SI9111779B - Lhrh-antagonists. - Google Patents

Lhrh-antagonists. Download PDF

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Publication number
SI9111779B
SI9111779B SI9111779A SI9111779A SI9111779B SI 9111779 B SI9111779 B SI 9111779B SI 9111779 A SI9111779 A SI 9111779A SI 9111779 A SI9111779 A SI 9111779A SI 9111779 B SI9111779 B SI 9111779B
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SI
Slovenia
Prior art keywords
leu7
pro1
nac
ser4
arg8
Prior art date
Application number
SI9111779A
Other languages
English (en)
Other versions
SI9111779A (en
Inventor
Shaobo Xiao
Original Assignee
Tianjin Municipal Res Inst For
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjin Municipal Res Inst For filed Critical Tianjin Municipal Res Inst For
Publication of SI9111779A publication Critical patent/SI9111779A/sl
Publication of SI9111779B publication Critical patent/SI9111779B/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (8)

  1. PATENTNI ZAHTEVKI 1. Postopek za konstruiranje in sintezo antagonistov LHRH-ja, označen s tem, da se kot izhodna spojina vzame zelo učinkovit antagonist LHRH-ja (NAc-D2Nal1, DpCIPhe2, D3Pal3, Ser4, Tyr\ DArg6, Leu7, Arg8, Pro1, DAIa2)NH2 (II) in se z modifikacijo tako alkalnega kot lipofilnega področja molekule (II) dobijo novi antagonisti LHRH-ja.
  2. 2. Spojina v skladu z zahtevkom 1, označena s tem, da je izražena s formulo (NAc-D2Nal\ DpCIPhe2, DPhe3, Ser4, Arg5, D3Pal6, Leu7, Arg8, Pro1, DAIa2)NH2.
  3. 3. Spojina v skladu z zahtevkom 1, označena s tem, da je izražena s formulo (Nac-D2Nal1, DpCIPhe2, DPhe3, Ser4, Τγι·5, D3Pal6, Leu7, Arg8, Pro1, DAla2) NH2.
  4. 4. (N-AC-D2Nal1, P-CI-D-Phe2, D3Pal3, Ser4, Mop5, D3Pal6, Leu7, Arg8, Pro1, D-Ala2)NH2.
  5. 5. (N-AC-D-2Nal1, D-Phe2, D3Pal3, Ser4, Mop5, D3Pal6, Leu7, Arg8, Pro1, D-Ala2)NH2.
  6. 6. (N-AC-D-2Nal\ P-CI-D-Phe2, D3Pal3, Set4, Arg5, D3Pal8, Leu7, Pap8, Pro1, D-Ala2)NH2.
  7. 7. Postopek konstruiranja in sinteze v skladu z zahtevkom 1, označen s tem, da se dobi spojina v skladu z zahtevkom 4.
  8. 8. Postopek konstruiranja in sinteze v skladu z zahtevkom 1, označen s tem, da se dobi spojina v skladu z zahtevkom 5. 1 Postopek konstruiranja in sinteze v skladu z zahtevkom 1, označen s tem, da se dobi 2 spojina v skladu z zahtevkom 6.
SI9111779A 1990-11-10 1991-11-08 Lhrh-antagonists. SI9111779B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN90108955A CN1036343C (zh) 1990-11-10 1990-11-10 新促黄体生成素释放激素拮抗类似物的制备方法
YU177991A YU48831B (sh) 1990-11-10 1991-11-08 Lhrh - antagonisti i postupak za njihovu proizvodnju

Publications (2)

Publication Number Publication Date
SI9111779A SI9111779A (en) 1997-04-30
SI9111779B true SI9111779B (en) 2001-12-31

Family

ID=4881223

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9111779A SI9111779B (en) 1990-11-10 1991-11-08 Lhrh-antagonists.

