TR200402046T4 - Büyüme hormonu salgılanmasını uyarıcı maddeler olarak ikameli dipeptitler. - Google Patents
Büyüme hormonu salgılanmasını uyarıcı maddeler olarak ikameli dipeptitler.Info
- Publication number
- TR200402046T4 TR200402046T4 TR2004/02046T TR200402046T TR200402046T4 TR 200402046 T4 TR200402046 T4 TR 200402046T4 TR 2004/02046 T TR2004/02046 T TR 2004/02046T TR 200402046 T TR200402046 T TR 200402046T TR 200402046 T4 TR200402046 T4 TR 200402046T4
- Authority
- TR
- Turkey
- Prior art keywords
- growth hormone
- hormone secretagogues
- compounds
- substituted dipeptides
- novel
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title 1
- 239000003324 growth hormone secretagogue Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Bu bulus bir memelide endojen (iç kaynakli) büyüme hormonu seviyelerinin degistirilmesinde yararli olan yeni bilesiklere iliskindir. Bulus ayrica adi geçen bilesiklerin sentezlenmesinde kullanilacak yeni aramaddelere ve bu sentezlerde kullanilan yeni islemlere iliskindir. Bir memeliyi tedavi etmek için adi geçen bilesiklerin uygulamasina dayanan yöntemler de bulusun kapsami içine girmektedir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24045600P | 2000-10-13 | 2000-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200402046T4 true TR200402046T4 (tr) | 2004-10-21 |
Family
ID=22906598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/02046T TR200402046T4 (tr) | 2000-10-13 | 2001-10-09 | Büyüme hormonu salgılanmasını uyarıcı maddeler olarak ikameli dipeptitler. |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP1326851B1 (tr) |
JP (1) | JP2004511552A (tr) |
KR (1) | KR20030042014A (tr) |
CN (1) | CN1469871A (tr) |
AT (1) | ATE270280T1 (tr) |
AU (2) | AU1121902A (tr) |
BR (1) | BR0114630A (tr) |
CA (1) | CA2419388A1 (tr) |
CZ (1) | CZ20031029A3 (tr) |
DE (1) | DE60104141T2 (tr) |
DZ (1) | DZ3482A1 (tr) |
EA (1) | EA006102B1 (tr) |
EC (1) | ECSP034551A (tr) |
ES (1) | ES2223926T3 (tr) |
HK (1) | HK1058194A1 (tr) |
HR (1) | HRP20030288B1 (tr) |
HU (1) | HUP0301351A3 (tr) |
IL (1) | IL154809A0 (tr) |
MX (1) | MXPA03003217A (tr) |
NO (1) | NO20031687L (tr) |
NZ (1) | NZ524232A (tr) |
PL (1) | PL361675A1 (tr) |
PT (1) | PT1326851E (tr) |
SK (1) | SK4182003A3 (tr) |
TR (1) | TR200402046T4 (tr) |
WO (1) | WO2002032888A1 (tr) |
ZA (1) | ZA200301720B (tr) |
Families Citing this family (47)
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---|---|---|---|---|
DE60306636T2 (de) * | 2002-04-09 | 2007-07-05 | Eli Lilly And Co., Indianapolis | Wachstumhormonsekretionsförderer |
US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US7547693B2 (en) | 2003-09-22 | 2009-06-16 | Banyu Pharmaceutical Co. Ltd. | Piperidine derivative |
US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
US8138206B2 (en) | 2005-05-30 | 2012-03-20 | Msd. K.K. | Piperidine derivative |
WO2007018248A1 (ja) | 2005-08-10 | 2007-02-15 | Banyu Pharmaceutical Co., Ltd. | ピリドン化合物 |
WO2007024004A1 (ja) | 2005-08-24 | 2007-03-01 | Banyu Pharmaceutical Co., Ltd. | フェニルピリドン誘導体 |
JPWO2007029847A1 (ja) | 2005-09-07 | 2009-03-19 | 萬有製薬株式会社 | 二環性芳香族置換ピリドン誘導体 |
