FI935529A0 - Aminometylensubstituerade icke-aromatiska heterocykliska foereningar - Google Patents
Aminometylensubstituerade icke-aromatiska heterocykliska foereningarInfo
- Publication number
- FI935529A0 FI935529A0 FI935529A FI935529A FI935529A0 FI 935529 A0 FI935529 A0 FI 935529A0 FI 935529 A FI935529 A FI 935529A FI 935529 A FI935529 A FI 935529A FI 935529 A0 FI935529 A0 FI 935529A0
- Authority
- FI
- Finland
- Prior art keywords
- aminomethylsubstituted
- aromatic heterocyclic
- heterocyclic derivatives
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98865392A | 1992-12-10 | 1992-12-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI935529A0 true FI935529A0 (fi) | 1993-12-09 |
FI935529A FI935529A (fi) | 1994-06-11 |
Family
ID=25534364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI935529A FI935529A (fi) | 1992-12-10 | 1993-12-09 | Aminometylensubstituerade icke-aromatiska heterocykliska foereningar |
Country Status (15)
Country | Link |
---|---|
EP (2) | EP0806423A1 (fi) |
JP (2) | JP2722279B2 (fi) |
CN (1) | CN1092771A (fi) |
AT (1) | ATE194340T1 (fi) |
AU (1) | AU5169693A (fi) |
CA (1) | CA2150123C (fi) |
DE (1) | DE69328975T2 (fi) |
DK (1) | DK0675886T3 (fi) |
ES (1) | ES2147759T3 (fi) |
FI (1) | FI935529A (fi) |
GR (1) | GR3034329T3 (fi) |
IL (1) | IL107843A0 (fi) |
MX (1) | MX9307810A (fi) |
PT (1) | PT675886E (fi) |
WO (1) | WO1994013663A1 (fi) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
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US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
EP1209157A1 (en) * | 1993-09-17 | 2002-05-29 | Pfizer Inc. | Heteroarylamino and heteroarylsulfonamido substituted 3-benzylaminomethyl piperidines and related compounds |
IS4208A (is) * | 1993-09-22 | 1995-03-23 | Glaxo Group Limited | 3-(tetrazólýl-benzyl)amínó-piperadidín afleiður |
EP0653208A3 (en) * | 1993-11-17 | 1995-10-11 | Pfizer | Substance P antagonists for the treatment or prevention of sunburn. |
EP0659409A3 (en) * | 1993-11-23 | 1995-08-09 | Pfizer | Substance P antagonists for the inhibition of angiogenesis. |
EP0655246A1 (en) * | 1993-11-30 | 1995-05-31 | Pfizer Inc. | Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria |
GB9505692D0 (en) * | 1995-03-21 | 1995-05-10 | Glaxo Group Ltd | Chemical compounds |
CA2216701A1 (en) * | 1995-03-27 | 1996-10-03 | Akira Okayama | Piperidine derivatives |
US6288225B1 (en) | 1996-05-09 | 2001-09-11 | Pfizer Inc | Substituted benzolactam compounds as substance P antagonists |
MX9800187A (es) | 1995-07-07 | 1998-05-31 | Pfizer | Compuestos de benzolactama substituidos como antagonistas de la substancia p. |
TW458774B (en) | 1995-10-20 | 2001-10-11 | Pfizer | Antiemetic pharmaceutical compositions |
US6541669B1 (en) * | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
GEP20043224B (en) * | 1999-05-06 | 2004-04-26 | Pfizer Prod Inc | Substituted Benzolactam Compounds |
JP2001172178A (ja) * | 1999-10-25 | 2001-06-26 | Pfizer Prod Inc | 偏頭痛治療用のnk−1レセプターアンタゴニスト及びエレトリプタン |
US7119207B2 (en) * | 2000-04-10 | 2006-10-10 | Pfizer Inc | Benzoamide piperidine containing compounds and related compounds |
DK1274675T3 (da) * | 2000-04-19 | 2004-12-06 | Neurotech Co Ltd | Forbindelser, sammensætninger og fremgangsmåder til forebyggelse af neurodegeneration ved akutte og kroniske skader i centralnervesystemet |
US6964982B2 (en) | 2000-04-20 | 2005-11-15 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