Country Status (29)

Country Link
EP (1) EP0564466B1 (sl)
KR (1) KR100244624B1 (sl)
CN (1) CN1036343C (sl)
AT (1) ATE149520T1 (sl)
AU (1) AU662496B2 (sl)
CA (1) CA2095932C (sl)
CZ (1) CZ284168B6 (sl)
DE (1) DE69125024T2 (sl)
DK (1) DK0564466T3 (sl)
EE (1) EE03141B1 (sl)
ES (1) ES2100965T3 (sl)
FI (1) FI933156A0 (sl)
GR (1) GR3023389T3 (sl)
HR (1) HRP920585B1 (sl)
IE (1) IE913915A1 (sl)
LT (1) LT3971B (sl)
LV (1) LV10106B (sl)
NO (1) NO931697L (sl)
NZ (1) NZ240505A (sl)
PH (1) PH31178A (sl)
PL (1) PL170564B1 (sl)
PT (1) PT99458B (sl)
RU (1) RU2123499C1 (sl)
SI (1) SI9111779B (sl)
SK (1) SK281319B6 (sl)
UA (1) UA41300C2 (sl)
WO (1) WO1992008733A1 (sl)
YU (1) YU48831B (sl)
ZA (1) ZA918847B (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2136079A1 (en) * 1992-12-18 1994-07-07 Fortuna Haviv Lhrh antagonists having modified aminoacyl residues at positions 5 and 6
US6828415B2 (en) 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE4305225A1 (de) * 1993-02-19 1994-08-25 Asta Medica Ag Neues Herstellverfahren für Cetrorelix Lyophilisat
DE4338015A1 (de) * 1993-11-08 1995-05-11 Asta Medica Ag Verwendung von D-glucopyranuronsäuren und deren Derivaten zum Einbau in pharmakologisch wirksame Peptide und deren Salze
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
CN102675418B (zh) * 2011-03-15 2016-04-20 中国人民解放军军事医学科学院毒物药物研究所 Lhrh拮抗剂衍生物、其制备方法及用途
CN103524599B (zh) * 2012-07-05 2016-04-20 中国人民解放军军事医学科学院毒物药物研究所 环肽lhrh拮抗剂衍生物及其药物用途
CN104418936B (zh) * 2013-08-20 2018-06-05 中国人民解放军军事医学科学院毒物药物研究所 Lhrh拮抗剂衍生物及其药物用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4851385A (en) * 1987-07-15 1989-07-25 Indiana University Foundation LHRH antagonist analogs having low histamine-release activity

Also Published As

Publication number Publication date
CZ84893A3 (en) 1994-02-16
CN1061605A (zh) 1992-06-03
FI933156A (fi) 1993-07-09
PH31178A (en) 1998-03-20
FI933156A0 (fi) 1993-07-09
EE03141B1 (et) 1998-12-15
NO931697L (no) 1993-07-07
CA2095932A1 (en) 1992-05-11
ATE149520T1 (de) 1997-03-15
CZ284168B6 (cs) 1998-09-16
KR100244624B1 (ko) 2000-02-15
LT3971B (en) 1996-05-27
UA41300C2 (uk) 2001-09-17
PL170564B1 (pl) 1996-12-31
LV10106B (en) 1995-04-20
PL295427A1 (en) 1993-09-06
DE69125024T2 (de) 1997-07-17
ZA918847B (en) 1992-08-26
LV10106A (lv) 1994-05-10
LTIP1513A (en) 1995-06-26
WO1992008733A1 (en) 1992-05-29
GR3023389T3 (en) 1997-08-29
NZ240505A (en) 1993-04-28
NO931697D0 (no) 1993-05-10
SI9111779A (en) 1997-04-30
HRP920585A2 (en) 1997-04-30
RU2123499C1 (ru) 1998-12-20
DE69125024D1 (de) 1997-04-10
DK0564466T3 (da) 1997-08-25
ES2100965T3 (es) 1997-07-01
CN1036343C (zh) 1997-11-05
PT99458B (pt) 1999-02-26
PT99458A (pt) 1992-10-30
EP0564466B1 (en) 1997-03-05
YU177991A (sh) 1994-06-24
IE913915A1 (en) 1992-05-20
CA2095932C (en) 2003-02-25
EP0564466A1 (en) 1993-10-13
SK45393A3 (en) 1993-10-06
YU48831B (sh) 2002-03-18
AU662496B2 (en) 1995-09-07
SK281319B6 (sk) 2001-02-12
AU8861291A (en) 1992-06-11
HRP920585B1 (en) 2000-08-31
KR930703353A (ko) 1993-11-29

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Effective date: 20090616