BR9811678A - Derivados de 6-azauracila de inibição de il-5 - Google Patents

Derivados de 6-azauracila de inibição de il-5

Info

Publication number
BR9811678A
BR9811678A BR9811678-9A BR9811678A BR9811678A BR 9811678 A BR9811678 A BR 9811678A BR 9811678 A BR9811678 A BR 9811678A BR 9811678 A BR9811678 A BR 9811678A
Authority
BR
Brazil
Prior art keywords
optionally substituted
alkyl
het3
cycloalkyl
aryl
Prior art date
Application number
BR9811678-9A
Other languages
English (en)
Inventor
Jean Fernand Armand Lacrampe
Eddy Jean Adgard Freyne
Marc Gaston Venet
Gustaaf Maria Boeckx
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR9811678A publication Critical patent/BR9811678A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE 6-AZAURACILA DE INIBIçãO DE IL-5"<D>. A presente invenção trata dos compostos da fórmula (I) os seus N-óxidos, os seus sais de adição farmaceuticamente aceitáveis e as suas formas estereoquimicamente isoméricas, p e q são 0, 1, 2, 3 ou 4 e q é também 5; X é O, S, NR³ ou uma ligação direta; R¹ hidrogênio, hidróxi, halo, amino opcionalmente substituído, C~ 1~-C~ 6~ alquila, C~ 1~-C~ 6~ alquilóxi, C~ 3~-C~ 7~ cicloalquila ou arila; R² arila, Het¹, C~ 3~-C~ 7~ cicloalquila, C~ 1~-C~ 6~ alquila opcionalmente substituída; e se X é O, S ou NR³, então R² pode também ser um substituinte ligado a carbonila ou a tiocarbonila; R³ é hidrogênio ou C~ 1~-C~ 4~ alquila; R^ 4^ e R^ 5^ independentemente são C~ 1~-C~ 6~ alquila opcionalmente substituída, halo, hidróxi, mercapto, C~ 1~-C~ 6~ alquilóxi, C~ 1~-C~ 6~ alquiltio, C~ 1~-C~ 6~ alquilcarbonilóxi, arila, ciano, nitro, Het³, R^ 6^ ou NR^ 7^R^ 8^; R^ 6^ é sulfinila ou sulfonila substituída; R^ 7^ e R^ 8^ são hidrogênio, C~ 1~-C~ 4~ alquila opcionalmente substituída, arila, um substituinte ligado a carbonila ou tiocarbonila, C~ 3~-C~ 7~ cicloalquila, Het³ e R^ 6;^ R^ 9^ e R^ 10^ são cada um independentemente selecionado de hidrogênio, C~ 1~-C~ 4~ alquila opcionalmente substituída, fenila, um substituinte ligado a carbonila ou a tiocarbonila, C~ 3~-C~ 7~ cicloalquila, Het³ e R^ 6^; R^ 11^ é hidróxi, mercapto, ciano, nitro, halo, trihalometila, C~ 1~-C~ 4~ alquilóxi, carboxila, C~ 1~-C~ 4~ alquiloxicarbonila, trihalo C~ 1~-C~ 4~ alquilsulfonilóxi, R^ 6,^ NR^ 7^R^ 8^, C(=O)NR^ 7^R^ 8^, arila, arilóxi, arilcarbonila, C~ 3~-C~ 7~ cicloalquila, C~ 3~-C~ 7~ cicloalquilóxi, ftalimida-2-ila, Het³ e C(=O)Het³; R^ 12^ e R^ 13^ são cada um independentemente selecionado de hidrogênio, C~ 1~-C~ 4~ alquila opcionalmente substituída, fenila, um substituinte ligado a carbonila ou a tiocarbonila, C~ 3~-C~ 7~ cicloalquila e R^ 6^; arila é fenila opcionalmente substituída; Het¹, Het², Het³ são heterociclos opcionalmente substituídos; de processos para sua preparação e composições compreendendo-os. Ela utleriormente refere-se a seu uso como um remédio.
BR9811678-9A 1997-07-10 1998-07-07 Derivados de 6-azauracila de inibição de il-5 BR9811678A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202118 1997-07-10
PCT/EP1998/004191 WO1999002505A1 (en) 1997-07-10 1998-07-07 Il-5 inhibiting 6-azauracil derivatives

