ES8604195A1 - Procedimiento para la preparacion de n-piridilindoles - Google Patents
Procedimiento para la preparacion de n-piridilindolesInfo
- Publication number
- ES8604195A1 ES8604195A1 ES545151A ES545151A ES8604195A1 ES 8604195 A1 ES8604195 A1 ES 8604195A1 ES 545151 A ES545151 A ES 545151A ES 545151 A ES545151 A ES 545151A ES 8604195 A1 ES8604195 A1 ES 8604195A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridyl
- alkylene
- lower alkyl
- indole
- substd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002475 indoles Chemical class 0.000 title 1
- -1 pyridyl N-oxides Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- GUXQOVBGUZZBPJ-MKMNVTDBSA-N (e)-2-methyl-5-(1-pyridin-3-ylindol-3-yl)pent-2-enoic acid Chemical compound C12=CC=CC=C2C(CC\C=C(/C)C(O)=O)=CN1C1=CC=CN=C1 GUXQOVBGUZZBPJ-MKMNVTDBSA-N 0.000 abstract 1
- VSKZGHVPGOMFAV-UHFFFAOYSA-N 1-pyridin-2-ylindole Chemical compound C1=CC2=CC=CC=C2N1C1=CC=CC=N1 VSKZGHVPGOMFAV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- UETRKVDAHIACJW-UHFFFAOYSA-N 5-(1-pyridin-3-ylindol-3-yl)pentanoic acid Chemical compound C12=CC=CC=C2C(CCCCC(=O)O)=CN1C1=CC=CN=C1 UETRKVDAHIACJW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE N-PIRIDILINDOLES. CONSISTENTE EN: CONDENSAR UN COMPUESTO DE FORMULA (IV) CON UN COMPUESTO ARX EN UN DISOLVENTE POLAR COMO PIRIDINA O DIMETILFORMAMIDA, CON UN CATALIZADOR DE REACCION DE ULLMANN Y UNA BASE ANHIDRA COMO CARBONATO POTASICO A UNA TEMPERATURA ENTRE 15 Y 150JC, PARA OBTENER COMPUESTOS DE FORMULA (I). SIENDO: AR 3- O 4-PIRIDILO O 3- O 4-PIRIDILO SUSTITUIDO POR ALQUILO INFERIOR; LOS R1 INDEPENDIENTEMENTE UNO DE OTRO, H, HALOGENO, TRIFLUORMETILO Y OTROS; PF1 O 2; R2FH O ALQUILO INFERIOR; UNO DE R3 Y R4 REPRESENTA H Y EL OTRO EL GRUPO A-B EN DONDE A ES ALQUILENO DE 1 A 12 C, ALQUINILENO Y OTROS, Y B ES CARBOXI, CARBOXI ESTERIFICADO Y OTROS; Y X REPRESENTA HIDROXI ESTERIFICADO REACTIVO CON PROTECCION TEMPORAL OPCIONAL DE GRUPOS REACTIVO INDIFERENTES. SE UTILIZAN PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/495,370 US4536505A (en) | 1983-05-17 | 1983-05-17 | Certain N-(pyridyl) indoles |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604195A1 true ES8604195A1 (es) | 1986-01-16 |
ES545151A0 ES545151A0 (es) | 1986-01-16 |
Family
ID=23968377
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532572A Expired ES8602652A1 (es) | 1983-05-17 | 1984-05-17 | Procedimiento para la preparacion de n-piridilindoles |
ES545151A Expired ES8604195A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
ES545153A Expired ES8604197A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
ES545154A Expired ES8604922A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
ES545152A Expired ES8604196A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532572A Expired ES8602652A1 (es) | 1983-05-17 | 1984-05-17 | Procedimiento para la preparacion de n-piridilindoles |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545153A Expired ES8604197A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
ES545154A Expired ES8604922A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
ES545152A Expired ES8604196A1 (es) | 1983-05-17 | 1985-07-12 | Procedimiento para la preparacion de n-piridilindoles |
Country Status (15)
Country | Link |
---|---|
US (1) | US4536505A (es) |
EP (1) | EP0126401A1 (es) |
JP (1) | JPS59212489A (es) |
KR (1) | KR840009302A (es) |
AU (1) | AU2809484A (es) |
DD (1) | DD224588A5 (es) |
DK (1) | DK242484A (es) |
ES (5) | ES8602652A1 (es) |
FI (1) | FI841925A (es) |
GR (1) | GR79934B (es) |
HU (1) | HUT34182A (es) |
IL (1) | IL71832A0 (es) |
NO (1) | NO841958L (es) |
PT (1) | PT78582A (es) |
ZA (1) | ZA843677B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4675332A (en) * | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
US4609733A (en) * | 1984-12-27 | 1986-09-02 | Ciba-Geigy Corporation | 3-keto-substituted-N-pyridylindoles |
US4758586A (en) * | 1985-02-01 | 1988-07-19 | Usv Pharmaceutical Corp. | Indolyl compounds and hyposensitivity use thereof |
US4880822A (en) * | 1987-04-24 | 1989-11-14 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyridinyl)-1H-indol-1-amines |
US4970218A (en) * | 1987-04-24 | 1990-11-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyridinyl)-1H-indol-1-amines |
US5039811A (en) * | 1987-04-24 | 1991-08-13 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-(pyridinyl)-1H-indol-1-amines |
US5550118A (en) * | 1994-01-31 | 1996-08-27 | Eli Lilly And Company | Polyhydronorharman synthase inhibitors |
US5977125A (en) * | 1994-10-31 | 1999-11-02 | Eisai Co., Ltd. | Mono-or polyenic carboxylic acid derivatives |
GB2295151B (en) * | 1994-11-18 | 1998-12-09 | Nmc | Polymerization of substituted heterocyclic monomers |
BR9908165A (pt) * | 1998-02-23 | 2000-10-31 | Univ South Alabama | Processos de prevenção de um citotóxico de proteìna beta amilóide em células, de tratamento de uma fibrilogênica em um sujeito humano, de diminuição da oxidação em uma amostra biológica e de tratamento de doenças ou outros quadros em que radicais livres e/ou tensão oxidativa desempenham um papel, e, uso de ácido indol-3-propiÈnico ou um seu sal ou éster. |
WO2003027107A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors |
BRPI0617271A2 (pt) * | 2005-10-11 | 2011-07-19 | Intermune Inc | inibidores de replicação viral |
KR100807718B1 (ko) * | 2006-10-17 | 2008-02-28 | 한국생명공학연구원 | 인돌 유도체를 유효성분으로 함유하는 대사성 질환 예방 및치료용 약학적 조성물 |
US20090047246A1 (en) * | 2007-02-12 | 2009-02-19 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
US8293781B2 (en) * | 2007-03-29 | 2012-10-23 | Daiichi Sankyo Company, Limited | Indole derivatives having cPLA2 inhibiting activity and applications and production methods of the same |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3449348A (en) * | 1968-01-08 | 1969-06-10 | Merck & Co Inc | Alpha-halomethyl-1-pyridine or quinoline carbonyl-3-indolylacetic acids |
AT299938B (de) * | 1971-02-03 | 1972-07-10 | Italiana Sint Spa | Verfahren zur Herstellung des neuen Natriumsalzes der (1-Nicotinoyl-2-methyl-5-methoxy-3-indolyl)-essigsäure, gegebenenfalls im Gemisch mit der freien Säure |
FR2171936B1 (es) * | 1972-02-16 | 1975-04-25 | Clin Midy | |
FR2171937A1 (en) * | 1972-02-16 | 1973-09-28 | Clin Midy | Aminoketo indoles - analgesics and antidepressants |
AT323154B (de) * | 1973-02-02 | 1975-06-25 | Hurka Wilhelm | Verfahren zur herstellung von neuen 5-methoxy-2-methylindol-3-essigsäurederivaten sowie von deren salzen |
DE2862340D1 (en) * | 1978-02-01 | 1983-11-24 | Wellcome Found | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
US4322533A (en) * | 1980-03-17 | 1982-03-30 | Lesher George Y | 1H-Indole-2,3-dione derivatives |
US4363912A (en) * | 1980-12-15 | 1982-12-14 | Pfizer Inc. | Indole thromboxane synthetase inhibitors |
CS229934B2 (en) * | 1981-07-07 | 1984-07-16 | Pfizer | Production method subst.indolylacryte acid derivative |
GB2102795A (en) * | 1981-07-31 | 1983-02-09 | Pfizer Ltd | Indole derivatives |
US4478842A (en) * | 1981-11-19 | 1984-10-23 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
US4460777A (en) * | 1981-11-19 | 1984-07-17 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
US4511573A (en) * | 1983-05-17 | 1985-04-16 | Ciba-Geigy Corporation | 3-Substituted-2-(heteroaryl) indoles |
-
1983
- 1983-05-17 US US06/495,370 patent/US4536505A/en not_active Expired - Fee Related
-
1984
- 1984-05-14 FI FI841925A patent/FI841925A/fi not_active Application Discontinuation
- 1984-05-14 EP EP84105449A patent/EP0126401A1/de not_active Ceased
- 1984-05-15 IL IL71832A patent/IL71832A0/xx unknown
- 1984-05-15 GR GR74706A patent/GR79934B/el unknown
- 1984-05-15 PT PT78582A patent/PT78582A/pt unknown
- 1984-05-15 JP JP59095771A patent/JPS59212489A/ja active Pending
- 1984-05-16 AU AU28094/84A patent/AU2809484A/en not_active Abandoned
- 1984-05-16 KR KR1019840002658A patent/KR840009302A/ko not_active Application Discontinuation
- 1984-05-16 DK DK242484A patent/DK242484A/da not_active Application Discontinuation
- 1984-05-16 NO NO841958A patent/NO841958L/no unknown
- 1984-05-16 ZA ZA843677A patent/ZA843677B/xx unknown
- 1984-05-16 DD DD84263081A patent/DD224588A5/de unknown
- 1984-05-16 HU HU841893A patent/HUT34182A/hu unknown
- 1984-05-17 ES ES532572A patent/ES8602652A1/es not_active Expired
-
1985
- 1985-07-12 ES ES545151A patent/ES8604195A1/es not_active Expired
- 1985-07-12 ES ES545153A patent/ES8604197A1/es not_active Expired
- 1985-07-12 ES ES545154A patent/ES8604922A1/es not_active Expired
- 1985-07-12 ES ES545152A patent/ES8604196A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IL71832A0 (en) | 1984-09-30 |
US4536505A (en) | 1985-08-20 |
ES532572A0 (es) | 1985-12-01 |
JPS59212489A (ja) | 1984-12-01 |
FI841925A0 (fi) | 1984-05-14 |
ES8604196A1 (es) | 1986-01-16 |
PT78582A (en) | 1984-06-01 |
NO841958L (no) | 1984-11-19 |
DK242484D0 (da) | 1984-05-16 |
ES8604922A1 (es) | 1986-02-16 |
KR840009302A (ko) | 1984-12-26 |
ES545153A0 (es) | 1986-01-16 |
ZA843677B (en) | 1985-02-27 |
DK242484A (da) | 1984-11-18 |
ES545154A0 (es) | 1986-02-16 |
AU2809484A (en) | 1984-11-22 |
ES8602652A1 (es) | 1985-12-01 |
EP0126401A1 (de) | 1984-11-28 |
ES545151A0 (es) | 1986-01-16 |
ES8604197A1 (es) | 1986-01-16 |
DD224588A5 (de) | 1985-07-10 |
ES545152A0 (es) | 1986-01-16 |
HUT34182A (en) | 1985-02-28 |
FI841925A (fi) | 1984-11-18 |
GR79934B (es) | 1984-10-31 |
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