NO167917C - Analogifremgangsmaate for fremstilling av terapeutisk aktive, nye derivater av ((4-(4-(4-fenyl-1-piperazinyl)fenoksymetyl)-1,3-dioksolan-2-yl)metyl)-1h-imidazoler og -1h-1,2,4-triazoler - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive, nye derivater av ((4-(4-(4-fenyl-1-piperazinyl)fenoksymetyl)-1,3-dioksolan-2-yl)metyl)-1h-imidazoler og -1h-1,2,4-triazoler

Info

Publication number
NO167917C
NO167917C NO865235A NO865235A NO167917C NO 167917 C NO167917 C NO 167917C NO 865235 A NO865235 A NO 865235A NO 865235 A NO865235 A NO 865235A NO 167917 C NO167917 C NO 167917C
Authority
NO
Norway
Prior art keywords
phenoxymethyl
dioxolan
piperazinyl
triazole
imidazole
Prior art date
Application number
NO865235A
Other languages
English (en)
Other versions
NO865235L (no
NO865235D0 (no
NO167917B (no
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Jozef Bertha August Thijssen
Alfonsus Guilielmus Knaeps
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO865235D0 publication Critical patent/NO865235D0/no
Publication of NO865235L publication Critical patent/NO865235L/no
Priority to NO910890A priority Critical patent/NO175150C/no
Publication of NO167917B publication Critical patent/NO167917B/no
Publication of NO167917C publication Critical patent/NO167917C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO865235A 1985-12-23 1986-12-22 Analogifremgangsmaate for fremstilling av terapeutisk aktive, nye derivater av ((4-(4-(4-fenyl-1-piperazinyl)fenoksymetyl)-1,3-dioksolan-2-yl)metyl)-1h-imidazoler og -1h-1,2,4-triazoler NO167917C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO910890A NO175150C (no) 1985-12-23 1991-03-06 Mellomprodukt for fremstilling av nye derivater av ((4-(4-(4-fenyl-1-piperazinyl)fenoksymetyl)1,3-dioksolan-2-yl)metyl)-1H-imidazoler og -1H-1,2,4-triazoler

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81267085A 1985-12-23 1985-12-23

Publications (4)

Publication Number Publication Date
NO865235D0 NO865235D0 (no) 1986-12-22
NO865235L NO865235L (no) 1987-06-24
NO167917B NO167917B (no) 1991-09-16
NO167917C true NO167917C (no) 1991-12-27

Family

ID=25210297

Family Applications (1)

Application Number Title Priority Date Filing Date
NO865235A NO167917C (no) 1985-12-23 1986-12-22 Analogifremgangsmaate for fremstilling av terapeutisk aktive, nye derivater av ((4-(4-(4-fenyl-1-piperazinyl)fenoksymetyl)-1,3-dioksolan-2-yl)metyl)-1h-imidazoler og -1h-1,2,4-triazoler

Country Status (18)

