ATE204875T1 - Fungizide tetrahydrofurane - Google Patents

Fungizide tetrahydrofurane

Info

Publication number
ATE204875T1
ATE204875T1 AT95906620T AT95906620T ATE204875T1 AT E204875 T1 ATE204875 T1 AT E204875T1 AT 95906620 T AT95906620 T AT 95906620T AT 95906620 T AT95906620 T AT 95906620T AT E204875 T1 ATE204875 T1 AT E204875T1
Authority
AT
Austria
Prior art keywords
independently
tetrahydrofuranes
fungicidal
ester
polyestherester
Prior art date
Application number
AT95906620T
Other languages
English (en)
Inventor
Anil K Saksena
Viyyoor M Girijavallabhan
Raymond G Lovey
Russell E Pike
Haiyan Wang
Yi-Tsung Liu
Ashit K Ganguly
Frank Bennett
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22622452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE204875(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE204875T1 publication Critical patent/ATE204875T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Lubricants (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
AT95906620T 1993-12-21 1994-12-20 Fungizide tetrahydrofurane ATE204875T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17108393A 1993-12-21 1993-12-21
PCT/US1994/014236 WO1995017407A1 (en) 1993-12-21 1994-12-20 Tetrahydrofuran antifungals

Publications (1)

Publication Number Publication Date
ATE204875T1 true ATE204875T1 (de) 2001-09-15

Family

ID=22622452

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95906620T ATE204875T1 (de) 1993-12-21 1994-12-20 Fungizide tetrahydrofurane

Country Status (28)

Country Link
EP (1) EP0736030B1 (de)
JP (1) JP2834889B2 (de)
KR (1) KR0179990B1 (de)
CN (1) CN1064685C (de)
AT (1) ATE204875T1 (de)
AU (1) AU681753B2 (de)
BR (1) BR1100154B1 (de)
CA (1) CA2179396C (de)
CO (1) CO4520281A1 (de)
CZ (1) CZ294823B6 (de)
DE (2) DE69428125T2 (de)
DK (1) DK0736030T3 (de)
ES (1) ES2159623T3 (de)
FI (1) FI118470B (de)
FR (1) FR06C0009I2 (de)
HU (1) HU225062B1 (de)
IL (1) IL112081A (de)
LU (1) LU91216I2 (de)
MY (1) MY130217A (de)
NL (1) NL300219I2 (de)
NO (2) NO316173B1 (de)
NZ (1) NZ278713A (de)
PL (1) PL181193B1 (de)
PT (1) PT736030E (de)
SK (1) SK283035B6 (de)
TW (1) TW377349B (de)
WO (1) WO1995017407A1 (de)
ZA (1) ZA9410142B (de)

