ZA986089B - Novel IL-5 inhibiting 6-azauracil derivatives. - Google Patents
Novel IL-5 inhibiting 6-azauracil derivatives.Info
- Publication number
- ZA986089B ZA986089B ZA9806089A ZA986089A ZA986089B ZA 986089 B ZA986089 B ZA 986089B ZA 9806089 A ZA9806089 A ZA 9806089A ZA 986089 A ZA986089 A ZA 986089A ZA 986089 B ZA986089 B ZA 986089B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibiting
- novel
- azauracil derivatives
- azauracil
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97202118 | 1997-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA986089B true ZA986089B (en) | 2000-01-10 |
Family
ID=8228531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9806089A ZA986089B (en) | 1997-07-10 | 1998-07-09 | Novel IL-5 inhibiting 6-azauracil derivatives. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1000040B1 (xx) |
| JP (1) | JP2002511882A (xx) |
| KR (1) | KR20010014049A (xx) |
| CN (1) | CN1262679A (xx) |
| AR (1) | AR013360A1 (xx) |
| AT (1) | ATE364597T1 (xx) |
| AU (1) | AU742145B2 (xx) |
| BR (1) | BR9811678A (xx) |
| CA (1) | CA2294145A1 (xx) |
| DE (1) | DE69837922D1 (xx) |
| EE (1) | EE200000016A (xx) |
| HR (1) | HRP20000003A2 (xx) |
| HU (1) | HUP0004687A3 (xx) |
| ID (1) | ID24390A (xx) |
| IL (1) | IL133916A0 (xx) |
| NO (1) | NO20000063L (xx) |
| NZ (1) | NZ502180A (xx) |
| PL (1) | PL337947A1 (xx) |
| SK (1) | SK183999A3 (xx) |
| TR (1) | TR200000153T2 (xx) |
| TW (1) | TW496865B (xx) |
| WO (1) | WO1999002505A1 (xx) |
| ZA (1) | ZA986089B (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2338968C (en) * | 1998-07-30 | 2010-04-27 | Michael J. Coghlan | Glucocorticoid-selective agents |
| EP0987265A1 (en) | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
| ID28880A (id) | 1998-12-18 | 2001-07-12 | Janssen Pharmaceutica Nv | Obat-obat lunak penghambat il-5 |
| CA2380759A1 (en) * | 1999-08-06 | 2001-02-15 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
| AU2001270304A1 (en) | 2000-07-07 | 2002-01-21 | The Administrators Of The Tulane Educational Fund | Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor |
| US7183276B2 (en) | 2002-02-28 | 2007-02-27 | Takeda Pharmaceutical Company Limited | Azole compounds |
| WO2004071448A2 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
| GB0305575D0 (en) | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
| AU2005247610A1 (en) * | 2004-05-29 | 2005-12-08 | 7Tm Pharma A/S | Substituted thiazoleacetic as crth2 ligands |
| DE102006049618A1 (de) * | 2006-10-20 | 2008-05-08 | Tschesche, Harald, Prof. Dr. | Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren |
| CN101265238B (zh) * | 2007-12-12 | 2010-06-16 | 重庆天极旅业有限公司 | 一种三嗪环衍生物的合成方法 |
| CN101265216B (zh) * | 2007-12-18 | 2012-06-27 | 重庆华邦胜凯制药有限公司 | 4-(取代乙氰基)-苯腙衍生物及其合成方法 |
| MX2013001872A (es) * | 2010-08-16 | 2013-09-02 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrieno. |
| WO2018011375A1 (en) * | 2016-07-13 | 2018-01-18 | Universite Paris Descartes | Meclozine derivatives and diclazuril derivatives for use in the prevention and/or the treatment of disorders associated to the inflammation induced by p. acnes |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2149645A1 (de) * | 1970-10-07 | 1972-09-14 | Pfizer | 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose |
