ES2031876T3 - Un procedimiento para la preparacion de 5,6-dihidro-2-(fenil sustituido)-1,2,4,-triazin-3,5(2h,4h)-dionas. - Google Patents

Un procedimiento para la preparacion de 5,6-dihidro-2-(fenil sustituido)-1,2,4,-triazin-3,5(2h,4h)-dionas.

Info

Publication number
ES2031876T3
ES2031876T3 ES198787200088T ES87200088T ES2031876T3 ES 2031876 T3 ES2031876 T3 ES 2031876T3 ES 198787200088 T ES198787200088 T ES 198787200088T ES 87200088 T ES87200088 T ES 87200088T ES 2031876 T3 ES2031876 T3 ES 2031876T3
Authority
ES
Spain
Prior art keywords
dionas
triazin
dihydro
substituted phenyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787200088T
Other languages
English (en)
Inventor
Gustaaf Maria Boeckx
Alfons Herman Margaretha Raeymaekers
Victor Sipido
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2031876T3 publication Critical patent/ES2031876T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTAN NUEVAS 5,6-DIHIDRO-2- (FENILO SUSTITUIDO)-1,2,4-TRIAZIN- 3,5(2H,4H)-DIONAS DE FORMULA (I), EN LA QUE AR ES TIENILO, TIENILO SUSTITUIDO CON HALOGENO, NAFTILO O UN RADICAL DE FORMULA (A); LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS OBTENIDAS POR ADICION DE ACIDOS Y SUS POSIBLES FORMAS ESTEREOQUIMICAMENTE ISOMERAS, LAS CUALES SON AGENTES ANTIPROTOZOARIOS; LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS COMO INGREDIENTE ACTIVO; PROCEDIMIENTOS PARA PREPARAR DICHOS COMPUESTOS Y COMPOSICIONES FARMACEUTICAS; NUEVOS COMPUESTOS CON ACTIVIDAD ANTIPROTOZOARIA USADOS EN DICHOS PROCEDIMIENTOS.
ES198787200088T 1986-01-30 1987-01-21 Un procedimiento para la preparacion de 5,6-dihidro-2-(fenil sustituido)-1,2,4,-triazin-3,5(2h,4h)-dionas. Expired - Lifetime ES2031876T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868602342A GB8602342D0 (en) 1986-01-30 1986-01-30 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones

Publications (1)

Publication Number Publication Date
ES2031876T3 true ES2031876T3 (es) 1993-01-01

Family

ID=10592258

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787200088T Expired - Lifetime ES2031876T3 (es) 1986-01-30 1987-01-21 Un procedimiento para la preparacion de 5,6-dihidro-2-(fenil sustituido)-1,2,4,-triazin-3,5(2h,4h)-dionas.

Country Status (21)