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ATE240319T1 (de) * 1995-06-02 2003-05-15 Schering Corp Antifungale tetrahydrofurane
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
EP0837859B1 (de) * 1995-06-19 2003-08-13 Schering Corporation Antifungale tetrahydrofurane
IL125007A (en) * 1995-12-20 2001-09-13 Schering Corp Process for the preparation of hydrazides
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
RU2207119C2 (ru) 1996-05-24 2003-06-27 Шеринг Корпорейшн Противогрибковый состав с повышенной биодоступностью
ATE273002T1 (de) * 1996-06-28 2004-08-15 Schering Corp Feste lösung eines fungizids mit erhöhter bioverfügbarkeit
US5972381A (en) * 1996-06-28 1999-10-26 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
CA2258683C (en) * 1996-06-28 2007-07-31 Schering Corporation Oral composition comprising a triazole antifungal compound
AU5178998A (en) * 1996-11-12 1998-06-03 Sepracor, Inc. 2(r),4(s),(r),(s)- and 2(s),4(r),(r),(s)-hydroxyitraconazole- and hydroxysaperconazole derivatives
AU5251398A (en) * 1996-11-12 1998-06-03 Sepracor, Inc. (2r,4s,r,r-) and (2s,4r,r,r-)hydroxyitraconazole
JP2001504465A (ja) 1996-11-12 2001-04-03 セプラコール，インク． ２ｒ，４ｓ，ｓ，ｓ―および２ｓ，４ｒ，ｓ，ｓ―ヒドロキシイトラコナゾール
JP2001504464A (ja) * 1996-11-12 2001-04-03 セプラコール，インク． ２ｒ，４ｓ，ｓ，ｒ―および２ｓ，４ｒ，ｓ，ｒ―ヒドロキシイトラコナゾール
US5684197A (en) * 1996-12-12 1997-11-04 Schering Corporation Process for preparation of hydrazides
ATE270290T1 (de) * 1997-02-11 2004-07-15 Janssen Pharmaceutica Nv Azole enthaltende antifungale aminosäure-ester
EP1027349B1 (de) * 1997-09-25 2005-01-05 Schering Corporation Tetrahydrofuran-phosphat- und hydroxy-ester als prodrugs der entsprechenden antifungiziden mittel
US6043245A (en) * 1997-09-25 2000-03-28 Schering Corporation Tetrahydrofuran antifungal phosphate
AR015947A1 (es) * 1997-10-07 2001-05-30 Schering Corp Una forma 1 polimorfica (-)-4-[4-[4-[4-[[(2r-cis]-5-(2,4-difluorfenil)tetrahidro-5-(1h-1,2,4-triazol-1-ilmetil)furan-3-il]-metoxi]fenil]-1-piperazinil]fenil-2,4-dihidro-2-[(s)-1-etil-2-(s)-hidroxipropil]-3h-1,2,4-triazol-3-ona, composicion farmaceutica que la contiene y su uso para preparar un medic
AU9592998A (en) * 1997-10-07 1999-04-27 Schering Corporation Crystalline antifungal glycine ester polymorph
US6713481B1 (en) * 1997-10-17 2004-03-30 David R. Andrews Crystalline antifungal polymorph
US5883097A (en) * 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
EP0957101A1 (de) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Wasserlösliche Azole als Breitspektrum-antifungus
US6147077A (en) * 1999-04-29 2000-11-14 Sepracor Inc. 2R,4S-hydroxyitraconazole isomers
US6583136B1 (en) * 1999-05-04 2003-06-24 Janssen Pharmacuetica N.V. Antifungal ethers
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
AU2002257104B2 (en) * 2001-04-03 2006-02-09 Merck Sharp & Dohme Corp. Antifungal composition with enhanced bioavailability
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7078526B2 (en) 2002-05-31 2006-07-18 Transform Pharmaceuticals, Inc. CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
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US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
ITMI20032020A1 (it) 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
BRPI0514098B1 (pt) * 2004-08-13 2021-01-19 Intervet International B. V. composição farmacêutica tópica para o tratamento de uma infecção ótica
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EP2130540A1 (de) * 2008-06-02 2009-12-09 Sandoz AG Pharmazeutische Zusammensetzungen mit einer kristallinen Form von Posaconazol
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BR112012029226A2 (pt) * 2010-05-19 2015-10-20 Sandoz Ag processo para a preparação de um composto quiral, composto quiral cristalino, sal de hcl do composto quiral cristalino, composto quiral e uso do composto
CN102892763B (zh) * 2010-05-19 2016-03-09 桑多斯股份公司 泊沙康唑及泊沙康唑中间体的纯化
BR112012029225B1 (pt) * 2010-05-19 2020-10-27 Sandoz Ag processo para a preparação de um composto quiral, composto quiral e uso de um composto quiral
RU2585760C2 (ru) * 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
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WO2015011224A1 (en) * 2013-07-25 2015-01-29 Sandoz Ag Improved process for the preparation of crystalline form iv of posaconazole
ITMI20132114A1 (it) 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
CN105287403A (zh) * 2014-08-02 2016-02-03 陕西合成药业股份有限公司 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
JP6669751B2 (ja) 2014-12-05 2020-03-18 プルモシデ リミテド 抗真菌化合物
ES2790723T3 (es) 2015-05-21 2020-10-29 Pulmocide Ltd Antifúngico 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-il)metil)-5-(2,4-difluorofenil)tetrahidrofurano-3-il)metoxi)-3-metilfenil)piperazina-1-il)-N -(2-hidroxiciclohexil)benzamida, o una sal farmacéuticamente aceptable del mismo
CN106317032A (zh) * 2015-06-15 2017-01-11 重庆圣华曦药业股份有限公司 一种制备高纯度的泊沙康唑的方法
CN106432338A (zh) * 2015-08-08 2017-02-22 陕西合成药业股份有限公司 泊沙康唑衍生物、合成和在长效制剂中的用途
ES2946734T3 (es) * 2015-09-23 2023-07-25 Biocon Ltd Formas cristalinas del intermedio de posaconazol y procedimiento para la preparación de posaconazol amorfo
CN105606736A (zh) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 分离测定泊沙康唑中间体z1及其有关物质的方法
SI3424911T1 (sl) * 2016-03-04 2021-11-30 Zhejiang Ausun Pharmaceutical Co., Ltd., Posakonazol, sestavek, intermediat, postopek priprave le-tega in uporabe le-tega
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
EP3558304A2 (de) 2016-12-23 2019-10-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitoren des mitglieds 1 der unterfamilie b der cytochrom-p450-familie 7 (cyp7b1) zur verwendung in der behandlung von krankheiten
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
CN106967054A (zh) * 2017-03-30 2017-07-21 成都绿林科技有限公司 一种泊沙康唑的制备方法
CN106883221A (zh) * 2017-04-17 2017-06-23 兰州大学 一种无定形泊沙康唑及其制备方法
CN108341754A (zh) * 2018-03-12 2018-07-31 扬子江药业集团有限公司 泊沙康唑杂质及其制备方法和用途
CN110938093B (zh) * 2018-09-21 2022-08-19 华创合成制药股份有限公司 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途
CN112778369B (zh) * 2019-11-05 2024-01-26 华创合成制药股份有限公司 一种三唑类衍生物及其制备方法和用途
GB201917867D0 (en) 2019-12-06 2020-01-22 Pulmocide Ltd Polymorphs
CN113666915B (zh) * 2021-08-27 2022-08-16 江苏海洋大学 一种泊沙康唑中间体的制备方法
CN114315811B (zh) * 2021-11-19 2024-04-30 江苏恒盛药业有限公司 一种三氮唑类似物化合物及其制备方法和应用
CN120794964A (zh) * 2025-07-03 2025-10-17 广州绿十字制药股份有限公司 泊沙康唑脂肪酸酯、泊沙康唑脂肪酸酯脂肪乳及其制备方法