US20020049211A1 (en) * | 2000-09-06 | 2002-04-25 | Sobolov-Jaynes Susan Beth | Combination treatment for depression and anxiety |
EP1192952A3 (en) * | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist |
AU2001292320A1 (en) * | 2000-10-02 | 2002-04-15 | Tanabe Seiyaku Co., Ltd. | Benzylamine compound, process for producing the same, and intermediate therefor |
WO2002070478A1 (en) | 2001-03-06 | 2002-09-12 | Astrazeneca Ab | Indolone derivatives having vascular-damaging activity |
CN101041626B (zh) | 2002-06-19 | 2010-08-25 | 艾克尔制药公司 | 四氟苄基衍生物及含有其成分的药物组合物 |
KR101389246B1 (ko) | 2004-07-15 | 2014-04-24 | 브리스톨-마이어스스퀴브컴파니 | 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
US8362075B2 (en) | 2005-05-17 | 2013-01-29 | Merck Sharp & Dohme Corp. | Cyclohexyl sulphones for treatment of cancer |
JP5258561B2 (ja) | 2005-07-15 | 2013-08-07 | アルバニー モレキュラー リサーチ, インコーポレイテッド | アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用 |
JP4879988B2 (ja) | 2005-09-29 | 2012-02-22 | メルク・シャープ・エンド・ドーム・コーポレイション | メラノコルチン−4受容体モジュレーターとしてのアシル化スピロピペリジン誘導体 |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
DK2004164T3 (en) | 2006-04-13 | 2018-10-29 | Neurotech Pharmaceuticals Co Ltd | PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES |
WO2008039327A2 (en) | 2006-09-22 | 2008-04-03 | Merck & Co., Inc. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
CA2674436C (en) | 2007-01-10 | 2012-07-17 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
EP2145884B1 (en) | 2007-04-02 | 2014-08-06 | Msd K.K. | Indoledione derivative |
CA2690191C (en) | 2007-06-27 | 2015-07-28 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
KR100852962B1 (ko) | 2007-11-12 | 2008-08-20 | 주식회사 뉴로테크 | 2-하이드록시-5-페닐알킬아미노벤조산 유도체 및 이의 염의제조방법 |
KR20100126467A (ko) | 2008-03-03 | 2010-12-01 | 타이거 파마테크 | 티로신 키나아제 억제제 |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
KR101204108B1 (ko) * | 2009-02-09 | 2012-11-22 | 주식회사 지엔티파마 | 5-벤질아미노살리실산 유도체 또는 이의 염의 의약 용도 |
US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
EP2429296B1 (en) | 2009-05-12 | 2017-12-27 | Albany Molecular Research, Inc. | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | (S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用 |
MX2011011901A (es) | 2009-05-12 | 2012-01-20 | Albany Molecular Res Inc | Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas. |
EA023838B1 (ru) | 2009-10-14 | 2016-07-29 | Мерк Шарп Энд Домэ Корп. | ЗАМЕЩЕННЫЕ ПИПЕРИДИНЫ, КОТОРЫЕ ПОВЫШАЮТ АКТИВНОСТЬ p53, И ИХ ПРИМЕНЕНИЕ |
WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
EP3330377A1 (en) | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
CA2807307C (en) | 2010-08-17 | 2021-02-09 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
WO2012036997A1 (en) | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
EP3766975A1 (en) | 2010-10-29 | 2021-01-20 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina) |
US9351965B2 (en) | 2010-12-21 | 2016-05-31 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
CN103732592A (zh) | 2011-04-21 | 2014-04-16 | 默沙东公司 | 胰岛素样生长因子-1受体抑制剂 |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
EP2844261B1 (en) | 2012-05-02 | 2018-10-17 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
US9233979B2 (en) | 2012-09-28 | 2016-01-12 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
SI2925888T1 (en) | 2012-11-28 | 2018-02-28 | Merck Sharp & Dohme Corp. | Compounds and methods for the treatment of cancer |
AU2013361694B2 (en) | 2012-12-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as HDM2 inhibitors |
