DE69738245D1 - 1,2-Diphenylpyrrol-Derivate, ihre Herstellung und therapeutische Verwendung - Google Patents

1,2-Diphenylpyrrol-Derivate, ihre Herstellung und therapeutische Verwendung

Info

Publication number
DE69738245D1
DE69738245D1 DE69738245T DE69738245T DE69738245D1 DE 69738245 D1 DE69738245 D1 DE 69738245D1 DE 69738245 T DE69738245 T DE 69738245T DE 69738245 T DE69738245 T DE 69738245T DE 69738245 D1 DE69738245 D1 DE 69738245D1
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
optionally substituted
preparation
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69738245T
Other languages
English (en)
Other versions
DE69738245T2 (de
Inventor
Tomio Kimura
Yasuo Noguchi
Akira Nakao
Keisuke Suzuki
Shigeru Ushiyama
Akihiro Kawara
Masaaki Miyamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13805966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69738245(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of DE69738245D1 publication Critical patent/DE69738245D1/de
Application granted granted Critical
Publication of DE69738245T2 publication Critical patent/DE69738245T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69738245T 1996-04-05 1997-04-02 1,2-Diphenylpyrrol-Derivate, ihre Herstellung und therapeutische Verwendung Expired - Lifetime DE69738245T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8356296 1996-04-05
JP8356296 1996-04-05

Publications (2)

Publication Number Publication Date
DE69738245D1 true DE69738245D1 (de) 2007-12-13
DE69738245T2 DE69738245T2 (de) 2008-08-14

Family

ID=13805966

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69738245T Expired - Lifetime DE69738245T2 (de) 1996-04-05 1997-04-02 1,2-Diphenylpyrrol-Derivate, ihre Herstellung und therapeutische Verwendung

Country Status (20)