Publications (1)

Publication Number Publication Date
BR9811678A true BR9811678A (pt) 2000-09-19

Family

ID=8228531

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811678-9A BR9811678A (pt) 1997-07-10 1998-07-07 Derivados de 6-azauracila de inibição de il-5

Country Status (23)

Country Link
EP (1) EP1000040B1 (pt)
JP (1) JP2002511882A (pt)
KR (1) KR20010014049A (pt)
CN (1) CN1262679A (pt)
AR (1) AR013360A1 (pt)
AT (1) ATE364597T1 (pt)
AU (1) AU742145B2 (pt)
BR (1) BR9811678A (pt)
CA (1) CA2294145A1 (pt)
DE (1) DE69837922D1 (pt)
EE (1) EE200000016A (pt)
HR (1) HRP20000003A2 (pt)
HU (1) HUP0004687A3 (pt)
ID (1) ID24390A (pt)
IL (1) IL133916A0 (pt)
NO (1) NO20000063L (pt)
NZ (1) NZ502180A (pt)
PL (1) PL337947A1 (pt)
SK (1) SK183999A3 (pt)
TR (1) TR200000153T2 (pt)
TW (1) TW496865B (pt)
WO (1) WO1999002505A1 (pt)
ZA (1) ZA986089B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1100483E (pt) * 1998-07-30 2005-02-28 Abbott Lab Agentes anti-inflamatorios selectivos para glicocorticoide
EP0987265A1 (en) * 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
DE69936396T2 (de) 1998-12-18 2008-06-19 Janssen Pharmaceutica N.V. Il-5 hemmende 6-uracilderivate
EE200200057A (et) * 1999-08-06 2003-04-15 Janssen Pharmaceutica N.V. Kasvutegurit IL-5 pärssiv asauratsiilderivaat, selle saamine ja kasutamine ravimi valmistamiseks ning seda sisaldav farmatseutiline kompositsioon
WO2002004411A1 (en) 2000-07-07 2002-01-17 The Administrators Of The Tulane Educational Fund Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor
AU2003211385A1 (en) * 2002-02-28 2003-09-09 Takeda Chemical Industries, Ltd. Azole compounds
US20040186151A1 (en) * 2003-02-12 2004-09-23 Mjalli Adnan M.M. Substituted azole derivatives as therapeutic agents
GB0305575D0 (en) 2003-03-11 2003-04-16 Glaxo Group Ltd Novel compounds
EA200602288A1 (ru) * 2004-05-29 2007-10-26 7ТиЭм ФАРМА А/С Замещённые тиазолуксусные кислоты в качестве лигандов crth2
DE102006049618A1 (de) * 2006-10-20 2008-05-08 Tschesche, Harald, Prof. Dr. Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren
CN101265238B (zh) * 2007-12-12 2010-06-16 重庆天极旅业有限公司 一种三嗪环衍生物的合成方法
CN101265216B (zh) * 2007-12-18 2012-06-27 重庆华邦胜凯制药有限公司 4-(取代乙氰基)-苯腙衍生物及其合成方法
PE20130751A1 (es) * 2010-08-16 2013-06-21 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrieno
SG11201900215YA (en) * 2016-07-13 2019-02-27 Univ Paris Descartes Meclozine derivatives and diclazuril derivatives for use in the prevention and/or the treatment of disorders associated to the inflammation induced by p. acnes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2149645A1 (de) * 1970-10-07 1972-09-14 Pfizer 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose
US3912723A (en) * 1971-03-29 1975-10-14 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
US3883528A (en) * 1974-04-19 1975-05-13 Pfizer Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats
CA1244024A (en) * 1984-08-01 1988-11-01 Gustaaf M. Boeckx .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
EP0476439A1 (de) * 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
TW403741B (en) * 1993-10-15 2000-09-01 Takeda Chemical Industries Ltd Triazine derivative, production and use thereof

Also Published As

Publication number Publication date
NZ502180A (en) 2000-11-24
AU8973898A (en) 1999-02-08
EP1000040A1 (en) 2000-05-17
NO20000063D0 (no) 2000-01-06
CA2294145A1 (en) 1999-01-21
TW496865B (en) 2002-08-01
HUP0004687A3 (en) 2002-03-28
EE200000016A (et) 2000-10-16
TR200000153T2 (tr) 2000-07-21
ATE364597T1 (de) 2007-07-15
SK183999A3 (en) 2000-08-14
EP1000040B1 (en) 2007-06-13
WO1999002505A1 (en) 1999-01-21
AU742145B2 (en) 2001-12-20
DE69837922D1 (de) 2007-07-26
AR013360A1 (es) 2000-12-27
JP2002511882A (ja) 2002-04-16
KR20010014049A (ko) 2001-02-26
ID24390A (id) 2000-07-13
HUP0004687A2 (hu) 2002-02-28
ZA986089B (en) 2000-01-10
IL133916A0 (en) 2001-04-30
HRP20000003A2 (en) 2000-12-31
NO20000063L (no) 2000-03-10
CN1262679A (zh) 2000-08-09
PL337947A1 (en) 2000-09-11

Similar Documents

Publication Publication Date Title
BR9811678A (pt) Derivados de 6-azauracila de inibição de il-5
EP1939175A4 (en) SULFONAMIDE DERIVATIVITY WITH PGD2 RECEPTOR ANTAGONISTIC EFFECT
DK1104760T3 (da) Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
BR0213790A (pt) Derivados de aminobenzamida como inibidores de glicogênio sintase cinase 3beta
CO5690551A2 (es) Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo
BR122017028096B8 (pt) composto, composição farmacêutica, e, uso do composto
NO308736B1 (no) 1,2-difenylpyrrolderivater, farmasøytiske preparater inneholdende disse, og deres anvendelse
BR0008173A (pt) Composto de amida e seu uso como campo técnico de medicina da invenção
HUP0302069A2 (hu) Heteroariloxi-acetamid-származékot tartalmazó szelektív és szinergetikus hatású herbicid készítmények, elżállításuk és alkalmazásuk
MX9203551A (es) Derivados de fenil amidinas utiles como inhibidores de agregacion de plaquetas.
AR063643A1 (es) Compuestos quimicos derivados de quinolina, un metodo de preparacion y composiciones farmaceuticas
BR9813124A (pt) Compostos indol 2,3-substituìdos como inibidores cox-2
BRPI0408767A (pt) inibidores de transcriptase reversa não-nucleosìdeos i para o tratamento de doenças mediadas pelo hiv
BR0100155A (pt) Azabenzimidazóis aril substituìdos e sua utilização no tratamento de hiv e doenças relacionadas com aids
BR0210531A (pt) Derivados de ácido sulfÈnico
BR9809652A (pt) Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3
BR0213731A (pt) Compostos de silìcio
BR9809496A (pt) Composto, processo para produzi-lo, uso do mesmo, preparação farmacêutica, e, processo para tratar pacientes necessitados de tratamento.
BR0102377A (pt) Inibidores de não-nucleosìdeo transcriptase reversa
ES2196332T3 (es) Derivados de hexahidro-pirido(4,3-b)indol como farmacos antipsicoticos.
BR9807330A (pt) Agentes inibidores do progresso de pterìgio e recorrência pós-operatória do mesmo
BR9810321A (pt) Derivados de piridazina de tiadiazolila de inibição de angiogênese
AR081810A1 (es) Piridinilpirazoles biciclicos
BR9811499A (pt) &#34;derivados da 6-azauracila como inibidores da il-5&#34;
BR0016673A (pt) Composto, composição, processos para preparar um composto e composições, composição, método para controlar vegetação indesejável e uso de um composto

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.