en) 2001-11-05
HRP20000878A2 (en) 2001-12-31
PT1087966E (pt) 2002-10-31
KR100619589B1 (ko) 2006-09-05

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU