ES2123829T3 - Derivados de 3-(5-tetrazolil-bencil)amino-piperidina y antagonistas de las taquiquininas. - Google Patents
Derivados de 3-(5-tetrazolil-bencil)amino-piperidina y antagonistas de las taquiquininas.Info
- Publication number
- ES2123829T3 ES2123829T3 ES94927627T ES94927627T ES2123829T3 ES 2123829 T3 ES2123829 T3 ES 2123829T3 ES 94927627 T ES94927627 T ES 94927627T ES 94927627 T ES94927627 T ES 94927627T ES 2123829 T3 ES2123829 T3 ES 2123829T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- sup
- atom
- hydrogen
- piperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE LA PIPERIDINA DE LA FORMULA (I), EN LA QUE R{SUP,1} ES UN GRUPO ALCOXI C{SUB,14}; R{SUP,2} ES LA FORMULA (A); R{SUP,3} ES UN ATOMO DE HIDROGENO O UNO DE HALOGENO; R{SUP,4} Y R{SUP,5} PUEDE REPRESENTAR CADA UNO, INDEPENDIENTEMENTE, UN ATOMO DE HIDROGENO O UNO DE HALOGENO, O UN GRUPO ALQUILO C{SUB,1-4}, UNO ALCOXI C{SUB,1-4} O UNO TRIFLUOROMETILO; R{SUP,6} ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO C{SUB,1-4}, UNO (CH{SUB,2}){SUB,M}CICLOPROPILO, UNO S(O){SUB,N}ALQUILO C{SUB,1-4}, UNO FENILO, UNO NR{SUP,7}R{SUP,8}, UNO CH{SUB,2}C(O)CF{SUB,3} O UNO TRIFLUOROMETILO; R{SUP,7} Y R{SUP,8} PUEDE REPRESENTAR CADA UNO, INDEPENDIENTEMENTE, UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C{SUB,1-4} O UNO ACILO; X REPRESENTA CERO O 1; N REPRESENTA CERO, 1 O 2; M REPRESENTA CERO O 1; Y A LAS SALES Y SOLVATOS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS; A PROCESOS PARA SU PREPARACION; Y A SU USO EN EL TRATAMIENTO DE ESTADOS EN LOS QUE INTERVIENEN TAQUIQUININAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939319606A GB9319606D0 (en) | 1993-09-22 | 1993-09-22 | Chemical compounds |
GB9326583A GB9326583D0 (en) | 1993-12-31 | 1993-12-31 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2123829T3 true ES2123829T3 (es) | 1999-01-16 |
Family
ID=26303560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94927627T Expired - Lifetime ES2123829T3 (es) | 1993-09-22 | 1994-09-20 | Derivados de 3-(5-tetrazolil-bencil)amino-piperidina y antagonistas de las taquiquininas. |
Country Status (30)
Country | Link |
---|---|
US (2) | US5703240A (es) |
EP (1) | EP0720609B1 (es) |
JP (2) | JP2865872B2 (es) |
CN (1) | CN1061041C (es) |
AP (1) | AP495A (es) |
AT (1) | ATE173255T1 (es) |
AU (1) | AU681190B2 (es) |
BG (1) | BG62169B1 (es) |
CA (1) | CA2172529A1 (es) |
CO (1) | CO4290298A1 (es) |
CZ (1) | CZ285479B6 (es) |
DE (1) | DE69414590T2 (es) |
DK (1) | DK0720609T3 (es) |
ES (1) | ES2123829T3 (es) |
FI (1) | FI961270A (es) |
GR (1) | GR3029354T3 (es) |
HK (1) | HK1004219A1 (es) |
HR (1) | HRP940575B1 (es) |
HU (1) | HU217428B (es) |
IL (1) | IL111002A (es) |
IS (1) | IS4208A (es) |
NO (1) | NO307830B1 (es) |
NZ (1) | NZ273614A (es) |
OA (1) | OA10576A (es) |
PE (1) | PE18295A1 (es) |
PL (1) | PL179585B1 (es) |
SI (1) | SI0720609T1 (es) |
SK (1) | SK280901B6 (es) |
UA (1) | UA44711C2 (es) |
WO (1) | WO1995008549A1 (es) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9317987D0 (en) * | 1993-08-26 | 1993-10-13 | Glaxo Group Ltd | Chemical compounds |
IL111002A (en) * | 1993-09-22 | 1998-09-24 | Glaxo Group Ltd | History of piperidine, their preparation and the pharmaceutical preparations containing them |
WO1996021661A1 (en) * | 1995-01-12 | 1996-07-18 | Glaxo Group Limited | Piperidine derivatives having tachykinin antagonist activity |
GB9505692D0 (en) * | 1995-03-21 | 1995-05-10 | Glaxo Group Ltd | Chemical compounds |
