ES2159623T3 - Antifungicos de tetrahidrofurano. - Google Patents

Antifungicos de tetrahidrofurano.

Info

Publication number
ES2159623T3
ES2159623T3 ES95906620T ES95906620T ES2159623T3 ES 2159623 T3 ES2159623 T3 ES 2159623T3 ES 95906620 T ES95906620 T ES 95906620T ES 95906620 T ES95906620 T ES 95906620T ES 2159623 T3 ES2159623 T3 ES 2159623T3
Authority
ES
Spain
Prior art keywords
sub
antifungics
tetrahydrofuran
ester
fungical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95906620T
Other languages
English (en)
Inventor
Anil K Saksena
Viyyoor M Girijavallabhan
Raymond G Lovey
Russell E Pike
Haiyan Wang
Yi-Tsung Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22622452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2159623(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2159623T3 publication Critical patent/ES2159623T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Dental Preparations (AREA)
  • Lubricants (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN COMPUESTO DE FORMULA (I) DONDE LAS X PUEDEN SER AMBAS F O CL O UNA X ES INDEPENDIENTEMENTE F Y LA OTRA ES CL; R{SUB,1} ES UN GRUPO ALQUILO (C{SUB,3}-C{SUB,8}) DE CADENA LINEAL O RAMIFICADA SUSTITUIDO POR UNA O DOS MITADES HIDROXI; TAMBIEN SE DESCRIBEN UN ETER O ESTER DEL MISMO (P. E. POLIESTERESTER O ESTER FOSFATO), SU SAL FARMACEUTICAMENTE ACEPTABLE Y SUS COMPOSICIONES FARMACEUTICAS UTILES PARA TRATAR Y/O PREVENIR INFECCIONES FUNGICAS.
ES95906620T 1993-12-21 1994-12-20 Antifungicos de tetrahidrofurano. Expired - Lifetime ES2159623T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17108393A 1993-12-21 1993-12-21

Publications (1)

Publication Number Publication Date
ES2159623T3 true ES2159623T3 (es) 2001-10-16

Family

ID=22622452

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95906620T Expired - Lifetime ES2159623T3 (es) 1993-12-21 1994-12-20 Antifungicos de tetrahidrofurano.

Country Status (29)

