AU2002226356A1 - Quinoline derivatives as nk-3 antagonists - Google Patents

Quinoline derivatives as nk-3 antagonists

Info

Publication number
AU2002226356A1
AU2002226356A1 AU2002226356A AU2635602A AU2002226356A1 AU 2002226356 A1 AU2002226356 A1 AU 2002226356A1 AU 2002226356 A AU2002226356 A AU 2002226356A AU 2635602 A AU2635602 A AU 2635602A AU 2002226356 A1 AU2002226356 A1 AU 2002226356A1
Authority
AU
Australia
Prior art keywords
antagonists
quinoline derivatives
quinoline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002226356A
Inventor
Carlo Farina
Stefania Gagliardi
Giuseppe Giardina
Mario Grugni
Marisa Martinelli
Guy Marguerite Marie Gerard Nadler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire GlaxoSmithKline SAS
GlaxoSmithKline SpA
Original Assignee
Laboratoire GlaxoSmithKline SAS
GlaxoSmithKline SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0028965.2A external-priority patent/GB0028965D0/en
Application filed by Laboratoire GlaxoSmithKline SAS, GlaxoSmithKline SpA filed Critical Laboratoire GlaxoSmithKline SAS
Publication of AU2002226356A1 publication Critical patent/AU2002226356A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61P37/02—Immunomodulators
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
AU2002226356A 2000-11-28 2001-11-26 Quinoline derivatives as nk-3 antagonists Abandoned AU2002226356A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0028965.2A GB0028965D0 (en) 2000-11-28 2000-11-28 Novel compounds
GB0028965 2000-11-28
GBGB0109118.0A GB0109118D0 (en) 2000-11-28 2001-04-11 Novel compounds
GB0109118 2001-04-11
PCT/EP2001/013833 WO2002044165A1 (en) 2000-11-28 2001-11-26 Quinoline derivatives as nk-3 antagonists

Publications (1)

Publication Number Publication Date
AU2002226356A1 true AU2002226356A1 (en) 2002-06-11

Family

ID=26245343

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002226356A Abandoned AU2002226356A1 (en) 2000-11-28 2001-11-26 Quinoline derivatives as nk-3 antagonists

Country Status (5)

Country Link
US (1) US20060223819A1 (en)
EP (1) EP1351953A1 (en)
JP (1) JP2004517082A (en)
AU (1) AU2002226356A1 (en)
WO (1) WO2002044165A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060111368A1 (en) * 2002-06-26 2006-05-25 Kyowa Hakko Kogyo Co., Ltd. Phosphodiesterase inhibitor
WO2004066950A2 (en) * 2003-01-30 2004-08-12 Smithkline Beecham Corporation Quinoline derivatives as nk-2 and nk-3 receptor antagonists
JP2006516632A (en) * 2003-01-30 2006-07-06 スミスクライン・ビーチャム・コーポレイション Quinoline derivatives as NK-2 and NK-3 receptor antagonists
US20070060593A1 (en) * 2003-06-25 2007-03-15 Kerns Jeffrey K 4-Carboxamido quinoline derivatives for use as nk-2 and nk-3
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
EP1915363A1 (en) * 2005-08-11 2008-04-30 AstraZeneca AB Oxopyridyl quinoline amides as nk3 receptor modulators
WO2007018465A1 (en) * 2005-08-11 2007-02-15 Astrazeneca Ab Amide alkyl pyridiyl quinolines as nk3 receptor modulators
JP2009504641A (en) * 2005-08-11 2009-02-05 アストラゼネカ・アクチエボラーグ Alkylpyridylquinolines as modulators of the NK-3 receptor
JP2009508944A (en) * 2005-09-21 2009-03-05 アストラゼネカ・アクチエボラーグ N-oxoheterocycles and N-oxo-alkylquinoline-4-carboxamides as NK-3 receptor ligands
AR057130A1 (en) 2005-09-21 2007-11-14 Astrazeneca Ab ALKYL SULFOXIDE QUINOLINS AND A PHARMACEUTICAL COMPOSITION
US20090054445A1 (en) * 2006-01-27 2009-02-26 Astrazeneca Ab Amide Substituted Quinolines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP9901695A0 (en) * 1997-05-23 1999-12-31 Smithkline Beecham Spa Quinoline-4-carbaoxamide derivatives as NK-2 and NK-3 receptor antagonists.
JP2002530377A (en) * 1998-11-20 2002-09-17 スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists

Also Published As

Publication number Publication date
EP1351953A1 (en) 2003-10-15
JP2004517082A (en) 2004-06-10
WO2002044165A1 (en) 2002-06-06
US20060223819A1 (en) 2006-10-05

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