BR9810321A - Derivados de piridazina de tiadiazolila de inibição de angiogênese - Google Patents
Derivados de piridazina de tiadiazolila de inibição de angiogêneseInfo
- Publication number
- BR9810321A BR9810321A BR9810321-0A BR9810321A BR9810321A BR 9810321 A BR9810321 A BR 9810321A BR 9810321 A BR9810321 A BR 9810321A BR 9810321 A BR9810321 A BR 9810321A
- Authority
- BR
- Brazil
- Prior art keywords
- alk
- alkyl
- hydrogen
- het
- formula
- Prior art date
Links
- 230000033115 angiogenesis Effects 0.000 title abstract 3
- -1 thiadiazolyl pyridazine derivatives Chemical class 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical class C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/83—Thioacids; Thioesters; Thioamides; Thioimides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Lubricants (AREA)
- Paper (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE PIRIDAZINA DE TIADIAZOLILA DE INIBIçãO DE ANGIOGêNESE"<D>. Esta invenção concerne os compostos de fórmula (I), as formas de N-óxido, os sais de adição de ácido farmaceuticamente aceitáveis e as suas formas esterioquimicamente isoméricas, onde R^ 1^ é hidrogênio, C~ 1-6~ alquila, C~ 1-6~ alquilóxi, C~ 1-6~ alquiltio, amino, mono- ou di(C~ 1-6~alquil)amino, Ar^ 1^, Ar^ 1^-NH-, C~ 3-6~ cicloalquila, hidroximetila ou benziloximetila; R^ 2^ e R^ 3^ são hidrogênio, ou tomados juntos podem formar um radical bivalente de fórmula -CH=CH-CH=CH-; R^ 4^, R^ 5^ e R^ 6^ são cada qual independentemente selecionados de hidrogênio, halo, C~ 1-6~alquila, C~ 1-6~alquilóxi, trifluorometila, nitro, amino, ciano, azido, C~ 1-6~ alquilóxiC~ 1-6~ alquila, C~ 1-6~ alquiltio, C~ 1-6~ alquiloxicarbonila ou Het^ 1^; ou quando R^ 4^ e R^ 5^ são adjacentes entre si eles podem ser tomados juntos para formar um radical de fórmula -CH=CH-CH=CH-; A é um radical bivalente de fórmula NR^ 7^-Alk^ 1^ -X-, NR^ 7^-Alk^ 1^-X-Alk^ 2^-, O-Alk^ 1^-X-, O-Alk^ 1^-X-Alk^ 2^ ou S-Alk^ 1^-X-; onde X é uma ligação direta, -O-, -S-, C=O, -NR^ 8^- ou Het^ 2^; R^ 7^ é hidrogênio, C~ 1-6~ alquila, ou Ar^ 2^ metila; R^ 8^ é hidrogênio, C~ 1-6~alquila, ou Ar^ 2^ metila; Alk^ 1^ é C~ 1-6~alcanodiila; Alk^ 2^ é C~ 1-4~alcanodiila; Ar^ 1^ e Ar^ 2^ são fenila opcionalmente substituída; fenila; Het^ 1^ e Het^ 2^ são heterociclos opcionalmente substituídos; tendo atividade de inibição de angiogênese; suas preparações, composições contendo-as e seus usos como um medicamento.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201930 | 1997-06-24 | ||
| US5219497P | 1997-07-10 | 1997-07-10 | |
| PCT/EP1998/004021 WO1998058929A1 (en) | 1997-06-24 | 1998-06-22 | Angiogenesis inhibiting thiadiazolyl pyridazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9810321A true BR9810321A (pt) | 2000-09-05 |
Family
ID=8228477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9810321-0A BR9810321A (pt) | 1997-06-24 | 1998-06-22 | Derivados de piridazina de tiadiazolila de inibição de angiogênese |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0991649B1 (pt) |
| JP (1) | JP2002512630A (pt) |
| CN (1) | CN1198822C (pt) |
| AT (1) | ATE235489T1 (pt) |
| AU (1) | AU732129B2 (pt) |
| BR (1) | BR9810321A (pt) |
| CA (1) | CA2294551A1 (pt) |
| CZ (1) | CZ296000B6 (pt) |
| DE (1) | DE69812623T2 (pt) |
| DK (1) | DK0991649T3 (pt) |
| EE (1) | EE03828B1 (pt) |
| ES (1) | ES2195374T3 (pt) |
| HU (1) | HU225154B1 (pt) |
| ID (1) | ID23443A (pt) |
| IL (1) | IL133652A (pt) |
| MY (1) | MY120046A (pt) |
| NZ (1) | NZ501649A (pt) |
| PL (1) | PL191409B1 (pt) |
| PT (1) | PT991649E (pt) |
| RU (1) | RU2194049C2 (pt) |
| SK (1) | SK283705B6 (pt) |
| TR (1) | TR199902955T2 (pt) |
| WO (1) | WO1998058929A1 (pt) |
| ZA (1) | ZA985467B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689883B1 (en) | 1999-09-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| US7977333B2 (en) | 2000-04-20 | 2011-07-12 | Bayer Healthcare Llc | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
| US6903101B1 (en) | 2000-08-10 | 2005-06-07 | Bayer Pharmaceuticals Corporation | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity |
| EP2148878A4 (en) * | 2007-04-20 | 2011-08-10 | Merck Canada Inc | NEW HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE |
| US9102669B2 (en) | 2011-12-06 | 2015-08-11 | Janssen Pharmaceutica Nv | Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors |
| US9238658B2 (en) | 2011-12-06 | 2016-01-19 | Janssen Pharmaceutica Nv | Substituted piperidinyl-carboxamide derivatives useful as SCD 1 inhibitors |
| GB201309508D0 (en) * | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| GB201311953D0 (en) * | 2013-07-03 | 2013-08-14 | Redx Pharma Ltd | Compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6339868A (ja) * | 1986-08-04 | 1988-02-20 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
| NZ326354A (en) * | 1996-01-15 | 1999-05-28 | Janssen Pharmaceutica Nv | 3-(substituted-1-piperazinyl)-6-(substituted-1,2,4-thiadiazol-5 -yl)-pyridazine derivatives and medicaments |
-
1998
- 1998-06-22 CZ CZ19994508A patent/CZ296000B6/cs not_active IP Right Cessation
- 1998-06-22 NZ NZ501649A patent/NZ501649A/en unknown
- 1998-06-22 HU HU0004457A patent/HU225154B1/hu not_active IP Right Cessation
- 1998-06-22 DK DK98940098T patent/DK0991649T3/da active
- 1998-06-22 MY MYPI98002818A patent/MY120046A/en unknown
- 1998-06-22 BR BR9810321-0A patent/BR9810321A/pt not_active Application Discontinuation
- 1998-06-22 AT AT98940098T patent/ATE235489T1/de not_active IP Right Cessation
- 1998-06-22 RU RU2000101868/04A patent/RU2194049C2/ru not_active IP Right Cessation
- 1998-06-22 SK SK1769-99A patent/SK283705B6/sk unknown
- 1998-06-22 ES ES98940098T patent/ES2195374T3/es not_active Expired - Lifetime
- 1998-06-22 DE DE69812623T patent/DE69812623T2/de not_active Expired - Fee Related
- 1998-06-22 WO PCT/EP1998/004021 patent/WO1998058929A1/en active IP Right Grant
- 1998-06-22 JP JP50381999A patent/JP2002512630A/ja not_active Ceased
- 1998-06-22 AU AU88537/98A patent/AU732129B2/en not_active Ceased
- 1998-06-22 TR TR1999/02955T patent/TR199902955T2/xx unknown
- 1998-06-22 CN CNB988064804A patent/CN1198822C/zh not_active Expired - Fee Related
- 1998-06-22 EP EP98940098A patent/EP0991649B1/en not_active Expired - Lifetime
- 1998-06-22 PL PL337657A patent/PL191409B1/pl not_active IP Right Cessation
- 1998-06-22 PT PT98940098T patent/PT991649E/pt unknown
- 1998-06-22 EE EEP199900591A patent/EE03828B1/xx not_active IP Right Cessation
- 1998-06-22 IL IL13365298A patent/IL133652A/xx not_active IP Right Cessation
- 1998-06-22 CA CA002294551A patent/CA2294551A1/en not_active Abandoned
- 1998-06-22 ID IDW991664A patent/ID23443A/id unknown
- 1998-06-23 ZA ZA9805467A patent/ZA985467B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL133652A (en) | 2003-04-10 |
| SK176999A3 (en) | 2000-09-12 |
| DE69812623T2 (de) | 2004-02-19 |
| AU8853798A (en) | 1999-01-04 |
| IL133652A0 (en) | 2001-04-30 |
| JP2002512630A (ja) | 2002-04-23 |
| TR199902955T2 (xx) | 2000-06-21 |
| EP0991649B1 (en) | 2003-03-26 |
| NZ501649A (en) | 2001-10-26 |
| EP0991649A1 (en) | 2000-04-12 |
| ZA985467B (en) | 1999-12-23 |
| CZ450899A3 (cs) | 2000-08-16 |
| MY120046A (en) | 2005-08-30 |
| CN1198822C (zh) | 2005-04-27 |
| RU2194049C2 (ru) | 2002-12-10 |
| PT991649E (pt) | 2003-08-29 |
| ATE235489T1 (de) | 2003-04-15 |
| DK0991649T3 (da) | 2003-07-21 |
| SK283705B6 (sk) | 2003-12-02 |
| CN1261364A (zh) | 2000-07-26 |
| AU732129B2 (en) | 2001-04-12 |
| DE69812623D1 (de) | 2003-04-30 |
| WO1998058929A1 (en) | 1998-12-30 |
| ID23443A (id) | 2000-04-20 |
| PL191409B1 (pl) | 2006-05-31 |
| HUP0004457A2 (hu) | 2002-02-28 |
| HU225154B1 (en) | 2006-07-28 |
| HUP0004457A3 (en) | 2002-03-28 |
| ES2195374T3 (es) | 2003-12-01 |
| EE9900591A (et) | 2000-08-15 |
| CZ296000B6 (cs) | 2005-12-14 |
| EE03828B1 (et) | 2002-08-15 |
| CA2294551A1 (en) | 1998-12-30 |
| PL337657A1 (en) | 2000-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |