NO308736B1 - 1,2-difenylpyrrolderivater, farmasøytiske preparater inneholdende disse, og deres anvendelse - Google Patents
1,2-difenylpyrrolderivater, farmasøytiske preparater inneholdende disse, og deres anvendelseInfo
- Publication number
- NO308736B1 NO308736B1 NO971564A NO971564A NO308736B1 NO 308736 B1 NO308736 B1 NO 308736B1 NO 971564 A NO971564 A NO 971564A NO 971564 A NO971564 A NO 971564A NO 308736 B1 NO308736 B1 NO 308736B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8356296 | 1996-04-05 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO971564D0 NO971564D0 (no) | 1997-04-04 |
NO971564L NO971564L (no) | 1997-10-06 |
NO308736B1 true NO308736B1 (no) | 2000-10-23 |
Family
ID=13805966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO971564A NO308736B1 (no) | 1996-04-05 | 1997-04-04 | 1,2-difenylpyrrolderivater, farmasøytiske preparater inneholdende disse, og deres anvendelse |
Country Status (21)
Country | Link |
---|---|
US (2) | US5908858A (no) |
EP (1) | EP0799823B1 (no) |
JP (1) | JP3034819B2 (no) |
KR (1) | KR100485426B1 (no) |
CN (1) | CN1151126C (no) |
AT (1) | ATE376998T1 (no) |
CA (1) | CA2201812C (no) |
CZ (1) | CZ293048B6 (no) |
DE (1) | DE69738245T2 (no) |
DK (1) | DK0799823T3 (no) |
ES (1) | ES2296303T3 (no) |
HK (1) | HK1003268A1 (no) |
HU (1) | HU227830B1 (no) |
ID (1) | ID17358A (no) |
IL (1) | IL120584A (no) |
NO (1) | NO308736B1 (no) |
NZ (1) | NZ314508A (no) |
PT (1) | PT799823E (no) |
RU (1) | RU2125044C1 (no) |
TW (1) | TW409122B (no) |
ZA (1) | ZA972846B (no) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH09212974A (ja) * | 1996-01-31 | 1997-08-15 | Mitsubishi Electric Corp | ディスク装置 |
JP3995716B2 (ja) * | 1996-03-18 | 2007-10-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合環含有カルボン酸誘導体 |
CN1098256C (zh) | 1996-04-12 | 2003-01-08 | G·D·瑟尔公司 | 作为cox-2抑制剂前药的取代的苯磺酰胺衍生物 |
DK0946507T3 (da) * | 1996-12-10 | 2004-01-26 | Searle & Co | Substituerede pyrrolylforbindelser til behandling af inflammation |
EP1369415A1 (en) * | 1996-12-10 | 2003-12-10 | G.D. Searle & Co. | Substituted pyrrolyl compounds for the treatment of inflammation |
NZ333399A (en) * | 1997-12-24 | 2000-05-26 | Sankyo Co | Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis |
AU3953899A (en) * | 1998-05-27 | 1999-12-13 | Nippon Shinyaku Co. Ltd. | Cyclooxygenase-2 inhibitors |
AU4395399A (en) * | 1998-07-02 | 2000-01-24 | Sankyo Company Limited | Five-membered heteroaryl compounds |
US6649645B1 (en) | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
WO2001030757A1 (fr) * | 1999-10-28 | 2001-05-03 | Microcide Pharmaceuticals, Inc. | Inhibiteurs de la pompe par liberation de medicaments |
US6376489B1 (en) * | 1999-12-23 | 2002-04-23 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
US6372777B1 (en) * | 1999-12-23 | 2002-04-16 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
RU2002119574A (ru) | 1999-12-23 | 2004-01-10 | Нитромед, Инк. (Us) | Нитрозированные и нитрозилированные ингибиторы циклооксигеназы-2, композиции на их основе и способы их применения |
US6440994B1 (en) * | 2000-03-29 | 2002-08-27 | Richard J. Sanders, Jr. | Method of treating acne |
US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
WO2002080974A1 (fr) * | 2001-04-04 | 2002-10-17 | Sankyo Company, Limited | Utilisation medicale d'inhibiteur de production de cytokine |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
