UA41300C2 - Аналоги гормонів-антагоністів lhrh і спосіб їх отримання - Google Patents

Аналоги гормонів-антагоністів lhrh і спосіб їх отримання

Info

Publication number
UA41300C2
UA41300C2 UA94030668A UA94030668A UA41300C2 UA 41300 C2 UA41300 C2 UA 41300C2 UA 94030668 A UA94030668 A UA 94030668A UA 94030668 A UA94030668 A UA 94030668A UA 41300 C2 UA41300 C2 UA 41300C2
Authority
UA
Ukraine
Prior art keywords
lhrh
antagonists
analogs
preparation
sections
Prior art date
Application number
UA94030668A
Other languages
English (en)
Russian (ru)
Inventor
Схаобо КСІАО
Шаобо КСИАО
Original Assignee
Тянджін Муніціпал Ресерч Інстітут Фор Фемілі Пленнінг
Тянджин Муниципал Ресерч Институт Фор Фемили Плэннинг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тянджін Муніціпал Ресерч Інстітут Фор Фемілі Пленнінг, Тянджин Муниципал Ресерч Институт Фор Фемили Плэннинг filed Critical Тянджін Муніціпал Ресерч Інстітут Фор Фемілі Пленнінг
Publication of UA41300C2 publication Critical patent/UA41300C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Цей винахід відноситься до нових пептидів і їх похідних, що мають точну хімічну структуру. Спосіб отримання аналогів антагоністів LHRH включає модифікацію ділянок молекули вихідної сполуки. Лужні і ліпофільні ділянки [NAc-D2Nall-DpClPhe2-DЗPal3-Ser4-Tyr5-Argб-Leu7-Arg8-Pro9-DAla]NH2 модифікують шляхом заміщення відповідних амінокислот.
UA94030668A 1990-11-10 1991-11-08 Аналоги гормонів-антагоністів lhrh і спосіб їх отримання UA41300C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN90108955A CN1036343C (zh) 1990-11-10 1990-11-10 新促黄体生成素释放激素拮抗类似物的制备方法
PCT/EP1991/002110 WO1992008733A1 (en) 1990-11-10 1991-11-08 Lhrh-antagonists

Publications (1)

Publication Number Publication Date
UA41300C2 true UA41300C2 (uk) 2001-09-17

Family

ID=4881223

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94030668A UA41300C2 (uk) 1990-11-10 1991-11-08 Аналоги гормонів-антагоністів lhrh і спосіб їх отримання

Country Status (29)

Country Link
EP (1) EP0564466B1 (uk)
KR (1) KR100244624B1 (uk)
CN (1) CN1036343C (uk)
AT (1) ATE149520T1 (uk)
AU (1) AU662496B2 (uk)
CA (1) CA2095932C (uk)
CZ (1) CZ284168B6 (uk)
DE (1) DE69125024T2 (uk)
DK (1) DK0564466T3 (uk)
EE (1) EE03141B1 (uk)
ES (1) ES2100965T3 (uk)
FI (1) FI933156A0 (uk)
GR (1) GR3023389T3 (uk)
HR (1) HRP920585B1 (uk)
IE (1) IE913915A1 (uk)
LT (1) LT3971B (uk)
LV (1) LV10106B (uk)
NO (1) NO931697L (uk)
NZ (1) NZ240505A (uk)
PH (1) PH31178A (uk)
PL (1) PL170564B1 (uk)
PT (1) PT99458B (uk)
RU (1) RU2123499C1 (uk)
SI (1) SI9111779B (uk)
SK (1) SK281319B6 (uk)
UA (1) UA41300C2 (uk)
WO (1) WO1992008733A1 (uk)
YU (1) YU48831B (uk)
ZA (1) ZA918847B (uk)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE206136T1 (de) * 1992-12-18 2001-10-15 Abbott Lab Lhrh antagonisten mit modifizierten aminoacylresten an den positionen 5 und 6
US6828415B2 (en) 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE4305225A1 (de) * 1993-02-19 1994-08-25 Asta Medica Ag Neues Herstellverfahren für Cetrorelix Lyophilisat
DE4338015A1 (de) * 1993-11-08 1995-05-11 Asta Medica Ag Verwendung von D-glucopyranuronsäuren und deren Derivaten zum Einbau in pharmakologisch wirksame Peptide und deren Salze
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
CN102675418B (zh) * 2011-03-15 2016-04-20 中国人民解放军军事医学科学院毒物药物研究所 Lhrh拮抗剂衍生物、其制备方法及用途
CN103524599B (zh) * 2012-07-05 2016-04-20 中国人民解放军军事医学科学院毒物药物研究所 环肽lhrh拮抗剂衍生物及其药物用途
CN104418936B (zh) * 2013-08-20 2018-06-05 中国人民解放军军事医学科学院毒物药物研究所 Lhrh拮抗剂衍生物及其药物用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4851385A (en) * 1987-07-15 1989-07-25 Indiana University Foundation LHRH antagonist analogs having low histamine-release activity

Also Published As

Publication number Publication date
NO931697D0 (no) 1993-05-10
ES2100965T3 (es) 1997-07-01
EP0564466A1 (en) 1993-10-13
LT3971B (en) 1996-05-27
DE69125024T2 (de) 1997-07-17
PL170564B1 (pl) 1996-12-31
CN1061605A (zh) 1992-06-03
PT99458B (pt) 1999-02-26
LTIP1513A (en) 1995-06-26
DE69125024D1 (de) 1997-04-10
YU48831B (sh) 2002-03-18
SI9111779B (en) 2001-12-31
GR3023389T3 (en) 1997-08-29
PT99458A (pt) 1992-10-30
YU177991A (sh) 1994-06-24
CZ284168B6 (cs) 1998-09-16
NZ240505A (en) 1993-04-28
SK281319B6 (sk) 2001-02-12
RU2123499C1 (ru) 1998-12-20
CN1036343C (zh) 1997-11-05
HRP920585A2 (en) 1997-04-30
PH31178A (en) 1998-03-20
DK0564466T3 (da) 1997-08-25
EE03141B1 (et) 1998-12-15
IE913915A1 (en) 1992-05-20
LV10106B (en) 1995-04-20
SK45393A3 (en) 1993-10-06
NO931697L (no) 1993-07-07
ZA918847B (en) 1992-08-26
HRP920585B1 (en) 2000-08-31
FI933156A (fi) 1993-07-09
PL295427A1 (en) 1993-09-06
CZ84893A3 (en) 1994-02-16
LV10106A (lv) 1994-05-10
EP0564466B1 (en) 1997-03-05
SI9111779A (en) 1997-04-30
CA2095932A1 (en) 1992-05-11
FI933156A0 (fi) 1993-07-09
AU8861291A (en) 1992-06-11
KR930703353A (ko) 1993-11-29
KR100244624B1 (ko) 2000-02-15
ATE149520T1 (de) 1997-03-15
WO1992008733A1 (en) 1992-05-29
CA2095932C (en) 2003-02-25
AU662496B2 (en) 1995-09-07

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