Country Link
US (3) US4767760A (es)
EP (1) EP0232932B1 (es)
JP (2) JPH0813806B2 (es)
CN (1) CN1017049B (es)
AT (1) ATE59644T1 (es)
AU (1) AU586731B2 (es)
CA (2) CA1288772C (es)
DE (1) DE3766839D1 (es)
DK (2) DK169032B1 (es)
ES (1) ES2031876T3 (es)
FI (1) FI94634C (es)
GB (1) GB8602342D0 (es)
GR (1) GR3001392T3 (es)
IE (1) IE59510B1 (es)
IL (1) IL81421A (es)
NO (1) NO172690C (es)
NZ (1) NZ218973A (es)
PT (1) PT84218B (es)
RU (1) RU2017736C1 (es)
SU (1) SU1595339A3 (es)
ZA (1) ZA87672B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097779A (en) * 1976-04-05 1978-06-27 Gte Sylvania Incorporated Fluorescent lamp containing a cathode heater circuit disconnect device
US4156831A (en) * 1978-05-24 1979-05-29 Gte Sylvania Incorporated Fluorescent lamp having heater circuit disconnect device
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
DE3826058A1 (de) * 1988-07-30 1990-02-08 Bayer Ag Mittel gegen fischparasiten
US5070091A (en) * 1989-01-09 1991-12-03 Bayer Aktiengesellschaft Substituted 1,2,4-triazinediones useful against protozoa in insects
EP0377903A3 (de) * 1989-01-09 1991-07-17 Bayer Ag Substituierte Hexahydro-1,2,4-triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
CN1044905A (zh) * 1989-02-16 1990-08-29 赫彻斯特股份公司 鱼和昆虫寄生虫对抗剂
CA2012004A1 (en) * 1989-03-15 1990-09-15 Frank Ellis Chemical compounds
EP0476439A1 (de) * 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
DE4120138A1 (de) * 1991-06-19 1992-12-24 Bayer Ag Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung
US5994355A (en) * 1993-10-15 1999-11-30 Takeda Chemical Industries, Ltd. 1, 2, 4-Triazin-3-one derivatives, production and use thereof
DE69615601T2 (de) * 1995-04-14 2002-07-11 Takeda Schering Plough Animal Verfahren zur Herstellung von Triazinderivate
US5747476A (en) * 1996-07-17 1998-05-05 Mortar & Pestle Veterinary Pharmacy, Inc. Treatment of equine protozoal myeloencephalitis
KR19980019182A (ko) * 1996-08-30 1998-06-05 다께다 구니오 1,2,4-트리아진-3,5-디온 유도체, 그의 생성법 및 그의 용도(1,2,4-triazine-3,5-dione derivatives, their production a nd use thereof)
US5883095A (en) * 1997-08-07 1999-03-16 University Of Kentucky Research Foundation Formulations and methods to treat and prevent equine protozoal myeloencephalitis
BR9808114A (pt) * 1997-03-31 2000-03-08 David Granstrom Formulação de ração para cavalos utilizável para tratar epm, processos para tratar pm em um cavalo que necessita deste tratamento, para prevenir infecção com s. neutrona em cavalos, e, para exterminar s. neurona em cavalos
US5830893A (en) * 1997-04-23 1998-11-03 Mortar & Pestle Veterinary Pharmacy, Inc. Treatment of equine protozoan myeloencephalitis using triazinediones
CN1261881A (zh) * 1997-07-10 2000-08-02 詹森药业有限公司 作为il－5－抑制剂的6－氮杂尿嘧啶衍生物
ATE364597T1 (de) * 1997-07-10 2007-07-15 Janssen Pharmaceutica Nv Il-5 hemmende 6-azauracilderivate
US6867207B2 (en) 1997-07-10 2005-03-15 Janssen Pharmaceutica N.V. IL-5 inhibiting 6-azauracil derivatives
TW450964B (en) 1997-08-29 2001-08-21 Takeda Schering Plough Animal Triazine derivatives, their production and use
WO2000006172A1 (en) * 1998-07-27 2000-02-10 Mortar & Pestle Veterinary Pharmacy, Inc. Treatment of equine protozoan myeloencephalitis using triazinediones
EP0987265A1 (en) 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
WO2000019964A2 (en) * 1998-10-08 2000-04-13 New Ace Research Company Novel compositions and methods for prevention and treatment of protozoal disease
BR9916366A (pt) * 1998-12-18 2001-09-18 Janssen Pharmaceutica Nv Derivados de 6-azauracila, inibidores de il-5
CN1188410C (zh) 1999-08-06 2005-02-09 詹森药业有限公司 非类固醇类的il－5抑制剂,其制备的方法以及包含该抑制剂的医药组合物
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
CN107746390B (zh) * 2017-11-21 2021-03-16 连云港市亚晖医药化工有限公司 抗球虫药地克珠利的制备方法
CN113999139A (zh) * 2021-12-03 2022-02-01 杭州臻峰科技有限公司 制备2，6-二氯-α-（4-氯代苯基） -4-硝基苯乙腈的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905971A (en) * 1971-03-29 1975-09-16 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
US3912723A (en) * 1971-03-29 1975-10-14 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
GB1448696A (en) * 1973-05-29 1976-09-08 Pfizer 2-phqnyl-astriazine-3,4-2h,4h-diones
DE3408924A1 (de) * 1984-03-12 1985-09-26 Hoechst Ag, 6230 Frankfurt Substituierte 2-phenyl-hexahydro-1,2,4-triazin-3,5-dione, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
US4631278A (en) * 1984-08-01 1986-12-23 Janssen Pharmaceutica N.V. Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
CA1244024A (en) * 1984-08-01 1988-11-01 Gustaaf M. Boeckx .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones

Also Published As

Publication number Publication date
EP0232932A1 (en) 1987-08-19
JPH0813806B2 (ja) 1996-02-14
DK65193A (da) 1993-06-04
AU6813487A (en) 1987-08-06
GR3001392T3 (en) 1992-09-11
DK48187A (da) 1987-07-31
JPH07285949A (ja) 1995-10-31
DK169032B1 (da) 1994-08-01
EP0232932B1 (en) 1991-01-02
JPS62190174A (ja) 1987-08-20
CA1288772C (en) 1991-09-10
FI94634C (fi) 1995-10-10
IE59510B1 (en) 1994-03-09
US4767760A (en) 1988-08-30
DE3766839D1 (de) 1991-02-07
FI870421A0 (fi) 1987-01-30
NO870378L (no) 1987-07-31
FI870421A (fi) 1987-07-31
IL81421A (en) 1991-11-21
SU1595339A3 (ru) 1990-09-23
PT84218B (pt) 1989-07-31
DK48187D0 (da) 1987-01-29
GB8602342D0 (en) 1986-03-05
NO172690C (no) 1993-08-25
IE870231L (en) 1987-07-30
NO870378D0 (no) 1987-01-29
ZA87672B (en) 1988-09-28
US4912106A (en) 1990-03-27
RU2017736C1 (ru) 1994-08-15
ATE59644T1 (de) 1991-01-15
AU586731B2 (en) 1989-07-20
IL81421A0 (en) 1987-08-31
CN87100531A (zh) 1987-09-02
JP2622510B2 (ja) 1997-06-18
US4952570A (en) 1990-08-28
FI94634B (fi) 1995-06-30
CA1302411C (en) 1992-06-02
NO172690B (no) 1993-05-18
NZ218973A (en) 1988-10-28
PT84218A (en) 1987-02-01
CN1017049B (zh) 1992-06-17
DK65193D0 (da) 1993-06-04

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