ES2084339T3 - Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central. - Google Patents

Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central.

Info

Publication number
ES2084339T3
ES2084339T3 ES92901652T ES92901652T ES2084339T3 ES 2084339 T3 ES2084339 T3 ES 2084339T3 ES 92901652 T ES92901652 T ES 92901652T ES 92901652 T ES92901652 T ES 92901652T ES 2084339 T3 ES2084339 T3 ES 2084339T3
Authority
ES
Spain
Prior art keywords
agents
tetrahidropiridinas
hidroxipiperidinas
nervous system
central nervous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901652T
Other languages
English (en)
Inventor
Shelly Glase
Juan Carlos Jaen
Sarah Jane Smith
Lawrence David Wise
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2084339T3 publication Critical patent/ES2084339T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE PRESENTAN TETRAHIDROPIRIDINAS E HIDROXIPIPERIDINAS SUSTITUIDAS DE LA FORMULA I Y DERIVADOS DE LAS MISMAS, ASI COMO METODOS PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA A PARTIR DE LAS MISMAS, LOS COMPUESTOS SON UTILES COMO AGENTES PARA EL SISTEMA NERVIOSO CENTRAL Y SON PARTICULARMENTE UTILES COMO AGENTES DOPAMINERGICOS, ANTIPSICOTICOS, ANTIHIPERTENSIVOS ASI COMO PARA EL TRATAMIENTO DE CONDICIONES RELACIONADAS CON LA HIPERPROLACTINEAMIA Y PARA ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL.
ES92901652T 1990-11-05 1991-10-29 Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central. Expired - Lifetime ES2084339T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60927490A 1990-11-05 1990-11-05
US07/778,248 US5273977A (en) 1990-11-05 1991-10-24 Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents

Publications (1)

Publication Number Publication Date
ES2084339T3 true ES2084339T3 (es) 1996-05-01

Family

ID=27085995

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92901652T Expired - Lifetime ES2084339T3 (es) 1990-11-05 1991-10-29 Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central.

Country Status (11)

Country Link
US (3) US5273977A (es)
EP (1) EP0556332B1 (es)
JP (1) JP3047470B2 (es)
AT (1) ATE135690T1 (es)
AU (1) AU670532B2 (es)
CA (1) CA2094702C (es)
DE (1) DE69118198T2 (es)
DK (1) DK0556332T3 (es)
ES (1) ES2084339T3 (es)
GR (1) GR3019782T3 (es)
WO (1) WO1992007831A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273977A (en) * 1990-11-05 1993-12-28 Warner-Lambert Company Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
DE4425145A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung von Thiazol- und Thiadiazolverbindungen
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
WO1998037070A1 (en) * 1997-02-21 1998-08-27 Takeda Chemical Industries, Ltd. Fused ring compounds, process for producing the same and use thereof
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
US6495550B2 (en) 1999-08-04 2002-12-17 Icagen, Inc. Pyridine-substituted benzanilides as potassium ion channel openers
BR0012934A (pt) * 1999-08-04 2003-07-29 Icagen Inc Processos para a redução de dor e de ansiedade
EP1208085B1 (en) * 1999-08-04 2007-12-05 Icagen, Inc. Benzanilides as potassium channel openers
MXPA02003979A (es) * 1999-10-22 2003-01-28 Sanofi Synthelabo Fenil- y piridil-tetrahidro-piridinas que tiene una actividad inhibidora de tnf.
FR2803593B1 (fr) * 2000-01-06 2002-02-15 Sanofi Synthelabo Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
GB0413605D0 (en) 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
CL2009000725A1 (es) 2008-03-24 2009-05-29 Medivation Technologies Inc Compuestos derivados de heterociclos con uniones puente sustituidos, moduladores de receptores adrenergicos, de serotonina, de dopamina y de histaminas; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento del trastorno cognitivo y trastorno psicotico.
WO2011038161A1 (en) * 2009-09-23 2011-03-31 Medivation Technologies, Inc. Pyrido[4,3-b]indoles and methods of use
EP2480081A4 (en) * 2009-09-23 2013-03-06 Medivation Technologies Inc Bridged heterocyclic compounds and methods for their use
CA3006745C (en) * 2010-11-05 2021-03-30 Oat Agrio Co., Ltd. Ethynylphenylamidine compound or salt thereof, method for producing same, and fungicide for agricultural and horticultural use
US8791132B2 (en) 2011-02-18 2014-07-29 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633474A (es) *
GB1055548A (en) * 1965-08-23 1967-01-18 Acraf New substituted 1-aryl-3-aminopropynes and process for their preparation
FR1490501A (fr) * 1966-02-23 1967-08-04 Docteur Jacques Auciair Lab Du Nouveaux dérivés du butyne-2 et leur procédé de préparation
US4208415A (en) * 1978-02-06 1980-06-17 E. R. Squibb & Sons, Inc. 4-[2-(2-Substituted phenyl)ethenyl]-N-alkenyl or alkinyl substituted 1,2,3,6-tetrahydropyridines
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
CA2071897A1 (en) * 1989-12-28 1991-06-29 Richard A. Glennon Sigma receptor ligands and the use thereof
US5034392A (en) * 1990-04-16 1991-07-23 Hoechst-Roussel Pharmaceuticals Incorporated 4-(3-(4-oxothiazolidinyl)butynylamines
US5273977A (en) * 1990-11-05 1993-12-28 Warner-Lambert Company Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents

Also Published As

Publication number Publication date
US5273977A (en) 1993-12-28
DK0556332T3 (da) 1996-06-03
GR3019782T3 (en) 1996-07-31
US5620988A (en) 1997-04-15
US5466698A (en) 1995-11-14
AU9123191A (en) 1992-05-26
JPH06501952A (ja) 1994-03-03
DE69118198D1 (de) 1996-04-25
ATE135690T1 (de) 1996-04-15
AU670532B2 (en) 1996-07-25
DE69118198T2 (de) 1996-11-14
JP3047470B2 (ja) 2000-05-29
CA2094702A1 (en) 1992-05-06
EP0556332B1 (en) 1996-03-20
WO1992007831A1 (en) 1992-05-14
EP0556332A1 (en) 1993-08-25
CA2094702C (en) 2002-02-12

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