| US3912723A (en) * | 1971-03-29 | 1975-10-14 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
| US3883528A (en) * | 1974-04-19 | 1975-05-13 | Pfizer | Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats |
| CA1244024A (en) * | 1984-08-01 | 1988-11-01 | Gustaaf M. Boeckx | .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES |
| GB8602342D0 (en) * | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
| EP0476439A1 (de) * | 1990-09-18 | 1992-03-25 | Bayer Ag | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
| RU2146674C1 (ru) * | 1993-10-15 | 2000-03-20 | Такеда Кемикал Индастриз, Лтд. | Производные триазина, способы их получения, антипротозойная композиция, добавка в пищу животных, способ ингибирования протозои у животных |
-
1998
- 1998-07-07 EE EEP200000016A patent/EE200000016A/xx unknown
- 1998-07-07 NZ NZ502180A patent/NZ502180A/xx unknown
- 1998-07-07 IL IL13391698A patent/IL133916A0/xx unknown
- 1998-07-07 JP JP50812699A patent/JP2002511882A/ja not_active Withdrawn
- 1998-07-07 PL PL98337947A patent/PL337947A1/xx unknown
- 1998-07-07 KR KR19997012079A patent/KR20010014049A/ko not_active Application Discontinuation
- 1998-07-07 BR BR9811678-9A patent/BR9811678A/pt not_active IP Right Cessation
- 1998-07-07 DE DE69837922T patent/DE69837922D1/de not_active Expired - Lifetime
- 1998-07-07 SK SK1839-99A patent/SK183999A3/sk unknown
- 1998-07-07 WO PCT/EP1998/004191 patent/WO1999002505A1/en active IP Right Grant
- 1998-07-07 CN CN98806978A patent/CN1262679A/zh active Pending
- 1998-07-07 TR TR2000/00153T patent/TR200000153T2/xx unknown
- 1998-07-07 HU HU0004687A patent/HUP0004687A3/hu unknown
- 1998-07-07 CA CA002294145A patent/CA2294145A1/en not_active Abandoned
- 1998-07-07 EP EP98941299A patent/EP1000040B1/en not_active Expired - Lifetime
- 1998-07-07 ID IDW20000034A patent/ID24390A/id unknown
- 1998-07-07 AU AU89738/98A patent/AU742145B2/en not_active Ceased
- 1998-07-07 AT AT98941299T patent/ATE364597T1/de not_active IP Right Cessation
- 1998-07-08 TW TW087111014A patent/TW496865B/zh active
- 1998-07-08 AR ARP980103336A patent/AR013360A1/es not_active Application Discontinuation
- 1998-07-09 ZA ZA9806089A patent/ZA986089B/xx unknown
-
2000
- 2000-01-05 HR HR20000003A patent/HRP20000003A2/xx not_active Application Discontinuation
- 2000-01-06 NO NO20000063A patent/NO20000063L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1000040B1 (en) | 2007-06-13 |
| AU8973898A (en) | 1999-02-08 |
| DE69837922D1 (de) | 2007-07-26 |
| WO1999002505A1 (en) | 1999-01-21 |
| KR20010014049A (ko) | 2001-02-26 |
| CA2294145A1 (en) | 1999-01-21 |
| HUP0004687A3 (en) | 2002-03-28 |
| EE200000016A (et) | 2000-10-16 |
| NZ502180A (en) | 2000-11-24 |
| HUP0004687A2 (hu) | 2002-02-28 |
| IL133916A0 (en) | 2001-04-30 |
| CN1262679A (zh) | 2000-08-09 |
| NO20000063D0 (no) | 2000-01-06 |
| TR200000153T2 (tr) | 2000-07-21 |
| ID24390A (id) | 2000-07-13 |
| EP1000040A1 (en) | 2000-05-17 |
| NO20000063L (no) | 2000-03-10 |
| AU742145B2 (en) | 2001-12-20 |
| HRP20000003A2 (en) | 2000-12-31 |
| BR9811678A (pt) | 2000-09-19 |
| PL337947A1 (en) | 2000-09-11 |
| SK183999A3 (en) | 2000-08-14 |
| ATE364597T1 (de) | 2007-07-15 |
| TW496865B (en) | 2002-08-01 |
| JP2002511882A (ja) | 2002-04-16 |
| AR013360A1 (es) | 2000-12-27 |
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