ATE321773T1 - Semisynthetisches verfahren zur herstellung von didemninanalogen - Google Patents
Semisynthetisches verfahren zur herstellung von didemninanalogenInfo
- Publication number
- ATE321773T1 ATE321773T1 AT97911896T AT97911896T ATE321773T1 AT E321773 T1 ATE321773 T1 AT E321773T1 AT 97911896 T AT97911896 T AT 97911896T AT 97911896 T AT97911896 T AT 97911896T AT E321773 T1 ATE321773 T1 AT E321773T1
- Authority
- AT
- Austria
- Prior art keywords
- didemnine
- analogues
- producing
- semisynthetic process
- semisynthetic
- Prior art date
Links
- KYHUYMLIVQFXRI-XYUQHQMCSA-N (2s)-n-[(2r)-1-[[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino Chemical class CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)O KYHUYMLIVQFXRI-XYUQHQMCSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2911296P | 1996-10-24 | 1996-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321773T1 true ATE321773T1 (de) | 2006-04-15 |
Family
ID=21847298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97911896T ATE321773T1 (de) | 1996-10-24 | 1997-10-24 | Semisynthetisches verfahren zur herstellung von didemninanalogen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6841530B2 (de) |
| EP (1) | EP0973518B1 (de) |
| JP (1) | JP2001503746A (de) |
| AT (1) | ATE321773T1 (de) |
| AU (1) | AU731757B2 (de) |
| CA (1) | CA2269881A1 (de) |
| DE (1) | DE69735583T2 (de) |
| ES (1) | ES2262175T3 (de) |
| WO (1) | WO1998017275A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030148933A1 (en) | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
| GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| US6509315B1 (en) | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
| DK1276491T3 (da) | 2000-04-07 | 2007-02-05 | Univ Pennsylvania | Tamandarin- og didemnin-analoger og fremgangsmåder til fremstilling og anvendelse af dem |
| GB0103750D0 (en) * | 2001-02-15 | 2001-04-04 | Pharma Mar Sa | Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them |
| GB0016148D0 (en) * | 2000-06-30 | 2000-08-23 | Pharma Mar Sa | Synthetic methods for aplidine and new antitiumoral derivatives |
| UA76718C2 (uk) * | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
| KR20030038812A (ko) | 2000-10-12 | 2003-05-16 | 파르마 마르, 에스.에이. | 암 치료 방법 |
| WO2004080421A2 (en) | 2003-03-12 | 2004-09-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
| NZ541611A (en) | 2003-03-12 | 2008-04-30 | Dana Farber Cancer Inst Inc | Aplidine for multiple myeloma treatment |
| WO2004084812A2 (en) | 2003-03-21 | 2004-10-07 | Joullie Madeleine M | Tamandarin analogs and fragments thereof and methods of making and using |
| MX2008010999A (es) | 2006-02-28 | 2008-09-08 | Pharma Mar Sa | Tratamientos anti-tumor mejorados. |
| US9644005B2 (en) | 2011-09-21 | 2017-05-09 | King Abdullah University Of Science And Technology | Didemnin biosynthetic gene cluster in Tistrella mobilis |
| TWI807411B (zh) | 2017-04-27 | 2023-07-01 | 西班牙商瑪製藥股份有限公司 | 抗腫瘤化合物 |
| CN115594739B (zh) * | 2021-06-28 | 2025-02-14 | 浙江珲达生物科技有限公司 | 一种dehydrodidemnin B类化合物的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4950649A (en) * | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
| US4493796A (en) * | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
| US4948791A (en) * | 1989-04-10 | 1990-08-14 | The Board Of Trustees Of The University Of Illinois | Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum |
-
1997
- 1997-10-24 JP JP51964898A patent/JP2001503746A/ja not_active Ceased
- 1997-10-24 DE DE69735583T patent/DE69735583T2/de not_active Expired - Fee Related
- 1997-10-24 AT AT97911896T patent/ATE321773T1/de not_active IP Right Cessation
- 1997-10-24 ES ES97911896T patent/ES2262175T3/es not_active Expired - Lifetime
- 1997-10-24 AU AU49165/97A patent/AU731757B2/en not_active Ceased
- 1997-10-24 EP EP97911896A patent/EP0973518B1/de not_active Expired - Lifetime
- 1997-10-24 WO PCT/US1997/019210 patent/WO1998017275A1/en not_active Ceased
- 1997-10-24 CA CA002269881A patent/CA2269881A1/en not_active Abandoned
-
2001
- 2001-09-10 US US09/949,947 patent/US6841530B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20020037835A1 (en) | 2002-03-28 |
| DE69735583T2 (de) | 2007-04-05 |
| EP0973518B1 (de) | 2006-03-29 |
| AU731757B2 (en) | 2001-04-05 |
| CA2269881A1 (en) | 1998-04-30 |
| EP0973518A1 (de) | 2000-01-26 |
| JP2001503746A (ja) | 2001-03-21 |
| EP0973518A4 (de) | 2004-05-26 |
| WO1998017275A1 (en) | 1998-04-30 |
| ES2262175T3 (es) | 2006-11-16 |
| AU4916597A (en) | 1998-05-15 |
| US6841530B2 (en) | 2005-01-11 |
| DE69735583D1 (de) | 2006-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |