ATE204875T1 - Fungizide tetrahydrofurane - Google Patents
Fungizide tetrahydrofuraneInfo
- Publication number
- ATE204875T1 ATE204875T1 AT95906620T AT95906620T ATE204875T1 AT E204875 T1 ATE204875 T1 AT E204875T1 AT 95906620 T AT95906620 T AT 95906620T AT 95906620 T AT95906620 T AT 95906620T AT E204875 T1 ATE204875 T1 AT E204875T1
- Authority
- AT
- Austria
- Prior art keywords
- independently
- tetrahydrofuranes
- fungicidal
- ester
- polyestherester
- Prior art date
Links
- 230000000855 fungicidal effect Effects 0.000 title 1
- 150000007984 tetrahydrofuranes Chemical class 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- -1 phosphate ester Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Dental Preparations (AREA)
- Lubricants (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17108393A | 1993-12-21 | 1993-12-21 | |
| PCT/US1994/014236 WO1995017407A1 (en) | 1993-12-21 | 1994-12-20 | Tetrahydrofuran antifungals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204875T1 true ATE204875T1 (de) | 2001-09-15 |
Family
ID=22622452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95906620T ATE204875T1 (de) | 1993-12-21 | 1994-12-20 | Fungizide tetrahydrofurane |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0736030B1 (de) |
| JP (1) | JP2834889B2 (de) |
| KR (1) | KR0179990B1 (de) |
| CN (1) | CN1064685C (de) |
| AT (1) | ATE204875T1 (de) |
| AU (1) | AU681753B2 (de) |
| BR (1) | BR1100154B1 (de) |
| CA (1) | CA2179396C (de) |
| CO (1) | CO4520281A1 (de) |
| CZ (1) | CZ294823B6 (de) |
| DE (2) | DE122006000004I2 (de) |
| DK (1) | DK0736030T3 (de) |
| ES (1) | ES2159623T3 (de) |
| FI (1) | FI118470B (de) |
| FR (1) | FR06C0009I2 (de) |
| HK (1) | HK1008820A1 (de) |
| HU (1) | HU225062B1 (de) |
| IL (1) | IL112081A (de) |
| LU (1) | LU91216I2 (de) |
| MY (1) | MY130217A (de) |
| NL (1) | NL300219I2 (de) |
| NO (2) | NO316173B1 (de) |
| NZ (1) | NZ278713A (de) |
| PL (1) | PL181193B1 (de) |
| PT (1) | PT736030E (de) |
| SK (1) | SK283035B6 (de) |
| TW (1) | TW377349B (de) |
| WO (1) | WO1995017407A1 (de) |
| ZA (1) | ZA9410142B (de) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ278882A (en) * | 1994-01-24 | 1997-06-24 | Janssen Pharmaceutica Nv | Piperazine-containing azole antifungal compounds |
| ATE240319T1 (de) * | 1995-06-02 | 2003-05-15 | Schering Corp | Antifungale tetrahydrofurane |
| WO1997000255A1 (en) * | 1995-06-19 | 1997-01-03 | Schering Corporation | Tetrahydrofuran antifungals |
| US5698557A (en) * | 1995-06-19 | 1997-12-16 | Schering Corporation | Hydroxy-substituted antifungals |
| AU716872B2 (en) * | 1995-12-20 | 2000-03-09 | Schering Corporation | Process for preparation of hydrazides |
| CA2255663C (en) * | 1996-05-24 | 2002-08-20 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5834472A (en) * | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| ATE273002T1 (de) * | 1996-06-28 | 2004-08-15 | Schering Corp | Feste lösung eines fungizids mit erhöhter bioverfügbarkeit |
| US5972381A (en) * | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
| US5846971A (en) * | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
| TR199802718T2 (xx) * | 1996-06-28 | 1999-03-22 | Schering Corporation | Bir triazol mantara kar�� bile�i�ini i�eren a��zdan al�nan bile�im. |
| CA2269608A1 (en) | 1996-11-12 | 1998-05-22 | Sepracor Inc. | 2r,4s,s,s- and 2s,4r,s,s-hydroxyitraconazole |
| EP0938484A1 (de) * | 1996-11-12 | 1999-09-01 | Sepracor, Inc. | 2r,4s,r,r- und 2s,4r,r,r-hydroxyitraconazol |
