BR9810314A - Derivados de 5-substituìdo-1,2,4-tiadiazolila que inibem de angiogênese - Google Patents
Derivados de 5-substituìdo-1,2,4-tiadiazolila que inibem de angiogêneseInfo
- Publication number
- BR9810314A BR9810314A BR9810314-8A BR9810314A BR9810314A BR 9810314 A BR9810314 A BR 9810314A BR 9810314 A BR9810314 A BR 9810314A BR 9810314 A BR9810314 A BR 9810314A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- amino
- het
- alkyloxy
- hydrogen
- Prior art date
Links
- -1 5-substituted-1,2,4-thiadiazolyl Chemical class 0.000 title abstract 4
- 230000033115 angiogenesis Effects 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/83—Thioacids; Thioesters; Thioamides; Thioimides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE 5-SUBSTITUìDO-1,2,4-TIADIAZOLILA QUE INIBEM DE ANGIOGêNESE"<D>. Esta invenção refere-se a compostos de fórmula (I), às formas de N-óxido, aos sais de adição de ácido farmaceuticamente aceitáveis e as formas estereoquimicamente isoméricas dos mesmos, em que X é CH ou N; R^ 1^ é hidrogênio, C~ 1-6~ alquila, C~ 1-6~ alquilóxi, C~ 1-6~ alquiltio, amino, mono- ou di(C~ 1-6~ alquil)amino, Ar^ 1^, Ar^ 1^NH-, C~ 3-6~ cicloalquila, hidroximetila ou benziloximetila; R^ 2^ é hidrogênio, C~ 1-6~ alquila, amino, aminocarbonila, mono- ou di(C~ 1-6~ alquil)amino, C~ 1-6~ alquiloxicarbonila, C~ 1-6~ alquilcarbonilamino, hidróxi ou C~ 1-6~ alquilóxi; R^ 3^, R^ 4^ e R^ 5^ são cada um independentemente selecionado entre hidrogênio, halo, C~ 1-6~ alquila, C~ 1-6~ alquilóxi, trifluorometila, nitro, amino, ciano, azido, C~ 1-6~ alquilóxi C~ 1-6~ alquila, C~ 1-6~ alquiltio, C~ 1-6~ alquiloxicarbonila ou Het^ 1^; fórmula (1) é Ar^ 2^, Ar^ 2^CH~ 2~- ou Het^ 2^; Ar^ 1^ e Ar^ 2^ fenila opcionalmente substituída; Het^ 1^ e Het^ 2^ são heterociclos monocíclicos opcionalmente substituídos; tendo atividade de inibição de angiogênese; sua preparação, composições contendo-os e seu uso como um medicamento.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201931 | 1997-06-24 | ||
| US5300397P | 1997-07-10 | 1997-07-10 | |
| PCT/EP1998/004022 WO1998058919A1 (en) | 1997-06-24 | 1998-06-22 | Angiogenesis inhibiting 5-substituted-1,2,4-thiadiazolyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9810314A true BR9810314A (pt) | 2000-09-05 |
Family
ID=8228478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9810314-8A BR9810314A (pt) | 1997-06-24 | 1998-06-22 | Derivados de 5-substituìdo-1,2,4-tiadiazolila que inibem de angiogênese |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0993452B1 (pt) |
| JP (1) | JP2002505680A (pt) |
| CN (1) | CN1084740C (pt) |
| AT (1) | ATE372328T1 (pt) |
| AU (1) | AU731712B2 (pt) |
| BR (1) | BR9810314A (pt) |
| CA (1) | CA2294581C (pt) |
| CZ (1) | CZ296266B6 (pt) |
| DE (1) | DE69838385T2 (pt) |
| EE (1) | EE04746B1 (pt) |
| ES (1) | ES2293687T3 (pt) |
| HU (1) | HU224812B1 (pt) |
| ID (1) | ID24231A (pt) |
| IL (2) | IL133653A (pt) |
| MY (1) | MY118312A (pt) |
| NZ (1) | NZ501694A (pt) |
| PL (1) | PL193438B1 (pt) |
| RU (1) | RU2199538C2 (pt) |
| SK (1) | SK284112B6 (pt) |
| TR (1) | TR199903082T2 (pt) |
| WO (1) | WO1998058919A1 (pt) |
| ZA (1) | ZA985465B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101163692B (zh) * | 2005-02-16 | 2012-01-18 | 先灵公司 | 具有cxcr3拮抗活性的杂环取代的哌嗪 |
| JP5216341B2 (ja) * | 2007-01-29 | 2013-06-19 | 参天製薬株式会社 | 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体 |