Country Link
EP (1) EP0228125B1 (no)
JP (2) JPH0749428B2 (no)
AT (1) ATE73799T1 (no)
AU (2) AU589726B2 (no)
CA (1) CA1292472C (no)
CY (1) CY1825A (no)
DE (1) DE3684431D1 (no)
DK (2) DK164167C (no)
ES (1) ES2032381T3 (no)
FI (1) FI88505C (no)
GR (1) GR3004114T3 (no)
HK (1) HK46295A (no)
IE (1) IE59564B1 (no)
IL (1) IL81054A (no)
NO (1) NO167917C (no)
NZ (1) NZ218553A (no)
PT (1) PT84007B (no)
ZA (1) ZA869637B (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
GR1000297B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000330B (el) * 1988-07-01 1992-06-25 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4 διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000298B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GR1000302B (el) * 1988-07-01 1992-05-12 Janssen Pharmaceutica Nv Μεθοδος παρασκευης παραγωγων 2,4-διυδρο-3η-1,2,4-τριαζολ-3-ονης.
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
CA2076257A1 (en) * 1991-09-13 1993-03-14 Jan Heeres 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h -1,2,4-triazol-3-one derivatives
TW279864B (no) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv
ES2159623T3 (es) * 1993-12-21 2001-10-16 Schering Corp Antifungicos de tetrahidrofurano.
WO1995019983A1 (en) * 1994-01-24 1995-07-27 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
US5571811A (en) * 1994-07-12 1996-11-05 Janssen Pharmaceutica N.V. Sulfonamide derivatives of azolones
SK281908B6 (sk) * 1994-10-27 2001-09-11 Janssen Pharmaceutica N. V. Heteroarylsubstituované deriváty 1,3-dioxolan-4-ylmetoxyfenyl-1- piperazinylfenyl-2,4-dihydro-2-alkyl-3h-1,2,4-triazol-3-ónu, spôsob a medziprodukty na ich výrobu a farmaceutické prostriedky
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
TW457240B (en) 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
AU6257596A (en) * 1995-06-19 1997-01-15 Schering Corporation Hydroxyalkyl-substituted triazolones antifungals
CA2269617A1 (en) * 1996-11-12 1998-05-22 Chris H. Senanayake 2r,4s,r,s- and 2s,4r,r,s-hydroxyitraconazole- and hydroxysaperconazole derivatives
AU773405B2 (en) * 1996-11-12 2004-05-27 Sepracor, Inc. Hydroxyitraconazole enantiomer mixtures
TW593312B (en) 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
JP4473350B2 (ja) * 1997-07-11 2010-06-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２，４，４−三置換−１，３−ジオキソラン抗菌・抗カビ剤
WO1999018111A1 (en) * 1997-10-07 1999-04-15 Schering Corporation Crystalline antifungal glycine ester polymorph
EA200101172A1 (ru) 1999-05-04 2002-04-25 Янссен Фармацевтика Н.В. Противогрибковые эфиры
KR100342383B1 (ko) * 1999-06-17 2002-12-06 한국화학연구원 이소옥사졸리딘 유도체, 그의 제조 방법 및 그를 포함하는 살균제 조성물
RU2585760C2 (ru) * 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
EP3227277B1 (en) 2014-12-05 2020-02-05 Pulmocide Limited Antimycotic compound
KR102653821B1 (ko) 2015-05-21 2024-04-02 풀모사이드 리미티드 항진균성 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-트리아졸-1-일)메틸)-5-(2,4-디플루오로페닐)테트라하이드로푸란-3-일)메톡시)-3-메틸페닐)피페라진-1-일)-n-(2-하이드록시사이클로헥실)벤즈아미드 또는 이의 약학적으로 허용가능한 염.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles

Also Published As

Publication number Publication date
IE59564B1 (en) 1994-03-09
JPH07285963A (ja) 1995-10-31
PT84007A (en) 1987-01-01
JPH0749428B2 (ja) 1995-05-31
ES2032381T3 (es) 1993-02-16
DK625586A (da) 1987-06-24
FI88505C (fi) 1993-05-25
NO865235L (no) 1987-06-24
DK625586D0 (da) 1986-12-22
DE3684431D1 (de) 1992-04-23
DK164167C (da) 1992-10-12
AU589726B2 (en) 1989-10-19
EP0228125B1 (en) 1992-03-18
DK74691A (da) 1991-04-23
AU593736B2 (en) 1990-02-15
AU6685386A (en) 1987-06-25
PT84007B (pt) 1989-06-30
FI865257A (fi) 1987-06-24
DK167356B1 (da) 1993-10-18
ATE73799T1 (de) 1992-04-15
CA1292472C (en) 1991-11-26
CY1825A (en) 1995-12-01
NO865235D0 (no) 1986-12-22
DK164167B (da) 1992-05-18
IE863369L (en) 1987-06-23
IL81054A0 (en) 1987-03-31
EP0228125A1 (en) 1987-07-08
DK74691D0 (da) 1991-04-23
NO167917B (no) 1991-09-16
NZ218553A (en) 1990-06-26
HK46295A (en) 1995-04-07
JP2574656B2 (ja) 1997-01-22
JPS62158275A (ja) 1987-07-14
AU1607688A (en) 1988-08-04
GR3004114T3 (no) 1993-03-31
FI88505B (fi) 1993-02-15
IL81054A (en) 1992-03-29
FI865257A0 (fi) 1986-12-22
ZA869637B (en) 1988-08-31

Similar Documents

Publication Publication Date Title
NO167917C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive, nye derivater av ((4-(4-(4-fenyl-1-piperazinyl)fenoksymetyl)-1,3-dioksolan-2-yl)metyl)-1h-imidazoler og -1h-1,2,4-triazoler
ES8505364A1 (es) Un procedimiento para la preparacion 1-imidazoles y 1h-1, 2, 4-triazoles
NO168476C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-(4-(4-(4-(((2,4-difluorfenyl)-2-(1h-azolylmetyl)-1,3-dioxolan-4-yl)metoksy)fenyl)-1-piperazinyl)fenyl)triazoloner.
KR960009422B1 (en) 4-(ardylamino)piperidinebutanamide derivatives