| JP2001504121A (ja) * | 1996-11-12 | 2001-03-27 | セプラコール，インク． | ２ｒ，４ｓ，ｒ，ｓ―および２ｓ，４ｒ，ｒ，ｓ―ヒドロキシイトラコナゾール―およびヒドロキシサパーコナゾール誘導体 |
| WO1998021203A1 (en) * | 1996-11-12 | 1998-05-22 | Sepracor, Inc. | 2r,4s,s,r- and 2s,4r,s,r-hydroxyitraconazole |
| US5684197A (en) * | 1996-12-12 | 1997-11-04 | Schering Corporation | Process for preparation of hydrazides |
| DE69824834T2 (de) * | 1997-02-11 | 2005-07-21 | Janssen Pharmaceutica N.V. | Azole enthaltende antifungale aminosäure-ester |
| US6043245A (en) * | 1997-09-25 | 2000-03-28 | Schering Corporation | Tetrahydrofuran antifungal phosphate |
| HUP0004616A3 (en) * | 1997-09-25 | 2002-04-29 | Schering Corp | Hydroxy ester of tetrahydrofurane derivative as prodrug for the corresponding antifungal agent |
| WO1999018111A1 (en) * | 1997-10-07 | 1999-04-15 | Schering Corporation | Crystalline antifungal glycine ester polymorph |
| PL189317B1 (pl) * | 1997-10-07 | 2005-07-29 | Schering Corp | Krystaliczny przeciwgrzybiczy polimorf (-)-4-[4-[4-[4-[(2R-cis)-5-(2,4-difluorofenylo)tetrahydro-5-(1H-1,2,4-triazol-1-ilo-metylo)furan-3-ilo]metoksy]fenylo]-1-piperazynylo]fenylo-2,4-dihydro-2-[(S)-1-etylo-2(S)-hydroksypropylo]-3H-1,2,4-triazol-3-onu |
| US6713481B1 (en) * | 1997-10-17 | 2004-03-30 | David R. Andrews | Crystalline antifungal polymorph |
| US5883097A (en) * | 1998-04-16 | 1999-03-16 | Schering Corporation | Soluble azole antifungal salt |
| EP0957101A1 (de) * | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Wasserlösliche Azole als Breitspektrum-antifungus |
| US6147077A (en) * | 1999-04-29 | 2000-11-14 | Sepracor Inc. | 2R,4S-hydroxyitraconazole isomers |
| EE200100575A (et) * | 1999-05-04 | 2003-02-17 | Janssen Pharmaceutica N.V. | Seentevastased eetrid, nende valmistamismeetod jakasutamine, kompositsioon ja selle valmistamismeetod |
| US6362172B2 (en) | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6448401B1 (en) | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
| EP1372394A1 (de) | 2001-04-03 | 2004-01-02 | Schering Corporation | Fungizide zusammensetzung mit verbesserter bioverfügbarkeit |
| US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| US7446107B2 (en) | 2002-02-15 | 2008-11-04 | Transform Pharmaceuticals, Inc. | Crystalline forms of conazoles and methods of making and using the same |
| US20030224006A1 (en) | 2002-03-01 | 2003-12-04 | Zaworotko Michael J. | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
| EP1511490A4 (de) | 2002-05-31 | 2009-03-11 | Transform Pharmaceuticals Inc | Neue kristalline conazol-formen und verwandte prozesse, pharmazeutische zusammensetzungen und verfahren |
| EP1515703A1 (de) | 2002-06-21 | 2005-03-23 | Transform Pharmaceuticals, Inc. | Pharmazeutische zusammensetzungen mit verbesserter auflösung |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| ITMI20032020A1 (it) * | 2003-10-17 | 2005-04-18 | Italfarmaco Spa | Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici |
| EP1776109B1 (de) * | 2004-08-13 | 2008-12-31 | Schering-Plough Ltd. | Pharmazeutische formulierungen mit einem antibiotikum, einem triazol und einem kortikosteroid |
| EP2130540A1 (de) * | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmazeutische Zusammensetzungen mit einer kristallinen Form von Posaconazol |
| EP2141159A1 (de) | 2008-07-03 | 2010-01-06 | Sandoz AG | Kristalline Form von Posaconazol |
| WO2011003992A1 (en) | 2009-07-09 | 2011-01-13 | Sandoz Ag | A crystalline form of posaconazole |
