PE120499A1 - Polimorfo antifungico cristalino - Google Patents

Polimorfo antifungico cristalino

Info

Publication number
PE120499A1
PE120499A1 PE1998000942A PE00094298A PE120499A1 PE 120499 A1 PE120499 A1 PE 120499A1 PE 1998000942 A PE1998000942 A PE 1998000942A PE 00094298 A PE00094298 A PE 00094298A PE 120499 A1 PE120499 A1 PE 120499A1
Authority
PE
Peru
Prior art keywords
crystalline polymorph
antifungal
fenil
triazol
hydroxylpropil
Prior art date
Application number
PE1998000942A
Other languages
English (en)
Inventor
R Andrews David
Leong William
Sudhakar Anantha
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE120499A1 publication Critical patent/PE120499A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

SE REFIERE A LA FORMA 1 DEL POLIMORFO CRISTALINO DE (-)-4-[4-[4-[4-[[(2R-CIS)-5-(2,4-DIFLUOROFENIL)TETRAHIDRO-5-(1H-1,2,4-TRIAZOL-1-ILMETIL)FURAN-3-IL]METOXI]FENIL]-1-PIPERAZINIL]FENIL-2,4-DIHIDRO-2-[(S)-1-ETIL-2(S)-HIDROXILPROPIL]-3H-1,2,4-TRIAZOL-3-ONA, DE FORMULA I; QUE SE CARACTERIZA POR SUS PROPIEDADES FISICAS COMO a)PATRON DE DIFRACCION DE RAYOS X; b)ESPECTRO INFRARROJO. EL POLIMORFO CRISTALINO PUEDE SER UTIL PARA TRATAR INFECCIONES FUNGICAS EN MAMIFEROS
PE1998000942A 1997-10-07 1998-10-05 Polimorfo antifungico cristalino PE120499A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94618397A 1997-10-07 1997-10-07

Publications (1)

Publication Number Publication Date
PE120499A1 true PE120499A1 (es) 1999-12-04

Family

ID=25484068

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000942A PE120499A1 (es) 1997-10-07 1998-10-05 Polimorfo antifungico cristalino

Country Status (31)

