GB8808839D0 - Pharmaceutical combinations - Google Patents

Pharmaceutical combinations

Info

Publication number
GB8808839D0
GB8808839D0 GB888808839A GB8808839A GB8808839D0 GB 8808839 D0 GB8808839 D0 GB 8808839D0 GB 888808839 A GB888808839 A GB 888808839A GB 8808839 A GB8808839 A GB 8808839A GB 8808839 D0 GB8808839 D0 GB 8808839D0
Authority
GB
United Kingdom
Prior art keywords
group
zero
trans
hydrogen atom
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB888808839A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GB888808839A priority Critical patent/GB8808839D0/en
Publication of GB8808839D0 publication Critical patent/GB8808839D0/en
Priority to GB8908319A priority patent/GB2217601A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The use of both (i) a compound of formula (1) <IMAGE> wherein R<1> is a hydrogen atom or a methyl group; X is cis or trans -CH=CH- or -CH2CH2-, m is 2, 3 or 4 and n is 1; or X is trans -CH=CH-, m is zero and n is 3; Y is a saturated heterocyclic amino group (attached to the cyclopentane ring via the nitrogen atom) which a has 5-8 ring members and (a) optionally contains in the ring -O-, -S-, -SO2- or NR<3a>; and/or (b) is optionally substituted by one or more alkyl groups; Alk is a straight or branched C1-5 alkyl chain; l is zero or 1; p is zero, 1, 2, 3 or 4; R<2> is a hydroxyl group or a group selected from -OCOR<3>, -CO2R<3>, -CONR<3>R<4>, -SO2NR<3>R<4> -NHCOR<3>, -NHSO2R<5>, -SO2R<5>, -SR<5>, -NR<3>R<4>, -COR<5>, NHCONR<3>R<4> and -NHCSNH2; R<3>, R<3a> and R<4>, which may be the same or different, represent a hydrogen atom or a C1-4alkyl or C7-10 aralkyl group; and R<5> is a C1-4 alkyl group; or a physiologically acceptable salt, solvate or cyclodextrin complex thereof and (ii) a thrombolytic agent in the therapy or prophylaxis of thrombotic disorders. Pharmaceutical compositions containing both (i) and (ii) are also described.
GB888808839A 1988-04-14 1988-04-14 Pharmaceutical combinations Pending GB8808839D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB888808839A GB8808839D0 (en) 1988-04-14 1988-04-14 Pharmaceutical combinations
GB8908319A GB2217601A (en) 1988-04-14 1989-04-13 Pharmaceutical combinations for the treatment of thrombotic disorders

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888808839A GB8808839D0 (en) 1988-04-14 1988-04-14 Pharmaceutical combinations

Publications (1)

Publication Number Publication Date
GB8808839D0 true GB8808839D0 (en) 1988-05-18

Family

ID=10635197

Family Applications (2)

Application Number Title Priority Date Filing Date
GB888808839A Pending GB8808839D0 (en) 1988-04-14 1988-04-14 Pharmaceutical combinations
GB8908319A Withdrawn GB2217601A (en) 1988-04-14 1989-04-13 Pharmaceutical combinations for the treatment of thrombotic disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB8908319A Withdrawn GB2217601A (en) 1988-04-14 1989-04-13 Pharmaceutical combinations for the treatment of thrombotic disorders

Country Status (1)

Country Link
GB (2) GB8808839D0 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86814A (en) * 1987-06-22 1993-03-15 Glaxo Group Ltd Aminocyclopentyl ethers, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
GB2217601A (en) 1989-11-01
GB8908319D0 (en) 1989-06-01

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