IL81054A - Derivatives of((4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoles and 1h-1,2,4-triazoles,their preparation and their use for combating microorganisms - Google Patents

Derivatives of((4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoles and 1h-1,2,4-triazoles,their preparation and their use for combating microorganisms

Info

Publication number
IL81054A
IL81054A IL81054A IL8105486A IL81054A IL 81054 A IL81054 A IL 81054A IL 81054 A IL81054 A IL 81054A IL 8105486 A IL8105486 A IL 8105486A IL 81054 A IL81054 A IL 81054A
Authority
IL
Israel
Prior art keywords
triazoles
imidazoles
phenoxymethyl
dioxolan
piperazinyl
Prior art date
Application number
IL81054A
Other languages
English (en)
Other versions
IL81054A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to IL9750086A priority Critical patent/IL97500A/xx
Publication of IL81054A0 publication Critical patent/IL81054A0/xx
Priority to IL97500A priority patent/IL97500A0/xx
Publication of IL81054A publication Critical patent/IL81054A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL81054A 1985-12-23 1986-12-22 Derivatives of((4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoles and 1h-1,2,4-triazoles,their preparation and their use for combating microorganisms IL81054A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL9750086A IL97500A (en) 1985-12-23 1986-12-22 Phenylpiperazine-substituted phenol compounds and their preparation
IL97500A IL97500A0 (en) 1985-12-23 1991-03-11 Phenylpiperazine-substituted phenol compounds and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81267085A 1985-12-23 1985-12-23

Publications (2)

Publication Number Publication Date
IL81054A0 IL81054A0 (en) 1987-03-31
IL81054A true IL81054A (en) 1992-03-29

Family

ID=25210297

Family Applications (1)

Application Number Title Priority Date Filing Date
IL81054A IL81054A (en) 1985-12-23 1986-12-22 Derivatives of((4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoles and 1h-1,2,4-triazoles,their preparation and their use for combating microorganisms

Country Status (18)

Country Link
EP (1) EP0228125B1 (da)
JP (2) JPH0749428B2 (da)
AT (1) ATE73799T1 (da)
AU (2) AU589726B2 (da)
CA (1) CA1292472C (da)
CY (1) CY1825A (da)
DE (1) DE3684431D1 (da)
DK (2) DK164167C (da)
ES (1) ES2032381T3 (da)
FI (1) FI88505C (da)
GR (1) GR3004114T3 (da)
HK (1) HK46295A (da)
IE (1) IE59564B1 (da)
IL (1) IL81054A (da)
NO (1) NO167917C (da)
NZ (1) NZ218553A (da)
PT (1) PT84007B (da)
ZA (1) ZA869637B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
GR1000298B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000297B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000302B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000330B (el) * 1988-07-01 1992-06-25 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4 διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
CA2076257A1 (en) * 1991-09-13 1993-03-14 Jan Heeres 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h -1,2,4-triazol-3-one derivatives
TW279864B (da) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv
PL181193B1 (pl) * 1993-12-21 2001-06-29 Schering Corp Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków
AU688455B2 (en) * 1994-01-24 1998-03-12 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
US5571811A (en) * 1994-07-12 1996-11-05 Janssen Pharmaceutica N.V. Sulfonamide derivatives of azolones
JP3025907B2 (ja) * 1994-10-27 2000-03-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アポリポタンパク質−ｂ合成阻害剤
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
TW457240B (en) * 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
AU6257596A (en) * 1995-06-19 1997-01-15 Schering Corporation Hydroxyalkyl-substituted triazolones antifungals
WO1998021213A2 (en) * 1996-11-12 1998-05-22 Sepracor, Inc. 2r,4s,r,s- and 2s,4r,r,s-hydroxyitraconazole- and hydroxysaperconazole derivatives
AU773405B2 (en) * 1996-11-12 2004-05-27 Sepracor, Inc. Hydroxyitraconazole enantiomer mixtures
CN100343249C (zh) * 1997-07-11 2007-10-17 詹森药业有限公司 2,4,4－三取代的1,3－二氧环戊烷抗真菌剂
TW593312B (en) 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
WO1999018111A1 (en) * 1997-10-07 1999-04-15 Schering Corporation Crystalline antifungal glycine ester polymorph
BR0010279A (pt) 1999-05-04 2002-05-14 Janssen Phamaceutica N V éteres antifúngicos
KR100342383B1 (ko) * 1999-06-17 2002-12-06 한국화학연구원 이소옥사졸리딘 유도체, 그의 제조 방법 및 그를 포함하는 살균제 조성물
CN102906087B (zh) * 2010-05-19 2016-03-23 桑多斯股份公司 制备手性三唑酮的方法
ES2786374T3 (es) 2014-12-05 2020-10-09 Pulmocide Ltd Compuesto antimicótico
HUE048843T2 (hu) 2015-05-21 2020-08-28 Pulmocide Ltd Gombaölõ szer 4-(4-(4-(((3R,5R)-5-((1H -1,2,4-triazol-1-YL)metil)-5-(2,4-difluor-fenil)tetra-hidro-furán-3-YL)metoxi)-3 metilfenil)piperazin-1-il)-n -(2-hidroxi-ciklohexil)benzamid, vagy annak gyógyszerészetileg elfogadható sója

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles

Also Published As

Publication number Publication date
JP2574656B2 (ja) 1997-01-22
CY1825A (en) 1995-12-01
IL81054A0 (en) 1987-03-31
DK625586A (da) 1987-06-24
ZA869637B (en) 1988-08-31
DK625586D0 (da) 1986-12-22
DK74691D0 (da) 1991-04-23
AU589726B2 (en) 1989-10-19
JPH07285963A (ja) 1995-10-31
HK46295A (en) 1995-04-07
DK74691A (da) 1991-04-23
FI865257A0 (fi) 1986-12-22
ES2032381T3 (es) 1993-02-16
IE863369L (en) 1987-06-23
FI88505B (fi) 1993-02-15
JPH0749428B2 (ja) 1995-05-31
FI865257A (fi) 1987-06-24
ATE73799T1 (de) 1992-04-15
AU1607688A (en) 1988-08-04
AU6685386A (en) 1987-06-25
DK167356B1 (da) 1993-10-18
NO167917B (no) 1991-09-16
FI88505C (fi) 1993-05-25
DK164167B (da) 1992-05-18
JPS62158275A (ja) 1987-07-14
EP0228125A1 (en) 1987-07-08
DE3684431D1 (de) 1992-04-23
CA1292472C (en) 1991-11-26
AU593736B2 (en) 1990-02-15
IE59564B1 (en) 1994-03-09
NO167917C (no) 1991-12-27
PT84007A (en) 1987-01-01
NO865235D0 (no) 1986-12-22
GR3004114T3 (da) 1993-03-31
PT84007B (pt) 1989-06-30
NZ218553A (en) 1990-06-26
EP0228125B1 (en) 1992-03-18
NO865235L (no) 1987-06-24
DK164167C (da) 1992-10-12

Similar Documents

Publication Publication Date Title
IL81054A0 (en) Derivatives of((4)(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoles and 1h-1,2,4-triazoles,their preparation and their use for combating microorganisms
ES8506007A1 (es) Un procedimiento para la preparacion de 1h-imidazoles y 1h-1, 2, 4-triazoles
GR3006420T3 (da)
KR960009422B1 (en) 4-(ardylamino)piperidinebutanamide derivatives
PT91613A (pt) Process for the preparation of antihypertensive 3-piperidinyl-indazole derivatives

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees