DK625586A - Derivater af ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoler og -1h-1,2,4-triazoler - Google Patents

Derivater af ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoler og -1h-1,2,4-triazoler

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Publication number
DK625586A
DK625586A DK625586A DK625586A DK625586A DK 625586 A DK625586 A DK 625586A DK 625586 A DK625586 A DK 625586A DK 625586 A DK625586 A DK 625586A DK 625586 A DK625586 A DK 625586A
Authority
DK
Denmark
Prior art keywords
triazoles
imidazoles
phenoxymethyl
dioxolan
piperazinyl
Prior art date
Application number
DK625586A
Other languages
English (en)
Other versions
DK164167B (da
DK625586D0 (da
DK164167C (da
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Jozef Bertha August Thijssen
Alfonsus Guilielmus Knaeps
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK625586D0 publication Critical patent/DK625586D0/da
Publication of DK625586A publication Critical patent/DK625586A/da
Publication of DK164167B publication Critical patent/DK164167B/da
Application granted granted Critical
Publication of DK164167C publication Critical patent/DK164167C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK625586A 1985-12-23 1986-12-22 Oeoe4-oe4-(4-phenyl-1-piperazinyl)phenoxymethylaa-1,3-dioxolan-2-ylaamethylaa-1h-imidazol- og 1h-1,2,4-triazolderivater, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse til bekaempelse af mikroorganismer DK164167C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81267085A 1985-12-23 1985-12-23
US81267085 1985-12-23

Publications (4)

Publication Number Publication Date
DK625586D0 DK625586D0 (da) 1986-12-22
DK625586A true DK625586A (da) 1987-06-24
DK164167B DK164167B (da) 1992-05-18
DK164167C DK164167C (da) 1992-10-12

Family

ID=25210297

Family Applications (2)

Application Number Title Priority Date Filing Date
DK625586A DK164167C (da) 1985-12-23 1986-12-22 Oeoe4-oe4-(4-phenyl-1-piperazinyl)phenoxymethylaa-1,3-dioxolan-2-ylaamethylaa-1h-imidazol- og 1h-1,2,4-triazolderivater, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse til bekaempelse af mikroorganismer
DK074691A DK167356B1 (da) 1985-12-23 1991-04-23 4-oe4-(substitueret phenyl)-1-piperazinylaaphenoler og fremgangsmaade til fremstilling deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK074691A DK167356B1 (da) 1985-12-23 1991-04-23 4-oe4-(substitueret phenyl)-1-piperazinylaaphenoler og fremgangsmaade til fremstilling deraf

Country Status (18)

Country Link
EP (1) EP0228125B1 (da)
JP (2) JPH0749428B2 (da)
AT (1) ATE73799T1 (da)
AU (2) AU589726B2 (da)
CA (1) CA1292472C (da)
CY (1) CY1825A (da)
DE (1) DE3684431D1 (da)
DK (2) DK164167C (da)
ES (1) ES2032381T3 (da)
FI (1) FI88505C (da)
GR (1) GR3004114T3 (da)
HK (1) HK46295A (da)
IE (1) IE59564B1 (da)
IL (1) IL81054A (da)
NO (1) NO167917C (da)
NZ (1) NZ218553A (da)
PT (1) PT84007B (da)
ZA (1) ZA869637B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
GR1000297B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000302B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000330B (el) * 1988-07-01 1992-06-25 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4 διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000298B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
CA2076257A1 (en) * 1991-09-13 1993-03-14 Jan Heeres 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h -1,2,4-triazol-3-one derivatives
TW279864B (da) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv
CO4520281A1 (es) * 1993-12-21 1997-10-15 Schering Corp Antifungicos de tetrahidrofurano
ATE186540T1 (de) * 1994-01-24 1999-11-15 Janssen Pharmaceutica Nv Wasserlösliche azol-antifungus
US5571811A (en) * 1994-07-12 1996-11-05 Janssen Pharmaceutica N.V. Sulfonamide derivatives of azolones
DK0788496T3 (da) * 1994-10-27 2001-06-18 Janssen Pharmaceutica Nv Inhibitorer for syntese af apolipoprotein-B
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
TW457240B (en) * 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
WO1997000248A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Hydroxyalkyl-substituted triazolones antifungals
US5952502A (en) * 1996-11-12 1999-09-14 Sepracor Inc. 2R,4S,R, S- and 2S,4R,R,S-hydroxyitraconazole
AU773405B2 (en) * 1996-11-12 2004-05-27 Sepracor, Inc. Hydroxyitraconazole enantiomer mixtures
TW593312B (en) 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
UA63954C2 (en) * 1997-07-11 2004-02-16 Janssen Pharmaceutica Nv (+/-) norcisapride, a process for the preparation thereof, intermediate compounds, composition based thereon for use in the manufacture of medicaments for treating gastro-intestinal disorders
AU9592998A (en) * 1997-10-07 1999-04-27 Schering Corporation Crystalline antifungal glycine ester polymorph
ID30409A (id) * 1999-05-04 2001-11-29 Jannsen Pharmaceutica N V Eter anti jamur
KR100342383B1 (ko) * 1999-06-17 2002-12-06 한국화학연구원 이소옥사졸리딘 유도체, 그의 제조 방법 및 그를 포함하는 살균제 조성물
AU2011254654B2 (en) * 2010-05-19 2016-01-07 Sandoz Ag Process for the preparation of chiral triazolones
CN107001343B (zh) 2014-12-05 2020-12-11 普尔莫赛德有限公司 抗真菌的化合物
SG11201708007VA (en) 2015-05-21 2017-12-28 Pulmocide Ltd Antifungal 4-(4-(4-(((3r,5r)-5-((1 h -1,2,4-triazol-1 -yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)- 3-methylphenyl)piperazin-1 -yl )-n -(2-h yd roxycyc lo h exyl) b e nzam i d e, or a pharmaceutically acceptable salt thereof.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles

Also Published As

Publication number Publication date
IE59564B1 (en) 1994-03-09
JPH0749428B2 (ja) 1995-05-31
JPS62158275A (ja) 1987-07-14
IL81054A (en) 1992-03-29
DK167356B1 (da) 1993-10-18
GR3004114T3 (da) 1993-03-31
DE3684431D1 (de) 1992-04-23
NO167917B (no) 1991-09-16
EP0228125B1 (en) 1992-03-18
EP0228125A1 (en) 1987-07-08
IL81054A0 (en) 1987-03-31
PT84007B (pt) 1989-06-30
DK164167B (da) 1992-05-18
ATE73799T1 (de) 1992-04-15
ZA869637B (en) 1988-08-31
FI88505B (fi) 1993-02-15
CA1292472C (en) 1991-11-26
NO865235L (no) 1987-06-24
FI865257A (fi) 1987-06-24
PT84007A (en) 1987-01-01
DK74691D0 (da) 1991-04-23
AU6685386A (en) 1987-06-25
FI865257A0 (fi) 1986-12-22
HK46295A (en) 1995-04-07
NO865235D0 (no) 1986-12-22
JPH07285963A (ja) 1995-10-31
IE863369L (en) 1987-06-23
AU589726B2 (en) 1989-10-19
CY1825A (en) 1995-12-01
DK74691A (da) 1991-04-23
DK625586D0 (da) 1986-12-22
JP2574656B2 (ja) 1997-01-22
NZ218553A (en) 1990-06-26
DK164167C (da) 1992-10-12
AU1607688A (en) 1988-08-04
NO167917C (no) 1991-12-27
AU593736B2 (en) 1990-02-15
ES2032381T3 (es) 1993-02-16
FI88505C (fi) 1993-05-25

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