IS4208A - 3-(tetrazólýl-benzyl)amínó-piperadidín afleiður - Google Patents

3-(tetrazólýl-benzyl)amínó-piperadidín afleiður

Info

Publication number
IS4208A
IS4208A IS4208A IS4208A IS4208A IS 4208 A IS4208 A IS 4208A IS 4208 A IS4208 A IS 4208A IS 4208 A IS4208 A IS 4208A IS 4208 A IS4208 A IS 4208A
Authority
IS
Iceland
Prior art keywords
piperadidine
tetrazolyl
benzyl
derivatives
amino
Prior art date
Application number
IS4208A
Other languages
English (en)
Inventor
Robert Armour Duncan
Evans Brian
Hubbard Tanja
Lewell Xiao-Qing
Middlemiss David
Naylor Alan
Anthony Pegg Neil
Victoria Vinader Maria
Paul Watson Stephen
Martin Gerard
Giblin Paul
Menteith Hann Michael
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939319606A external-priority patent/GB9319606D0/en
Priority claimed from GB9326583A external-priority patent/GB9326583D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of IS4208A publication Critical patent/IS4208A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
IS4208A 1993-09-22 1994-09-19 3-(tetrazólýl-benzyl)amínó-piperadidín afleiður IS4208A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939319606A GB9319606D0 (en) 1993-09-22 1993-09-22 Chemical compounds
GB9326583A GB9326583D0 (en) 1993-12-31 1993-12-31 Chemical compounds

Publications (1)

Publication Number Publication Date
IS4208A true IS4208A (is) 1995-03-23

Family

ID=26303560

Family Applications (1)

Application Number Title Priority Date Filing Date
IS4208A IS4208A (is) 1993-09-22 1994-09-19 3-(tetrazólýl-benzyl)amínó-piperadidín afleiður

Country Status (30)

