MY137535A - New pyrrolidinium derivatives - Google Patents

New pyrrolidinium derivatives

Info

Publication number
MY137535A
MY137535A MYPI20031408A MYPI20031408A MY137535A MY 137535 A MY137535 A MY 137535A MY PI20031408 A MYPI20031408 A MY PI20031408A MY PI20031408 A MYPI20031408 A MY PI20031408A MY 137535 A MY137535 A MY 137535A
Authority
MY
Malaysia
Prior art keywords
new
pyrrolidinium derivatives
derivatives
new pyrrolidinium
antagonists
Prior art date
Application number
MYPI20031408A
Inventor
Prat Quinones Maria
Fernandez Forner Maria Dolors
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Lab filed Critical Almirall Lab
Publication of MY137535A publication Critical patent/MY137535A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

NEW PYRROLIDINIUM DERIVATIVES HAVING THE CHEMICAL STRUCTURE OF GENERAL FORMULA (1)ARE DISCLOSED; AS WELL AS PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THERAPY AS ANTAGONISTS OF M3 MUSCARINIC RECEPTORS.
MYPI20031408A 2002-04-16 2003-04-15 New pyrrolidinium derivatives MY137535A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200200889A ES2206021B1 (en) 2002-04-16 2002-04-16 NEW DERIVATIVES OF PIRROLIDINIO.

Publications (1)

Publication Number Publication Date
MY137535A true MY137535A (en) 2009-02-27

Family

ID=29225796

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20031408A MY137535A (en) 2002-04-16 2003-04-15 New pyrrolidinium derivatives

Country Status (21)