Country Link
US (2) US5908858A (de)
EP (1) EP0799823B1 (de)
JP (1) JP3034819B2 (de)
KR (1) KR100485426B1 (de)
CN (1) CN1151126C (de)
AT (1) ATE376998T1 (de)
CA (1) CA2201812C (de)
CZ (1) CZ293048B6 (de)
DE (1) DE69738245T2 (de)
DK (1) DK0799823T3 (de)
ES (1) ES2296303T3 (de)
HU (1) HU227830B1 (de)
ID (1) ID17358A (de)
IL (1) IL120584A (de)
NO (1) NO308736B1 (de)
NZ (1) NZ314508A (de)
PT (1) PT799823E (de)
RU (1) RU2125044C1 (de)
TW (1) TW409122B (de)
ZA (1) ZA972846B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09212974A (ja) * 1996-01-31 1997-08-15 Mitsubishi Electric Corp ディスク装置
JP3995716B2 (ja) * 1996-03-18 2007-10-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合環含有カルボン酸誘導体
BR9708574A (pt) 1996-04-12 1999-08-03 Searle & Co Derivados benzeno sulfonamida substituídos como pródrogas de inibidores cox-2
CA2273836A1 (en) * 1996-12-10 1998-06-18 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation
EP1369415A1 (de) * 1996-12-10 2003-12-10 G.D. Searle & Co. Pyrrole Derivate zur Behandlung von Entzündungen
RU2220721C2 (ru) * 1997-12-24 2004-01-10 Санкио Компани, Лимитед Активный агент для ингибирования роста опухолей у млекопитающих, лечения и/или профилактики связанных с опухолями нарушений и метастаз опухолей у млекопитающих
US6887893B1 (en) 1997-12-24 2005-05-03 Sankyo Company, Limited Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia
WO1999061016A1 (fr) * 1998-05-27 1999-12-02 Nippon Shinyaku Co., Ltd. Inhibiteurs de cyclo-oxygenase-2
WO2000001688A1 (en) * 1998-07-02 2000-01-13 Sankyo Company, Limited Five-membered heteroaryl compounds
RU2190399C2 (ru) * 1998-07-21 2002-10-10 Санкио Компани Лимитед Средство для лечения и предотвращения кахексии
US6649645B1 (en) * 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
EP1652839A3 (de) * 1999-10-28 2006-07-05 Daiichi Pharmaceutical Co., Ltd. Pumpeninhibitoren zur Freisetzung von Medikamenten
CO5261556A1 (es) 1999-12-08 2003-03-31 Pharmacia Corp Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico
US6376489B1 (en) * 1999-12-23 2002-04-23 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
IL150368A0 (en) * 1999-12-23 2002-12-01 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
US6372777B1 (en) * 1999-12-23 2002-04-16 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
RU2198170C2 (ru) * 1999-12-27 2003-02-10 Санкио Компани, Лимитед Производные пиррола, фармацевтические композиции на их основе и способ лечения
US6440994B1 (en) * 2000-03-29 2002-08-27 Richard J. Sanders, Jr. Method of treating acne
MY137736A (en) 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
WO2002080974A1 (en) * 2001-04-04 2002-10-17 Sankyo Company, Limited Novel medicinal use of cytokine production inhibitor
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
GB0212785D0 (en) * 2002-05-31 2002-07-10 Glaxo Group Ltd Compounds
WO2004002420A2 (en) * 2002-06-28 2004-01-08 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
JP4458514B2 (ja) * 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
JP4601274B2 (ja) * 2002-08-20 2010-12-22 第一三共株式会社 γ−ケトアセタール類の製造方法
ES2384792T3 (es) * 2002-08-20 2012-07-12 Daiichi Sankyo Company, Limited Procedimiento para la producción de gamma-cetoacetales
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
RU2308264C2 (ru) * 2002-12-02 2007-10-20 Каунсел Оф Сайнтифик Энд Индастриал Рисерч Способ профилактики и/или лечения астмы с использованием рврв
ES2341240T3 (es) 2002-12-13 2010-06-17 Warner-Lambert Company Llc Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior.
DK1622630T3 (da) * 2003-05-07 2012-12-17 Osteologix As P009368epdk1
ATE342722T1 (de) * 2003-05-07 2006-11-15 Osteologix As Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
GB0328024D0 (en) * 2003-12-03 2004-01-07 Glaxo Group Ltd Compounds
EP1708718A1 (de) 2004-01-22 2006-10-11 Pfizer Limited Triazol-derivate zur hemmung der vasopressing-antagonistischen aktivität
AU2006294579A1 (en) * 2005-09-27 2007-04-05 Myriad Genetics, Inc. Pyrrole derivatives as therapeutic compounds
WO2007084853A2 (en) * 2006-01-13 2007-07-26 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods for inhibiting osteoclastogenesis
MX2008016338A (es) 2006-06-27 2009-01-16 Abbott Lab Derivados de pirrol y sus metodos de uso.
EP1889617A1 (de) * 2006-07-11 2008-02-20 Freie Universität Berlin Triphenylsubstituierte fünfgliedrige Heterocyclen und deren Verwendung als Antikreb- und entzündungshemmende Mittel
US7906551B2 (en) 2006-08-03 2011-03-15 Rottapharm S.P.A. 3-substituted-1,5-diarly-2-alkyl-pyrroles highly selective and orally effective COX-2 inhibitors
TW200812950A (en) * 2006-08-18 2008-03-16 Daiichi Sankyo Co Ltd Process for producing acetophenone bromide
WO2008031034A2 (en) * 2006-09-07 2008-03-13 Myriad Genetics, Inc. Therapeutic compounds for diseases and disorders
