BR9809652A - Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3 - Google Patents

Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3

Info

Publication number
BR9809652A
BR9809652A BR9809652-4A BR9809652A BR9809652A BR 9809652 A BR9809652 A BR 9809652A BR 9809652 A BR9809652 A BR 9809652A BR 9809652 A BR9809652 A BR 9809652A
Authority
BR
Brazil
Prior art keywords
alkyl
optionally substituted
group
aryl
cycloalkyl
Prior art date
Application number
BR9809652-4A
Other languages
English (en)
Inventor
Giuseppe Arnaldo Mari Giardina
Mario Grugni
Davide Graziani
Luca Francesco Raveglia
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en
Priority claimed from IT002354 external-priority patent/IT1295358B1/it
Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of BR9809652A publication Critical patent/BR9809652A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

"DERIVADOS DE QUINOLINA-4-CARBOXAMIDA COMO ANTAGONISTAS DE RECEPTOR NK-2 E NK-3". Composto, ou um solvato ou um sal do mesmo, de fórmula (I): em que, Ar é um grupo arila ou um cicloalquidienila C~ 5-7~ opcionalmente substituído, ou um grupo cicloalquila C~ 5-7~ ou um grupo heterocíclico aromático com anel único ou fundido opcionalmente substituído; R é alquila C~ 1-6~, cicloalquila C~ 3-7~, cicloalquilalquila C~ 3-7~, fenila ou fenil-alquila C~ 1-6~ opcionalmente substituída, um anel heteroaromático com cinco membros opcionalmente substituído compreendendo até quatro heteroátomos selecionados dentre O e N, hidroxi alquila C~ 1-6~, amino alquila C~ 1-6~, alquilaminoalquila C~ 1-6~, di-alquilaminoalquila C~ 1-6~, acilaminoalquila C~ 1-6~, alcoxialquila C~ 1-6~, alquilcarbonila C~ 1-6~, carboxi, alcoxicarbonila C~ 1-6~, alcoxicarbonila C~ 1-6~ alquila C~ 1-6~, aminocarbonila, alquilaminocarbonila C~ 1-6~, dialquilaminocarbonila C~ 1-6~, halogênio alquila C~ 1-6~; ou R é um grupo -(CH~ 2~)~ p~- em que p é 2 ou 3, cujo grupo forma um anel com um átomo de carbono de Ar; R~ 1~ representa hidrogênio ou até quatro substituintes opcionais selecionados dentre a lista consistindo de: alquila C~ 1-6~, alquenila C~ 1-6~, arila, alcoxi C~ 1-6~, hidroxi, halogênio, nitro, ciano, carboxi, carboxamido, sulfonamido, alcoxicarbonila C~ 1-6~, trifluorometila, aciloxi, ftalimido, amino ou mono- e di-alquilamino C~ 1-6~; R~ 2~ representa uma porção - (CH~ 2~)~ n~-NY~ 1~Y~ 2~ em que n é um número inteiro na faixa de 1 a 9, Y~ 1~ e Y~ 2~ são independentemente selecionados dentre hidrogênio; alquila C~ 1-6~; alquila C~ 1-6~ substituída com hidroxi, alquilamino C~ 1-6~ ou bis (alquil C~ 1-6~) amino; alquenila C~ 1-6~; arila ou aril-alquila C~ 1-6~ ou Y~ 1~ e Y~ 2~ juntos com o átomo de nitrogênio, em que eles são fixados, representam um grupo heterocíclico com anel único ou fundido N-ligado opcionalmente substituído; R~ 3~ é alquila C~ 1-6~, cicloalquila C~ 3-7~, cicloalquilquila C~ 4-7~ ramificado ou linear, arila opcionalmente substituída, ou um grupo heterocíclico aromático com anel único ou fundido opcionalmente substituído; e R~ 4~ representa hidrogênio ou alquila C~ 1-6~; uma composição farmacêutica compreendendo este composto, processo para preparar este composto e o uso deste composto em remédios.
BR9809652-4A 1997-05-23 1998-05-18 Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3 BR9809652A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9710750.2A GB9710750D0 (en) 1997-05-23 1997-05-23 Novel compounds
IT002354 IT1295358B1 (it) 1997-10-17 1997-10-17 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it) 1997-12-16 1997-12-16 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
PCT/EP1998/003014 WO1998052942A1 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists

Publications (1)

