DE69827706D1 - 5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems - Google Patents

5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems

Info

Publication number
DE69827706D1
DE69827706D1 DE69827706T DE69827706T DE69827706D1 DE 69827706 D1 DE69827706 D1 DE 69827706D1 DE 69827706 T DE69827706 T DE 69827706T DE 69827706 T DE69827706 T DE 69827706T DE 69827706 D1 DE69827706 D1 DE 69827706D1
Authority
DE
Germany
Prior art keywords
treatment
nervous system
central nervous
disorders
pbi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69827706T
Other languages
English (en)
Other versions
DE69827706T2 (de
Inventor
Allen B Reitz
Louis J Fitzpatrick
Alfonzo D Jordan
Pauline J Sanfilippo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Publication of DE69827706D1 publication Critical patent/DE69827706D1/de
Application granted granted Critical
Publication of DE69827706T2 publication Critical patent/DE69827706T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69827706T 1997-06-30 1998-06-29 5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems Expired - Fee Related DE69827706T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/884,804 US5922731A (en) 1997-06-30 1997-06-30 5- (heteroaryl)alkyl!-3-oxo-pyrido 1,2-a!benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
US884804 1997-06-30

Publications (2)

Publication Number Publication Date
DE69827706D1 true DE69827706D1 (de) 2004-12-30
DE69827706T2 DE69827706T2 (de) 2005-10-06

Family

ID=25385433

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69827706T Expired - Fee Related DE69827706T2 (de) 1997-06-30 1998-06-29 5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems

Country Status (12)

Country Link
US (1) US5922731A (de)
EP (1) EP0889044B1 (de)
JP (1) JPH11100380A (de)
AT (1) ATE283269T1 (de)
AU (2) AU7589298A (de)
CA (1) CA2242261A1 (de)
DE (1) DE69827706T2 (de)
ES (1) ES2234076T3 (de)
MX (1) MXPA98005355A (de)
NZ (1) NZ330832A (de)
PT (1) PT889044E (de)
WO (1) WO1999000389A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1224499A (en) * 1997-12-09 1999-06-28 Neurosearch A/S Chemical compounds for use as anxiolytic agents and a method for the identification of anxiolytic compounds
EP1153130B1 (de) * 1999-02-19 2005-11-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Polymorphismus im gen für die menschliche gaba a rezeptor alpha 6 untereinheit
US6762294B2 (en) 1999-02-19 2004-07-13 The United States Of America As Represented By The Department Of Health And Human Services Polynucleotides encoding polymorphic human GABAA receptor α-6 subunit
ES2260034T3 (es) * 1999-08-02 2006-11-01 Ortho-Mcneil Pharmaceutical, Inc. Derivados de pirido (1.2-a) bencimidazol sustituidos en c-6 utiles en el tratamiento de transtornos del sistema nervioso central.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2153842T3 (es) * 1992-08-19 2001-03-16 Mcneilab Inc Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central.
US5521200A (en) * 1993-12-30 1996-05-28 Ho; Winston 2-oxo-pyrrolo[1,2-A]benzimidazole-3-carboxyl derivatives useful in treating central nervous system disorders
WO1998015553A1 (en) * 1996-10-07 1998-04-16 Ortho-Mcneil Pharmaceutical, Inc. 5-HETEROATOM-CONTAINING ALKYL SUBSTITUTED-3-OXO-PYRIDO(1,2-a) BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS

Also Published As

Publication number Publication date
AU757320B2 (en) 2003-02-13
NZ330832A (en) 2000-01-28
CA2242261A1 (en) 1998-12-30
JPH11100380A (ja) 1999-04-13
WO1999000389A1 (en) 1999-01-07
AU7589298A (en) 1999-01-19
MXPA98005355A (es) 2004-10-28
ES2234076T3 (es) 2005-06-16
AU7395098A (en) 1999-01-07
EP0889044A1 (de) 1999-01-07
US5922731A (en) 1999-07-13
EP0889044B1 (de) 2004-11-24
PT889044E (pt) 2005-01-31
ATE283269T1 (de) 2004-12-15
DE69827706T2 (de) 2005-10-06

Similar Documents

Publication Publication Date Title
FI935529A0 (fi) Aminometylensubstituerade icke-aromatiska heterocykliska foereningar
HU9600834D0 (en) Quinazoline derivatives
DK1004578T3 (da) 5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
DE60012751D1 (de) Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz
DE69716810T2 (de) 2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one
ES2132284T3 (es) Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
NO941884D0 (no) 1,3-substituerte cykloalkener og cykloalkaner som sentralnervesystem-midler
PT992509E (pt) Novos derivados macrolidos
EA200100516A1 (ru) Производные 3,3-биарилпиперидина и 2,2-биарилморфолина
DE69828197D1 (de) Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut
ATE283269T1 (de) 5-(heteroaryl)alkyl)-3-oxo-pyrido(1,2- a)benzimidazol-4-carboxamid (pbi) derivate zur behandlung von störungen des zentralen nervensystems
ATE209633T1 (de) Pyridinderivate,als arzneimittel zur behandlung von geschwüren und als antibakterielle mittel
ATE229953T1 (de) Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
DE3778642D1 (de) Therapeutikum zur behandlung von magengeschwueren.
PL1603877T3 (pl) Nowe pochodne aminopirydyny jako antagoniści mGluR5
ATE252546T1 (de) 3-(3-hydroxyphenyl)-3-amino-propionamidderivate
DE69327077T2 (de) Carbamoylpyrrolidon-Derivate zur Behandlung von Depressionen und cerebrovasculären Störungen
DE69619088D1 (de) Quinoxalin-Derivate zur Behandlung von Tinnitus
ATE264840T1 (de) Azetidincarboxamid-derivate zur behandlung von zns störungen
ITMI920082A1 (it) Derivati solforati di acidi biliari
DE69908855D1 (de) 9a, 11b-dehydro Derivative von 9-oxime-3-keto-6-0-methylerythromycin
BR9900024A (pt) Biciclo[3.1.0]hexanos e compostos relacionados.
DK0810223T3 (da) Adamantylsubstituerede oxindoler som farmaceutiske midler

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN

8339 Ceased/non-payment of the annual fee