GB9513117D0 (en) * | 1995-06-28 | 1995-08-30 | Merck Sharp & Dohme | Therapeutic agents |
TW458774B (en) | 1995-10-20 | 2001-10-11 | Pfizer | Antiemetic pharmaceutical compositions |
US6211199B1 (en) | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
GB9525296D0 (en) * | 1995-12-11 | 1996-02-07 | Merck Sharp & Dohme | Therapeutic agents |
US5922737A (en) * | 1996-02-21 | 1999-07-13 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases |
US5998439A (en) * | 1996-02-21 | 1999-12-07 | Hoescht Marion Roussel, Inc. | Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
US5932571A (en) * | 1996-02-21 | 1999-08-03 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases |
NZ333062A (en) * | 1996-06-26 | 2000-06-23 | Warner Lambert Co | Use of [R,S]-[2-(1H-indol-3-yl)-1-methyl-1-(1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2yl methyl ester in the treatment of emesis |
MX9706196A (es) * | 1996-08-14 | 1998-02-28 | Pfizer | Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p. |
MX9706944A (es) * | 1996-09-12 | 1998-08-30 | Pfizer | Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p. |
US6117855A (en) | 1996-10-07 | 2000-09-12 | Merck Sharp & Dohme Ltd. | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent |
WO1998024441A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating major depressive disorders with anxiety |
CA2273806A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating substance use disorders |
EP0942732B1 (en) * | 1996-12-02 | 2004-11-17 | MERCK SHARP & DOHME LTD. | Use of nk-1 receptor antagonists for treating movement disorders |
US6100256A (en) * | 1996-12-02 | 2000-08-08 | Merck Sharp & Dohme Ltd. | Use of NK-1 receptors antagonists for treating schizophrenic disorders |
ES2227728T3 (es) * | 1996-12-02 | 2005-04-01 | MERCK SHARP & DOHME LTD. | Uso de antagonistas del receptor de nk-1 para tratar trastornos de ests. |
WO1998024442A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating sexual dysfunction |
JP2001508412A (ja) * | 1996-12-02 | 2001-06-26 | メルク シヤープ エンド ドーム リミテツド | 認識障害の治療のためのnk−1受容体拮抗薬の使用 |
WO1998024443A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating bipolar disorders |
US6613765B1 (en) | 1996-12-02 | 2003-09-02 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating major depressive disorders |
WO1998024445A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating schizophrenic disorders |
US6114315A (en) * | 1996-12-02 | 2000-09-05 | Merck Sharp & Dohme Ltd. | Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety |
US5977104A (en) * | 1996-12-02 | 1999-11-02 | Merck Sharp & Dohme Ltd. | Use of NK-1 receptor antagonists for treating bipolar disorders |
CA2273785A1 (en) * | 1996-12-02 | 1998-06-11 | Raymond Baker | Use of nk-1 receptor antagonists for treating severe anxiety disorders |
CA2273810A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating major depressive disorders |
US5861417A (en) * | 1996-12-19 | 1999-01-19 | Hoechst Marion Roussel, Inc. | Heterocyclic substituted pyrrolidine amide derivatives |
JP2001524960A (ja) * | 1997-04-24 | 2001-12-04 | メルク シヤープ エンド ドーム リミテツド | 摂食障害を治療するためのnk−1受容体拮抗薬の使用 |
EP0991622A1 (en) * | 1997-06-27 | 2000-04-12 | MERCK SHARP & DOHME LTD. | Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents |
GB9716463D0 (en) * | 1997-08-04 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic agents |