GB0212785D0 (en) * | 2002-05-31 | 2002-07-10 | Glaxo Group Ltd | Compounds |
CA2492066A1 (en) * | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
JP4458514B2 (ja) * | 2002-07-18 | 2010-04-28 | 第一三共株式会社 | 高純度のエナミン類の製造方法 |
JP4601274B2 (ja) * | 2002-08-20 | 2010-12-22 | 第一三共株式会社 | γ−ケトアセタール類の製造方法 |
CA2496225C (en) | 2002-08-20 | 2012-08-07 | Sankyo Company Limited | Process for the production of .gamma.-keto acetals |
GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
PT1572173E (pt) | 2002-12-13 | 2010-05-10 | Warner Lambert Co | Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior |
ES2394782T3 (es) * | 2003-05-07 | 2013-02-05 | Osteologix A/S | Composición con estroncio y vitamina D para la profilaxis y/o tratamiento de afecciones de cartílagos y/o huesos |
DE602004002832T2 (de) * | 2003-05-07 | 2007-06-06 | Osteologix A/S | Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen |
GB0328024D0 (en) * | 2003-12-03 | 2004-01-07 | Glaxo Group Ltd | Compounds |
EP1928827B1 (en) * | 2005-09-27 | 2012-08-22 | Myriad Genetics, Inc. | Pyrrole derivatives as therapeutic compounds |
US20070167510A1 (en) * | 2006-01-13 | 2007-07-19 | Suzanne Lentzsch | Methods for inhibiting osteoclastogenesis |
EP2041085A1 (en) * | 2006-06-27 | 2009-04-01 | Abbott Laboratories | Pyrrole derivatives and their methods of use |
EP1889617A1 (en) * | 2006-07-11 | 2008-02-20 | Freie Universität Berlin | Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents |
JP5072965B2 (ja) * | 2006-08-03 | 2012-11-14 | ロッタファルム・ソシエタ・ペル・アチオニ | 高選択性および経口有効性cox−2インヒビターである3−置換−1,5−ジアリール−2−アルキルピロール |
TW200812950A (en) * | 2006-08-18 | 2008-03-16 | Daiichi Sankyo Co Ltd | Process for producing acetophenone bromide |
CA2662870A1 (en) * | 2006-09-07 | 2008-03-13 | Myriad Genetics, Inc. | Therapeutic compounds for diseases and disorders |
CA2673545A1 (en) | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids |
EP2114461A2 (en) * | 2007-01-19 | 2009-11-11 | Mallinckrodt Inc. | Diagnostic and therapeutic cyclooxygenase-2 binding ligands |
US20120016002A1 (en) * | 2007-07-12 | 2012-01-19 | TRAGARA PHARMACEUTICALS ,Inc. | Patient Selection and Therapeutic Methods Using Markers of Prostaglandin Metabolism |
EA201000016A1 (ru) * | 2007-07-12 | 2010-10-29 | Трагара Фармасьютикалс, Инк. | Способы и композиции для лечения рака, опухолей и нарушений, связанных с опухолями |
JP2010540460A (ja) * | 2007-09-24 | 2010-12-24 | トラガラ ファーマシューティカルズ,インク. | COX‐2阻害薬と抗HER2[ErbB2]抗体の混合物又はCOX‐2阻害薬とHER2[ErbB2]受容体チロシンキナーゼ阻害薬の混合物を用いた癌の治療 |
EP2284154A1 (en) * | 2009-07-29 | 2011-02-16 | Argon Pharma S.L. | Antitumor 1,2-diphenylpyrrole compounds and their preparation process |
ES2372769B1 (es) * | 2010-07-08 | 2012-12-03 | Universitat De Barcelona | Fenil metil sulfonas con actividad antiiflamatoria y actividad antitumoral. |
EP2691368A1 (en) * | 2011-03-31 | 2014-02-05 | Lupin Limited | Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease |
JP2020527539A (ja) | 2017-07-18 | 2020-09-10 | フイルメニツヒ ソシエテ アノニムFirmenich Sa | シクラメンにおい物質 |
IL305573A (en) | 2021-03-15 | 2023-10-01 | Saul Yedgar | Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases |
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1997
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