Country Link
US (2) US5703240A (is)
EP (1) EP0720609B1 (is)
JP (2) JP2865872B2 (is)
CN (1) CN1061041C (is)
AP (1) AP495A (is)
AT (1) ATE173255T1 (is)
AU (1) AU681190B2 (is)
BG (1) BG62169B1 (is)
CA (1) CA2172529A1 (is)
CO (1) CO4290298A1 (is)
CZ (1) CZ285479B6 (is)
DE (1) DE69414590T2 (is)
DK (1) DK0720609T3 (is)
ES (1) ES2123829T3 (is)
FI (1) FI961270A (is)
GR (1) GR3029354T3 (is)
HK (1) HK1004219A1 (is)
HR (1) HRP940575B1 (is)
HU (1) HU217428B (is)
IL (1) IL111002A (is)
IS (1) IS4208A (is)
NO (1) NO307830B1 (is)
NZ (1) NZ273614A (is)
OA (1) OA10576A (is)
PE (1) PE18295A1 (is)
PL (1) PL179585B1 (is)
SI (1) SI0720609T1 (is)
SK (1) SK280901B6 (is)
UA (1) UA44711C2 (is)
WO (1) WO1995008549A1 (is)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317987D0 (en) * 1993-08-26 1993-10-13 Glaxo Group Ltd Chemical compounds
IS4208A (is) * 1993-09-22 1995-03-23 Glaxo Group Limited 3-(tetrazólýl-benzyl)amínó-piperadidín afleiður
JP3925662B2 (ja) * 1995-01-12 2007-06-06 グラクソ，グループ，リミテッド タキキニンアンタゴニスト活性を有するピペリジン誘導体
GB9505692D0 (en) * 1995-03-21 1995-05-10 Glaxo Group Ltd Chemical compounds
GB9513117D0 (en) * 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
GB9525296D0 (en) * 1995-12-11 1996-02-07 Merck Sharp & Dohme Therapeutic agents
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
JP2000514047A (ja) * 1996-06-26 2000-10-24 ワーナー―ランバート・コンパニー 催吐の処置用医薬の製造のためのタキキニンアンタゴニストの使用
MX9706196A (es) * 1996-08-14 1998-02-28 Pfizer Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p.
MX9706944A (es) * 1996-09-12 1998-08-30 Pfizer Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.
US6117855A (en) 1996-10-07 2000-09-12 Merck Sharp & Dohme Ltd. Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
WO1998024439A1 (en) * 1996-12-02 1998-06-11 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating severe anxiety disorders
CA2273807A1 (en) * 1996-12-02 1998-06-11 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating schizophrenic disorders
CA2273853A1 (en) * 1996-12-02 1998-06-11 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating cognitive disorders
US6100256A (en) * 1996-12-02 2000-08-08 Merck Sharp & Dohme Ltd. Use of NK-1 receptors antagonists for treating schizophrenic disorders
US5977104A (en) * 1996-12-02 1999-11-02 Merck Sharp & Dohme Ltd. Use of NK-1 receptor antagonists for treating bipolar disorders
EP0941093B1 (en) * 1996-12-02 2005-02-09 MERCK SHARP & DOHME LTD. Use of nk-1 receptor antagonists for treating major depressive disorders with anxiety
JP2001507678A (ja) * 1996-12-02 2001-06-12 メルク シヤープ エンド ドーム リミテツド 運動障害の治療のためのｎｋ−１受容体拮抗薬の使用
US6613765B1 (en) 1996-12-02 2003-09-02 Merck Sharp & Dohme Limited Use of NK-1 receptor antagonists for treating major depressive disorders
EP0942729B1 (en) * 1996-12-02 2004-09-01 MERCK SHARP & DOHME LTD. Use of nk-1 receptor antagonists for treating stress disorders
CA2273856A1 (en) * 1996-12-02 1998-06-11 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating bipolar disorders
JP2001504853A (ja) * 1996-12-02 2001-04-10 メルク シヤープ エンド ドーム リミテツド 物質使用障害の治療のためのｎｋ−１受容体拮抗薬の使用
US6114315A (en) * 1996-12-02 2000-09-05 Merck Sharp & Dohme Ltd. Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety
AU733855B2 (en) * 1996-12-02 2001-05-31 Merck Sharp & Dohme Limited Use of NK-1 receptor antagonists for treating major depressive disorders
JP2001504851A (ja) * 1996-12-02 2001-04-10 メルク シヤープ エンド ドーム リミテツド 性的機能不全の治療のためのｎｋ−１受容体拮抗薬の使用
US5861417A (en) * 1996-12-19 1999-01-19 Hoechst Marion Roussel, Inc. Heterocyclic substituted pyrrolidine amide derivatives
EP0977572A1 (en) * 1997-04-24 2000-02-09 Merck Sharp & Dohme Ltd. Use of nk-1 receptor antagonists for treating eating disorders
JP2002506459A (ja) 1997-06-27 2002-02-26 メルク シヤープ エンド ドーム リミテツド 置換された３−（ベンジルアミノ）ピペリジン誘導体およびその治療薬としての使用
GB9716457D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
GB9716463D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
AU738047B2 (en) * 1997-08-04 2001-09-06 Merck Sharp & Dohme Limited Use of NK-1 receptor antagonists for treating mania
WO1999007375A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
GB9723544D0 (en) * 1997-11-07 1998-01-07 Merck Sharp & Dohme Therapeutic agents
US6087348A (en) * 1997-12-01 2000-07-11 Merck Sharp & Dohme Ltd. Use of NK-1 receptor antagonists for treating stress disorders
US6271230B1 (en) 1997-12-01 2001-08-07 Merck Sharp & Dohme Limited Use of NK-1 receptor antagonists for treating cognitive disorders
US6156749A (en) * 1997-12-01 2000-12-05 Merck Sharp & Dohme Limited Use of NK-1 receptor antagonists for treating movement disorders
GB9816897D0 (en) * 1998-08-04 1998-09-30 Merck Sharp & Dohme Therapeutic use
ATE434437T1 (de) * 1999-02-18 2009-07-15 Novasearch Ag Verwendung von antagonisten der 5-ht3-rezeptoren zur behandlung von muskuloeskeletalen erkrankungen