Country Link
EP (1) EP0736030B1 (es)
JP (1) JP2834889B2 (es)
KR (1) KR0179990B1 (es)
CN (1) CN1064685C (es)
AT (1) ATE204875T1 (es)
AU (1) AU681753B2 (es)
BR (1) BR1100154B1 (es)
CA (1) CA2179396C (es)
CO (1) CO4520281A1 (es)
CZ (1) CZ294823B6 (es)
DE (2) DE69428125T2 (es)
DK (1) DK0736030T3 (es)
ES (1) ES2159623T3 (es)
FI (1) FI118470B (es)
FR (1) FR06C0009I2 (es)
HK (1) HK1008820A1 (es)
HU (1) HU225062B1 (es)
IL (1) IL112081A (es)
LU (1) LU91216I2 (es)
MY (1) MY130217A (es)
NL (1) NL300219I2 (es)
NO (2) NO316173B1 (es)
NZ (1) NZ278713A (es)
PL (1) PL181193B1 (es)
PT (1) PT736030E (es)
SK (1) SK283035B6 (es)
TW (1) TW377349B (es)
WO (1) WO1995017407A1 (es)
ZA (1) ZA9410142B (es)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019983A1 (en) * 1994-01-24 1995-07-27 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
CA2197672C (en) * 1995-06-02 2011-05-17 Anil K. Saksena Tetrahydrofuran antifungals
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
AU6257396A (en) * 1995-06-19 1997-01-15 Schering Corporation Tetrahydrofuran antifungals
IL125007A (en) * 1995-12-20 2001-09-13 Schering Corp Process for the preparation of hydrazides
BR9711167A (pt) * 1996-05-24 1999-08-17 Schering Corp Composi-Æo antifÚngica com maior biodisponibilidade
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
AU731704B2 (en) * 1996-06-28 2001-04-05 Schering Corporation Oral composition comprising a triazole antifungal compound
US5972381A (en) * 1996-06-28 1999-10-26 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
EP0954288B1 (en) * 1996-06-28 2004-08-11 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
CA2269617A1 (en) * 1996-11-12 1998-05-22 Chris H. Senanayake 2r,4s,r,s- and 2s,4r,r,s-hydroxyitraconazole- and hydroxysaperconazole derivatives
EP0942907A1 (en) * 1996-11-12 1999-09-22 Sepracor, Inc. 2r, 4s, s, r- and 2s, 4r, s, r-hydroxyitraconazole
JP2001504466A (ja) * 1996-11-12 2001-04-03 セプラコール，インク． ２ｒ，４ｓ，ｒ，ｒ―および２ｓ，４ｒ，ｒ，ｒ―ヒドロキシイトラコナゾール
JP2001504465A (ja) 1996-11-12 2001-04-03 セプラコール，インク． ２ｒ，４ｓ，ｓ，ｓ―および２ｓ，４ｒ，ｓ，ｓ―ヒドロキシイトラコナゾール
US5684197A (en) * 1996-12-12 1997-11-04 Schering Corporation Process for preparation of hydrazides
US6262052B1 (en) * 1997-02-11 2001-07-17 Janssen Pharmaceutica N.V. Amino acid ester containing azole antifungals
WO1999015522A1 (en) * 1997-09-25 1999-04-01 Schering Corporation Tetrahydrofuran phosphate- and hydroxy esters, as prodrugs for the corresponding antifungal agent
US6043245A (en) * 1997-09-25 2000-03-28 Schering Corporation Tetrahydrofuran antifungal phosphate
WO1999018111A1 (en) * 1997-10-07 1999-04-15 Schering Corporation Crystalline antifungal glycine ester polymorph
DE69822859T2 (de) * 1997-10-07 2005-01-27 Schering Corp. Krytallinischer fungizider polymorph
US6713481B1 (en) * 1997-10-17 2004-03-30 David R. Andrews Crystalline antifungal polymorph
US5883097A (en) * 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
US6147077A (en) * 1999-04-29 2000-11-14 Sepracor Inc. 2R,4S-hydroxyitraconazole isomers
EA200101172A1 (ru) 1999-05-04 2002-04-25 Янссен Фармацевтика Н.В. Противогрибковые эфиры
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
HUP0400856A3 (en) * 2001-04-03 2012-09-28 Merck Sharp & Dohme Antifungal composition
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
JP4906233B2 (ja) 2002-03-01 2012-03-28 ユニバーシティー オブ サウス フロリダ 少なくとも１種の有効薬剤成分を含有する多構成要素固相