KR20080048502A (ko) | 2005-09-29 | 2008-06-02 | 머크 앤드 캄파니 인코포레이티드 | 멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체 |
WO2007048027A2 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent |
US8163770B2 (en) | 2005-10-27 | 2012-04-24 | Msd. K. K. | Benzoxathiin derivative |
WO2007055418A1 (ja) | 2005-11-10 | 2007-05-18 | Banyu Pharmaceutical Co., Ltd. | アザ置換スピロ誘導体 |
WO2008039327A2 (en) | 2006-09-22 | 2008-04-03 | Merck & Co., Inc. | Method of treatment using fatty acid synthesis inhibitors |
AU2007301126A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Msd株式会社 | インドールジオン誘導体 |
ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
JPWO2009110510A1 (ja) | 2008-03-06 | 2011-07-14 | Msd株式会社 | アルキルアミノピリジン誘導体 |
CN101981025A (zh) | 2008-03-28 | 2011-02-23 | 万有制药株式会社 | 具有黑色素浓缩激素受体拮抗作用的二芳基甲基酰胺衍生物 |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
AU2009261248A1 (en) | 2008-06-19 | 2009-12-23 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diarylketoxime derivative |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
WO2010013595A1 (ja) | 2008-07-30 | 2010-02-04 | 萬有製薬株式会社 | 5員-5員又は5員-6員縮環シクロアルキルアミン誘導体 |
MX2011004258A (es) | 2008-10-22 | 2011-06-01 | Merck Sharp & Dohme | Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos. |
BRPI0919876A8 (pt) | 2008-10-30 | 2016-02-10 | Merck Sharp & Dohme | Composto, composição farmacêutica, uso de um composto, e, método para intensificar a qualidade do sono, para tratar insônia, e para tratar ou controlar obesidade em um paciente mamífero que necessita do mesmo. |
CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US8314250B2 (en) * | 2009-11-24 | 2012-11-20 | Hoffmann-La Roche Inc. | Sultam derivatives |
CA2786314A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
KR101668514B1 (ko) | 2011-02-25 | 2016-10-21 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병제로서 유용한 신규 시클릭 아자벤즈이미다졸 유도체 |
AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
JP2015525782A (ja) | 2012-08-02 | 2015-09-07 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 抗糖尿病性三環式化合物 |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
MX2017002610A (es) | 2014-08-29 | 2017-10-11 | Tes Pharma S R L | INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA. |
US20180134667A1 (en) | 2016-10-14 | 2018-05-17 | TES Pharma S.r.I. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
MX2021005904A (es) | 2018-11-20 | 2021-09-08 | Tes Pharma S R L | Inhibidores de la ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa. |
WO2020167706A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
WO2021026047A1 (en) | 2019-08-08 | 2021-02-11 | Merck Sharp & Dohme Corp. | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
US20230365533A1 (en) | 2020-08-18 | 2023-11-16 | Merck Sharp & Dohme Llc | Bicycloheptane pyrrolidine orexin receptor agonists |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4993497A (en) * | 1996-10-25 | 1998-05-22 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
UA53716C2 (uk) * | 1997-06-25 | 2003-02-17 | Пфайзер Продактс Інк. | Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти) |
-
2001
- 2001-10-09 CA CA002419388A patent/CA2419388A1/en not_active Abandoned
- 2001-10-09 DE DE60104141T patent/DE60104141T2/de not_active Expired - Lifetime
- 2001-10-09 TR TR2004/02046T patent/TR200402046T4/tr unknown
- 2001-10-09 NZ NZ524232A patent/NZ524232A/en unknown
- 2001-10-09 ES ES01979233T patent/ES2223926T3/es not_active Expired - Lifetime
- 2001-10-09 KR KR10-2003-7005203A patent/KR20030042014A/ko not_active Application Discontinuation
- 2001-10-09 DZ DZ013482A patent/DZ3482A1/fr active
- 2001-10-09 EA EA200300462A patent/EA006102B1/ru not_active IP Right Cessation
- 2001-10-09 SK SK418-2003A patent/SK4182003A3/sk unknown
- 2001-10-09 CZ CZ20031029A patent/CZ20031029A3/cs unknown
- 2001-10-09 MX MXPA03003217A patent/MXPA03003217A/es unknown
- 2001-10-09 AU AU1121902A patent/AU1121902A/xx active Pending
- 2001-10-09 CN CNA018172822A patent/CN1469871A/zh active Pending
- 2001-10-09 AU AU2002211219A patent/AU2002211219B2/en not_active Ceased
- 2001-10-09 EP EP01979233A patent/EP1326851B1/en not_active Expired - Lifetime
- 2001-10-09 HU HU0301351A patent/HUP0301351A3/hu unknown
- 2001-10-09 PT PT01979233T patent/PT1326851E/pt unknown
- 2001-10-09 AT AT01979233T patent/ATE270280T1/de not_active IP Right Cessation
- 2001-10-09 BR BR0114630-0A patent/BR0114630A/pt not_active IP Right Cessation
- 2001-10-09 PL PL01361675A patent/PL361675A1/xx not_active Application Discontinuation
- 2001-10-09 IL IL15480901A patent/IL154809A0/xx unknown
- 2001-10-09 JP JP2002536270A patent/JP2004511552A/ja active Pending
- 2001-10-09 WO PCT/US2001/027756 patent/WO2002032888A1/en active IP Right Grant
-
2003
- 2003-02-28 ZA ZA200301720A patent/ZA200301720B/en unknown
- 2003-04-10 EC EC2003004551A patent/ECSP034551A/es unknown
- 2003-04-11 NO NO20031687A patent/NO20031687L/no unknown
- 2003-04-14 HR HR20030288A patent/HRP20030288B1/xx not_active IP Right Cessation
- 2003-12-31 HK HK03109504A patent/HK1058194A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MXPA03003217A (es) | 2003-06-06 |
BR0114630A (pt) | 2003-07-01 |
PL361675A1 (en) | 2004-10-04 |
CA2419388A1 (en) | 2002-04-25 |
CZ20031029A3 (cs) | 2003-09-17 |
HRP20030288A2 (en) | 2004-02-29 |
NZ524232A (en) | 2005-01-28 |
DE60104141T2 (de) | 2005-06-30 |
HK1058194A1 (en) | 2004-05-07 |
KR20030042014A (ko) | 2003-05-27 |
HUP0301351A3 (en) | 2007-05-29 |
ATE270280T1 (de) | 2004-07-15 |
DE60104141D1 (de) | 2004-08-05 |
AU2002211219B2 (en) | 2006-09-14 |
DZ3482A1 (fr) | 2002-04-25 |
PT1326851E (pt) | 2004-11-30 |
WO2002032888A1 (en) | 2002-04-25 |
EA200300462A1 (ru) | 2003-08-28 |
IL154809A0 (en) | 2003-10-31 |
HUP0301351A2 (hu) | 2003-11-28 |
CN1469871A (zh) | 2004-01-21 |
AU1121902A (en) | 2002-04-29 |
ES2223926T3 (es) | 2005-03-01 |
EA006102B1 (ru) | 2005-08-25 |
EP1326851A1 (en) | 2003-07-16 |
SK4182003A3 (en) | 2004-01-08 |
ZA200301720B (en) | 2004-06-21 |
NO20031687L (no) | 2003-05-08 |
ECSP034551A (es) | 2003-05-26 |
NO20031687D0 (no) | 2003-04-11 |
EP1326851B1 (en) | 2004-06-30 |
HRP20030288B1 (en) | 2005-02-28 |
JP2004511552A (ja) | 2004-04-15 |
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