JP2001039954A (ja) * 1999-05-24 2001-02-13 Tomono Agrica Co Ltd ヘテロ環誘導体
AU2001292320A1 (en) * 2000-10-02 2002-04-15 Tanabe Seiyaku Co., Ltd. Benzylamine compound, process for producing the same, and intermediate therefor
US7498332B2 (en) 2001-02-14 2009-03-03 Duke University Therapy for cerebral vasospasm
US20040142929A1 (en) * 2001-07-06 2004-07-22 Ramon Merce-Vidal Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
AU2003284975B2 (en) * 2002-10-30 2009-04-02 Merck Sharp & Dohme Corp. Heteroarylpiperidine modulators of chemokine receptor activity
GB0308968D0 (en) * 2003-04-17 2003-05-28 Glaxo Group Ltd Medicaments
JP4710608B2 (ja) * 2003-08-01 2011-06-29 東洋紡績株式会社 アルコキシ−テトラゾール−１−イル−ベンズアルデヒド化合物およびその製造方法
CN1580283A (zh) * 2003-08-13 2005-02-16 清华大学 一种检测核酸分子的方法
WO2005051919A1 (en) * 2003-11-26 2005-06-09 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
GB0409098D0 (en) * 2004-04-23 2004-05-26 Glaxo Group Ltd Medicament
ZA200701232B (en) 2004-07-15 2008-08-27 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
JP2006137691A (ja) * 2004-11-11 2006-06-01 Toyo Kasei Kogyo Co Ltd ２−アルコキシ−５−テトラゾリル−ベンズアルデヒド化合物の製造方法
ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
EP1904069B1 (en) 2005-07-15 2018-06-13 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US8293900B2 (en) 2005-09-29 2012-10-23 Merck Sharp & Dohme Corp Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
CA2664113C (en) 2006-09-22 2013-05-28 Merck & Co., Inc. Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
BRPI0806245B1 (pt) 2007-01-10 2022-01-25 Msd Italia S.R.L. Compostos de fórmula i e seus usos
KR20090112722A (ko) 2007-01-24 2009-10-28 글락소 그룹 리미티드 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물
CA2682727C (en) 2007-04-02 2016-03-22 Banyu Pharmaceutical Co., Ltd. Indoledione derivative
US7858666B2 (en) * 2007-06-08 2010-12-28 Mannkind Corporation IRE-1α inhibitors
EP2170076B1 (en) 2007-06-27 2016-05-18 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8598184B2 (en) 2008-03-03 2013-12-03 Tiger Pharmatech Protein kinase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
MX2010014461A (es) * 2008-06-24 2011-04-28 Valeant Pharmaceuticals Int Derivados de benciloxi anilida utiles como moduladores de canales de potasio.
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
CA2760837C (en) 2009-05-12 2018-04-03 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
KR20120034644A (ko) 2009-05-12 2012-04-12 알바니 몰레큘라 리써치, 인크. 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
WO2011046771A1 (en) 2009-10-14 2011-04-21 Schering Corporation SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
CA2805265A1 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
WO2012024170A2 (en) 2010-08-17 2012-02-23 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
US8946216B2 (en) 2010-09-01 2015-02-03 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
JP2014514321A (ja) 2011-04-21 2014-06-19 メルク・シャープ・アンド・ドーム・コーポレーション インスリン様増殖因子１受容体阻害剤
EP2729147B1 (en) 2011-07-04 2017-09-06 IRBM - Science Park S.p.A. Nk-1 receptor antagonists for treating corneal neovascularisation
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
US20150299696A1 (en) 2012-05-02 2015-10-22 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
WO2014052563A2 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
MX363243B (es) 2012-11-28 2019-03-14 Merck Sharp & Dohme Composiciones para tratar cáncer y usos de dichas composiciones.
RU2690663C2 (ru) 2012-12-20 2019-06-05 Мерк Шарп И Доум Корп. Замещенные имидазопиридины в качестве ингибиторов hdm2
US9540377B2 (en) 2013-01-30 2017-01-10 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as HDM2 inhibitors
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
MX2019015150A (es) 2017-06-30 2020-08-13 Chase Therapeutics Corp Composiciones antagonistas de nk-1 y métodos para su uso en el tratamiento de la depresión.
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
RU2020131446A (ru) 2018-02-26 2022-03-28 Оспедале Сан Раффаэле С.Р.Л. Антагонисты nk-1 для применения в лечении глазной боли
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3833668A4 (en) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. PRMT5 INHIBITORS
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
US5332817A (en) * 1990-01-04 1994-07-26 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles
US5232929A (en) * 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
KR0154882B1 (ko) * 1991-06-20 1998-11-16 알렌 제이. 스피겔 질소 함유 헤테로사이클릭 화합물의 플루오로알콕시벤질아미노 유도체
WO1994013663A1 (en) * 1992-12-10 1994-06-23 Pfizer Inc. Aminomethylene substituted non-aromatic heterocycles and use as substance p antagonists
IS4208A (is) * 1993-09-22 1995-03-23 Glaxo Group Limited 3-(tetrazólýl-benzyl)amínó-piperadidín afleiður

