BR9812866A - Polimorfo antifúngico cristalino - Google Patents

Polimorfo antifúngico cristalino

Info

Publication number
BR9812866A
BR9812866A BR9812866-3A BR9812866A BR9812866A BR 9812866 A BR9812866 A BR 9812866A BR 9812866 A BR9812866 A BR 9812866A BR 9812866 A BR9812866 A BR 9812866A
Authority
BR
Brazil
Prior art keywords
polymorph
crystalline
antifungal
phenyl
crystalline antifungal
Prior art date
Application number
BR9812866-3A
Other languages
English (en)
Inventor
David R Andrews
William Leong
Anantha R Sudhakar
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9812866A publication Critical patent/BR9812866A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Patente de Invenção: <B>"POLIMORFO ANTIFúNGICO CRISTALINO"<D>. São descritas a forma I do polimorfo cristalino de (-)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorfenil)tetrahidro-5-(1H-1,2,4-triazol- 1-ilmetil)furan-3-il]-metóxi]fenil]-1-piperazinil]fenil]-2,4-dihidro-2-[(S)-1- etil-2(S)-hidroxipropil]-3H-1,2,4-triazol-3-ona, representada pela fórmula (I) composições farmacêuticas contendo tal polimorfo e métodos de uso de tal polimorfo para tratar infecções fúngicas em mamíferos.
BR9812866-3A 1997-10-07 1998-10-05 Polimorfo antifúngico cristalino BR9812866A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94618397A 1997-10-07 1997-10-07
PCT/US1998/020476 WO1999018097A1 (en) 1997-10-07 1998-10-05 Crystalline antifungal polymorph

Publications (1)

Publication Number Publication Date
BR9812866A true BR9812866A (pt) 2000-08-08

Family

ID=25484068

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812866-3A BR9812866A (pt) 1997-10-07 1998-10-05 Polimorfo antifúngico cristalino

Country Status (31)

Country Link
EP (1) EP1021439B1 (pt)
JP (4) JP2001519346A (pt)
KR (1) KR100626109B1 (pt)
CN (1) CN1125067C (pt)
AR (1) AR015947A1 (pt)
AT (1) ATE263163T1 (pt)
AU (1) AU759982B2 (pt)
BR (1) BR9812866A (pt)
CA (1) CA2305803C (pt)
CO (1) CO4970829A1 (pt)
CZ (1) CZ299835B6 (pt)
DE (1) DE69822859T2 (pt)
DK (1) DK1021439T3 (pt)
ES (1) ES2217594T3 (pt)
HK (1) HK1029588A1 (pt)
HU (1) HU225233B1 (pt)
ID (1) ID29290A (pt)
IL (1) IL135331A (pt)
IN (1) IN1998CH02232A (pt)
MX (1) MX225999B (pt)
MY (1) MY130126A (pt)
NO (1) NO318827B1 (pt)
NZ (1) NZ503662A (pt)
PE (1) PE120499A1 (pt)
PH (1) PH11998002606B1 (pt)
PL (1) PL189317B1 (pt)
PT (1) PT1021439E (pt)
SK (1) SK285190B6 (pt)
TW (1) TW589310B (pt)
WO (1) WO1999018097A1 (pt)
ZA (1) ZA989063B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2130540A1 (en) * 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) * 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
WO2011003992A1 (en) 2009-07-09 2011-01-13 Sandoz Ag A crystalline form of posaconazole
BR112012029226A2 (pt) 2010-05-19 2015-10-20 Sandoz Ag processo para a preparação de um composto quiral, composto quiral cristalino, sal de hcl do composto quiral cristalino, composto quiral e uso do composto
RU2585760C2 (ru) * 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
MX2012013331A (es) 2010-05-19 2013-02-01 Sandoz Ag Purificacion de posaconazol y de intermediarios de posaconazol.
MX337804B (es) 2010-05-19 2016-03-18 Sandoz Ag Proceso para la preparacion de hidrazinas quirales.
CN103635465A (zh) 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
WO2013042138A2 (en) * 2011-09-19 2013-03-28 Msn Laboratories Limited Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof
CN105579448B (zh) 2013-07-25 2018-12-21 桑多斯股份公司 制备泊沙康唑的晶型iv的改进方法
ITMI20132115A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132117A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132118A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
ITMI20132114A1 (it) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
AU2015335950B2 (en) 2014-10-21 2018-01-25 Takeda Pharmaceutical Company Limited Crystalline forms of 5-chloro-N4-[-2-(dimethylphosphoryl) phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl}pyrimidine-2,4-diamine
CN104387374A (zh) * 2014-10-21 2015-03-04 江苏恒盛药业有限公司 泊沙康唑晶型i的制备工艺
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
WO2017025292A1 (en) 2015-08-08 2017-02-16 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant formulation containing posaconazole
SG11201805331QA (en) 2015-12-24 2018-07-30 Takeda Pharmaceuticals Co Cocrystal, production method thereof, and medicament containing cocrystal
EP4424308A2 (en) 2016-02-26 2024-09-04 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
TR201722493A2 (tr) 2017-12-28 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon
WO2022034232A1 (en) 2020-08-13 2022-02-17 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant high-strength formulation containing posaconazole
AU2022324717A1 (en) 2021-11-25 2024-06-13 Alfred E. Tiefenbacher (Gmbh Und Co. Kg) Granules containing posaconazole
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
ES2159623T3 (es) * 1993-12-21 2001-10-16 Schering Corp Antifungicos de tetrahidrofurano.
WO1995019983A1 (en) * 1994-01-24 1995-07-27 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
CA2197672C (en) * 1995-06-02 2011-05-17 Anil K. Saksena Tetrahydrofuran antifungals

