ES2147759T3 - Heterociclos no aromaticos sustituidos con aminometileno y uso como antagonistas de la sustancia p. - Google Patents

Heterociclos no aromaticos sustituidos con aminometileno y uso como antagonistas de la sustancia p.

Info

Publication number
ES2147759T3
ES2147759T3 ES93922821T ES93922821T ES2147759T3 ES 2147759 T3 ES2147759 T3 ES 2147759T3 ES 93922821 T ES93922821 T ES 93922821T ES 93922821 T ES93922821 T ES 93922821T ES 2147759 T3 ES2147759 T3 ES 2147759T3
Authority
ES
Spain
Prior art keywords
aromatic hetero
aminomethylene
antagonists
substance
hetero cycles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93922821T
Other languages
English (en)
Inventor
Harry R Howard
Brian T O'neill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2147759T3 publication Critical patent/ES2147759T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS HETEROCICLOS NO AROMATICOS SUSTITUIDOS CON AMINOETILENO Y, ESPECIFICAMENTE, A COMPUESTOS DE LA FORMULA (IA) O (IB) EN DONDE W, R1, R2, R3, A, X'', Y'' Y Z'' SON SEGUN SE DEFINEN EN LAS ESPECIFICACIONES, Y A LOS PRODUCTOS INTERMEDIOS USADOS EN LA SINTESIS DE DICHOS COMPUESTOS. LOS NUEVOS COMPUESTOS DE LA FORMULA (IA) Y (IB) SON UTILES EN EL TRATAMIENTO DE DESORDENES DEL SISTEMA INFLAMATORIO Y DEL SISTEMA NERVIOSO CENTRAL, ASI COMO EN OTRAS ENFERMEDADES.
ES93922821T 1992-12-10 1993-10-07 Heterociclos no aromaticos sustituidos con aminometileno y uso como antagonistas de la sustancia p. Expired - Lifetime ES2147759T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98865392A 1992-12-10 1992-12-10

Publications (1)

Publication Number Publication Date
ES2147759T3 true ES2147759T3 (es) 2000-10-01

Family

ID=25534364

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93922821T Expired - Lifetime ES2147759T3 (es) 1992-12-10 1993-10-07 Heterociclos no aromaticos sustituidos con aminometileno y uso como antagonistas de la sustancia p.

Country Status (15)

Country Link
EP (2) EP0675886B1 (es)
JP (2) JP2722279B2 (es)
CN (1) CN1092771A (es)
AT (1) ATE194340T1 (es)
AU (1) AU5169693A (es)
CA (1) CA2150123C (es)
DE (1) DE69328975T2 (es)
DK (1) DK0675886T3 (es)
ES (1) ES2147759T3 (es)
FI (1) FI935529A7 (es)
GR (1) GR3034329T3 (es)
IL (1) IL107843A0 (es)
MX (1) MX9307810A (es)
PT (1) PT675886E (es)
WO (1) WO1994013663A1 (es)

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US6288225B1 (en) 1996-05-09 2001-09-11 Pfizer Inc Substituted benzolactam compounds as substance P antagonists
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Also Published As

Publication number Publication date
EP0675886A1 (en) 1995-10-11
JP3165401B2 (ja) 2001-05-14
WO1994013663A1 (en) 1994-06-23
GR3034329T3 (en) 2000-12-29
JP2722279B2 (ja) 1998-03-04
PT675886E (pt) 2000-12-29
IL107843A0 (en) 1994-04-12
AU5169693A (en) 1994-07-04
MX9307810A (es) 1994-07-29
ATE194340T1 (de) 2000-07-15
DE69328975T2 (de) 2000-11-09
DE69328975D1 (de) 2000-08-10
EP0806423A1 (en) 1997-11-12
JPH07509490A (ja) 1995-10-19
DK0675886T3 (da) 2000-09-18
CA2150123A1 (en) 1994-06-23
FI935529A0 (fi) 1993-12-09
EP0675886B1 (en) 2000-07-05
CN1092771A (zh) 1994-09-28
JPH1095780A (ja) 1998-04-14
FI935529L (fi) 1994-06-11
FI935529A7 (fi) 1994-06-11
CA2150123C (en) 2004-12-07

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