Country Link
EP (1) EP1021439B1 (es)
JP (4) JP2001519346A (es)
KR (1) KR100626109B1 (es)
CN (1) CN1125067C (es)
AR (1) AR015947A1 (es)
AT (1) ATE263163T1 (es)
AU (1) AU759982B2 (es)
BR (1) BR9812866A (es)
CA (1) CA2305803C (es)
CO (1) CO4970829A1 (es)
CZ (1) CZ299835B6 (es)
DE (1) DE69822859T2 (es)
DK (1) DK1021439T3 (es)
ES (1) ES2217594T3 (es)
HK (1) HK1029588A1 (es)
HU (1) HU225233B1 (es)
ID (1) ID29290A (es)
IL (1) IL135331A (es)
IN (1) IN1998CH02232A (es)
MX (1) MX225999B (es)
MY (1) MY130126A (es)
NO (1) NO318827B1 (es)
NZ (1) NZ503662A (es)
PE (1) PE120499A1 (es)
PH (1) PH11998002606B1 (es)
PL (1) PL189317B1 (es)
PT (1) PT1021439E (es)
SK (1) SK285190B6 (es)
TW (1) TW589310B (es)
WO (1) WO1999018097A1 (es)
ZA (1) ZA989063B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2130540A1 (en) 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) * 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
CA2767489A1 (en) 2009-07-09 2011-01-13 Sandoz Ag A crystalline form of posaconazole
EP2571871B1 (en) * 2010-05-19 2017-06-21 Sandoz AG Process for the preparation of chiral triazolones
EP2571868B1 (en) 2010-05-19 2016-05-04 Sandoz AG Preparation of posaconazole intermediates
MX337804B (es) 2010-05-19 2016-03-18 Sandoz Ag Proceso para la preparacion de hidrazinas quirales.
MX2012013331A (es) 2010-05-19 2013-02-01 Sandoz Ag Purificacion de posaconazol y de intermediarios de posaconazol.
WO2012172015A1 (en) 2011-06-16 2012-12-20 Sandoz Ag Process for the preparation of a chiral compound
WO2013042138A2 (en) 2011-09-19 2013-03-28 Msn Laboratories Limited Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof
WO2015011224A1 (en) * 2013-07-25 2015-01-29 Sandoz Ag Improved process for the preparation of crystalline form iv of posaconazole
ITMI20132118A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132114A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132117A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132115A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
CN104387374A (zh) * 2014-10-21 2015-03-04 江苏恒盛药业有限公司 泊沙康唑晶型i的制备工艺
MX2017005120A (es) 2014-10-21 2018-02-12 Ariad Pharma Inc Formas cristalinas de 5-cloro-n4-[-2-(dimetilfosforil) fenil]-n2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il] pirimidin-2,4-diamina.
ES2759801T3 (es) 2015-08-08 2020-05-12 Tiefenbacher Alfred E Gmbh & Co Kg Formulación gastro-resistente que contiene posaconazol
CN108473467B (zh) 2015-12-24 2021-08-13 武田药品工业株式会社 共结晶、其制造方法及含有共结晶的药物
EP3210599A1 (en) 2016-02-26 2017-08-30 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
TR201722493A2 (tr) 2017-12-28 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon
EP4196096A1 (en) 2020-08-13 2023-06-21 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant high-strength formulation containing posaconazole
WO2023012378A1 (en) 2021-11-25 2023-02-09 Alfred E. Tiefenbacher (Gmbh Und Co. Kg) Granules containing posaconazole
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
CN1064685C (zh) * 1993-12-21 2001-04-18 先灵公司 四氢呋喃抗真菌剂
PT741737E (pt) * 1994-01-24 2000-04-28 Janssen Pharmaceutica Nv Antifungicos do tipo azole soluveis em agua
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
IL118464A (en) * 1995-06-02 2000-08-13 Schering Corp (2R-cis)-4-¬4-¬4-¬4¬¬-5-(2',4 dihalophenyl)-tetrahydro-5-(1-H-1,2,4,triazol-1-yl-methyl)furan-3-yl(methoxy¾phenyl¾-1-piperazinyl¬phenyl2,4,dihydro2¬(5)-1-ethyl-2-(5)hydroxy propyl¾-3H-1,2,4-triazol-3-one and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
ID29290A (id) 2001-08-16
CA2305803C (en) 2009-12-22
JP2001519346A (ja) 2001-10-23
NO20001779D0 (no) 2000-04-06
CA2305803A1 (en) 1999-04-15
AU9780398A (en) 1999-04-27
TW589310B (en) 2004-06-01
MXPA00003404A (es) 2000-11-01
NO20001779L (no) 2000-06-06
KR100626109B1 (ko) 2006-09-20
KR20010030959A (ko) 2001-04-16
IN1998CH02232A (es) 2005-03-04
IL135331A (en) 2005-08-31
EP1021439B1 (en) 2004-03-31
PH11998002606B1 (en) 2006-08-10
HK1029588A1 (en) 2001-04-06
EP1021439A1 (en) 2000-07-26
NZ503662A (en) 2002-10-25
IL135331A0 (en) 2001-05-20
DE69822859D1 (de) 2004-05-06
ATE263163T1 (de) 2004-04-15
CN1281449A (zh) 2001-01-24
NO318827B1 (no) 2005-05-09
SK285190B6 (sk) 2006-08-03
PL189317B1 (pl) 2005-07-29
SK5122000A3 (en) 2000-09-12
DK1021439T3 (da) 2004-05-10
AR015947A1 (es) 2001-05-30
ZA989063B (en) 1999-04-06
CZ20001264A3 (cs) 2000-08-16
JP2012153730A (ja) 2012-08-16
BR9812866A (pt) 2000-08-08
CN1125067C (zh) 2003-10-22
WO1999018097A1 (en) 1999-04-15
PT1021439E (pt) 2004-07-30
HUP0004899A2 (hu) 2002-02-28
JP2008106075A (ja) 2008-05-08
AU759982B2 (en) 2003-05-01
ES2217594T3 (es) 2004-11-01
HU225233B1 (en) 2006-08-28
CO4970829A1 (es) 2000-11-07
HUP0004899A3 (en) 2002-03-28
PL339659A1 (en) 2001-01-02
MY130126A (en) 2007-06-29
CZ299835B6 (cs) 2008-12-10
DE69822859T2 (de) 2005-01-27
JP2012153729A (ja) 2012-08-16
MX225999B (es) 2005-02-02

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