Publication Number Publication Date
BR9809652A true BR9809652A (pt) 2001-09-11

Family

ID=27268859

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809652-4A BR9809652A (pt) 1997-05-23 1998-05-18 Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3

Country Status (26)

Country Link
EP (1) EP0983262B1 (pt)
JP (1) JP2002500645A (pt)
CN (1) CN1264378A (pt)
AP (1) AP9901695A0 (pt)
AR (1) AR012732A1 (pt)
AT (1) ATE244711T1 (pt)
AU (1) AU8209898A (pt)
BG (1) BG104009A (pt)
BR (1) BR9809652A (pt)
CA (1) CA2291111A1 (pt)
CO (1) CO4950515A1 (pt)
DE (1) DE69816290T2 (pt)
DZ (1) DZ2498A1 (pt)
EA (1) EA199901062A1 (pt)
ES (1) ES2201509T3 (pt)
HU (1) HUP0002300A3 (pt)
ID (1) ID22876A (pt)
IL (1) IL133036A0 (pt)
MA (1) MA26501A1 (pt)
NO (1) NO995711L (pt)
OA (1) OA11515A (pt)
PE (1) PE75199A1 (pt)
PL (1) PL336942A1 (pt)
SK (1) SK159299A3 (pt)
TR (1) TR199902883T2 (pt)
WO (1) WO1998052942A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9825554D0 (en) 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
IL143137A0 (en) * 1998-11-20 2002-04-21 Smithkline Beecham Spa Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
US6780875B2 (en) * 1998-11-20 2004-08-24 Smithkline Beecham S.P.A. Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
EP1165542B1 (en) 1999-03-29 2003-08-20 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
AU4802500A (en) * 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
WO2002013825A1 (en) * 2000-08-11 2002-02-21 Smithkline Beecham P.L.C. Novel pharmaceutical use of quinnoline derivatives
WO2002038547A1 (en) * 2000-11-13 2002-05-16 Glaxosmithkline Spa Quinoline derivatives as nk-3 and nk-2 antagonists
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
AU2002226356A1 (en) * 2000-11-28 2002-06-11 Glaxosmithkline S.P.A. Quinoline derivatives as nk-3 antagonists
US6540733B2 (en) 2000-12-29 2003-04-01 Corazon Technologies, Inc. Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
EP1385839B1 (en) * 2001-04-11 2006-02-22 GlaxoSmithKline S.p.A. 3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
MY134211A (en) * 2001-05-18 2007-11-30 Smithkline Beecham Corp Novel use
GB0425075D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425076D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
CN101189211A (zh) * 2005-06-03 2008-05-28 阿斯利康(瑞典)有限公司 作为nk3拮抗剂的喹啉衍生物
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
DE202007017299U1 (de) * 2007-12-12 2009-04-23 Drebo Werkzeugfabrik Gmbh Bohrer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69533408T2 (de) * 1994-05-27 2005-09-08 Glaxosmithkline S.P.A. Chinolinderivate als Tachykinin NK3 Rezeptor Antagonisten
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

Also Published As

Publication number Publication date
EP0983262A1 (en) 2000-03-08
ATE244711T1 (de) 2003-07-15
CN1264378A (zh) 2000-08-23
EA199901062A1 (ru) 2000-08-28
IL133036A0 (en) 2001-03-19
ES2201509T3 (es) 2004-03-16
BG104009A (en) 2000-07-31
AU8209898A (en) 1998-12-11
NO995711D0 (no) 1999-11-22
DE69816290T2 (de) 2004-05-27
DE69816290D1 (de) 2003-08-14
WO1998052942A1 (en) 1998-11-26
CA2291111A1 (en) 1998-11-26
ID22876A (id) 1999-12-16
DZ2498A1 (fr) 2003-01-25
SK159299A3 (en) 2000-06-12
TR199902883T2 (xx) 2000-05-22
CO4950515A1 (es) 2000-09-01
EP0983262B1 (en) 2003-07-09
OA11515A (en) 2004-02-04
NO995711L (no) 2000-01-19
MA26501A1 (fr) 2004-12-20
PL336942A1 (en) 2000-07-17
AR012732A1 (es) 2000-11-08
PE75199A1 (es) 1999-10-22
HUP0002300A3 (en) 2002-01-28
HUP0002300A2 (hu) 2001-06-28
JP2002500645A (ja) 2002-01-08
AP9901695A0 (en) 1999-12-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A,7A,8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.