EP2951180B1 (en) | 2013-01-30 | 2018-05-02 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
WO2019094311A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
CN109174181B (zh) * | 2018-08-10 | 2021-05-25 | 华东师范大学 | 一种负载双功能离子液体介孔聚合物的制备及其应用 |
WO2020136441A1 (en) * | 2018-12-28 | 2020-07-02 | Gnt Pharma Co., Ltd. | Compositions and methods for treating neurodegenerative disorders |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990005525A1 (en) * | 1988-11-23 | 1990-05-31 | Pfizer Inc. | Quinuclidine derivatives as substance p antagonists |
UA41251C2 (uk) * | 1990-01-04 | 2001-09-17 | Пфайзер, Інк. | Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі |
US5232929A (en) * | 1990-11-28 | 1993-08-03 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use |
WO1991018878A1 (en) * | 1990-05-31 | 1991-12-12 | Pfizer Inc. | Preparation of substituted piperidines |
ATE116317T1 (de) * | 1990-07-23 | 1995-01-15 | Pfizer | Chinuclidinderivate. |
HUT68667A (en) * | 1990-09-28 | 1995-07-28 | Pfizer | Fused ring analogs of nitrogen containing nonaromatic heterocycles |
EP0499313B1 (en) * | 1991-02-11 | 1997-06-11 | MERCK SHARP & DOHME LTD. | Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy |
KR0145432B1 (ko) * | 1991-03-26 | 1998-07-15 | 알렌 제이. 스피겔 | 치환된 피페리딘의 입체선택적 제조 방법 |
WO1992020676A1 (en) * | 1991-05-22 | 1992-11-26 | Pfizer Inc. | Substituted 3-aminoquinuclidines |
TW202432B (fi) * | 1991-06-21 | 1993-03-21 | Pfizer |
-
1993
- 1993-10-07 WO PCT/US1993/009407 patent/WO1994013663A1/en active IP Right Grant
- 1993-10-07 PT PT93922821T patent/PT675886E/pt unknown
- 1993-10-07 DE DE69328975T patent/DE69328975T2/de not_active Expired - Fee Related
- 1993-10-07 DK DK93922821T patent/DK0675886T3/da active
- 1993-10-07 AT AT93922821T patent/ATE194340T1/de not_active IP Right Cessation
- 1993-10-07 EP EP97202174A patent/EP0806423A1/en not_active Withdrawn
- 1993-10-07 ES ES93922821T patent/ES2147759T3/es not_active Expired - Lifetime
- 1993-10-07 EP EP93922821A patent/EP0675886B1/en not_active Expired - Lifetime
- 1993-10-07 AU AU51696/93A patent/AU5169693A/en not_active Abandoned
- 1993-10-07 JP JP6514136A patent/JP2722279B2/ja not_active Expired - Fee Related
- 1993-10-07 CA CA002150123A patent/CA2150123C/en not_active Expired - Fee Related
- 1993-12-02 IL IL10784393A patent/IL107843A0/xx unknown
- 1993-12-09 MX MX9307810A patent/MX9307810A/es unknown
- 1993-12-09 CN CN93120193A patent/CN1092771A/zh active Pending
- 1993-12-09 FI FI935529A patent/FI935529A/fi unknown
-
1997
- 1997-08-22 JP JP24030897A patent/JP3165401B2/ja not_active Expired - Fee Related
-
2000
- 2000-09-05 GR GR20000402017T patent/GR3034329T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP3165401B2 (ja) | 2001-05-14 |
JPH07509490A (ja) | 1995-10-19 |
AU5169693A (en) | 1994-07-04 |
ES2147759T3 (es) | 2000-10-01 |
CA2150123C (en) | 2004-12-07 |
DE69328975D1 (de) | 2000-08-10 |
WO1994013663A1 (en) | 1994-06-23 |
JPH1095780A (ja) | 1998-04-14 |
DK0675886T3 (da) | 2000-09-18 |
CN1092771A (zh) | 1994-09-28 |
CA2150123A1 (en) | 1994-06-23 |
PT675886E (pt) | 2000-12-29 |
ATE194340T1 (de) | 2000-07-15 |
JP2722279B2 (ja) | 1998-03-04 |
EP0675886A1 (en) | 1995-10-11 |
EP0806423A1 (en) | 1997-11-12 |
FI935529A (fi) | 1994-06-11 |
GR3034329T3 (en) | 2000-12-29 |
EP0675886B1 (en) | 2000-07-05 |
MX9307810A (es) | 1994-07-29 |
IL107843A0 (en) | 1994-04-12 |
DE69328975T2 (de) | 2000-11-09 |
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