CO4970829A1 - Polimorfo antifungico cristalino - Google Patents

Polimorfo antifungico cristalino

Info

Publication number
CO4970829A1
CO4970829A1 CO98057733A CO98057733A CO4970829A1 CO 4970829 A1 CO4970829 A1 CO 4970829A1 CO 98057733 A CO98057733 A CO 98057733A CO 98057733 A CO98057733 A CO 98057733A CO 4970829 A1 CO4970829 A1 CO 4970829A1
Authority
CO
Colombia
Prior art keywords
antifungal
crystalline polymorph
polymorph
triazol
phenyl
Prior art date
Application number
CO98057733A
Other languages
English (en)
Inventor
David R Andrews
William Leong
Anantha R Sudhakar
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO4970829A1 publication Critical patent/CO4970829A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describe la Forma I del polimorfo cristalino de(-)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorofenil)te-trahidro-5-(1H-1,2,4-triazol-1-ilmetil)furan-3-il]metoxi]fenil]-1-piperazinil]fenil-2,4-dihidro-2-[(S)-1-etil-2(S)-hidroxilpropil]-3H-1,2,4-triazol- 3-ona representado por la fórmula I:composiciones farmacéuticas que contienen dicho polimorfo y métodos para utilizar este tipo de polimorfo en el tratamiento de infecciones fúngicas en mamíferos.
CO98057733A 1997-10-07 1998-10-05 Polimorfo antifungico cristalino CO4970829A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94618397A 1997-10-07 1997-10-07

Publications (1)

Publication Number Publication Date
CO4970829A1 true CO4970829A1 (es) 2000-11-07

Family

ID=25484068

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98057733A CO4970829A1 (es) 1997-10-07 1998-10-05 Polimorfo antifungico cristalino

Country Status (31)

Country Link
EP (1) EP1021439B1 (es)
JP (4) JP2001519346A (es)
KR (1) KR100626109B1 (es)
CN (1) CN1125067C (es)
AR (1) AR015947A1 (es)
AT (1) ATE263163T1 (es)
AU (1) AU759982B2 (es)
BR (1) BR9812866A (es)
CA (1) CA2305803C (es)
CO (1) CO4970829A1 (es)
CZ (1) CZ299835B6 (es)
DE (1) DE69822859T2 (es)
DK (1) DK1021439T3 (es)
ES (1) ES2217594T3 (es)
HK (1) HK1029588A1 (es)
HU (1) HU225233B1 (es)
ID (1) ID29290A (es)
IL (1) IL135331A (es)
IN (1) IN1998CH02232A (es)
MX (1) MX225999B (es)
MY (1) MY130126A (es)
NO (1) NO318827B1 (es)
NZ (1) NZ503662A (es)
PE (1) PE120499A1 (es)
PH (1) PH11998002606B1 (es)
PL (1) PL189317B1 (es)
PT (1) PT1021439E (es)
SK (1) SK285190B6 (es)
TW (1) TW589310B (es)
WO (1) WO1999018097A1 (es)
ZA (1) ZA989063B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2130540A1 (en) * 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
WO2011003992A1 (en) 2009-07-09 2011-01-13 Sandoz Ag A crystalline form of posaconazole
WO2011144653A1 (en) 2010-05-19 2011-11-24 Sandoz Ag Process for the preparation of chiral triazolones
AU2011254658B2 (en) 2010-05-19 2016-02-18 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
CN102892750B (zh) 2010-05-19 2016-03-02 桑多斯股份公司 制备手性酰肼的方法
WO2011144656A1 (en) 2010-05-19 2011-11-24 Sandoz Ag Preparation of posaconazole intermediates
CA2838051C (en) 2011-06-16 2019-09-24 Sandoz Ag Process for the preparation of a chiral compound
EP2758385B1 (en) * 2011-09-19 2018-03-28 MSN Laboratories Limited Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof
MX370849B (es) * 2013-07-25 2020-01-08 Sandoz Ag Proceso mejorado para preparar la forma cristalina iv del posaconazol.
ITMI20132118A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132114A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132115A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132117A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
KR102331856B1 (ko) 2014-10-21 2021-11-29 다케다 야쿠힌 고교 가부시키가이샤 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-｛2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민
CN104387374A (zh) * 2014-10-21 2015-03-04 江苏恒盛药业有限公司 泊沙康唑晶型i的制备工艺
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
EP3590505A1 (en) 2015-08-08 2020-01-08 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole
UY37046A (es) 2015-12-24 2017-07-31 Takeda Pharmaceuticals Co Cocristal, método de produccion del mismo,y medicamento que contiene dicho cocristal
EP4424308A2 (en) 2016-02-26 2024-09-04 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
TR201722493A2 (tr) 2017-12-28 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon
EP4196096A1 (en) 2020-08-13 2023-06-21 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant high-strength formulation containing posaconazole
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole
AU2022324717A1 (en) 2021-11-25 2024-06-13 Alfred E. Tiefenbacher (Gmbh Und Co. Kg) Granules containing posaconazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
AU681753B2 (en) * 1993-12-21 1997-09-04 Merck Sharp & Dohme Corp. Tetrahydrofuran antifungals
NZ278882A (en) * 1994-01-24 1997-06-24 Janssen Pharmaceutica Nv Piperazine-containing azole antifungal compounds
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
ATE240319T1 (de) * 1995-06-02 2003-05-15 Schering Corp Antifungale tetrahydrofurane

Also Published As

Publication number Publication date
WO1999018097A1 (en) 1999-04-15
CZ299835B6 (cs) 2008-12-10
JP2012153730A (ja) 2012-08-16
ID29290A (id) 2001-08-16
IN1998CH02232A (es) 2005-03-04
IL135331A0 (en) 2001-05-20
HUP0004899A2 (hu) 2002-02-28
PH11998002606B1 (en) 2006-08-10
PT1021439E (pt) 2004-07-30
DE69822859T2 (de) 2005-01-27
ES2217594T3 (es) 2004-11-01
PL339659A1 (en) 2001-01-02
CZ20001264A3 (cs) 2000-08-16
AU759982B2 (en) 2003-05-01
MX225999B (es) 2005-02-02
ATE263163T1 (de) 2004-04-15
CA2305803C (en) 2009-12-22
NO20001779L (no) 2000-06-06
KR100626109B1 (ko) 2006-09-20
NO318827B1 (no) 2005-05-09
JP2001519346A (ja) 2001-10-23
HK1029588A1 (en) 2001-04-06
EP1021439B1 (en) 2004-03-31
BR9812866A (pt) 2000-08-08
PE120499A1 (es) 1999-12-04
SK285190B6 (sk) 2006-08-03
CN1281449A (zh) 2001-01-24
AR015947A1 (es) 2001-05-30
NO20001779D0 (no) 2000-04-06
JP2012153729A (ja) 2012-08-16
ZA989063B (en) 1999-04-06
HUP0004899A3 (en) 2002-03-28
IL135331A (en) 2005-08-31
HU225233B1 (en) 2006-08-28
DE69822859D1 (de) 2004-05-06
CA2305803A1 (en) 1999-04-15
AU9780398A (en) 1999-04-27
TW589310B (en) 2004-06-01
EP1021439A1 (en) 2000-07-26
NZ503662A (en) 2002-10-25
MY130126A (en) 2007-06-29
DK1021439T3 (da) 2004-05-10
MXPA00003404A (es) 2000-11-01
JP2008106075A (ja) 2008-05-08
PL189317B1 (pl) 2005-07-29
SK5122000A3 (en) 2000-09-12
CN1125067C (zh) 2003-10-22
KR20010030959A (ko) 2001-04-16

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