PE20000328A1 - Azoles - Google Patents

Azoles

Info

Publication number
PE20000328A1
PE20000328A1 PE1999000171A PE00017199A PE20000328A1 PE 20000328 A1 PE20000328 A1 PE 20000328A1 PE 1999000171 A PE1999000171 A PE 1999000171A PE 00017199 A PE00017199 A PE 00017199A PE 20000328 A1 PE20000328 A1 PE 20000328A1
Authority
PE
Peru
Prior art keywords
cyanophenyl
triazol
refers
trifluorophenil
hydroxibutyl
Prior art date
Application number
PE1999000171A
Other languages
English (en)
Inventor
Shigeyasu Ichihara
Jun Ohwada
Nobuo Shimma
Tadakatsu Hayase
Pingli Liu
Masao Tsukazaki
Toshikazu Yamazaki
Toshiya Sakai
Yoshiaki Isshiki
Isao Umeda
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20000328A1 publication Critical patent/PE20000328A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE AZOL DE FORMULA I, DONDE R14 Y R15 SON H o F; T ES UN GRUPO T1 o T2; R9 ES PIRROLIDINILO, A-NH-B-; A ES H, ALQUILO C1-C5; B ES ALQUILENO C1-C4, -CH2-CONH-CH2; -CH2CH2CH2-CH(NH2); X ES UN ANION. SON COMPUESTOS PREFERIDOS BROMURO DE 1-[(2R, 3R)-3-[4-(4-CIANOFENIL)-TIAZOL-2-IL]-2-(2,4,5-TRIFLUOROFENIL)-2-HIDROXIBUTIL]-4-[(S)-3,5-DIMETIL-4-(PIRROLIDIN-2-CARBONILOXI)-BENCIL]-1H-[1,2,4]TRIAZOL-4-ONIO; (2R,3R)-3-[4-(4-CIANOFENIL)TIAZOL-2-IL)]-1-(1H-1,2,4-TRIAZOL-1-IL)-2-(2,4,5-TRIFLUOROFENIL)-BUTAN-2-OL, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO TOPICO O SISTEMICO DE INFECCIONES FUNGICAS Y MICOSIS
PE1999000171A 1998-03-06 1999-03-02 Azoles PE20000328A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98104036 1998-03-06
EP98123310 1998-12-08
EP99101360 1999-01-26

Publications (1)

Publication Number Publication Date
PE20000328A1 true PE20000328A1 (es) 2000-05-08

Family

ID=27239027

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000171A PE20000328A1 (es) 1998-03-06 1999-03-02 Azoles

Country Status (6)

Country Link
US (1) US6300353B1 (es)
AR (1) AR018303A1 (es)
AU (1) AU2931399A (es)
MA (1) MA27677A1 (es)
PE (1) PE20000328A1 (es)
WO (1) WO1999045008A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812238B1 (en) 1999-11-02 2004-11-02 Basilea Pharmaceutica Ag N-substituted carbamoyloxyalkyl-azolium derivatives
ES2238341T3 (es) * 1999-11-02 2005-09-01 Basilea Pharmaceutica Ag Derivados de carbamoiloxialquilazoles sustituidos por n.
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
CA2822457C (en) 2001-12-14 2016-03-08 The University Of Wyoming Methods and compositions for controlled resease of drugs
ATE508122T1 (de) 2003-07-18 2011-05-15 Kaneka Corp Optisch aktives halogenhydrinderivat und verfahren zur herstellung eines optisch aktiven epoxyalkoholderivats davon
JP4404611B2 (ja) * 2003-11-27 2010-01-27 住友化学株式会社 エポキシトリアゾール化合物の製造方法及びその中間体
DE102004059725A1 (de) 2004-12-11 2006-06-22 Bayer Cropscience Ag 2-Alkyl-cycloalk(en)yl-carboxamide
DK1954264T3 (da) 2005-12-01 2010-01-11 Basilea Pharmaceutica Ag Fremgangsmåde til fremstilling af epoxybutanol-mellemprodukter
WO2009024590A2 (en) 2007-08-21 2009-02-26 Basilea Pharmaceutica Ag Antifungal composition
US8207352B2 (en) * 2009-10-08 2012-06-26 Drug Process Licensing Associates LLC Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
ES2616412T3 (es) 2012-08-07 2017-06-13 Basilea Pharmaceutica Ag Proceso para la producción de isavuconazol o ravuconazol
WO2015150947A1 (en) * 2014-03-29 2015-10-08 Wockhardt Limited A process for the preparation of isavuconazole and its intermediates
WO2016055918A1 (en) 2014-10-08 2016-04-14 Wockhardt Limited Novel stable polymorphs of isavuconazole or its salt thereof
CN106565699B (zh) * 2015-10-10 2019-07-26 江苏正大丰海制药有限公司 一种艾沙康唑硫酸盐晶体及其制备方法
CN105367528A (zh) * 2015-11-10 2016-03-02 南通诺泰生物医药技术有限公司 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法
CN105777740B (zh) * 2016-02-24 2018-03-27 苏州金点生物科技有限公司 一种艾沙康唑的制备方法
WO2018149359A1 (zh) * 2017-02-17 2018-08-23 武汉朗来科技发展有限公司 三氮唑抗菌衍生物、其药物组合物和用途
CN108558846B (zh) * 2018-05-17 2020-07-07 天津莱茵泰克生物科技有限公司 艾莎康唑中间体的合成方法及其应用
CN110498774A (zh) * 2018-05-18 2019-11-26 上海医药工业研究院 一种艾沙康唑中间体的制备方法
WO2021245590A1 (en) * 2020-06-04 2021-12-09 Metrochem Api Private Limited An improved process for the preparation of triazole derivatives
CN115215850B (zh) * 2021-04-19 2024-08-16 同济大学 一种四氮唑醇类化合物、制备方法以及一种抗真菌药物
JP7454905B2 (ja) * 2021-09-28 2024-03-25 旭化成ファーマ株式会社 有効成分であるイサブコナゾール又はそのプロドラッグを含有する真菌症治療及び／又は予防剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861879A (en) 1983-02-28 1989-08-29 Janssen Pharmaceutica N.V. [[4-[4-Phenyl-1-piperazinyl)phenoxymethyl]-1-3-dioxolan-2-yl]-methyl]-1H-imidazoles and 1H-1,2,4-triazoles
GB9107055D0 (en) * 1991-04-04 1991-05-22 Pfizer Ltd Triazole antifungal agents
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
NZ328607A (en) 1996-09-09 1999-08-30 Hoffmann La Roche Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions
AU726495B2 (en) * 1996-09-09 2000-11-09 F. Hoffmann-La Roche Ag N-benzylazolium derivatives

