ES2032381T3 - Un compuesto quimico. (reserva del art. 167.2 cpe). - Google Patents

Un compuesto quimico. (reserva del art. 167.2 cpe).

Info

Publication number
ES2032381T3
ES2032381T3 ES198686202230T ES86202230T ES2032381T3 ES 2032381 T3 ES2032381 T3 ES 2032381T3 ES 198686202230 T ES198686202230 T ES 198686202230T ES 86202230 T ES86202230 T ES 86202230T ES 2032381 T3 ES2032381 T3 ES 2032381T3
Authority
ES
Spain
Prior art keywords
cpe
reservation
compounds
art
chemical compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686202230T
Other languages
English (en)
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Jozef Bertha August Thijssen
Alfonsus Guilielms Knaeps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2032381T3 publication Critical patent/ES2032381T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS 1H-IMIDAZOLES Y 1H-1, 2, 4-TRIAZOLES DE FORMULA (I) FIG.1. EN LA QUE Y-R1 ES UN RADICAL DE FORMULA (A), O (B) FIG.2. A LAS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES Y A LAS FORMAS ESTEREOQUIMICAMENTE ISOMERAS POSIBLES DE ELLAS. DICHOS COMPUESTOS SON AGENTES ANTIMICROBIANOS; EN LA INVENCION SE CONTEMPLAN TAMBIEN LAS PREPARACIONES FARMACEUTICAS QUE CONTIENEN LOS CITADOS COMPUESTOS COMO INGREDIENTE ACTIVO Y LOS METODOS PARA PREPARAR DICHOS COMPUESTOS Y PREPARACIONES FARMACEUTICAS.
ES198686202230T 1985-12-23 1986-12-10 Un compuesto quimico. (reserva del art. 167.2 cpe). Expired - Lifetime ES2032381T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81267085A 1985-12-23 1985-12-23

Publications (1)

Publication Number Publication Date
ES2032381T3 true ES2032381T3 (es) 1993-02-16

Family

ID=25210297

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686202230T Expired - Lifetime ES2032381T3 (es) 1985-12-23 1986-12-10 Un compuesto quimico. (reserva del art. 167.2 cpe).

Country Status (18)

Country Link
EP (1) EP0228125B1 (es)
JP (2) JPH0749428B2 (es)
AT (1) ATE73799T1 (es)
AU (2) AU589726B2 (es)
CA (1) CA1292472C (es)
CY (1) CY1825A (es)
DE (1) DE3684431D1 (es)
DK (2) DK164167C (es)
ES (1) ES2032381T3 (es)
FI (1) FI88505C (es)
GR (1) GR3004114T3 (es)
HK (1) HK46295A (es)
IE (1) IE59564B1 (es)
IL (1) IL81054A (es)
NO (1) NO167917C (es)
NZ (1) NZ218553A (es)
PT (1) PT84007B (es)
ZA (1) ZA869637B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
GR1000330B (el) * 1988-07-01 1992-06-25 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4 διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000298B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000297B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000302B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
CA2076257A1 (en) * 1991-09-13 1993-03-14 Jan Heeres 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h -1,2,4-triazol-3-one derivatives
TW279864B (es) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv
DK0736030T3 (da) * 1993-12-21 2001-10-29 Schering Corp Fungicide tetrahydrofuraner
PL181947B1 (en) * 1994-01-24 2001-10-31 Janssen Pharmaceutica Nv Water-soluble azole-type antimycotic agents
US5571811A (en) * 1994-07-12 1996-11-05 Janssen Pharmaceutica N.V. Sulfonamide derivatives of azolones
DK0788496T3 (da) * 1994-10-27 2001-06-18 Janssen Pharmaceutica Nv Inhibitorer for syntese af apolipoprotein-B
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
TW457240B (en) * 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
WO1997000248A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Hydroxyalkyl-substituted triazolones antifungals
CN1237172A (zh) * 1996-11-12 1999-12-01 塞普拉科公司 2r,4s,r,s－和2s,4r,r,s－羟基伊曲康唑－和羟基沙波康唑衍生物
AU773405B2 (en) * 1996-11-12 2004-05-27 Sepracor, Inc. Hydroxyitraconazole enantiomer mixtures
CN100343249C (zh) * 1997-07-11 2007-10-17 詹森药业有限公司 2,4,4－三取代的1,3－二氧环戊烷抗真菌剂
TW593312B (en) 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
WO1999018111A1 (en) * 1997-10-07 1999-04-15 Schering Corporation Crystalline antifungal glycine ester polymorph
CA2372691C (en) * 1999-05-04 2009-11-17 Janssen Pharmaceutica N.V. Antifungal ethers
KR100342383B1 (ko) * 1999-06-17 2002-12-06 한국화학연구원 이소옥사졸리딘 유도체, 그의 제조 방법 및 그를 포함하는 살균제 조성물
US9040539B2 (en) * 2010-05-19 2015-05-26 Sandoz Ag Process for the preparation of chiral triazolones
ES2786374T3 (es) 2014-12-05 2020-10-09 Pulmocide Ltd Compuesto antimicótico
ES2790723T3 (es) 2015-05-21 2020-10-29 Pulmocide Ltd Antifúngico 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-il)metil)-5-(2,4-difluorofenil)tetrahidrofurano-3-il)metoxi)-3-metilfenil)piperazina-1-il)-N -(2-hidroxiciclohexil)benzamida, o una sal farmacéuticamente aceptable del mismo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles

Also Published As

Publication number Publication date
FI865257A (fi) 1987-06-24
FI88505B (fi) 1993-02-15
PT84007B (pt) 1989-06-30
ATE73799T1 (de) 1992-04-15
AU593736B2 (en) 1990-02-15
JPS62158275A (ja) 1987-07-14
JPH0749428B2 (ja) 1995-05-31
CY1825A (en) 1995-12-01
NO167917C (no) 1991-12-27
IL81054A0 (en) 1987-03-31
DK625586D0 (da) 1986-12-22
NO167917B (no) 1991-09-16
IL81054A (en) 1992-03-29
IE863369L (en) 1987-06-23
EP0228125B1 (en) 1992-03-18
FI88505C (fi) 1993-05-25
DE3684431D1 (de) 1992-04-23
IE59564B1 (en) 1994-03-09
PT84007A (en) 1987-01-01
DK164167B (da) 1992-05-18
EP0228125A1 (en) 1987-07-08
DK167356B1 (da) 1993-10-18
CA1292472C (en) 1991-11-26
NZ218553A (en) 1990-06-26
DK625586A (da) 1987-06-24
ZA869637B (en) 1988-08-31
NO865235L (no) 1987-06-24
DK74691D0 (da) 1991-04-23
GR3004114T3 (es) 1993-03-31
AU6685386A (en) 1987-06-25
NO865235D0 (no) 1986-12-22
JP2574656B2 (ja) 1997-01-22
DK164167C (da) 1992-10-12
FI865257A0 (fi) 1986-12-22
HK46295A (en) 1995-04-07
JPH07285963A (ja) 1995-10-31
AU589726B2 (en) 1989-10-19
AU1607688A (en) 1988-08-04
DK74691A (da) 1991-04-23

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