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Also Published As

Publication number Publication date
NO2006002I2 (no) 2011-03-07
DE122006000004I2 (de) 2007-03-29
PL315169A1 (en) 1996-10-14
HU9601709D0 (en) 1996-08-28
CZ180596A3 (en) 1997-01-15
CA2179396A1 (en) 1995-06-29
DE122006000004I1 (de) 2006-04-27
CN1142828A (zh) 1997-02-12
ES2159623T3 (es) 2001-10-16
PL181193B1 (pl) 2001-06-29
NL300219I1 (nl) 2006-04-03
FR06C0009I2 (de) 2006-12-29
CN1064685C (zh) 2001-04-18
MY130217A (en) 2007-06-29
CZ294823B6 (cs) 2005-03-16
TW377349B (en) 1999-12-21
ZA9410142B (en) 1996-05-02
HK1008820A1 (en) 1999-05-21
DK0736030T3 (da) 2001-10-29
JP2834889B2 (ja) 1998-12-14
HUT75879A (en) 1997-05-28
BR1100154B1 (pt) 2013-11-26
EP0736030A1 (de) 1996-10-09
NZ278713A (en) 1997-12-19
FI118470B (fi) 2007-11-30
FI962577A0 (fi) 1996-06-20
EP0736030B1 (de) 2001-08-29
AU681753B2 (en) 1997-09-04
DE69428125T2 (de) 2002-05-02
HU225062B1 (en) 2006-05-29
NO316173B1 (no) 2003-12-22
FR06C0009I1 (de) 2006-05-19
LU91216I2 (en) 2006-03-27
NO2006002I1 (no) 2006-02-20
JPH09500658A (ja) 1997-01-21
WO1995017407A1 (en) 1995-06-29
NO962616D0 (no) 1996-06-20
SK82696A3 (en) 1997-03-05
NL300219I2 (nl) 2006-05-01
FI962577L (fi) 1996-06-20
CO4520281A1 (es) 1997-10-15
IL112081A0 (en) 1995-03-15
KR0179990B1 (en) 1999-03-20
NO962616L (no) 1996-08-07
SK283035B6 (sk) 2003-02-04
CA2179396C (en) 2001-04-17
AU1512795A (en) 1995-07-10
PT736030E (pt) 2002-01-30
DE69428125D1 (de) 2001-10-04
IL112081A (en) 2001-08-26

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