AU2003243354A1 (en) 2002-05-31 2003-12-19 Transform Pharmaceuticals, Inc. Novel conazole crystalline forms and related processes, pharmaceutical compositions and methods
MXPA05000232A (es) 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Composiciones farmaceuticas con disolucion mejorada.
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
PL1776109T3 (pl) * 2004-08-13 2009-06-30 Schering Plough Ltd Farmaceutyczna formulacja zawierająca antybiotyk, triazol i kortykosteroid
EP2130540A1 (en) * 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
WO2011003992A1 (en) 2009-07-09 2011-01-13 Sandoz Ag A crystalline form of posaconazole
WO2011158248A2 (en) * 2010-05-12 2011-12-22 Glenmark Generics Limited Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole
MX337804B (es) * 2010-05-19 2016-03-18 Sandoz Ag Proceso para la preparacion de hidrazinas quirales.
RU2585760C2 (ru) * 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
MX2012013331A (es) 2010-05-19 2013-02-01 Sandoz Ag Purificacion de posaconazol y de intermediarios de posaconazol.
BR112012029226A2 (pt) * 2010-05-19 2015-10-20 Sandoz Ag processo para a preparação de um composto quiral, composto quiral cristalino, sal de hcl do composto quiral cristalino, composto quiral e uso do composto
MX338685B (es) 2010-06-29 2016-04-26 Merck Sharp & Dohme Formulaciones de solucion intravenosa de posaconacol estabilizadas mediante beta-ciclodextrina sustituida.
CN103635465A (zh) * 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
EP2789610A1 (en) 2013-04-10 2014-10-15 Sandoz Ag Purification of Posaconazole Intermediates
CN105579448B (zh) * 2013-07-25 2018-12-21 桑多斯股份公司 制备泊沙康唑的晶型iv的改进方法
ITMI20132114A1 (it) 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
CN105287403A (zh) * 2014-08-02 2016-02-03 陕西合成药业股份有限公司 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
EP3227277B1 (en) 2014-12-05 2020-02-05 Pulmocide Limited Antimycotic compound
KR102653821B1 (ko) * 2015-05-21 2024-04-02 풀모사이드 리미티드 항진균성 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-트리아졸-1-일)메틸)-5-(2,4-디플루오로페닐)테트라하이드로푸란-3-일)메톡시)-3-메틸페닐)피페라진-1-일)-n-(2-하이드록시사이클로헥실)벤즈아미드 또는 이의 약학적으로 허용가능한 염.
CN106317032A (zh) * 2015-06-15 2017-01-11 重庆圣华曦药业股份有限公司 一种制备高纯度的泊沙康唑的方法
CN106432338A (zh) * 2015-08-08 2017-02-22 陕西合成药业股份有限公司 泊沙康唑衍生物、合成和在长效制剂中的用途
JP7054381B2 (ja) * 2015-09-23 2022-04-13 バイオコン・リミテッド 結晶形態のポサコナゾール中間体および非晶質ポサコナゾールの調製のためのプロセス
CN105606736A (zh) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 分离测定泊沙康唑中间体z1及其有关物质的方法
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
US11185548B2 (en) 2016-12-23 2021-11-30 Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
CN106967054A (zh) * 2017-03-30 2017-07-21 成都绿林科技有限公司 一种泊沙康唑的制备方法
CN106883221A (zh) * 2017-04-17 2017-06-23 兰州大学 一种无定形泊沙康唑及其制备方法
CN108341754A (zh) * 2018-03-12 2018-07-31 扬子江药业集团有限公司 泊沙康唑杂质及其制备方法和用途
CN110938093B (zh) * 2018-09-21 2022-08-19 华创合成制药股份有限公司 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途
CN112778369B (zh) * 2019-11-05 2024-01-26 华创合成制药股份有限公司 一种三唑类衍生物及其制备方法和用途
CN113666915B (zh) * 2021-08-27 2022-08-16 江苏海洋大学 一种泊沙康唑中间体的制备方法
CN114315811B (zh) * 2021-11-19 2024-04-30 江苏恒盛药业有限公司 一种三氮唑类似物化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
AU2811689A (en) * 1987-11-20 1989-06-14 Schering Corporation Tri-and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals

Also Published As

Publication number Publication date
LU91216I2 (en) 2006-03-27
CO4520281A1 (es) 1997-10-15
DE69428125D1 (de) 2001-10-04
ATE204875T1 (de) 2001-09-15
NZ278713A (en) 1997-12-19
AU1512795A (en) 1995-07-10
NL300219I2 (nl) 2006-05-01
WO1995017407A1 (en) 1995-06-29
NL300219I1 (nl) 2006-04-03
HK1008820A1 (en) 1999-05-21
NO962616D0 (no) 1996-06-20
CZ294823B6 (cs) 2005-03-16
JPH09500658A (ja) 1997-01-21
FR06C0009I1 (es) 2006-05-19
DE122006000004I1 (de) 2006-04-27
CA2179396C (en) 2001-04-17
CN1142828A (zh) 1997-02-12
IL112081A0 (en) 1995-03-15
IL112081A (en) 2001-08-26
AU681753B2 (en) 1997-09-04
SK283035B6 (sk) 2003-02-04
EP0736030B1 (en) 2001-08-29
FI962577A (fi) 1996-06-20
FI118470B (fi) 2007-11-30
FR06C0009I2 (es) 2006-12-29
NO2006002I1 (no) 2006-02-20
CZ180596A3 (en) 1997-01-15
ZA9410142B (en) 1996-05-02
CN1064685C (zh) 2001-04-18
SK82696A3 (en) 1997-03-05
PL181193B1 (pl) 2001-06-29
EP0736030A1 (en) 1996-10-09
NO962616L (no) 1996-08-07
KR0179990B1 (en) 1999-03-20
MY130217A (en) 2007-06-29
CA2179396A1 (en) 1995-06-29
DE69428125T2 (de) 2002-05-02
HUT75879A (en) 1997-05-28
NO316173B1 (no) 2003-12-22
FI962577A0 (fi) 1996-06-20
HU225062B1 (en) 2006-05-29
TW377349B (en) 1999-12-21
NO2006002I2 (no) 2011-03-07
BR1100154B1 (pt) 2013-11-26
DK0736030T3 (da) 2001-10-29
PT736030E (pt) 2002-01-30
HU9601709D0 (en) 1996-08-28
PL315169A1 (en) 1996-10-14
JP2834889B2 (ja) 1998-12-14
DE122006000004I2 (de) 2007-03-29

Similar Documents

Publication Publication Date Title
ES2159623T3 (es) Antifungicos de tetrahidrofurano.
BR9107124A (pt) Novos derivados de acido hidroxamico e de n-hidroxiureia e seu uso
ES2161291T3 (es) N-(indol-2-carbonil)amidas y derivados como inhibidores de la glucogeno fosforilasa.
TR199901127T2 (xx) Antibakteriyel etkili 6-O-ikameli ketolitler.
PT78179A (fr) Procede de preparation de nouveaux sulfates avec activite anti--thrombotique et hypolipemiante et de compositions pharmaceuti-ques les contenant
FI943805A (fi) Substituoituja adeniinijohdannaisten käyttö multippeliskleroosin hoitoon
PT1023267E (pt) Compostos de piridilo e composicoes farmaceuticas que os contem
NO178923C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 24-homo-vitamin-D-derivater
ID820B (id) Turunan benzisotiazolinon-1-dioksid sebagai penghambat elastase
FI933902A (fi) Substituerade cyklohexanderivat foer behandling av sjukdomar
NO180482C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive hydroksamsyrer og N-hydroksyurinstoffer
FI851261L (fi) Substituerade bensopyraner, foerfarande foer deras framstaellning och deras anvaendning i laekemedel.
FI803264L (fi) 2-hydroxialkyl-3,4,5-trihydroxipiperidiner foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel
FI931079A0 (fi) Mikrobmotverkande karbapenemderivat, deras framstaellning och terapeutiska anvaendning
NO982229D0 (no) Svovelholdige di-tert-butylfenol-forbindelser anvendbare som antiinflammatoriske midler
ATE236133T1 (de) Benzimidazolderivate
GB1469797A (en) Antibacterial cephalosporin derivatives
DE3166235D1 (en) Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them
ATE15044T1 (de) Bis-ester von alkandiolen, pharmazeutische zusammensetzungen und zwischenprodukte.
FI810710L (fi) Oligoribocidderivat av homocitronsyra foerfarande foer framstaellning av dessa och anvaendningen av dessa foer foerhindrande av karies
RU94046312A (ru) Применение биологически активных уреидопроизводных для лечения индуцируемых лентивирусами заболеваний, продукты, содержащие уреидопроизводные
AU2670284A (en) 2-n-cycloalkylmethyl-3-oxo-5,6-diaryl-as-triazines
SE8404556D0 (sv) Farmaceutisk komposition
GB8808839D0 (en) Pharmaceutical combinations

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 736030

Country of ref document: ES