ES2044901T3 - Procedimiento para la preparacion de un derivado de imidazol y su utilizacion. - Google Patents
Procedimiento para la preparacion de un derivado de imidazol y su utilizacion.Info
- Publication number
- ES2044901T3 ES2044901T3 ES87117820T ES87117820T ES2044901T3 ES 2044901 T3 ES2044901 T3 ES 2044901T3 ES 87117820 T ES87117820 T ES 87117820T ES 87117820 T ES87117820 T ES 87117820T ES 2044901 T3 ES2044901 T3 ES 2044901T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- derivative
- preparation
- pyridile
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE DESCRIBEN NUEVOS IMIDAZOLES DE LA FORMULA (I) DONDE EL ANILLO A ES UN GRUPO PIRIDILO O UN GRUPO PIRIDILO SUSTITUIDO; EL ANILLO B ES UN GRUPO FENILO O UN GRUPO FENILO SUSTITUIDO; R1 Y R2 SON ATOMOS DE HIDROGENO O ESTAN COMBINADOS JUNTOS PARA FORMAR UN GRUPO DE LA FORMULA (CH2)Q; M ES 1 O 2; N ES 0, 1 O 2; Y Q ES 3 O 4, O UNA SAL DEL MISMO. DICHO DERIVADO (I) Y LA SAL DEL MISMO SON UTILES COMO AGENTES ANTIULCERA. TAMBIEN SE EXPLICA UN PROCESO DE PREPARACION DE DICHOS DERIVADOS, JUNTO CON PRODUCTOS INTERMEDIOS QUIMICOS FORMADOS DURANTE DICHO PROCESO. TAMBIEN SE PROPORCIONAN COMPOSICIONES FARMACEUTICAS QUE LO CONTIENEN. ADEMAS SE EXPLICA EL USO DE DICHOS COMPUESTOS PARA LA FABRICACION DE MEDICAMENTOS CON VALOR TERAPEUTICO.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28751286 | 1986-12-02 | ||
JP8047587 | 1987-03-31 | ||
JP21581387 | 1987-08-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2044901T3 true ES2044901T3 (es) | 1994-01-16 |
Family
ID=27303307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87117820T Expired - Lifetime ES2044901T3 (es) | 1986-12-02 | 1987-12-02 | Procedimiento para la preparacion de un derivado de imidazol y su utilizacion. |
Country Status (15)
Country | Link |
---|---|
US (3) | US5002945A (es) |
EP (1) | EP0270091B1 (es) |
JP (1) | JPH064623B2 (es) |
KR (1) | KR930004843B1 (es) |
CN (1) | CN1020902C (es) |
AU (1) | AU597446B2 (es) |
DE (1) | DE3782621T2 (es) |
DK (1) | DK631587A (es) |
ES (1) | ES2044901T3 (es) |
FI (1) | FI91754C (es) |
FR (1) | FR2607502B1 (es) |
GR (1) | GR3006257T3 (es) |
HU (2) | HU204812B (es) |
IL (1) | IL84554A (es) |
TW (1) | TW203048B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
JP2614756B2 (ja) * | 1988-08-10 | 1997-05-28 | 日本ケミファ株式会社 | イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
MY106533A (en) * | 1990-02-20 | 1995-06-30 | Sumitomo Chemical Co | A 4-tert.-butyl imidazole derivative and its production and use. |
SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
CA2036148A1 (en) * | 1990-06-29 | 1991-12-30 | Hiroki Tomioka | A 1-phenylimidazole derivative and its production and use |
MY110439A (en) * | 1991-02-07 | 1998-05-30 | Ishihara Sangyo Kaisha | N-phenylcarbamate compound, process for preparing the same and biocidal composition for control of harmful organisms |
US5252590A (en) * | 1991-06-28 | 1993-10-12 | Sumitomo Chemical Company, Limited | 1-pyridylimidazole derivative |
US5635521A (en) * | 1991-09-23 | 1997-06-03 | Sandoz Ltd. | Imidazolylmethyl-pyridines |
DE19541146A1 (de) * | 1995-10-25 | 1997-04-30 | Schering Ag | Imidazolderivate und deren Verwendung als Stickstoffmonoxid-Synthase-Inhibitoren |
CN1874772A (zh) | 2003-11-03 | 2006-12-06 | 阿斯利康(瑞典)有限公司 | 治疗隐匿性胃食管反流的咪唑并[1,2-a]吡啶衍生物 |
US7880009B2 (en) * | 2004-05-26 | 2011-02-01 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
JPWO2006038738A1 (ja) * | 2004-10-08 | 2008-05-15 | 武田薬品工業株式会社 | 受容体機能調節剤 |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
PE20081791A1 (es) | 2007-02-28 | 2009-02-07 | Eisai Randd Man Co Ltd | Dos derivados ciclicos de oxomorfolina |
BRPI0815773A2 (pt) | 2007-08-31 | 2019-09-24 | Eisai R&D Man Co Ltd | composto, e, medicamento. |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1234058A (es) * | 1968-10-21 | 1971-06-03 | ||
IN148930B (es) * | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