Also Published As

Publication number Publication date
KR100626109B1 (ko) 2006-09-20
PL339659A1 (en) 2001-01-02
CN1281449A (zh) 2001-01-24
JP2001519346A (ja) 2001-10-23
IN1998CH02232A (pt) 2005-03-04
DE69822859D1 (de) 2004-05-06
NO318827B1 (no) 2005-05-09
CA2305803A1 (en) 1999-04-15
HUP0004899A2 (hu) 2002-02-28
PL189317B1 (pl) 2005-07-29
SK5122000A3 (en) 2000-09-12
PT1021439E (pt) 2004-07-30
NO20001779L (no) 2000-06-06
CZ20001264A3 (cs) 2000-08-16
JP2012153729A (ja) 2012-08-16
CZ299835B6 (cs) 2008-12-10
CO4970829A1 (es) 2000-11-07
PH11998002606B1 (en) 2006-08-10
CA2305803C (en) 2009-12-22
PE120499A1 (es) 1999-12-04
NO20001779D0 (no) 2000-04-06
EP1021439A1 (en) 2000-07-26
HU225233B1 (en) 2006-08-28
EP1021439B1 (en) 2004-03-31
WO1999018097A1 (en) 1999-04-15
CN1125067C (zh) 2003-10-22
NZ503662A (en) 2002-10-25
AU9780398A (en) 1999-04-27
ZA989063B (en) 1999-04-06
TW589310B (en) 2004-06-01
HUP0004899A3 (en) 2002-03-28
MX225999B (es) 2005-02-02
IL135331A0 (en) 2001-05-20
DK1021439T3 (da) 2004-05-10
JP2008106075A (ja) 2008-05-08
ES2217594T3 (es) 2004-11-01
MXPA00003404A (es) 2000-11-01
ID29290A (id) 2001-08-16
SK285190B6 (sk) 2006-08-03
AU759982B2 (en) 2003-05-01
JP2012153730A (ja) 2012-08-16
IL135331A (en) 2005-08-31
ATE263163T1 (de) 2004-04-15
DE69822859T2 (de) 2005-01-27
KR20010030959A (ko) 2001-04-16
HK1029588A1 (en) 2001-04-06
MY130126A (en) 2007-06-29
AR015947A1 (es) 2001-05-30

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO ESTABECIDO NOS ART. 8O, 13 E 24 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B25E Requested change of name of applicant rejected

Owner name: SCHERING CORPORATION (US)

B25H Request for change of headquarter rejected

Owner name: SCHERING CORPORATION (US)