BR0210701A - Derivados de halofenila intermediária e seu uso em um processo para a preparação de derivados de azol - Google Patents

Derivados de halofenila intermediária e seu uso em um processo para a preparação de derivados de azol

Info

Publication number
BR0210701A
BR0210701A BR0210701-5A BR0210701A BR0210701A BR 0210701 A BR0210701 A BR 0210701A BR 0210701 A BR0210701 A BR 0210701A BR 0210701 A BR0210701 A BR 0210701A
Authority
BR
Brazil
Prior art keywords
sup
derivatives
halophenyl
preparation
halogen
Prior art date
Application number
BR0210701-5A
Other languages
English (en)
Inventor
Milan Soukup
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of BR0210701A publication Critical patent/BR0210701A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

"DERIVADOS DE HALOFENILA INTERMEDIáRIA E SEU USO EM UM PROCESSO PARA A PREPARAçãO DE DERIVADOS DE AZOL". A presente invenção refere-se à descrição de derivados de halofenila da fórmula geral (1), em que R^ 1^ é halogênio, um grupo de saída ou 1H-1,2,4-triazol-1-ila e R^ 2^ é etinila ou carbóxi, X^ 1^ é halogênio e X^ 2^ e X^ 3^ são cada independentemente hidrogênio ou halogênio, e a sua fabricação. Eles são intermediários para a fabricação de derivados de azol da fórmula geral (V) que são valiosos medicamentos úteis para o tratamento de micoses sistêmicas.
BR0210701-5A 2001-06-26 2002-06-17 Derivados de halofenila intermediária e seu uso em um processo para a preparação de derivados de azol BR0210701A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01115355 2001-06-26
PCT/EP2002/006644 WO2003002498A1 (en) 2001-06-26 2002-06-17 Intermediate halophenyl derivatives and their use in a process for preparing azole derivatives

Publications (1)

Publication Number Publication Date
BR0210701A true BR0210701A (pt) 2004-07-20

Family

ID=8177821

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0210701-5A BR0210701A (pt) 2001-06-26 2002-06-17 Derivados de halofenila intermediária e seu uso em um processo para a preparação de derivados de azol

Country Status (17)

Country Link
US (1) US7115643B2 (pt)
EP (1) EP1399402B1 (pt)
JP (1) JP4125672B2 (pt)
KR (1) KR100898887B1 (pt)
CN (1) CN1223564C (pt)
AT (1) ATE482920T1 (pt)
AU (1) AU2002321068B2 (pt)
BR (1) BR0210701A (pt)
CA (1) CA2449800C (pt)
CY (1) CY1111510T1 (pt)
DE (1) DE60237817D1 (pt)
DK (1) DK1399402T3 (pt)
ES (1) ES2349918T3 (pt)
MX (1) MXPA03010914A (pt)
PT (1) PT1399402E (pt)
WO (1) WO2003002498A1 (pt)
ZA (1) ZA200309101B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207352B2 (en) * 2009-10-08 2012-06-26 Drug Process Licensing Associates LLC Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
CA2878361C (en) * 2012-08-07 2020-09-22 Basilea Pharmaceutica Ag Process for the manufacture of isavuconazole or ravuconazole
US20140371179A1 (en) * 2013-06-13 2014-12-18 Professional Compounding Centers Of America Methods and Compositions for Treating Esophageal Diseases
CN105801500B (zh) * 2014-12-31 2018-08-24 四川科伦药物研究院有限公司 拆分艾沙康唑中间化合物消旋体的方法
CN115611822B (zh) * 2022-10-12 2023-09-19 四川澄华生物科技有限公司 艾沙康唑中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395942A (en) * 1980-06-02 1995-03-07 Zeneca Limited Heterocyclic compounds
DE3942790A1 (de) * 1989-12-23 1991-06-27 Hoechst Ag Verfahren zur herstellung von 2-(4-chlorphenyl)-3-methylbuttersaeure
GB9107055D0 (en) * 1991-04-04 1991-05-22 Pfizer Ltd Triazole antifungal agents
JP3471831B2 (ja) * 1991-12-09 2003-12-02 富山化学工業株式会社 新規なトリアゾール誘導体およびその塩
ES2062941B1 (es) 1993-03-15 1995-10-01 Uriach & Cia Sa J Nuevos derivados de azol activos por via oral.
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions

Also Published As

Publication number Publication date
ATE482920T1 (de) 2010-10-15
JP4125672B2 (ja) 2008-07-30
DE60237817D1 (de) 2010-11-11
EP1399402A1 (en) 2004-03-24
DK1399402T3 (da) 2010-11-15
JP2004535444A (ja) 2004-11-25
US20040176432A1 (en) 2004-09-09
US7115643B2 (en) 2006-10-03
EP1399402B1 (en) 2010-09-29
KR20040012982A (ko) 2004-02-11
WO2003002498A1 (en) 2003-01-09
ES2349918T3 (es) 2011-01-13
CN1223564C (zh) 2005-10-19
MXPA03010914A (es) 2004-02-17
CA2449800C (en) 2009-09-29
KR100898887B1 (ko) 2009-05-21
CN1520390A (zh) 2004-08-11
AU2002321068B2 (en) 2007-11-15
PT1399402E (pt) 2010-11-30
CY1111510T1 (el) 2015-08-05
CA2449800A1 (en) 2003-01-09
ZA200309101B (en) 2005-03-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 15A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]