| CN108774215A (zh) * | 2018-08-15 | 2018-11-09 | 翟学旭 | 含氮杂环类衍生物及其在视网膜新生血管疾病中的应用 |
| CN108864064A (zh) * | 2018-08-15 | 2018-11-23 | 翟学旭 | 含氮杂环类衍生物及其在视网膜新生血管疾病中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6339868A (ja) * | 1986-08-04 | 1988-02-20 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
| PT876366E (pt) * | 1996-01-15 | 2002-01-30 | Janssen Pharmaceutica Nv | Piridazinaminas inibidoras da angiogenese |
-
1998
- 1998-06-22 PL PL98337649A patent/PL193438B1/pl not_active IP Right Cessation
- 1998-06-22 JP JP50382099A patent/JP2002505680A/ja not_active Ceased
- 1998-06-22 IL IL13365398A patent/IL133653A/xx not_active IP Right Cessation
- 1998-06-22 CZ CZ0448999A patent/CZ296266B6/cs not_active IP Right Cessation
- 1998-06-22 AT AT98937560T patent/ATE372328T1/de not_active IP Right Cessation
- 1998-06-22 ES ES98937560T patent/ES2293687T3/es not_active Expired - Lifetime
- 1998-06-22 AU AU86309/98A patent/AU731712B2/en not_active Ceased
- 1998-06-22 HU HU0004357A patent/HU224812B1/hu not_active IP Right Cessation
- 1998-06-22 RU RU2000101856/04A patent/RU2199538C2/ru not_active IP Right Cessation
- 1998-06-22 NZ NZ501694A patent/NZ501694A/xx unknown
- 1998-06-22 TR TR1999/03082T patent/TR199903082T2/xx unknown
- 1998-06-22 BR BR9810314-8A patent/BR9810314A/pt not_active Application Discontinuation
- 1998-06-22 EP EP98937560A patent/EP0993452B1/en not_active Expired - Lifetime
- 1998-06-22 EE EEP199900582A patent/EE04746B1/xx not_active IP Right Cessation
- 1998-06-22 ID IDW991665A patent/ID24231A/id unknown
- 1998-06-22 WO PCT/EP1998/004022 patent/WO1998058919A1/en active IP Right Grant
- 1998-06-22 DE DE69838385T patent/DE69838385T2/de not_active Expired - Fee Related
- 1998-06-22 MY MYPI98002817A patent/MY118312A/en unknown
- 1998-06-22 CN CN98806394A patent/CN1084740C/zh not_active Expired - Fee Related
- 1998-06-22 CA CA002294581A patent/CA2294581C/en not_active Expired - Fee Related
- 1998-06-22 IL IL14983098A patent/IL149830A/en not_active IP Right Cessation
- 1998-06-22 SK SK1759-99A patent/SK284112B6/sk unknown
- 1998-06-23 ZA ZA9805465A patent/ZA985465B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0004357A3 (en) | 2002-03-28 |
| CZ448999A3 (cs) | 2000-08-16 |
| AU8630998A (en) | 1999-01-04 |
| AU731712B2 (en) | 2001-04-05 |
| EP0993452A1 (en) | 2000-04-19 |
| ZA985465B (en) | 1999-12-23 |
| ID24231A (id) | 2000-07-13 |
| ATE372328T1 (de) | 2007-09-15 |
| ES2293687T3 (es) | 2008-03-16 |
| RU2199538C2 (ru) | 2003-02-27 |
| CZ296266B6 (cs) | 2006-02-15 |
| PL337649A1 (en) | 2000-08-28 |
| IL149830A (en) | 2005-12-18 |
| EE04746B1 (et) | 2006-12-15 |
| IL133653A0 (en) | 2001-04-30 |
| HUP0004357A2 (hu) | 2002-02-28 |
| CA2294581A1 (en) | 1998-12-30 |
| WO1998058919A1 (en) | 1998-12-30 |
| HU224812B1 (en) | 2006-02-28 |
| EE9900582A (et) | 2000-08-15 |
| DE69838385T2 (de) | 2008-05-29 |
| CN1261358A (zh) | 2000-07-26 |
| IL133653A (en) | 2003-01-12 |
| CN1084740C (zh) | 2002-05-15 |
| PL193438B1 (pl) | 2007-02-28 |
| TR199903082T2 (xx) | 2000-07-21 |
| MY118312A (en) | 2004-09-30 |
| SK284112B6 (sk) | 2004-09-08 |
| NZ501694A (en) | 2000-10-27 |
| DE69838385D1 (de) | 2007-10-18 |
| IL149830A0 (en) | 2002-11-10 |
| CA2294581C (en) | 2007-04-03 |
| EP0993452B1 (en) | 2007-09-05 |
| SK175999A3 (en) | 2000-12-11 |
| JP2002505680A (ja) | 2002-02-19 |
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