UA94979C2 (uk) 2006-12-22 2011-06-25 Рекордати Айеленд Лимитед КОМБІНОВАНА ТЕРАПІЯ ПОРУШЕНЬ НИЖНІХ СЕЧОВИВІДНИХ ШЛЯХІВ ЛІГАНДАМИ α2δ І НПЗП
EP2114461A2 (de) * 2007-01-19 2009-11-11 Mallinckrodt Inc. Diagnostische und therapeutische cyclooxygenase-2-bindende liganden
WO2009009776A2 (en) * 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Patient selection and therapeutic methods using markers of prostaglandin metabolism
AU2008274941A1 (en) * 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
WO2009042618A1 (en) * 2007-09-24 2009-04-02 Tragara Pharmaceuticals, Inc. Therapies for treating cancer using combinations of cox-2 inhibitors and anti-her2(erbb2) antibodies or combinations of cox-2 inhibitors and her2(erbb2) receptor tyrosine kinase inhibitors
EP2284154A1 (de) * 2009-07-29 2011-02-16 Argon Pharma S.L. Antitumorigene 1,2-Diphenylpyrrolverbindungen und deren Herstellungsverfahren
ES2372769B1 (es) * 2010-07-08 2012-12-03 Universitat De Barcelona Fenil metil sulfonas con actividad antiiflamatoria y actividad antitumoral.
CA2829860A1 (en) * 2011-03-31 2012-10-04 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
JP2020527539A (ja) 2017-07-18 2020-09-10 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ シクラメンにおい物質
US20240165148A1 (en) 2021-03-15 2024-05-23 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1356901A (fr) 1958-03-13 1964-04-03 Nouveaux aminoétheroxydes, aminothioéthers et aminoesters dérivés du pyrrole, etleur procédé de préparation
US3168532A (en) 1963-06-12 1965-02-02 Parke Davis & Co 1, 5-diarylpyrrole-2-propionic acid compounds
US3168531A (en) 1963-06-12 1965-02-02 Parke Davis & Co 1-aryl-5-(p-lower alkoxyphenyl)-pyrrole-2-propionic acid compounds
US3285931A (en) 1964-12-21 1966-11-15 Union Carbide Corp Preparation of substituted pyrrole derivatives
US3427305A (en) * 1966-11-01 1969-02-11 Searle & Co 5 - ((halo/alkoxy)phenyl) - 1 - (p - sulfonamido(phenyl/benzyl)) - 2 - pyrrolepropionic acids
US3551571A (en) 1967-05-19 1970-12-29 Endo Lab Methods for reducing pain,reducing fever and alleviating inflammatory syndromes with heteroaromatic pyrrol-3-yl ketones
GB1271082A (en) 1968-05-07 1972-04-19 Wyeth John & Brother Ltd Furan, pyrrole and thiophene derivatives
FR2054474A2 (en) 1969-07-09 1971-04-23 Innothera Lab Sa Analgesic, antiinflammatory 1-phenyl-2, 5-di
DE1938904A1 (de) * 1968-08-02 1970-02-05 Innothera Lab Sa 1-Phenylpyrrole
US3714232A (en) 1969-06-25 1973-01-30 Merck & Co Inc 5-arylphenyl sulfonic acids
US4093735A (en) 1974-04-25 1978-06-06 Hoechst Aktiengesellschaft 5-Sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent
DE2419970C3 (de) 1974-04-25 1980-06-12 Hoechst Ag, 6000 Frankfurt 3-<l-Pyrrolidinyl)-4-phenoxy-5sulfamoylbenzoesäure und Verfahren zu ihrer Herstellung
CH628622A5 (de) 1976-12-24 1982-03-15 Ciba Geigy Ag Verfahren zur herstellung von neuen in 4-stellung substituierten 3-sulfamoylbenzoesaeuren.
US4335136A (en) 1980-04-18 1982-06-15 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines
DE3309355A1 (de) 1983-03-16 1984-09-27 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von pyrrolen
US4694018A (en) * 1985-11-29 1987-09-15 G. D. Serale & Co. Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives
US4792568A (en) 1986-04-14 1988-12-20 Rorer Pharmaceutical Corporation Aryl pyrroles as useful antiallergy compounds
NO881411L (no) 1987-04-14 1988-10-17 Bayer Ag Substituerte pyrroler.
US5455263A (en) * 1987-07-29 1995-10-03 American Cyanamid Company Methods for the control and the protection of warm-blooded animals against infestation and infection by helminths, acarids and arthropod endo- and ectoparasites
US5010098A (en) * 1987-07-29 1991-04-23 American Cyanamid Company Arylpyrrole insecticidal acaricidal and nematicidal agents and methods for the preparation thereof
DE3727114A1 (de) 1987-08-14 1989-02-23 Basf Ag Verfahren zur herstellung von pyrrolen
CA1334975C (en) 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
AU641905B2 (en) * 1988-12-09 1993-10-07 Rhone-Poulenc Agrochimie 1-substituted-phenyl pyrrole derivatives as insecticides and methods for their production
US5096919A (en) 1989-01-05 1992-03-17 Ciba-Geigy Corporation Pyrrolylphenyl-substituted hydroxamic acid derivatives
DE3903993A1 (de) * 1989-02-10 1990-08-16 Basf Ag Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus
AU5938390A (en) 1989-06-26 1991-01-17 Research Foundation Of The State University Of New York, The Bis-acyloxymethyl derivatives
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
DD298912A5 (de) 1989-11-17 1992-03-19 �������@������������@��k�� Verfahren zur herstellung von 3-aminopyrrolen
IL98784A0 (en) * 1990-07-17 1992-07-15 Lilly Co Eli Heterocyclyl sulfonamide derivatives,process for their preparation and pharmaceutical compositions containing them
