HRP920585B1 - Method of design and synthesis of lutheinizing hormone releasing hormone antagonists, products and use thereof - Google Patents

Method of design and synthesis of lutheinizing hormone releasing hormone antagonists, products and use thereof

Info

Publication number
HRP920585B1
HRP920585B1 HR920585A HRP920585A HRP920585B1 HR P920585 B1 HRP920585 B1 HR P920585B1 HR 920585 A HR920585 A HR 920585A HR P920585 A HRP920585 A HR P920585A HR P920585 B1 HRP920585 B1 HR P920585B1
Authority
HR
Croatia
Prior art keywords
synthesis
design
products
parent compound
lutheinizing
Prior art date
Application number
HR920585A
Other languages
English (en)
Inventor
Shaobo Xiao
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of HRP920585A2 publication Critical patent/HRP920585A2/xx
Publication of HRP920585B1 publication Critical patent/HRP920585B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
HR920585A 1990-11-10 1992-09-29 Method of design and synthesis of lutheinizing hormone releasing hormone antagonists, products and use thereof HRP920585B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN90108955A CN1036343C (zh) 1990-11-10 1990-11-10 新促黄体生成素释放激素拮抗类似物的制备方法
YU177991A YU48831B (sh) 1990-11-10 1991-11-08 Lhrh - antagonisti i postupak za njihovu proizvodnju

Publications (2)

Publication Number Publication Date
HRP920585A2 HRP920585A2 (en) 1997-04-30
HRP920585B1 true HRP920585B1 (en) 2000-08-31

Family

ID=4881223

Family Applications (1)

Application Number Title Priority Date Filing Date
HR920585A HRP920585B1 (en) 1990-11-10 1992-09-29 Method of design and synthesis of lutheinizing hormone releasing hormone antagonists, products and use thereof

Country Status (29)

Country Link
EP (1) EP0564466B1 (xx)
KR (1) KR100244624B1 (xx)
CN (1) CN1036343C (xx)
AT (1) ATE149520T1 (xx)
AU (1) AU662496B2 (xx)
CA (1) CA2095932C (xx)
CZ (1) CZ284168B6 (xx)
DE (1) DE69125024T2 (xx)
DK (1) DK0564466T3 (xx)
EE (1) EE03141B1 (xx)
ES (1) ES2100965T3 (xx)
FI (1) FI933156A0 (xx)
GR (1) GR3023389T3 (xx)
HR (1) HRP920585B1 (xx)
IE (1) IE913915A1 (xx)
LT (1) LT3971B (xx)
LV (1) LV10106B (xx)
NO (1) NO931697L (xx)
NZ (1) NZ240505A (xx)
PH (1) PH31178A (xx)
PL (1) PL170564B1 (xx)
PT (1) PT99458B (xx)
RU (1) RU2123499C1 (xx)
SI (1) SI9111779B (xx)
SK (1) SK281319B6 (xx)
UA (1) UA41300C2 (xx)
WO (1) WO1992008733A1 (xx)
YU (1) YU48831B (xx)
ZA (1) ZA918847B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0683792T3 (da) * 1992-12-18 2002-01-14 Abbott Lab LHRH-antagonister med modificerede aminoacylrester i stilling 5 og 6
DE4305225A1 (de) * 1993-02-19 1994-08-25 Asta Medica Ag Neues Herstellverfahren für Cetrorelix Lyophilisat
US6828415B2 (en) 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE4338015A1 (de) * 1993-11-08 1995-05-11 Asta Medica Ag Verwendung von D-glucopyranuronsäuren und deren Derivaten zum Einbau in pharmakologisch wirksame Peptide und deren Salze
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
CN102675418B (zh) * 2011-03-15 2016-04-20 中国人民解放军军事医学科学院毒物药物研究所 Lhrh拮抗剂衍生物、其制备方法及用途
CN103524599B (zh) * 2012-07-05 2016-04-20 中国人民解放军军事医学科学院毒物药物研究所 环肽lhrh拮抗剂衍生物及其药物用途
CN104418936B (zh) * 2013-08-20 2018-06-05 中国人民解放军军事医学科学院毒物药物研究所 Lhrh拮抗剂衍生物及其药物用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4851385A (en) * 1987-07-15 1989-07-25 Indiana University Foundation LHRH antagonist analogs having low histamine-release activity

Also Published As

Publication number Publication date
AU8861291A (en) 1992-06-11
CN1036343C (zh) 1997-11-05
PH31178A (en) 1998-03-20
PT99458B (pt) 1999-02-26
IE913915A1 (en) 1992-05-20
LV10106B (en) 1995-04-20
EP0564466A1 (en) 1993-10-13
WO1992008733A1 (en) 1992-05-29
FI933156A (fi) 1993-07-09
CA2095932C (en) 2003-02-25
CN1061605A (zh) 1992-06-03
UA41300C2 (uk) 2001-09-17
NO931697L (no) 1993-07-07
KR100244624B1 (ko) 2000-02-15
GR3023389T3 (en) 1997-08-29
SI9111779A (en) 1997-04-30
PT99458A (pt) 1992-10-30
PL295427A1 (en) 1993-09-06
ZA918847B (en) 1992-08-26
ES2100965T3 (es) 1997-07-01
HRP920585A2 (en) 1997-04-30
CZ284168B6 (cs) 1998-09-16
LT3971B (en) 1996-05-27
SK45393A3 (en) 1993-10-06
DK0564466T3 (da) 1997-08-25
NO931697D0 (no) 1993-05-10
CZ84893A3 (en) 1994-02-16
YU177991A (sh) 1994-06-24
CA2095932A1 (en) 1992-05-11
DE69125024D1 (de) 1997-04-10
SI9111779B (en) 2001-12-31
NZ240505A (en) 1993-04-28
DE69125024T2 (de) 1997-07-17
RU2123499C1 (ru) 1998-12-20
AU662496B2 (en) 1995-09-07
ATE149520T1 (de) 1997-03-15
LV10106A (lv) 1994-05-10
PL170564B1 (pl) 1996-12-31
LTIP1513A (en) 1995-06-26
EE03141B1 (et) 1998-12-15
FI933156A0 (fi) 1993-07-09
SK281319B6 (sk) 2001-02-12
YU48831B (sh) 2002-03-18
EP0564466B1 (en) 1997-03-05
KR930703353A (ko) 1993-11-29

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PPPP Transfer of rights

Owner name: TIANJIN MUNICIPAL RESEARCH INSTITUTE FOR FAMILY PL

ODRP Renewal fee for the maintenance of a patent

Payment date: 20031125

Year of fee payment: 13

PBON Lapse due to non-payment of renewal fee

Effective date: 20041109