| WO2011158248A2 (en) * | 2010-05-12 | 2011-12-22 | Glenmark Generics Limited | Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole |
| CN102892750B (zh) * | 2010-05-19 | 2016-03-02 | 桑多斯股份公司 | 制备手性酰肼的方法 |
| WO2011144656A1 (en) * | 2010-05-19 | 2011-11-24 | Sandoz Ag | Preparation of posaconazole intermediates |
| AU2011254658B2 (en) * | 2010-05-19 | 2016-02-18 | Sandoz Ag | Purification of posaconazole and of posaconazole intermediates |
| WO2011144653A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Process for the preparation of chiral triazolones |
| PL3391890T3 (pl) | 2010-06-29 | 2021-12-20 | Merck Sharp & Dohme Corp. | Preparaty dożylnego roztworu pozakonazolu stabilizowane podstawioną beta-cyklodekstryną |
| CA2838051C (en) | 2011-06-16 | 2019-09-24 | Sandoz Ag | Process for the preparation of a chiral compound |
| EP2789610A1 (de) | 2013-04-10 | 2014-10-15 | Sandoz Ag | Reinigung von Posaconazol-Zwischenprodukten |
| MX370849B (es) * | 2013-07-25 | 2020-01-08 | Sandoz Ag | Proceso mejorado para preparar la forma cristalina iv del posaconazol. |
| ITMI20132114A1 (it) | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| CN105287403A (zh) * | 2014-08-02 | 2016-02-03 | 陕西合成药业股份有限公司 | 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途 |
| CN104370894A (zh) * | 2014-10-21 | 2015-02-25 | 江苏恒盛药业有限公司 | 无定型泊沙康唑的制备工艺 |
| WO2016087878A1 (en) | 2014-12-05 | 2016-06-09 | Pulmocide Limited | Antimycotic compound |
| DK3298006T3 (da) | 2015-05-21 | 2020-03-30 | Pulmocide Ltd | Antifungal 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorphenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-n-(2-hydroxycyclohexyl)benzamid eller et farmaceutisk acceptabelt salt deraf |
| CN106317032A (zh) * | 2015-06-15 | 2017-01-11 | 重庆圣华曦药业股份有限公司 | 一种制备高纯度的泊沙康唑的方法 |
| CN106432338A (zh) * | 2015-08-08 | 2017-02-22 | 陕西合成药业股份有限公司 | 泊沙康唑衍生物、合成和在长效制剂中的用途 |
| WO2017051342A1 (en) * | 2015-09-23 | 2017-03-30 | Biocon Limited | Crystalline forms of posaconazole intermediate and process for the preparation of amorphous posaconazole |
| CN105606736A (zh) * | 2016-01-27 | 2016-05-25 | 重庆华邦制药有限公司 | 分离测定泊沙康唑中间体z1及其有关物质的方法 |
| CN105949278B (zh) * | 2016-03-30 | 2019-12-06 | 南京曼杰生物科技有限公司 | 一种取代的四氢呋喃水溶性衍生物及其应用 |
| WO2017032908A1 (en) | 2016-07-08 | 2017-03-02 | Synthon B.V. | Pharmaceutical composition comprising amorphous posaconazole |
| US11185548B2 (en) | 2016-12-23 | 2021-11-30 | Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases |
| TR201620462A2 (tr) | 2016-12-31 | 2018-07-23 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
| CN106967054A (zh) * | 2017-03-30 | 2017-07-21 | 成都绿林科技有限公司 | 一种泊沙康唑的制备方法 |
| CN106883221A (zh) * | 2017-04-17 | 2017-06-23 | 兰州大学 | 一种无定形泊沙康唑及其制备方法 |
| CN108341754A (zh) * | 2018-03-12 | 2018-07-31 | 扬子江药业集团有限公司 | 泊沙康唑杂质及其制备方法和用途 |
| CN110938093B (zh) * | 2018-09-21 | 2022-08-19 | 华创合成制药股份有限公司 | 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途 |
| CN112778369B (zh) * | 2019-11-05 | 2024-01-26 | 华创合成制药股份有限公司 | 一种三唑类衍生物及其制备方法和用途 |
| CN113666915B (zh) * | 2021-08-27 | 2022-08-16 | 江苏海洋大学 | 一种泊沙康唑中间体的制备方法 |
| CN114315811B (zh) * | 2021-11-19 | 2024-04-30 | 江苏恒盛药业有限公司 | 一种三氮唑类似物化合物及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4218458A (en) * | 1978-06-23 | 1980-08-19 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| CA1292472C (en) * | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| EP0318214B1 (de) * | 1987-11-20 | 1994-12-14 | Schering Corporation | Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte |
| US5039676A (en) * | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| IL103558A0 (en) * | 1991-10-30 | 1993-03-15 | Schering Corp | Tri-substituted tetrahydrofuran antifungals |
-
1994
- 1994-12-20 AU AU15127/95A patent/AU681753B2/en not_active Expired
- 1994-12-20 PL PL94315169A patent/PL181193B1/pl unknown
- 1994-12-20 TW TW083111949A patent/TW377349B/zh not_active IP Right Cessation
- 1994-12-20 DE DE1994628125 patent/DE122006000004I2/de active Active
- 1994-12-20 ES ES95906620T patent/ES2159623T3/es not_active Expired - Lifetime
- 1994-12-20 ZA ZA9410142A patent/ZA9410142B/xx unknown
- 1994-12-20 EP EP95906620A patent/EP0736030B1/de not_active Expired - Lifetime
- 1994-12-20 NZ NZ278713A patent/NZ278713A/en not_active IP Right Cessation
- 1994-12-20 CN CN94195025A patent/CN1064685C/zh not_active Expired - Lifetime
- 1994-12-20 AT AT95906620T patent/ATE204875T1/de active
- 1994-12-20 PT PT95906620T patent/PT736030E/pt unknown
- 1994-12-20 MY MYPI94003426A patent/MY130217A/en unknown
- 1994-12-20 CZ CZ19961805A patent/CZ294823B6/cs not_active IP Right Cessation
- 1994-12-20 SK SK826-96A patent/SK283035B6/sk not_active IP Right Cessation
- 1994-12-20 IL IL11208194A patent/IL112081A/xx active Protection Beyond IP Right Term
- 1994-12-20 DK DK95906620T patent/DK0736030T3/da active
- 1994-12-20 HU HU9601709A patent/HU225062B1/hu active Protection Beyond IP Right Term
- 1994-12-20 DE DE69428125T patent/DE69428125T2/de not_active Expired - Lifetime
- 1994-12-20 CA CA002179396A patent/CA2179396C/en not_active Expired - Lifetime
- 1994-12-20 CO CO94057442A patent/CO4520281A1/es unknown
- 1994-12-20 JP JP7517469A patent/JP2834889B2/ja not_active Expired - Lifetime
- 1994-12-20 WO PCT/US1994/014236 patent/WO1995017407A1/en active IP Right Grant
-
1996
- 1996-06-20 NO NO19962616A patent/NO316173B1/no not_active IP Right Cessation
- 1996-06-20 FI FI962577A patent/FI118470B/fi not_active IP Right Cessation
- 1996-06-21 KR KR1019960703319A patent/KR0179990B1/ko not_active IP Right Cessation
-
1997
- 1997-03-06 BR BR1100154A patent/BR1100154B1/pt unknown
-
1998
- 1998-07-29 HK HK98109516A patent/HK1008820A1/xx not_active IP Right Cessation
-
2006
- 2006-01-27 LU LU91216C patent/LU91216I2/en unknown
- 2006-02-01 NL NL300219C patent/NL300219I2/nl unknown
- 2006-02-10 NO NO2006002C patent/NO2006002I2/no unknown
- 2006-03-13 FR FR06C0009C patent/FR06C0009I2/fr active Active
Also Published As
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|---|---|---|
| ATE204875T1 (de) | Fungizide tetrahydrofurane | |
| ATE306261T1 (de) | Antithrombosemittel | |
| IL133623A0 (en) | Antithrombotic agents | |
| EA199600104A1 (ru) | Повышенная биодоступность биологически активных соединений при связывании с производными полипирролкарбоксамидонафталиновой кислоты | |
| MX9701229A (es) | Antifungicos de tetrahidrofurano. | |
| ATE247108T1 (de) | Antifungale tetrahydrofurane | |
| AU8226891A (en) | Benzopyran derivative, production thereof, and pharmaceutical composition containing the same | |
| AU8889998A (en) | Water soluble analogs and prodrugs of paclitaxel | |
| ES2140531T3 (es) | Inhibidor de la interleucina-1. | |
| DE69528984D1 (de) | Hemmung der leukotrienbiosynthese mittels harnstoffderivaten | |
| AR003437A1 (es) | Un compuesto antifungico de tetrahidrofurano, una composicion farmaceutica que los contiene, su uso para preparar un medicamento antifungico y una sal deester aminoacido del mismo |