WO1999007375A1 (en) * | 1997-08-04 | 1999-02-18 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating aggressive behaviour disorders |
CA2298777A1 (en) * | 1997-08-04 | 1999-02-18 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating mania |
GB9716457D0 (en) * | 1997-08-04 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic agents |
GB9723544D0 (en) * | 1997-11-07 | 1998-01-07 | Merck Sharp & Dohme | Therapeutic agents |
US6271230B1 (en) | 1997-12-01 | 2001-08-07 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating cognitive disorders |
US6156749A (en) * | 1997-12-01 | 2000-12-05 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating movement disorders |
US6087348A (en) * | 1997-12-01 | 2000-07-11 | Merck Sharp & Dohme Ltd. | Use of NK-1 receptor antagonists for treating stress disorders |
GB9816897D0 (en) * | 1998-08-04 | 1998-09-30 | Merck Sharp & Dohme | Therapeutic use |
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-
1994
- 1994-09-19 IL IL11100294A patent/IL111002A/en not_active IP Right Cessation
- 1994-09-19 IS IS4208A patent/IS4208A/is unknown
- 1994-09-20 CZ CZ96830A patent/CZ285479B6/cs not_active IP Right Cessation
- 1994-09-20 SI SI9430208T patent/SI0720609T1/xx unknown
- 1994-09-20 AT AT94927627T patent/ATE173255T1/de not_active IP Right Cessation
- 1994-09-20 CO CO94042544A patent/CO4290298A1/es unknown
- 1994-09-20 DE DE69414590T patent/DE69414590T2/de not_active Expired - Lifetime
- 1994-09-20 EP EP94927627A patent/EP0720609B1/en not_active Expired - Lifetime
- 1994-09-20 SK SK383-96A patent/SK280901B6/sk unknown
- 1994-09-20 PL PL94313619A patent/PL179585B1/pl unknown
- 1994-09-20 UA UA96031099A patent/UA44711C2/uk unknown
- 1994-09-20 HR HR940575A patent/HRP940575B1/xx not_active IP Right Cessation
- 1994-09-20 HU HU9600722A patent/HU217428B/hu not_active IP Right Cessation
- 1994-09-20 JP JP7509554A patent/JP2865872B2/ja not_active Expired - Lifetime
- 1994-09-20 PE PE1994251007A patent/PE18295A1/es not_active Application Discontinuation
- 1994-09-20 NZ NZ273614A patent/NZ273614A/en unknown
- 1994-09-20 CA CA002172529A patent/CA2172529A1/en not_active Abandoned
- 1994-09-20 AU AU76974/94A patent/AU681190B2/en not_active Ceased
- 1994-09-20 DK DK94927627T patent/DK0720609T3/da active
- 1994-09-20 US US08/612,843 patent/US5703240A/en not_active Expired - Lifetime
- 1994-09-20 ES ES94927627T patent/ES2123829T3/es not_active Expired - Lifetime
- 1994-09-20 WO PCT/EP1994/003129 patent/WO1995008549A1/en active IP Right Grant
- 1994-09-20 CN CN94194145A patent/CN1061041C/zh not_active Expired - Fee Related
- 1994-09-21 AP APAP/P/1994/000671A patent/AP495A/en active
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1996
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- 1996-03-21 NO NO961156A patent/NO307830B1/no not_active IP Right Cessation
- 1996-03-21 OA OA60801A patent/OA10576A/en unknown
- 1996-04-09 BG BG100487A patent/BG62169B1/bg unknown
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1997
- 1997-07-23 US US08/899,190 patent/US5843966A/en not_active Expired - Lifetime
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1998
- 1998-04-24 HK HK98103471A patent/HK1004219A1/xx not_active IP Right Cessation
- 1998-08-07 JP JP10224991A patent/JPH11106341A/ja active Pending
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1999
- 1999-02-10 GR GR990400441T patent/GR3029354T3/el unknown
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