EP0004648B1 (de) * | 1978-04-11 | 1982-08-25 | Ciba-Geigy Ag | Neue Mercaptoimidazolderivate, Verfahren zu deren Herstellung, Mercaptoimidazolderivate zur Behandlung entzündlicher Erkrankungen und diese enthaltende pharmazeutische Präparate |
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4492708A (en) * | 1982-09-27 | 1985-01-08 | Eli Lilly And Company | Antiviral benzimidazoles |
ATE25521T1 (de) * | 1982-12-20 | 1987-03-15 | Merck & Co Inc | 5-(amino oder substituierte amino)-imidazole. |
GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
FI833794A0 (fi) * | 1983-10-18 | 1983-10-18 | Farmos Oy | Substituerade 2-merkapto-imidazoler |
GB8417171D0 (en) * | 1984-07-05 | 1984-08-08 | Beecham Group Plc | Compounds |
CA1341314C (en) * | 1984-07-06 | 2001-11-06 | David Cox | Derivatives of benzimidazole, benzothiazole and benzoxazole |
AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
US4600430A (en) * | 1985-02-22 | 1986-07-15 | Eli Lilly And Company | Pyridinylimidazolidinone compounds |
US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
US4591377A (en) * | 1985-09-10 | 1986-05-27 | Stauffer Chemical Company | Herbicidal esters of 2-bromo-4-methylimidazole-5-carboxylic acid |
IL82401A0 (en) * | 1986-05-06 | 1987-11-30 | Merrell Dow Pharma | Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them |
JPH0674273B2 (ja) * | 1986-06-19 | 1994-09-21 | 日産化学工業株式会社 | イミダゾ−ルスルホンアミド誘導体、製法および除草剤 |
-
1987
- 1987-11-18 FI FI875102A patent/FI91754C/fi not_active IP Right Cessation
- 1987-11-20 IL IL84554A patent/IL84554A/xx not_active IP Right Cessation
- 1987-11-23 TW TW076107112A patent/TW203048B/zh active
- 1987-11-26 JP JP62298783A patent/JPH064623B2/ja not_active Expired - Lifetime
- 1987-11-26 AU AU81812/87A patent/AU597446B2/en not_active Ceased
- 1987-12-01 DK DK631587A patent/DK631587A/da not_active Application Discontinuation
- 1987-12-01 HU HU905023A patent/HU204812B/hu unknown
- 1987-12-01 CN CN87108111A patent/CN1020902C/zh not_active Expired - Fee Related
- 1987-12-01 HU HU875393A patent/HU201751B/hu not_active IP Right Cessation
- 1987-12-01 KR KR1019870013642A patent/KR930004843B1/ko not_active IP Right Cessation
- 1987-12-02 EP EP87117820A patent/EP0270091B1/en not_active Expired - Lifetime
- 1987-12-02 ES ES87117820T patent/ES2044901T3/es not_active Expired - Lifetime
- 1987-12-02 FR FR878716732A patent/FR2607502B1/fr not_active Expired - Fee Related
- 1987-12-02 DE DE8787117820T patent/DE3782621T2/de not_active Expired - Fee Related
-
1989
- 1989-06-09 US US07/364,999 patent/US5002945A/en not_active Expired - Fee Related
- 1989-06-28 US US07/372,534 patent/US4996217A/en not_active Expired - Fee Related
-
1990
- 1990-08-03 US US07/562,513 patent/US5053417A/en not_active Expired - Fee Related
-
1992
- 1992-11-16 GR GR920402604T patent/GR3006257T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
TW203048B (es) | 1993-04-01 |
KR880007477A (ko) | 1988-08-27 |
US5053417A (en) | 1991-10-01 |
GR3006257T3 (es) | 1993-06-21 |
HU201751B (en) | 1990-12-28 |
KR930004843B1 (ko) | 1993-06-09 |
FI875102A (fi) | 1988-06-03 |
IL84554A (en) | 1992-03-29 |
US4996217A (en) | 1991-02-26 |
FR2607502B1 (fr) | 1990-01-19 |
FI91754C (fi) | 1994-08-10 |
JPH064623B2 (ja) | 1994-01-19 |
HU905023D0 (en) | 1991-01-28 |
FR2607502A1 (fr) | 1988-06-03 |
FI875102A0 (fi) | 1987-11-18 |
DE3782621D1 (de) | 1992-12-17 |
AU8181287A (en) | 1988-06-02 |
HUT49128A (en) | 1989-08-28 |
JPH01131175A (ja) | 1989-05-24 |
DK631587D0 (da) | 1987-12-01 |
EP0270091A1 (en) | 1988-06-08 |
EP0270091B1 (en) | 1992-11-11 |
DK631587A (da) | 1988-06-03 |
US5002945A (en) | 1991-03-26 |
IL84554A0 (en) | 1988-04-29 |
CN1020902C (zh) | 1993-05-26 |
CN87108111A (zh) | 1988-09-28 |
AU597446B2 (en) | 1990-05-31 |
HU204812B (en) | 1992-02-28 |
FI91754B (fi) | 1994-04-29 |
DE3782621T2 (de) | 1993-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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