US5157047A (en) * 1990-10-18 1992-10-20 American Cyanamid Company Bis- and tris(trifluoromethyl)arylpyrrole insecticidal and acaricidal agents
DE4036706A1 (de) 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
US5128485A (en) 1990-12-17 1992-07-07 American Cyanamid Company Synthesis of 2-aryl-5-(trifluoromethyl)pyrroles useful as pesticidal agents and as intermediates for the preparation of said agents
US5144041A (en) 1990-12-26 1992-09-01 American Cyanamid Company Process for the preparation of 2-aryl-1-substituted-5-(trifluoromethyl) pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents
US5118816A (en) * 1990-12-26 1992-06-02 American Cyanamid Company 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles
US5254713A (en) 1991-04-09 1993-10-19 Nihon Bayer Agrochem K.K. 2- and 3-chloropyrroles and process for preparing the same
JPH051027A (ja) 1991-04-09 1993-01-08 Nippon Bayeragrochem Kk 新規２−又は３−クロロピロール類及びその製造方法
YU8592A (sh) 1991-08-28 1994-06-10 Flumroc Ag. Postupak i uređaj za izradu ploča od mineralnih vlakana primenjenih kao nosač zidnog premaza
US5928635A (en) 1994-12-07 1999-07-27 Schmidt; Karlheinz Process for producing active agent complexes
ATE160345T1 (de) * 1993-01-15 1997-12-15 Searle & Co 3,4-diarylthiophene und analoga davon, sowie deren verwendung als entzündungshemmende mittel
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5344991A (en) * 1993-10-29 1994-09-06 G.D. Searle & Co. 1,2 diarylcyclopentenyl compounds for the treatment of inflammation
RU2139281C1 (ru) * 1993-11-30 1999-10-10 Джи Ди Сирл энд Компани Пиразолилзамещенный бензолсульфонамид или его фармацевтически приемлемая соль, фармацевтическая композиция, способ лечения от воспаления или связанного с воспалением заболевания
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
US5418254A (en) * 1994-05-04 1995-05-23 G. D. Searle & Co. Substituted cyclopentadienyl compounds for the treatment of inflammation
US5496845A (en) 1994-05-25 1996-03-05 American Cyanamid Co. Suspension concentrate compositions of arylpyrrole insecticidal and acaricidal agents
US5486534A (en) * 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
JPH10504542A (ja) * 1994-07-27 1998-05-06 ジー．ディー．サール アンド カンパニー 炎症処置用の置換チアゾール化合物
US5616601A (en) * 1994-07-28 1997-04-01 Gd Searle & Co 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5521213A (en) 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
GB2294879A (en) 1994-10-19 1996-05-15 Merck & Co Inc Cylcooxygenase-2 Inhibitors
JP2636819B2 (ja) * 1994-12-20 1997-07-30 日本たばこ産業株式会社 オキサゾール系複素環式芳香族化合物
RO119946B1 (ro) * 1995-02-13 2005-06-30 G.D. Searle & Co. Derivaţi de izoxazol, utilizaţi pentru tratamentul inflamaţiilor
US5643933A (en) 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
ATE301457T1 (de) 1995-06-12 2005-08-15 Searle & Co Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US5792778A (en) 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
KR19990064310A (ko) 1995-10-17 1999-07-26 윌리암스 로저 에이 시클로옥시게나제-2의 검출방법
EP0983265A4 (de) 1996-02-01 2001-10-17 Smithkline Beecham Corp Endothelinrezeptor-antagonisten
BR9708574A (pt) 1996-04-12 1999-08-03 Searle & Co Derivados benzeno sulfonamida substituídos como pródrogas de inibidores cox-2
CA2273836A1 (en) 1996-12-10 1998-06-18 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation
US5972986A (en) 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
US6025353A (en) 1997-11-19 2000-02-15 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
DE19812059C1 (de) * 1998-03-19 1999-09-23 Wella Ag Diaminobenzol-Derivate sowie diese Diaminobenzol-Derivate enthaltende Haarfärbemittel
US8887786B2 (en) * 2011-03-07 2014-11-18 Hunter Douglas Inc. Control for movable rail

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NO971564D0 (no) 1997-04-04
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NZ314508A (en) 1999-06-29
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US5908858A (en) 1999-06-01
AU710380B2 (en) 1999-09-16
CA2201812A1 (en) 1997-10-05
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AU1665397A (en) 1997-10-09
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RU2125044C1 (ru) 1999-01-20
HUP9700709A3 (en) 2000-04-28
ES2296303T3 (es) 2008-04-16
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NO971564L (no) 1997-10-06
EP0799823A1 (de) 1997-10-08
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KR100485426B1 (ko) 2005-10-12
IL120584A (en) 2003-10-31
EP0799823B1 (de) 2007-10-31
HK1003268A1 (en) 1998-10-23
HU227830B1 (hu) 2012-05-02
HUP9700709A2 (hu) 1999-05-28
USRE39420E1 (en) 2006-12-05
ATE376998T1 (de) 2007-11-15
TW409122B (en) 2000-10-21
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