Also Published As

Publication number Publication date
AR018303A1 (es) 2001-11-14
US6300353B1 (en) 2001-10-09
MA27677A1 (fr) 2006-01-02
AU2931399A (en) 1999-09-20
WO1999045008A1 (en) 1999-09-10

Similar Documents

Publication Publication Date Title
PE20000328A1 (es) Azoles
KR890006593A (ko) 아르마타제 억제4(5)- 이미다졸
KR910021398A (ko) 트리아졸 항진균제
KR900003157A (ko) 트리아졸 항진균제
CA2388320A1 (en) N-substituted carbamoyloxyalkyl-azolium derivatives
WO2001072714A3 (en) Aryl substituted pyrazoles, triazoles and tetrazoles as sodium channel blocker
EA199800633A1 (ru) Новые замещенные производные имидазола
JP2011508774A5 (es)
BR9608591A (pt) Compostos de imidazol
CA2301093A1 (en) Fluoropyrazole-biphenylamide fungicides
AR015391A1 (es) DERIVADOS DE COMPUESTOS HETEROAROMATICOS, COMPOSICION FARMACÉUTICA Y USO DE LOS MISMOS EN LA FABRICACIoN DE MEDICAMENTOS.
KR940005616A (ko) 아졸 화합물, 그의 제법 및 용도
CO4970829A1 (es) Polimorfo antifungico cristalino
RS50209B (sr) Derivati pirazolokarboksilne kiseline, njihova priprema, farmaceutske kompozicije sa sadržajem istih
ATE73799T1 (de) Derivate des ((4-(4-(4-phenyl-1piperazinyl)phenoxymethyl>-1,3-dioxolan2yl>methyl>-1h-imidazol und 1h-1,2,4-triazol.
PE20001419A1 (es) COMPLEJO DEL INHIBIDOR DE RAS-FARNESILTRANSFERASA Y SULFOBUTILETER-7-ß-CICLODEXTRINA O 2-HIDROXIPROPIL-ß-CICLODEXTRINA Y METODO
JP2001519346A5 (es)
PH31217A (en) Triazole and imidazole compounds and their use as antifungal therapeutic agents.
DE59200199D1 (de) Fungizide Mischung.
WO2001036425A3 (de) Imidazolverbindungen als phosphodiesterase vii-hemmer
MXPA02011039A (es) Combinaciones de productos activos fungicidas.
PL365072A1 (en) Azole compounds as therapeutic agents for fungal infections
BRPI0610423B8 (pt) sal de mono-lisina de di-hidrogênio fosfato de ((2r, 3r)-3-(4-(4-cianofenil)-tiazol-2-il)-2-(2,4-difluorofenil)-1-(1h-1,2,4-triazol-1-il)butan-2-iloxi)metila, solvatos do mesmo, composição farma-cêutica compreendendo os mesmos, uso do dito sal para tratar infecções fúngicas e processos para preparar ditos sal e sol- vato
PE20050440A1 (es) Derivados de n-heterociclo sustituidos para modificar la recaptacion de monoaminas
PE20010954A1 (es) Bencimidazoles, su preparacion y su empleo como medicamentos

Legal Events

Date Code Title Description
FC Refusal