Country Link
US (2) US7192978B2 (en)
EP (1) EP1497284A2 (en)
CN (1) CN100548978C (en)
AR (1) AR039412A1 (en)
AU (1) AU2003233967B2 (en)
BR (1) BR0309167A (en)
CA (1) CA2482536A1 (en)
CO (1) CO5611106A2 (en)
ES (1) ES2206021B1 (en)
IL (1) IL164522A0 (en)
MX (1) MXPA04010076A (en)
MY (1) MY137535A (en)
NO (1) NO20044826L (en)
NZ (1) NZ535884A (en)
PE (1) PE20040409A1 (en)
RU (1) RU2320657C2 (en)
TW (1) TW200403237A (en)
UA (1) UA79283C2 (en)
UY (1) UY27760A1 (en)
WO (1) WO2003087094A2 (en)
ZA (1) ZA200408335B (en)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
AR044519A1 (en) 2003-05-02 2005-09-14 Novartis Ag DERIVATIVES OF PIRIDIN-TIAZOL AMINA AND PIRIMIDIN-TIAZOL AMINA
AR044851A1 (en) * 2003-06-24 2005-10-05 Novartis Ag HETEROCICLIC COMPOUNDS, MTA MUSCARINIC RECEIVER ANTAGONISTS
US20050026887A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a steroid
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
US20070179131A1 (en) * 2004-03-11 2007-08-02 Jian Jin Novel M3 Muscarinic Acetylcholine Receptor Antagonists
PE20060259A1 (en) 2004-04-27 2006-03-25 Glaxo Group Ltd QUINUCLIDINE COMPOUNDS AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
ES2257152B1 (en) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. COMBINATIONS THAT INCLUDE ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS.
MXPA06013850A (en) * 2004-05-31 2007-03-02 Almirall Lab Combinations comprising antimuscarinic agents and corticosteroids.
GT200500281A (en) 2004-10-22 2006-04-24 Novartis Ag ORGANIC COMPOUNDS.
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0428418D0 (en) * 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0428416D0 (en) * 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
TW200722418A (en) * 2005-04-20 2007-06-16 Astrazeneca Ab Novel compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
CA2618089A1 (en) * 2005-08-08 2007-02-15 Argenta Discovery Ltd. Bicyclo[2.2.]hept-7-ylamine derivatives and their uses
AR058104A1 (en) 2005-10-21 2008-01-23 Novartis Ag ORGANIC COMPOUNDS
EP1971572A1 (en) * 2005-12-16 2008-09-24 Argenta Discovery Limited Cyclic amine derivatives and their uses
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
PL2322525T3 (en) 2006-04-21 2014-03-31 Novartis Ag Purine derivatives for use as adenosin A2A receptor agonists
ES2298049B1 (en) * 2006-07-21 2009-10-20 Laboratorios Almirall S.A. PROCEDURE FOR MANUFACTURING BROMIDE OF 3 (R) - (2-HIDROXI-2,2-DITIEN-2-ILACETOXI) -1- (3-PHENOXIPROPIL) -1-AZONIABICICLO (2.2.2) OCTANO.
RU2009115954A (en) 2006-09-29 2010-11-10 Новартис АГ (CH) Pyrazolopyrimidines as P13K Lipid Kinase Inhibitors
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
WO2008075006A1 (en) * 2006-12-19 2008-06-26 Astrazeneca Ab Piperldinum compounds for treatment of obstructive pulmonary diseases ( copd)
EP2104535B9 (en) 2007-01-10 2011-06-15 Irm Llc Compounds and compositions as channel activating protease inhibitors
WO2008096094A1 (en) * 2007-02-06 2008-08-14 Argenta Discovery Ltd. Bicyclor[2.2.1]hept-7-ylamine derivatives as muscarinic m3 receptor modulators
AU2008218962B2 (en) * 2007-02-23 2013-03-14 Theravance Biopharma R&D Ip, Llc Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
AU2008248598B2 (en) 2007-05-07 2011-11-17 Novartis Ag Organic compounds
CN101796026B (en) * 2007-09-07 2013-10-23 施万制药 Guanidine-containing compounds useful as muscarinic receptor antagonists
CA2608561A1 (en) * 2007-10-29 2009-04-29 Carl Paluszkiewicz Motorcycle wind deflector accessory support
MX2010006421A (en) 2007-12-10 2010-06-25 Novartis Ag Organic compounds.
US8017617B2 (en) 2007-12-14 2011-09-13 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists
BRPI0906838A2 (en) 2008-01-11 2015-07-14 Novartis Ag Pyrimidines as kinase inhibitors
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
WO2009138707A1 (en) 2008-05-13 2009-11-19 Astrazeneca Ab Quinuclidine derivatives as muscarinic m3 receptor antagonists
AU2009256645A1 (en) 2008-06-10 2009-12-17 Novartis Ag Pyrazine derivatives as epithelial sodium channel blockers
DK2391366T3 (en) 2009-01-29 2013-01-07 Novartis Ag Substituted benzimidazoles for the treatment of astrocytomas
WO2010115937A1 (en) * 2009-04-09 2010-10-14 Novartis Ag Process for preparing pyrrolidinium salts
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
MX2012001838A (en) 2009-08-12 2012-02-29 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation.
AU2010284254B2 (en) 2009-08-17 2015-09-17 Intellikine, Llc Heterocyclic compounds and uses thereof
AU2010284972A1 (en) 2009-08-20 2012-03-08 Novartis Ag Heterocyclic oxime compounds
CA2777245A1 (en) 2009-10-22 2011-04-28 Vertex Pharmaceuticals Incorporated Compositions for treatment of cystic fibrosis and other chronic diseases
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
UY33597A (en) 2010-09-09 2012-04-30 Irm Llc COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF THE TRK
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
WO2012107500A1 (en) 2011-02-10 2012-08-16 Novartis Ag [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
US9127000B2 (en) 2011-02-23 2015-09-08 Intellikine, LLC. Heterocyclic compounds and uses thereof
EA201391230A1 (en) 2011-02-25 2014-01-30 АйАрЭм ЭлЭлСи COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
UY34305A (en) 2011-09-01 2013-04-30 Novartis Ag DERIVATIVES OF BICYCLIC HETEROCICLES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION
JP5957526B2 (en) 2011-09-15 2016-07-27 ノバルティス アーゲー 6-Substituted 3- (quinolin-6-ylthio)-[1,2,4] triazolo [4,3-A] pyrazine as tyrosine kinase
ES2882807T3 (en) 2011-09-16 2021-12-02 Novartis Ag N-substituted heterocyclyl carboxamides
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038386A1 (en) 2011-09-16 2013-03-21 Novartis Ag Heterocyclic compounds for the treatment of cystic fibrosis
EP2793893A4 (en) 2011-11-23 2015-07-08 Intellikine Llc Enhanced treatment regimens using mtor inhibitors
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
CN104245701A (en) 2012-04-03 2014-12-24 诺华有限公司 Combination products with tyrosine kinase inhibitors and their use
US9156833B2 (en) 2012-07-16 2015-10-13 Barry University, Inc. Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof
CN103965178B (en) * 2013-02-06 2018-03-02 中国药科大学 Purposes as the pyrrolidin derivatives of M3 muscarinic receptor antagonists and its in pharmacy
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
EP2968340A4 (en) 2013-03-15 2016-08-10 Intellikine Llc Combination of kinase inhibitors and uses thereof
WO2015084804A1 (en) 2013-12-03 2015-06-11 Novartis Ag Combination of mdm2 inhibitor and braf inhibitor and their use
US9862711B2 (en) 2014-04-24 2018-01-09 Novartis Ag Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
ES2761569T3 (en) 2014-04-24 2020-05-20 Novartis Ag Aminopyridine derivatives as phosphatidylinositol 3-kinase inhibitors
EA032075B1 (en) 2014-04-24 2019-04-30 Новартис Аг Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
CA2954862A1 (en) 2014-07-31 2016-02-04 Novartis Ag Combination therapy
CN105085355B (en) * 2015-06-25 2017-11-14 御盛隆堂药业有限责任公司 A kind of substituted pyrrolidine carboxylic acid's ester type compound and its preparation method and application
CN108698989B (en) * 2016-02-10 2021-05-11 住友化学株式会社 Process for the preparation of 1-methylpyrrolidin-3-ol
CA3030772A1 (en) 2016-08-02 2018-02-08 Dermira, Inc. Processes for making, and methods of using, glycopyrronium compounds
WO2020250116A1 (en) 2019-06-10 2020-12-17 Novartis Ag Pyridine and pyrazine derivative for the treatment of cf, copd, and bronchiectasis
KR20220052934A (en) 2019-08-28 2022-04-28 노파르티스 아게 Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of diseases
TW202140550A (en) 2020-01-29 2021-11-01 瑞士商諾華公司 Methods of treating an inflammatory or obstructive airway disease using anti-tslp antibody