Also Published As

Publication number Publication date
HU217428B (hu) 2000-01-28
UA44711C2 (uk) 2002-03-15
CO4290298A1 (es) 1996-04-17
NO307830B1 (no) 2000-06-05
GR3029354T3 (en) 1999-05-28
CN1135218A (zh) 1996-11-06
WO1995008549A1 (en) 1995-03-30
DE69414590T2 (de) 1999-04-15
HK1004219A1 (en) 1998-11-20
AU681190B2 (en) 1997-08-21
IL111002A (en) 1998-09-24
NO961156L (no) 1996-05-21
NZ273614A (en) 1997-09-22
HU9600722D0 (en) 1996-05-28
AU7697494A (en) 1995-04-10
SI0720609T1 (en) 1999-02-28
JPH11106341A (ja) 1999-04-20
PL313619A1 (en) 1996-07-08
US5843966A (en) 1998-12-01
CZ83096A3 (en) 1996-09-11
JPH09505275A (ja) 1997-05-27
PE18295A1 (es) 1995-07-27
IL111002A0 (en) 1994-11-28
HRP940575B1 (en) 2000-06-30
AP9400671A0 (en) 1994-10-31
DK0720609T3 (da) 1999-07-26
BG100487A (bg) 1996-12-31
CN1061041C (zh) 2001-01-24
DE69414590D1 (de) 1998-12-17
CZ285479B6 (cs) 1999-08-11
JP2865872B2 (ja) 1999-03-08
OA10576A (en) 2002-06-03
US5703240A (en) 1997-12-30
FI961270A (fi) 1996-05-03
SK280901B6 (sk) 2000-09-12
HRP940575A2 (en) 1997-02-28
HUT75648A (en) 1997-05-28
NO961156D0 (no) 1996-03-21
EP0720609B1 (en) 1998-11-11
PL179585B1 (pl) 2000-09-29
ES2123829T3 (es) 1999-01-16
AP495A (en) 1996-05-28
EP0720609A1 (en) 1996-07-10
SK38396A3 (en) 1997-02-05
ATE173255T1 (de) 1998-11-15
FI961270A0 (fi) 1996-03-19
BG62169B1 (bg) 1999-04-30
CA2172529A1 (en) 1995-03-30

Similar Documents

Publication Publication Date Title
IS4208A (is) 3-(tetrazólýl-benzyl)amínó-piperadidín afleiður
ATA75293A (de) Indolderivate
NO952854D0 (no) 1-arylpyrimidin-derivater
DE59508427D1 (de) 3-aryl-4-hydroxy-delta 3 -dihydrothiophenon-derivate
ATE199150T1 (de) Diphenylmethylenpiperidin-derivate
NO961475D0 (no) Indol-derivater
DE69330497T2 (de) Chinazolin-derivate
FI940154A0 (fi) Substituoidut dialkyylitioeetterit
DE59308714D1 (de) Cyclobutan-benzol-derivate
DE69430587T2 (de) Pyrimidin-acyclonukleosid-derivate
NO954323D0 (no) Heterocykliske derivater
ATA100695A (de) Prothrombin-derivate
DE59403503D1 (de) Substituierte 1-Aryltriazolinone
EE9600011A (et) Uudsed dialkoksü-püridinüül-bensimidasooli derivaadid
DE69425742D1 (de) Kaolin-derivate
FI954326A0 (fi) Varjoaineisiin liittyviä parannuksia
NO952288D0 (no) Benzazepinon-derivater
DE69527786D1 (de) Diaminomethyliden-derivate
DE69313890D1 (de) 5-Aminoflavon-Derivate
ATE177102T1 (de) Chromanderivate
DE59509209D1 (de) Diphenyloxazolin-derivate
DE59407726D1 (de) 3-Aryl-4-hydroxy-3-dihydrofuranon-Derivate
DE69510792D1 (de) Naphtochinonderivate
BR9405830A (pt) Oxazois substituidos
ATA45796A (de) Lysin-prolin-derivate