ES8604922A1 - Procedimiento para la preparacion de n-piridilindoles - Google Patents

Procedimiento para la preparacion de n-piridilindoles

Info

Publication number
ES8604922A1
ES8604922A1 ES545154A ES545154A ES8604922A1 ES 8604922 A1 ES8604922 A1 ES 8604922A1 ES 545154 A ES545154 A ES 545154A ES 545154 A ES545154 A ES 545154A ES 8604922 A1 ES8604922 A1 ES 8604922A1
Authority
ES
Spain
Prior art keywords
pyridyl
alkylene
lower alkyl
indole
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545154A
Other languages
English (en)
Other versions
ES545154A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8604922A1 publication Critical patent/ES8604922A1/es
Publication of ES545154A0 publication Critical patent/ES545154A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE N-PIRIDILINDOLES. CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER N-PIRIDILINDONES DE FORMULA (I) EN DONDE AR ES 3- O 4-PIRIDILO O 3- O 4-PIRIDILO SUSTITUIDO POR ALQUILO INFERIOR; LOS RADICALES R1 REPRESENTAN INDEPENDIENTEMENTE UNO DE OTRO, H, HALOGENO, TRIFLUORMETILO Y OTROS; P ES 1 O 2; R2 ES H O ALQUILO INFERIOR; UNO DE R3 Y R4 REPRESENTA H Y EL OTRO DE R3 Y R4 REPRESENTA EL GRUPO A-B EN DONDE A ES ALQUILENO DE C 1 A 12, ALQUINILENO Y OTROS, Y B REPRESENTA CARBOXI, CARBOXI ESTERIFICADO, CARBAMOILO, MONO O DI-ALQUIL(INFERIOR)CARBAMOILO Y OTROS.
ES545154A 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles Expired ES8604922A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/495,370 US4536505A (en) 1983-05-17 1983-05-17 Certain N-(pyridyl) indoles

Publications (2)

Publication Number Publication Date
ES8604922A1 true ES8604922A1 (es) 1986-02-16
ES545154A0 ES545154A0 (es) 1986-02-16

Family

ID=23968377

Family Applications (5)

Application Number Title Priority Date Filing Date
ES532572A Expired ES8602652A1 (es) 1983-05-17 1984-05-17 Procedimiento para la preparacion de n-piridilindoles
ES545151A Expired ES8604195A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles
ES545153A Expired ES8604197A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles
ES545154A Expired ES8604922A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles
ES545152A Expired ES8604196A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES532572A Expired ES8602652A1 (es) 1983-05-17 1984-05-17 Procedimiento para la preparacion de n-piridilindoles
ES545151A Expired ES8604195A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles
ES545153A Expired ES8604197A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES545152A Expired ES8604196A1 (es) 1983-05-17 1985-07-12 Procedimiento para la preparacion de n-piridilindoles

Country Status (15)

Country Link
US (1) US4536505A (es)
EP (1) EP0126401A1 (es)
JP (1) JPS59212489A (es)
KR (1) KR840009302A (es)
AU (1) AU2809484A (es)
DD (1) DD224588A5 (es)
DK (1) DK242484A (es)
ES (5) ES8602652A1 (es)
FI (1) FI841925A (es)
GR (1) GR79934B (es)
HU (1) HUT34182A (es)
IL (1) IL71832A0 (es)
NO (1) NO841958L (es)
PT (1) PT78582A (es)
ZA (1) ZA843677B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675332A (en) * 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
US4758586A (en) * 1985-02-01 1988-07-19 Usv Pharmaceutical Corp. Indolyl compounds and hyposensitivity use thereof
US4880822A (en) * 1987-04-24 1989-11-14 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyridinyl)-1H-indol-1-amines
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
US5039811A (en) * 1987-04-24 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-(pyridinyl)-1H-indol-1-amines
US5550118A (en) * 1994-01-31 1996-08-27 Eli Lilly And Company Polyhydronorharman synthase inhibitors
US5977125A (en) * 1994-10-31 1999-11-02 Eisai Co., Ltd. Mono-or polyenic carboxylic acid derivatives
GB2295151B (en) * 1994-11-18 1998-12-09 Nmc Polymerization of substituted heterocyclic monomers
BR9908165A (pt) * 1998-02-23 2000-10-31 Univ South Alabama Processos de prevenção de um citotóxico de proteìna beta amilóide em células, de tratamento de uma fibrilogênica em um sujeito humano, de diminuição da oxidação em uma amostra biológica e de tratamento de doenças ou outros quadros em que radicais livres e/ou tensão oxidativa desempenham um papel, e, uso de ácido indol-3-propiÈnico ou um seu sal ou éster.
WO2003027107A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors
BRPI0617271A2 (pt) * 2005-10-11 2011-07-19 Intermune Inc inibidores de replicação viral
KR100807718B1 (ko) * 2006-10-17 2008-02-28 한국생명공학연구원 인돌 유도체를 유효성분으로 함유하는 대사성 질환 예방 및치료용 약학적 조성물
US20090047246A1 (en) * 2007-02-12 2009-02-19 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
US8293781B2 (en) * 2007-03-29 2012-10-23 Daiichi Sankyo Company, Limited Indole derivatives having cPLA2 inhibiting activity and applications and production methods of the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449348A (en) * 1968-01-08 1969-06-10 Merck & Co Inc Alpha-halomethyl-1-pyridine or quinoline carbonyl-3-indolylacetic acids
AT299938B (de) * 1971-02-03 1972-07-10 Italiana Sint Spa Verfahren zur Herstellung des neuen Natriumsalzes der (1-Nicotinoyl-2-methyl-5-methoxy-3-indolyl)-essigsäure, gegebenenfalls im Gemisch mit der freien Säure
FR2171936B1 (es) * 1972-02-16 1975-04-25 Clin Midy
FR2171937A1 (en) * 1972-02-16 1973-09-28 Clin Midy Aminoketo indoles - analgesics and antidepressants
AT323154B (de) * 1973-02-02 1975-06-25 Hurka Wilhelm Verfahren zur herstellung von neuen 5-methoxy-2-methylindol-3-essigsäurederivaten sowie von deren salzen
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives
US4363912A (en) * 1980-12-15 1982-12-14 Pfizer Inc. Indole thromboxane synthetase inhibitors
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
GB2102795A (en) * 1981-07-31 1983-02-09 Pfizer Ltd Indole derivatives
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles

Also Published As

Publication number Publication date
IL71832A0 (en) 1984-09-30
US4536505A (en) 1985-08-20
ES532572A0 (es) 1985-12-01
JPS59212489A (ja) 1984-12-01
FI841925A0 (fi) 1984-05-14
ES8604196A1 (es) 1986-01-16
PT78582A (en) 1984-06-01
NO841958L (no) 1984-11-19
DK242484D0 (da) 1984-05-16
KR840009302A (ko) 1984-12-26
ES545153A0 (es) 1986-01-16
ZA843677B (en) 1985-02-27
DK242484A (da) 1984-11-18
ES545154A0 (es) 1986-02-16
AU2809484A (en) 1984-11-22
ES8604195A1 (es) 1986-01-16
ES8602652A1 (es) 1985-12-01
EP0126401A1 (de) 1984-11-28
ES545151A0 (es) 1986-01-16
ES8604197A1 (es) 1986-01-16
DD224588A5 (de) 1985-07-10
ES545152A0 (es) 1986-01-16
HUT34182A (en) 1985-02-28
FI841925A (fi) 1984-11-18
GR79934B (es) 1984-10-31

Similar Documents

Publication Publication Date Title
ES8604197A1 (es) Procedimiento para la preparacion de n-piridilindoles
NZ334476A (en) substituted indol-3-yl glyoxylamides
PH31566A (en) Pyridine and pyridine n-oxide derivatives for diaryl methyl piperidines or piperazines and compositions and methods of use thereof.
NO174508C (es)
AU5140290A (en) Pyrrolidine derivatives
MY123199A (en) Gastrokinetic bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
FI101224B1 (fi) Menetelmä terapeuttisesti käyttökelpoisten alkoksipyrimidiinijohdannaisten valmistamiseksi
EP0378984A3 (en) Use of N-butyl-deoxynojirimycin in the treatment of herpes
ES8304569A1 (es) Un procedimiento para la preparacion de una sal soluble en agua de lisina o arginina del 1,1-dioxido de n-(2-piridil)-2-metil-4-hidroxi-2h-1,2-benzotiazin-3-carboxamida.
ES8602705A1 (es) Un procedimiento para la preparacion de un compuesto.
ES8306742A1 (es) "un procedimiento para la preparacion de 4-(4-imidazolil)-piridinas 2-sustituidas".
AU572672B2 (en) 2-quinolyl or 1,8-naphthyridin-2-yl amides
GB9419318D0 (en) Therapeutic agents
IL97054A0 (en) Pharmaceutical compositions comprising buspirones for the treatment of sleep apneas
FR2511375B1 (es)
AU8447991A (en) Antineoplastic effect potentiator and antineoplastic agent
ES8701712A1 (es) Un procedimiento para la preparacion de una forma polimorfo i de una sal de monoetanolamina
MX9604019A (es) Derivados de biotina.
IE41135L (en) Tetrazole derivatives.
IT1255467B (it) Ammidi acriliche farmacologicamente attive
IT8248610A0 (it) Prodotto farmaceutico in polvere per la terapia dell'ulcera peptica, a base di 2,4-diammino-6-(2,5-diclo rofenil)-1,3,5-triazina o dei suoi sali farmaceuticamente accettabili
NZ309498A (en) 2-substituted benzyl-benzimidazole derivatives as inhibitors of smooth muscle cell proliferation
GB1535778A (en) Compounds useful in treatment of unipolar depression
RU1799384C (ru) Способ получени производных цефалоспорина, включающих в заместителе в положении 3 азотсодержащий гетероцикл, или их фармацевтически совместимых солей с щелочными металлами
BG101180A (en) Benzoxazoles and pyridine derivatives useful in the treatment of the type ii diabetes