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2956062A (en) * 1959-02-26 1960-10-11 Robins Co Inc A H Esters of amino alcohols
US3301869A (en) * 1960-05-16 1967-01-31 Robins Co Inc A H Methobromide and hydrochloride of 1-ethyl-3-pyrrolidyl benzilate
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
FR2155927A1 (en) 1971-10-15 1973-05-25 Synthelabo 1-phenylcyclo hexane carboxylic acid esters - with antispasmodic and anticholinergic activity
JPS5679688A (en) * 1979-12-04 1981-06-30 Ota Seiyaku Kk 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production
WO1997013766A1 (en) * 1995-10-13 1997-04-17 Banyu Pharmaceutical Co., Ltd. Substituted heteroaromatic derivatives
ATE238280T1 (en) * 1996-11-11 2003-05-15 Christian R Noe USE OF A PHARMACEUTICALLY APPLICABLE SALT OF (3R,2'R)-3-((CYCLOPENTYL-HYDROXYPHENYLACETYL)OXY)-1,1-DIMETHYL-PYRROLIDINIUM FOR THE PRODUCTION OF A MEDICINAL PRODUCT
US6613795B2 (en) * 1996-11-11 2003-09-02 Christian Noe Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments
ES2165768B1 (en) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
JP5124074B2 (en) * 2000-06-30 2013-01-23 コクレア リミテッド Cochlear implant
US6846835B2 (en) * 2000-07-11 2005-01-25 Banyu Pharmaceutical Co., Ltd. Ester derivatives
US7174126B2 (en) * 2002-05-03 2007-02-06 Time Warner Interactive Video Group Inc. Technique for effectively accessing programming listing information in an entertainment delivery system

Also Published As

Publication number Publication date
WO2003087094A3 (en) 2004-03-18
TW200403237A (en) 2004-03-01
RU2004133371A (en) 2005-08-10
AU2003233967B2 (en) 2009-08-06
ES2206021B1 (en) 2005-08-01
US7192978B2 (en) 2007-03-20
CO5611106A2 (en) 2006-02-28
NZ535884A (en) 2007-11-30
AU2003233967A1 (en) 2003-10-27
ZA200408335B (en) 2005-11-02
IL164522A0 (en) 2005-12-18
MXPA04010076A (en) 2004-12-13
CN100548978C (en) 2009-10-14
CA2482536A1 (en) 2003-10-23
CN1662527A (en) 2005-08-31
AR039412A1 (en) 2005-02-16
UA79283C2 (en) 2007-06-11
NO20044826L (en) 2005-01-14
UY27760A1 (en) 2003-11-28
EP1497284A2 (en) 2005-01-19
PE20040409A1 (en) 2004-07-14
US20050282875A1 (en) 2005-12-22
RU2320657C2 (en) 2008-03-27
WO2003087094A2 (en) 2003-10-23
BR0309167A (en) 2005-01-25
ES2206021A1 (en) 2004-05-01
US20070129420A1 (en) 2007-06-07

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