ATE306261T1 - Antithrombosemittel - Google Patents
AntithrombosemittelInfo
- Publication number
- ATE306261T1 ATE306261T1 AT98932911T AT98932911T ATE306261T1 AT E306261 T1 ATE306261 T1 AT E306261T1 AT 98932911 T AT98932911 T AT 98932911T AT 98932911 T AT98932911 T AT 98932911T AT E306261 T1 ATE306261 T1 AT E306261T1
- Authority
- AT
- Austria
- Prior art keywords
- antithrombotic agents
- compound
- prodrug
- inhibitor
- factor
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229960004676 antithrombotic agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5088197P | 1997-06-26 | 1997-06-26 | |
| PCT/US1998/013384 WO1999000126A1 (en) | 1997-06-26 | 1998-06-26 | Antithrombotic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE306261T1 true ATE306261T1 (de) | 2005-10-15 |
Family
ID=21968062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98932911T ATE306261T1 (de) | 1997-06-26 | 1998-06-26 | Antithrombosemittel |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6313151B1 (de) |
| EP (1) | EP0999834B1 (de) |
| JP (1) | JP2002506462A (de) |
| AT (1) | ATE306261T1 (de) |
| AU (1) | AU8269398A (de) |
| CA (1) | CA2295153A1 (de) |
| DE (1) | DE69831868T2 (de) |
| ES (1) | ES2248911T3 (de) |
| IL (1) | IL133627A0 (de) |
| WO (1) | WO1999000126A1 (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1007037A4 (de) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | Antithrombose mittel |
| EP1014962A4 (de) | 1997-06-26 | 2007-06-27 | Lilly Co Eli | Antitrombotische mitteln |
| AU8270298A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
| US6689780B1 (en) | 1998-12-23 | 2004-02-10 | Eli Lilly And Company | Heteroroaromatic amides as inhibitor of factor Xa |
| DE69931393T2 (de) | 1998-12-23 | 2007-03-29 | Eli Lilly And Co., Indianapolis | Antithrombotische amide |
| EP1140903B1 (de) | 1998-12-23 | 2004-08-04 | Eli Lilly And Company | Aromatische amiden |
| DE69915687T2 (de) | 1998-12-24 | 2005-02-10 | Eli Lilly And Co., Indianapolis | Heterocyclische amide als inhibitoren von faktor xa |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| EP1178964A1 (de) * | 1999-05-19 | 2002-02-13 | Pharmacia Corporation | Substituierte polyzyclische aryl und heteroaryl pyridone, verwendbar zur selektiven hemmung der blutgerinnungskaskade |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| US6720317B1 (en) | 1999-09-17 | 2004-04-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6376515B2 (en) | 2000-02-29 | 2002-04-23 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor Xa |
| US6660885B2 (en) | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| AU776053B2 (en) * | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| US6693121B2 (en) | 2000-04-05 | 2004-02-17 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| PT1268463E (pt) | 2000-04-05 | 2005-05-31 | Pharmacia Corp | 4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao |
| TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| EP1274676A2 (de) | 2000-04-17 | 2003-01-15 | Pharmacia Corporation | Polycyclische aryl- und heteroaryl- substuierte 1,4-chinone zur selektiven hemmung des blutgerinnungsprozesses |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| WO2002010154A2 (en) | 2000-07-27 | 2002-02-07 | Eli Lilly And Company | Substituted heterocyclic amides |
| WO2002014308A1 (en) | 2000-08-17 | 2002-02-21 | Eli Lilly And Company | Antithrombotic agents |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| CA2430037A1 (en) | 2000-11-20 | 2002-05-30 | Michael S. South | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| CN1283626C (zh) | 2000-11-22 | 2006-11-08 | 安斯泰来制药有限公司 | 取代苯衍生物或其盐 |
| WO2002064567A2 (en) | 2000-11-28 | 2002-08-22 | Eli Lilly And Company | Substituted carboxamides as inhibitors of factor xa |
| US6878714B2 (en) * | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US20030134836A1 (en) * | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| US6998408B2 (en) | 2001-03-23 | 2006-02-14 | Bristol-Myers Squibb Pharma Company | 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors |
| WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| JP2005519866A (ja) | 2001-10-03 | 2005-07-07 | ファルマシア・コーポレーション | 凝固カスケードの選択阻害に有用な６員複素環式化合物 |
| JP2005525413A (ja) | 2001-10-03 | 2005-08-25 | ファルマシア・コーポレーション | 凝固カスケードの選択的抑制に有用な置換５員多環状化合物 |
| AU2002350172A1 (en) | 2001-12-07 | 2003-06-23 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| US7307088B2 (en) * | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| HUE025683T2 (hu) | 2002-12-03 | 2016-04-28 | Pharmacyclics Llc | VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok |
| DE602004011064T2 (de) * | 2003-05-30 | 2008-12-11 | Eli Lilly And Co., Indianapolis | Antitrombotische aether |
| EP1670783A2 (de) * | 2003-09-30 | 2006-06-21 | Eli Lilly And Company | Aromatische ether mit antithrombotischer wirkung |
| US7700628B2 (en) | 2004-11-24 | 2010-04-20 | Eli Lilly And Company | Aromatic ether derivatives useful as thrombin inhibitors |
| DE602005016297D1 (de) * | 2004-11-29 | 2009-10-08 | Lilly Co Eli | Antithrombotische diamide |
| US7264402B2 (en) * | 2005-03-10 | 2007-09-04 | Corning Cable Systems Llc | Multi-fiber optic receptacle and plug assembly |
| US8247556B2 (en) * | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| JP4884072B2 (ja) * | 2006-05-12 | 2012-02-22 | 三井化学アグロ株式会社 | 複素環誘導体ならびにその殺虫剤としての使用方法 |
| ES2382055T3 (es) | 2006-11-02 | 2012-06-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa |
| MX2022000133A (es) | 2019-07-01 | 2022-04-27 | Tonix Pharma Ltd | Anticuerpos anti-cd154 y usos de los mismos. |
| WO2022150452A1 (en) | 2021-01-06 | 2022-07-14 | Seth Lederman | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
| WO2025248134A1 (en) | 2024-05-31 | 2025-12-04 | Tonix Pharma Limited | Treatment methods comprising administration of modified cd154 antibodies |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2927988A1 (de) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel |
| US5518725A (en) | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
| AU8868991A (en) | 1990-11-15 | 1992-06-11 | Pentapharm Ag | Meta-substituted phenyl alanine derivatives |
| EP0684830B1 (de) * | 1993-02-12 | 1999-06-16 | Corvas International, Inc. | Inhibitoren gegen thrombose |
| US5721214A (en) * | 1995-06-07 | 1998-02-24 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
| US6264958B1 (en) | 1996-07-25 | 2001-07-24 | The Johns Hopkins University | Genes of kaposi's sarcoma associated herpesvirus |
| EP1007037A4 (de) * | 1997-06-26 | 2004-10-06 | Lilly Co Eli | Antithrombose mittel |
| EP1014962A4 (de) | 1997-06-26 | 2007-06-27 | Lilly Co Eli | Antitrombotische mitteln |
| AU8270298A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
| US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| PT1040108E (pt) | 1997-12-19 | 2004-06-30 | Schering Ag | Derivados de orto-antranilamida como anticoagulantes |
| EP0937711A1 (de) | 1998-02-18 | 1999-08-25 | Roche Diagnostics GmbH | Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
| EP1140903B1 (de) | 1998-12-23 | 2004-08-04 | Eli Lilly And Company | Aromatische amiden |
| ES2196917T3 (es) | 1998-12-23 | 2003-12-16 | Lilly Co Eli | Amidas heteroaromaticas como inhibidores del factor xa`. |
| DE69931393T2 (de) | 1998-12-23 | 2007-03-29 | Eli Lilly And Co., Indianapolis | Antithrombotische amide |
| DE69915687T2 (de) | 1998-12-24 | 2005-02-10 | Eli Lilly And Co., Indianapolis | Heterocyclische amide als inhibitoren von faktor xa |
-
1998
- 1998-06-26 AT AT98932911T patent/ATE306261T1/de not_active IP Right Cessation
- 1998-06-26 DE DE69831868T patent/DE69831868T2/de not_active Expired - Fee Related
- 1998-06-26 US US09/445,973 patent/US6313151B1/en not_active Expired - Fee Related
- 1998-06-26 EP EP98932911A patent/EP0999834B1/de not_active Expired - Lifetime
- 1998-06-26 IL IL13362798A patent/IL133627A0/xx unknown
- 1998-06-26 ES ES98932911T patent/ES2248911T3/es not_active Expired - Lifetime
- 1998-06-26 WO PCT/US1998/013384 patent/WO1999000126A1/en not_active Ceased
- 1998-06-26 AU AU82693/98A patent/AU8269398A/en not_active Abandoned
- 1998-06-26 CA CA002295153A patent/CA2295153A1/en not_active Abandoned
- 1998-06-26 JP JP50580999A patent/JP2002506462A/ja active Pending
-
2001
- 2001-09-28 US US09/967,203 patent/US6586459B2/en not_active Expired - Fee Related
- 2001-09-28 US US09/967,054 patent/US6583173B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6583173B2 (en) | 2003-06-24 |
| US20020072531A1 (en) | 2002-06-13 |
| JP2002506462A (ja) | 2002-02-26 |
| ES2248911T3 (es) | 2006-03-16 |
| CA2295153A1 (en) | 1999-01-07 |
| US6313151B1 (en) | 2001-11-06 |
| EP0999834A1 (de) | 2000-05-17 |
| US20020049234A1 (en) | 2002-04-25 |
| WO1999000126A1 (en) | 1999-01-07 |
| DE69831868D1 (en) | 2006-02-23 |
| DE69831868T2 (de) | 2006-07-13 |
| US6586459B2 (en) | 2003-07-01 |
| AU8269398A (en) | 1999-01-19 |
| EP0999834A4 (de) | 2001-04-04 |
| IL133627A0 (en) | 2001-04-30 |
| EP0999834B1 (de) | 2005-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |